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Immunocompetent host and mortality-related coccidioidomycosis: A case report and narrative review 免疫功能宿主和死亡率相关的球孢子菌病：一个病例报告和叙述回顾
IF 1.3
Medical Mycology Case Reports Pub Date : 2026-03-01 Epub Date: 2026-01-21 DOI: 10.1016/j.mmcr.2026.100766
Efrén Rafael Ríos-Burgueño , Luis Antonio Ochoa-Ramírez , Ismael Velarde-Rodríguez , Juan Manuel Ramírez-Sánchez , Víctor Michael Salinas-Torres , Jesús Salvador Velarde-Félix
{"title":"Immunocompetent host and mortality-related coccidioidomycosis: A case report and narrative review","authors":"Efrén Rafael Ríos-Burgueño ,&nbsp;Luis Antonio Ochoa-Ramírez ,&nbsp;Ismael Velarde-Rodríguez ,&nbsp;Juan Manuel Ramírez-Sánchez ,&nbsp;Víctor Michael Salinas-Torres ,&nbsp;Jesús Salvador Velarde-Félix","doi":"10.1016/j.mmcr.2026.100766","DOIUrl":"10.1016/j.mmcr.2026.100766","url":null,"abstract":"<div><div>Coccidioidomycosis, caused by <em>Coccidioides</em> infection, is typically subclinical and self-limited in immunocompetent patients. Occupational soil exposure, age ≥55 years, pregnancy, comorbidities, or immunosuppression states are common contributors to disease progression and potential mortality. This report describes a 34-year-old woman from Northwest Mexico, without evident risk factors, who presented chest pain and odynophagia as initial clinical symptoms and died at the 19th day of progressive clinical evolution consequence of pulmonary coccidioidomycosis. Findings in this report, along with those reviewed from the literature, highlight potential disparities that may be helpful in limited clinical settings, so eventual mortality-related coccidioidomycosis can be prevented.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"51 ","pages":"Article 100766"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146078046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subcutaneous abscess caused by Chondrostereum purpureum, an unusual infection from plant to human: The first case report in a transplant recipient 由紫软骨肿引起的皮下脓肿，一种罕见的植物到人的感染：首例移植接受者的病例报告
IF 1.3
Medical Mycology Case Reports Pub Date : 2026-03-01 Epub Date: 2026-02-26 DOI: 10.1016/j.mmcr.2026.100775
Piriya Kijacharoenchai , Arsa Thammahong , Natavudh Townamchai , Jakapat Vanichanan
{"title":"Subcutaneous abscess caused by Chondrostereum purpureum, an unusual infection from plant to human: The first case report in a transplant recipient","authors":"Piriya Kijacharoenchai ,&nbsp;Arsa Thammahong ,&nbsp;Natavudh Townamchai ,&nbsp;Jakapat Vanichanan","doi":"10.1016/j.mmcr.2026.100775","DOIUrl":"10.1016/j.mmcr.2026.100775","url":null,"abstract":"<div><div>Filamentous basidiomycetes have been recognized as emerging causes of human infection. <em>Schizophyllum commune</em> is the most frequently reported, whereas infections caused by other species are exceedingly rare. We report a case of subcutaneous abscess caused <em>by Chondrostereum purpureum</em> in a kidney transplant recipient. Definitive identification was achieved by sequencing the internal transcribed spacer and the D1/D2 regions. The patient was successfully treated with the surgical procedure and oral posaconazole. This report emphasizes the potential pathogenicity of plant fungi and the importance of molecular tools for identification.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"51 ","pages":"Article 100775"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147397150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An invasive Aspergillus flavus infection in an extremely preterm neonate: a case report 侵袭性黄曲霉感染在一个极早产新生儿：1例报告
IF 1.3
Medical Mycology Case Reports Pub Date : 2026-03-01 Epub Date: 2025-12-11 DOI: 10.1016/j.mmcr.2025.100757
Neema Pithia , Margie Morgan , Thea Tagliaferro , Priya R. Soni
