发布求助
文献互助 智能选刊 最新文献

Obstetric Medicine最新文献

筛选
英文 中文
Postpartum cardiogenic shock with rapid recovery in a Titin gene variant: The role of genetic predisposition in peripartum cardiomyopathy 产后心源性休克与快速恢复的Titin基因变异:遗传易感性在围产期心肌病中的作用
Obstetric Medicine Pub Date : 2023-11-13 DOI: 10.1177/1753495x231214379
Eva Karner, Hans Keller, Lilian Schäffl-Doweik, Franco Laccone, Claudia Stöllberger
{"title":"Postpartum cardiogenic shock with rapid recovery in a Titin gene variant: The role of genetic predisposition in peripartum cardiomyopathy","authors":"Eva Karner, Hans Keller, Lilian Schäffl-Doweik, Franco Laccone, Claudia Stöllberger","doi":"10.1177/1753495x231214379","DOIUrl":"https://doi.org/10.1177/1753495x231214379","url":null,"abstract":"Peripartum cardiomyopathy is defined as heart failure secondary to left ventricular (LV) dysfunction with a left ventricular ejection fraction <45% occurring towards the end of pregnancy or in the months following delivery without other identifiable cause. Pathogenesis of peripartum cardiomyopathy and the role of genetic variants are unknown. We present a previously healthy 33-year-old woman in her first pregnancy with acute onset of heart failure postpartum. She developed cardiogenic shock four days after caesarean section and was treated with levosimendan, cabergoline, ramipril and bisoprolol. She used a wearable cardioverter/defibrillator for 3 months. After 8 months, she was free of symptoms with normal left ventricular function and brain-natriuretic-peptide-levels. Genetic analysis was carried out due to a positive family history and disclosed a heterozygous variant c7627dupA in the TTN gene. Genetic analysis in patients with a positive family history should be carried out since that may provide insights in the pathogenesis of heart failure due to systolic dysfunction including peripartum cardiomyopathy.","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":"128 11","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136351585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Postpartum diagnosis and management of pulmonary arterial hypertension 肺动脉高压的产后诊断与处理
Obstetric Medicine Pub Date : 2023-10-30 DOI: 10.1177/1753495x231207436
Micaela J Tobin, Gianna L Wilkie, Alejandro Folch, Margaret M Cabral, Theo E Meyer, Lara C Kovell
{"title":"Postpartum diagnosis and management of pulmonary arterial hypertension","authors":"Micaela J Tobin, Gianna L Wilkie, Alejandro Folch, Margaret M Cabral, Theo E Meyer, Lara C Kovell","doi":"10.1177/1753495x231207436","DOIUrl":"https://doi.org/10.1177/1753495x231207436","url":null,"abstract":"A 38-year-old female who was found to have severe pulmonary arterial hypertension (PAH) secondary to HIV in the postpartum period. This case illustrates the treatment and challenges of postpartum PAH. It also demonstrates the need for expert guidance and additional research on the optimal management of PAH in pregnancy and postpartum.","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136067744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Late pregnancy in women with renal transplants: A multidisciplinary guide 肾移植后晚期妊娠:多学科指南
Obstetric Medicine Pub Date : 2023-10-26 DOI: 10.1177/1753495x231209647
Carmen Mallett, Rachel Scale, Yavor Metodiev, Aamna Ali, Helen Thomas, Usman Khalid, Sian Griffin
{"title":"Late pregnancy in women with renal transplants: A multidisciplinary guide","authors":"Carmen Mallett, Rachel Scale, Yavor Metodiev, Aamna Ali, Helen Thomas, Usman Khalid, Sian Griffin","doi":"10.1177/1753495x231209647","DOIUrl":"https://doi.org/10.1177/1753495x231209647","url":null,"abstract":"Kidney transplant recipients are at risk of complications in late pregnancy, with increased rates of pre-eclampsia, intrauterine growth restriction and preterm birth. It is recommended that these women receive more intensive monitoring after 20 weeks’ gestation, ideally provided by a multidisciplinary team in a tertiary centre. This review