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Pregnancy-associated pulmonary embolism (PA-PE): catheter-directed thrombolysis as first-line rescue. 妊娠相关性肺栓塞（PA-PE）：导管引导溶栓作为一线抢救措施。
IF 0.5
Obstetric Medicine Pub Date : 2024-10-15 eCollection Date: 2025-09-01 DOI: 10.1177/1753495X241290662
Suzanne Luong, Wei-Yun Mak, Daniel L Rolnik, Ryan Hodges, Yang Yang, Yen Chieng, Timothy Crozier
{"title":"Pregnancy-associated pulmonary embolism (PA-PE): catheter-directed thrombolysis as first-line rescue.","authors":"Suzanne Luong, Wei-Yun Mak, Daniel L Rolnik, Ryan Hodges, Yang Yang, Yen Chieng, Timothy Crozier","doi":"10.1177/1753495X241290662","DOIUrl":"10.1177/1753495X241290662","url":null,"abstract":"<p><p>Pregnancy-associated pulmonary embolism (PA-PE) is a life-threatening presentation however literature surrounding its optimal management is limited. This case describes a case of PA-PE treated with catheter-directed thrombolysis after clinical deterioration despite standard anticoagulation therapy. Careful multidisciplinary planning is required to successfully manage the deteriorating patient with PA-PE with catheter-directed thrombolysis being considered as potential first-line therapy in these patients.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"197-199"},"PeriodicalIF":0.5,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Familial chylomicronaemia syndrome in pregnancy - report of two cases managed with plasma exchange. 妊娠期家族性乳糜微粒血症综合征--两例血浆置换治疗病例的报告。
IF 0.5
Obstetric Medicine Pub Date : 2024-09-19 eCollection Date: 2025-09-01 DOI: 10.1177/1753495X241283628
Francois Dos Santos, Shahenaz Walji, Jaimini Cegla, Sheba Jarvis, Catherine Nelson-Piercy
{"title":"Familial chylomicronaemia syndrome in pregnancy - report of two cases managed with plasma exchange.","authors":"Francois Dos Santos, Shahenaz Walji, Jaimini Cegla, Sheba Jarvis, Catherine Nelson-Piercy","doi":"10.1177/1753495X241283628","DOIUrl":"10.1177/1753495X241283628","url":null,"abstract":"<p><p>Familial chylomicronaemia syndrome (FCS) is a rare genetic disorder characterised by significantly elevated triglyceride levels which increases the risk of acute pancreatitis. Due to the changes in lipid metabolism during pregnancy, triglyceride levels may rise further, particularly in the third trimester, and cause challenges in the management of these patients. Apart from strict dietary restriction of all fats, there is limited evidence on the efficacy of pharmacological treatment with omega-3 fatty acids and fibrates in maintaining triglyceride levels below the desired threshold of 10 mmol/L. Familial chylomicronaemia syndromes are particularly resistant to treatment and escalation of treatment to more invasive procedures such as plasma exchange may be required in pregnancy. We present two cases of FCS in pregnancy which posed different challenges and both required management with plasma exchange but led to the safe delivery near term without adverse consequences to the mother or fetus.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"186-189"},"PeriodicalIF":0.5,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Does having a patient attend a postpartum vascular risk reduction clinic improve physician knowledge and management of preeclampsia as a cardiovascular risk factor? 让患者参加产后血管风险降低门诊是否能提高医生对作为心血管风险因素的子痫前期的认识和管理？
IF 0.5
Obstetric Medicine Pub Date : 2024-09-17 eCollection Date: 2025-09-01 DOI: 10.1177/1753495X241275847
Jaslyn Rasmuson, Winnie W Sia
{"title":"Does having a patient attend a postpartum vascular risk reduction clinic improve physician knowledge and management of preeclampsia as a cardiovascular risk factor?","authors":"Jaslyn Rasmuson, Winnie W Sia","doi":"10.1177/1753495X241275847","DOIUrl":"10.1177/1753495X241275847","url":null,"abstract":"<p><strong>Background: </strong>Preeclampsia is an independent risk factor for vascular diseases. The Postpartum Preeclampsia Clinic (PPPC) intervenes in the first year postpartum to address these risks. This study aims to characterize physicians' understanding and management of the cardiovascular risk associated with preeclampsia and whether this differs in physicians who had a patient attend the PPPC.</p><p><strong>Methods: </strong>Family physicians, obstetricians, internists, obstetric internists, and cardiologists in Edmonton were anonymously surveyed. Results were analyzed using SPSS.</p><p><strong>Results: </strong>Sixty-four surveys were returned, with physicians correctly identifying preeclampsia as a vascular risk factor 73% of the time. Physicians who had a patient attend the PPPC were more likely to counsel patients on their increased cardiovascular risk, although increased knowledge did not reach statistical significance.