{"title":"An invasive Aspergillus flavus infection in an extremely preterm neonate: a case report","authors":"Neema Pithia ,&nbsp;Margie Morgan ,&nbsp;Thea Tagliaferro ,&nbsp;Priya R. Soni","doi":"10.1016/j.mmcr.2025.100757","DOIUrl":"10.1016/j.mmcr.2025.100757","url":null,"abstract":"<div><div>Extremely preterm neonates are at heightened risk for invasive fungal infections. We report a fatal case of <em>Aspergillus flavus</em> infection in a 25-week infant, outlining the clinical course, antifungal treatment, and challenges in management. This case highlights the need for early recognition, rapid biopsy and aggressive therapy in vulnerable neonates.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"51 ","pages":"Article 100757"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Allergic bronchopulmonary aspergillosis in a patient without history of asthma: a case report 无哮喘史的过敏性支气管肺曲菌病1例
IF 1.3
Medical Mycology Case Reports Pub Date : 2026-03-01 Epub Date: 2026-02-05 DOI: 10.1016/j.mmcr.2026.100770
Mengying Zhang, Ting Jiao, Wei Li
{"title":"Allergic bronchopulmonary aspergillosis in a patient without history of asthma: a case report","authors":"Mengying Zhang,&nbsp;Ting Jiao,&nbsp;Wei Li","doi":"10.1016/j.mmcr.2026.100770","DOIUrl":"10.1016/j.mmcr.2026.100770","url":null,"abstract":"<div><div>Allergic bronchopulmonary aspergillosis (ABPA) is a pulmonary hypersensitivity disease triggered by <em>Aspergillus fumigatus</em>. While the standard first-line therapy per International Society for Human and Animal Mycology (ISHAM) guidelines is glucocorticoids or itraconazole alone, combination therapy may be used briefly for rapid symptom control. We present a 39-year-old man without asthma who presented with cough and sputum. Chest computed tomography (CT) revealed diagnostic findings of central bronchiectasis and high-attenuation mucus, later confirmed as mucus plugs by bronchoscopy. Bronchoalveolar lavage fluid (BALF) metagenomic next-generation sequencing (mNGS) detected a high load of <em>A. fumigatus</em>. Markedly elevated total IgE, <em>A. fumigatus</em>-specific IgE, and eosinophils confirmed ABPA. Although initial voriconazole monotherapy failed, adding oral glucocorticoids led to rapid clinical and radiographic improvement. No recurrence was observed on CT 7 months post-treatment, reinforcing that asthma is not a prerequisite for ABPA diagnosis.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"51 ","pages":"Article 100770"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146188987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rituximab-associated cryptococcal meningitis in systemic lupus erythematosus: A case report 系统性红斑狼疮伴利妥昔单抗隐球菌性脑膜炎1例报告
IF 1.3
Medical Mycology Case Reports Pub Date : 2026-03-01 Epub Date: 2026-01-20 DOI: 10.1016/j.mmcr.2026.100762
Sheyla Cadena , Ricardo Bedón-Galarza , Miguel Cachumba , Fabricio González-Andrade , Lucy Baldeón-Rojas
{"title":"Rituximab-associated cryptococcal meningitis in systemic lupus erythematosus: A case report","authors":"Sheyla Cadena ,&nbsp;Ricardo Bedón-Galarza ,&nbsp;Miguel Cachumba ,&nbsp;Fabricio González-Andrade ,&nbsp;Lucy Baldeón-Rojas","doi":"10.1016/j.mmcr.2026.100762","DOIUrl":"10.1016/j.mmcr.2026.100762","url":null,"abstract":"<div><div>We report a 41-year-old woman with systemic lupus erythematosus who developed cryptococcal meningitis five months after a second rituximab cycle. Initial symptoms mimicked an SLE flare, delaying diagnosis. Worsening neurologic deficits prompted lumbar puncture, revealing findings consistent with fungal meningitis and CSF culture positive for <em>Cryptococcus neoformans</em>. Treatment with amphotericin B and fluconazole resulted in clinical improvement, highlighting the diagnostic challenges and the need for early evaluation in immunosuppressed SLE patients.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"51 ","pages":"Article 100762"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146038159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uncommon clinical presentations and diagnostic difficulties of antiphospholipid syndrome associated with cryptococcal meningitis: A case study 与隐球菌性脑膜炎相关的抗磷脂综合征的罕见临床表现和诊断困难：一个病例研究
IF 1.3