focuses on the management of late pregnancy in kidney transplant recipients, from the perspective of different members of the multidisciplinary team. This includes evidence and guidance to inform the nephrologist, obstetrician, obstetric anaesthetist, transplant surgeon, midwife, and a summary of the woman's perspective. The review outlines a late pregnancy and early postnatal care pathway as a common algorithm to be used by the whole multidisciplinary team.","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135017826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thalassemia screening by third-generation sequencing: Pilot study in a Thai population 通过第三代测序筛查地中海贫血:在泰国人群中的试点研究
Obstetric Medicine Pub Date : 2023-10-26 DOI: 10.1177/1753495x231207676
Kuntharee Traisrisilp, Yu Zheng, Kwong Wai Choy, Pimlak Chareonkwan
{"title":"Thalassemia screening by third-generation sequencing: Pilot study in a Thai population","authors":"Kuntharee Traisrisilp, Yu Zheng, Kwong Wai Choy, Pimlak Chareonkwan","doi":"10.1177/1753495x231207676","DOIUrl":"https://doi.org/10.1177/1753495x231207676","url":null,"abstract":"Background Conventional thalassemia screening takes a stepwise approach and has limitations in comprehensively identifying all spectrums of mutations. This study aimed to investigate the performance of third-generation sequencing (TGS) compared to conventional molecular testing. Methods TGS was applied to validate all known variants detected by conventional testing and to detect missing variants in undiagnosed cases. The study was conducted at Maharaj Nakorn Chiang Mai Hospital between December 2021 and April 2022. Results In total, 19 cases were included in this study, among which 52.6% (10/19) had known thalassemia variants, while 47.7% (9/19) cases were undiagnosed by conventional methods. All 16 variants previously detected were validated by TGS, and TGS additionally detected 43.8% (7/16) thalassemia variants for 36.8% (7/19) cases. Conclusion TGS could provide additional genetic diagnoses compared with conventional methods. Further cost-effectiveness studies with a larger sample size are needed to explore the role of TGS in clinical practices.","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":"104 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135013367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Report of the ISTH registry on pregnancy and COVID-19-associated coagulopathy (COV-PREG-COAG) ISTH妊娠和covid -19相关凝血功能(COV-PREG-COAG)登记报告
Obstetric Medicine Pub Date : 2023-10-16 DOI: 10.1177/1753495x231206931
Sajida Kazi, Maha Othman, Rasha Khoury, Peter S Bernstein, Jecko Thachil, Etienne Ciantar, Laura Ferrara, Manju Netto, Rezan Abdul-Kadir, A Kinga Malinowski
{"title":"Report of the ISTH registry on pregnancy and COVID-19-associated coagulopathy (COV-PREG-COAG)","authors":"Sajida Kazi, Maha Othman, Rasha Khoury, Peter S Bernstein, Jecko Thachil, Etienne Ciantar, Laura Ferrara, Manju Netto, Rezan Abdul-Kadir, A Kinga Malinowski","doi":"10.1177/1753495x231206931","DOIUrl":"https://doi.org/10.1177/1753495x231206931","url":null,"abstract":"Background Concerns about COVID-19-associated coagulopathy (CAC) in pregnant individuals were raised in early pandemic. Methods An ISTH-sponsored COVID-19 coagulopathy in pregnancy (COV-PREG-COAG) international registry was developed to describe incidence of coagulopathy, VTE, and anticoagulation in this group. Results All pregnant patients with COVID-19 from participating centers were entered, providing 430 pregnancies for the first pandemic wave. Isolated abnormal coagulation parameters were seen in 20%; more often with moderate/severe disease than asymptomatic/mild disease (49% vs 15%; p < 0.0001). No one met the ISTH criteria for DIC, though 5/21 (24%) met the pregnancy DIC score. There was no difference in APH with asymptomatic/mild disease versus moderate/severe disease (3.4% vs 7.7%; p = 0.135). More individuals with moderate/severe disease experienced PPH (22.4% vs 9.3%; p = 0.006). There were no arterial thrombotic events. Only one COVID-associated VTE was reported. Conclusions Low rates of coagulopathy, bleeding, and thrombosis were observed among pregnant people in the first pandemic wave.","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136078840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigating gastrointestinal disorders in pregnancy 调查妊娠期胃肠道疾病