</p><p><strong>Conclusion: </strong>Vascular risk reduction clinics may benefit the long-term management of patients with a history of preeclampsia by improving counseling by physicians, which may reduce the disproportionate vascular morbidity these patients face.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"157-166"},"PeriodicalIF":0.5,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preconception and antenatal care for women with a history of haematopoietic stem cell transplantation: Results of a UK clinician survey. 为有造血干细胞移植史的妇女提供孕前和产前护理：英国临床医生调查结果。
IF 0.5
Obstetric Medicine Pub Date : 2024-09-04 eCollection Date: 2025-09-01 DOI: 10.1177/1753495X241272942
Katherine A Birchenall, Anna L David, Melanie Davies, Victoria Grandage, Melanie Griffin
{"title":"Preconception and antenatal care for women with a history of haematopoietic stem cell transplantation: Results of a UK clinician survey.","authors":"Katherine A Birchenall, Anna L David, Melanie Davies, Victoria Grandage, Melanie Griffin","doi":"10.1177/1753495X241272942","DOIUrl":"10.1177/1753495X241272942","url":null,"abstract":"<p><strong>Background: </strong>Female childhood cancer survivors with history of bone marrow transplant with or without total body irradiation have increased pregnancy risks. Preconception counselling and early referral to appropriate clinical pathways may improve pregnancy outcomes.</p><p><strong>Methods: </strong>UK-wide survey of clinicians, promoted via social media and conferences, jointly funded by Action Medical Research/Borne.</p><p><strong>Results: </strong>Forty responses received between 22 October 2020 and 21 October 2021: 43% reviewed this group monthly, 15% annually, 15% less than annually, and 27% never (for O & G only: 13%, 13%, 26%, and 48%, respectively).Pre-pregnancy, most discussed potential fertility/pregnancy implications.Early pregnancy discussions included late miscarriage (34%), preterm birth (44%), fetal growth restriction (31%), and health risks other than cancer (30%).During pregnancy: 80% refer to specialist clinics; 87% offer extra investigations; 33% prescribed aspirin; 20% offered cervical cerclage; and 13% prescribed progesterone.</p><p><strong>Conclusions: </strong>Evidence of variation in care. As previous observations suggest pregnancy outcomes improve when managed in specialist clinics, clearer guidance is required.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"167-173"},"PeriodicalIF":0.5,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extracellular vesicles: A potential new way to assess cholestasis. 细胞外囊泡：评估胆汁淤积症的潜在新方法。
IF 0.5
Obstetric Medicine Pub Date : 2024-09-01 Epub Date: 2024-07-25 DOI: 10.1177/1753495X241264325
Zivile Useckaite
{"title":"Extracellular vesicles: A potential new way to assess cholestasis.","authors":"Zivile Useckaite","doi":"10.1177/1753495X241264325","DOIUrl":"10.1177/1753495X241264325","url":null,"abstract":"<p><p>Extracellular vesicles (EVs) are small, nonreplicating, lipid-encapsulated nanoparticles that carry protein and nucleic acid cargo derived from their tissue of origin. Due to their capacity to provide comparable insights to solid organ biopsy through a minimally invasive collection procedure, EVs provide an attractive biomarker source. This review will provide an insight, how EVs in circulation may provide a novel way to assess cholestasis and will address the possibility of getting a better understanding of the mechanisms of cholestasis of pregnancy through the use of serial hepatic-specific EVs as a window.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":"17 3","pages":"179-183"},"PeriodicalIF":0.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11384818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142300560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Measuring bile acids: Are we all talking the same language? 测量胆汁酸：我们说的是同一种语言吗？
IF 0.5
Obstetric Medicine Pub Date : 2024-09-01 Epub Date: 2024-09-10 DOI: 10.1177/1753495X241259663
Corey Markus, Wm Bill Hague