Medical Mycology Case Reports Pub Date : 2026-03-01 Epub Date: 2026-01-07 DOI: 10.1016/j.mmcr.2026.100760
Zhengxiang Lv , Xiaodong Liu , Ping Xu
{"title":"Uncommon clinical presentations and diagnostic difficulties of antiphospholipid syndrome associated with cryptococcal meningitis: A case study","authors":"Zhengxiang Lv ,&nbsp;Xiaodong Liu ,&nbsp;Ping Xu","doi":"10.1016/j.mmcr.2026.100760","DOIUrl":"10.1016/j.mmcr.2026.100760","url":null,"abstract":"<div><div>Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by thrombosis and obstetric morbidity. We report a 23-year-old female with APS who developed cryptococcal meningitis (CM) following immunosuppressive therapy. Diagnosed via cerebrospinal fluid (CSF) culture and MRI showing infarction, she had concomitant renal and hepatic failure, making amphotericin B contraindicated. Consequently, an individualized regimen comprising voriconazole and 5-fluorocytosine (5-FC) was initiated, resulting in significant clinical improvement. This case underscores that CM is a serious opportunistic infection in patients undergoing immunosuppression for APS, highlighting the need for vigilant monitoring and tailored antifungal strategies for multi-organ dysfunction.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"51 ","pages":"Article 100760"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146078044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Skull base invasive aspergillosis in a peritoneal dialysis patient: A rare and devastating complication 腹膜透析患者的颅底侵袭性曲霉病：一种罕见且破坏性的并发症
IF 1.3
Medical Mycology Case Reports Pub Date : 2026-03-01 Epub Date: 2025-12-23 DOI: 10.1016/j.mmcr.2025.100758
Nattapakorn Mai-on , Rubash Nath Yogi , Piyaporn Towangnang , Talerngsak Kanjanabuch
{"title":"Skull base invasive aspergillosis in a peritoneal dialysis patient: A rare and devastating complication","authors":"Nattapakorn Mai-on ,&nbsp;Rubash Nath Yogi ,&nbsp;Piyaporn Towangnang ,&nbsp;Talerngsak Kanjanabuch","doi":"10.1016/j.mmcr.2025.100758","DOIUrl":"10.1016/j.mmcr.2025.100758","url":null,"abstract":"<div><div><em>Aspergillus</em> mastoiditis with skull base osteomyelitis is an exceptionally rare but life-threatening infection in patients undergoing peritoneal dialysis (PD). We report a 60-year-old man with diabetic kidney failure on PD who developed invasive <em>Aspergillus flavus</em> mastoiditis progressing to skull base osteomyelitis. Despite early mastoidectomy, PD catheter removal, and voriconazole therapy achieving therapeutic levels, the infection advanced to involve the carotid sheath and parapharyngeal space, resulting in severe neurologic and systemic complications. Molecular sequencing confirmed <em>A. flavus</em>, excluding cryptic species such as <em>A. tamarii</em>. This case represents the first documented instance of skull base invasive aspergillosis in a PD patient and underscores the importance of early suspicion, species-level molecular confirmation, and multidisciplinary management in this formidable and rapidly progressive condition.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"51 ","pages":"Article 100758"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145841752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isolated knee septic arthritis revealing disseminated coccidioidomycosis without apparent pulmonary involvement: A case report 孤立性膝脓毒性关节炎表现为弥散性球孢子菌病，无明显肺部累及：1例报告
IF 1.3
Medical Mycology Case Reports Pub Date : 2026-03-01 Epub Date: 2026-01-05 DOI: 10.1016/j.mmcr.2026.100759
Elias Ledezma Flores , Arturo Urias Pompa , Ariadna Betsabel Heredia Pulido , César Noé López Barrón