Obstetric Medicine Pub Date : 2023-10-16 DOI: 10.1177/1753495x231206211
Adam Morton
{"title":"Investigating gastrointestinal disorders in pregnancy","authors":"Adam Morton","doi":"10.1177/1753495x231206211","DOIUrl":"https://doi.org/10.1177/1753495x231206211","url":null,"abstract":"This article reviews anatomical and physiological changes and alterations in reference intervals for laboratory tests in healthy pregnancy, pertinent to investigation of the gastrointestinal system. The safety of procedures and radiological investigations relevant to the investigation of gastrointestinal disorders in pregnancy are also reviewed.","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":"94 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136079046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pregnancy in women with nephrotic-range proteinuria: A retrospective cohort study 肾病性蛋白尿妇女的妊娠:一项回顾性队列研究
Obstetric Medicine Pub Date : 2023-10-09 DOI: 10.1177/1753495x231201896
Shuli Svetitsky, Liz Lightstone, Kate Wiles
{"title":"Pregnancy in women with nephrotic-range proteinuria: A retrospective cohort study","authors":"Shuli Svetitsky, Liz Lightstone, Kate Wiles","doi":"10.1177/1753495x231201896","DOIUrl":"https://doi.org/10.1177/1753495x231201896","url":null,"abstract":"Background Obstetric and kidney outcomes following detection of nephrotic-range proteinuria in early pregnancy have not been well described. Methods A retrospective cohort study of chronic kidney disease (CKD) in pregnancy between 2008 and 2018. Outcomes in those with nephrotic-range proteinuria before 20 weeks’ gestation were compared to those without nephrotic-range proteinuria. Results The study included 37 women with nephrotic-range proteinuria and 62 women without. Pre-pregnancy estimated glomerular filtration rate (eGFR) was similar. Nephrotic-range proteinuria was associated with higher rates of preterm (odds ratio [OR] 1.77, 95% confidence interval [CI]: 1.07–2.92) and early preterm delivery (OR 2.63, 95% CI: 1.12–6.2), and with a requirement for renal replacement therapy at 3 years post-partum (OR 10.72, 95% CI: 2.58–44.47). Tubulointerstitial scarring on kidney biopsy was associated with early preterm delivery and progression to advanced CKD, independent of pre-pregnancy eGFR. Conclusion Compared to CKD without nephrotic-range proteinuria, nephrotic-range proteinuria early in pregnancy is associated with higher rates of pre-term delivery and progression to advanced CKD.","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135146749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blinding lights: Acute persistent vision loss in pregnancy 致盲光:妊娠期急性持续性视力丧失
Obstetric Medicine Pub Date : 2023-09-24 DOI: 10.1177/1753495x231200658
Marie Leung, Ilia Ostrovski, Melin Peng-Franklin, Ahraaz Wyne
{"title":"Blinding lights: Acute persistent vision loss in pregnancy","authors":"Marie Leung, Ilia Ostrovski, Melin Peng-Franklin, Ahraaz Wyne","doi":"10.1177/1753495x231200658","DOIUrl":"https://doi.org/10.1177/1753495x231200658","url":null,"abstract":"Acute persistent vision loss in pregnancy is an emergent presentation with a broad differential and should prompt rapid assessment and treatment of the underlying etiology. In pregnancy, causes can include preeclampsia, severe gestational hypertension, and hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome. Nonobstetrically related etiologies that can exacerbate in pregnancy include optic neuritis, giant cell arteritis, central retinal artery occlusion, or retinal detachment. In this case report, we describe a case of acute vision loss due to Purtscher's-like retinopathy, a rare but serious complication of pancreatitis in pregnancy. To our knowledge, this is the first published case of Purtscher's-like retinopathy in pregnancy unrelated to preeclampsia. Given the impact of permanent visual loss associated with Purtscher's-like retinopathy, more research is needed to determine treatments to substantively improve outcomes.","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135925571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful multi-disciplinary management of anti-NMDAR encephalitis during pregnancy 妊娠期抗nmdar脑炎的成功多学科管理
Obstetric Medicine Pub Date : 2023-09-20 DOI: 10.1177/1753495x231190594
Clare Margaret Crowley, Nyan Chin Liew, Consol Plans, Sinead O’Brien, Mendinaro Imcha
{"title":"Successful multi-disciplinary management of anti-NMDAR encephalitis during pregnancy","authors":"Clare Margaret Crowley, Nyan Chin Liew, Consol Plans, Sinead O’Brien, Mendinaro Imcha","doi":"10.1177/1753495x231190594","DOIUrl":"https://doi.org/10.1177/1753495x231190594","url":null,"abstract":"The comorbid presentation of anti-NMDAR encephalitis with ovarian teratomas was first described in 2005. The incidence of anti-NMDAR encephalitis during pregnancy is rare, with 16 cases reported to date. We describe the case of a 31-year-old nulliparous woman who presented with status epilepticus in early pregnancy and was subsequently diagnosed with anti-NMDAR encephalitis. The inter-hospital transfer was required for higher-level care and ventilation. A comprehensive work-up identified anti-NMDAR antibodies in both serum and cerebrospinal fluid. Pelvic imaging showed a unilateral ovarian cyst, proceeding to right salpingo-oophorectomy and cystectomy of a mature cystic teratoma. Post-operatively, she was admitted to the intensive care unit for two months. Immunotherapy was commenced, and clinical status improved. She recovered well and at 35 weeks and 2 days of gestation delivered a live male infant via uncomplicated caesarean section. We discuss the diagnostic steps and multi-disciplinary management to care for this pregnant patient.","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136314024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An audit of CTPA and V/Q scan for investigation of pulmonary embolism in pregnancy CTPA和V/Q扫描检查妊娠期肺栓塞的审计
Obstetric Medicine Pub Date : 2023-09-11 DOI: 10.1177/1753495x231197563
Romy Ehrlich, Sandra Lowe
{"title":"An audit of CTPA and V/Q scan for investigation of pulmonary embolism in pregnancy","authors":"Romy Ehrlich, Sandra Lowe","doi":"10.1177/1753495x231197563","DOIUrl":"https://doi.org/10.1177/1753495x231197563","url":null,"abstract":"Background Pulmonary embolism (PE) can be fatal yet difficult to diagnose in pregnancy. Computed tomography pulmonary angiogram (CTPA) or ventilation/perfusion (V/Q) scans are often conducted, potentially leading to low positive scan rates. Methods Retrospective data analysis was conducted for pregnant women and non-pregnant age-matched control who underwent CTPA and/or V/Q scan for investigation of PE. The main outcomes were the positive and non-diagnostic imaging rates. Results In total, 440 women underwent V/Q or CTPA scans, 86 of whom were pregnant (19.5%). The positive scan rate was 3.5% and 8.8% in the pregnant and non-pregnant groups, respectively ( p = 0.1). The non-diagnostic scan rate was similar between pregnant and non-pregnant groups (13.9% vs 9.9%, p = 0.3). Within the pregnant group, there were more non-diagnostic CTPAs than V/Q scans ( p = 0.005). Conclusion Our study confirms a low positive imaging rate and a relatively high non-diagnostic CTPA rate in pregnancy. Newer strategies are needed to reduce the number of negative imaging studies conducted.","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136023646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信