{"title":"Isolated knee septic arthritis revealing disseminated coccidioidomycosis without apparent pulmonary involvement: A case report","authors":"Elias Ledezma Flores ,&nbsp;Arturo Urias Pompa ,&nbsp;Ariadna Betsabel Heredia Pulido ,&nbsp;César Noé López Barrón","doi":"10.1016/j.mmcr.2026.100759","DOIUrl":"10.1016/j.mmcr.2026.100759","url":null,"abstract":"<div><div>Coccidioidomycosis is an endemic fungal infection that rarely presents as isolated osteoarticular disease in immunocompetent hosts. We report a case of disseminated coccidioidomycosis manifesting as chronic septic arthritis of the tibiofemoral joint without apparent pulmonary involvement in a 32-year-old male. Diagnostic delay and initial immunosuppressive therapy contributed to disease progression. Histopathology confirmed the diagnosis and combined surgical debridement and prolonged antifungal therapy led to favorable outcomes. This case highlights the importance of considering fungal etiologies in chronic monoarthritis in endemic regions.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"51 ","pages":"Article 100759"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145978203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bury my axe in wounded knee: A case of native knee septic arthritis caused by multidrug resistant Lomentospora prolificans 把我的斧头埋在受伤的膝盖上：由多药耐药的增殖性番茄孢子虫引起的原发性膝脓毒性关节炎一例。
IF 1.3
Medical Mycology Case Reports Pub Date : 2026-03-01 Epub Date: 2026-02-21 DOI: 10.1016/j.mmcr.2026.100774
Weston Carpenter , Catherine Pulaski , Alexander Hahn , Brenton Nash , Michael Sobieraj , Jeffrey Aeschlimann , Lisa M. Chirch
{"title":"Bury my axe in wounded knee: A case of native knee septic arthritis caused by multidrug resistant Lomentospora prolificans","authors":"Weston Carpenter ,&nbsp;Catherine Pulaski ,&nbsp;Alexander Hahn ,&nbsp;Brenton Nash ,&nbsp;Michael Sobieraj ,&nbsp;Jeffrey Aeschlimann ,&nbsp;Lisa M. Chirch","doi":"10.1016/j.mmcr.2026.100774","DOIUrl":"10.1016/j.mmcr.2026.100774","url":null,"abstract":"<div><div>A 39-year-old male presenting with swelling and pain in the left knee after traumatic injury was diagnosed with rapidly progressive septic arthritis of the knee due to pan-resistant <em>Lomentospora prolificans</em>. While <em>L. prolificans</em> is an environmental mold, it infrequently causes infection in immunocompetent patients. These hosts most commonly suffer soft tissue or osteoarticular infections following direct, often traumatic inoculation, as opposed to the disseminated infection seen in patients with profound immunocompromise. This report describes a case of osteoarticular infection following traumatic inoculation in an immunocompetent host. Following several unsuccessful attempts at repeated incision and drainage alongside salvage antifungal therapy, the patient was successfully treated with olorofim, a novel investigational antifungal agent.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"51 ","pages":"Article 100774"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147379644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insect-related sporotrichosis oculoglandular syndrome: A case report 昆虫相关孢子虫病眼腺综合征1例报告
IF 1.3
Medical Mycology Case Reports Pub Date : 2026-03-01 Epub Date: 2026-01-17 DOI: 10.1016/j.mmcr.2026.100765
Kosol Kampitak , Thanat Kampitak , Naree Warnnissorn , Arvemas Watcharakorn , Worakit Kaewnopparat , Panarat Hematulin
{"title":"Insect-related sporotrichosis oculoglandular syndrome: A case report","authors":"Kosol Kampitak ,&nbsp;Thanat Kampitak ,&nbsp;Naree Warnnissorn ,&nbsp;Arvemas Watcharakorn ,&nbsp;Worakit Kaewnopparat ,&nbsp;Panarat Hematulin","doi":"10.1016/j.mmcr.2026.100765","DOIUrl":"10.1016/j.mmcr.2026.100765","url":null,"abstract":"<div><div>Sporotrichosis oculoglandular syndrome is an infectious disease caused by the thermodimorphic fungus <em>Sporothrix</em> species. Humans can become accidentally infected through vegetative trauma and contact with cats. However, there are no reported cases of this disease being transmitted by insects. In this report, we present a case of insect-related sporotrichosis oculoglandular syndrome.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"51 ","pages":"Article 100765"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146078045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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