{"title":"Measuring bile acids: Are we all talking the same language?","authors":"Corey Markus, Wm Bill Hague","doi":"10.1177/1753495X241259663","DOIUrl":"10.1177/1753495X241259663","url":null,"abstract":"<p><p>In this paper, we discuss the Bile Acid Comparison and Harmonisation project, a sub-study of the Trial of URsodeoxycholic acid vs RIFampicin in early-onset severe Intrahepatic Cholestasis of pregnancy, giving an overview of the current state of affairs for total bile acid measurements.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":"17 3","pages":"162-167"},"PeriodicalIF":0.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11384810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142300564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hanns-Ulrich Marschall (15.2.1954-1.8.2023). 汉斯-乌尔里希-马夏尔（Hanns-Ulrich Marschall）（15.2.1954-1.8.2023）。
IF 0.5
Obstetric Medicine Pub Date : 2024-09-01 Epub Date: 2024-09-10 DOI: 10.1177/1753495X241264961
{"title":"Hanns-Ulrich Marschall (15.2.1954-1.8.2023).","authors":"","doi":"10.1177/1753495X241264961","DOIUrl":"10.1177/1753495X241264961","url":null,"abstract":"","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":"17 3","pages":"137"},"PeriodicalIF":0.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11384817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142300561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ICP: A midwifery perspective. ICP：助产士的视角。
IF 0.5
Obstetric Medicine Pub Date : 2024-09-01 Epub Date: 2024-05-28 DOI: 10.1177/1753495X241257709
Annette Briley, Megan Cooper
{"title":"ICP: A midwifery perspective.","authors":"Annette Briley, Megan Cooper","doi":"10.1177/1753495X241257709","DOIUrl":"10.1177/1753495X241257709","url":null,"abstract":"<p><strong>Background: </strong>ICP is a liver condition specific to pregnancy affecting 0.5-0.6% of pregnancies in Australia.</p><p><strong>Aims: </strong>to review the SOMANZ guidelines and extrapolate information relevant to midwives proving care for women with ICP.</p><p><strong>Findings: </strong>Multidisciplinary input is essential in caring for women with ICP and their families. Non-fasting TSBA samples ≥19 µmol/L are diagnostic in the presence of pruritus. Peak TSBA denotes the severity of the disease. Increased risk of stillbirth is small when peak TSBA ≥100 µmol/L.</p><p><strong>Conclusion: </strong>Midwives play an essential role in supporting women with ICP helping them navigate complex appointments and manage the pruritus and concomitant issues.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":"17 3","pages":"152-156"},"PeriodicalIF":0.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11384816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142300562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meta-analyses in cholestatic pregnancy: The outstanding clinical questions. 胆汁淤积性妊娠的元分析：悬而未决的临床问题。
IF 0.8
Obstetric Medicine Pub Date : 2024-09-01 Epub Date: 2024-04-28 DOI: 10.1177/1753495X241251425
Nadejda Capatina, Caroline Ovadia
{"title":"Meta-analyses in cholestatic pregnancy: The outstanding clinical questions.","authors":"Nadejda Capatina, Caroline Ovadia","doi":"10.1177/1753495X241251425","DOIUrl":"https://doi.org/10.1177/1753495X241251425","url":null,"abstract":"<p><p>Reports of adverse pregnancy outcomes associated with maternal pruritus and liver impairment have circulated since the 1800s, yet the precise diagnosis and management of intrahepatic cholestasis of pregnancy have varied markedly. Recent evidence, including that from individual participant data meta-analyses, has provided an evidence that brings us closer to standardised, and optimal, management of the condition. Based upon increased adverse perinatal outcomes with higher bile acid concentrations, disease management should be according to severity (defined by peak bile acid concentration) in order to recommend appropriate gestation of birth. Similarly, the reduced spontaneous preterm birth rate for patients receiving ursodeoxycholic acid treatment suggests potential benefit for the treatment of patients with moderate-severe disease.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":"17 3","pages":"147-151"},"PeriodicalIF":0.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11384813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142300565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intrahepatic cholestasis of pregnancy: Introduction and overview 2024. 妊娠期肝内胆汁淤积症：简介和概述 2024。
IF 0.5
Obstetric Medicine Pub Date : 2024-09-01 Epub Date: 2024-09-10 DOI: 10.1177/1753495X241265772
Wm Bill Hague, Catherine Williamson, Ulrich Beuers
{"title":"Intrahepatic cholestasis of pregnancy: Introduction and overview 2024.","authors":"Wm Bill Hague, Catherine Williamson, Ulrich Beuers","doi":"10.1177/1753495X241265772","DOIUrl":"10.1177/1753495X241265772","url":null,"abstract":"<p><p>Considerable progress has been made to explain the aetiology of intrahepatic cholestasis of pregnancy (ICP) and of the adverse pregnancy outcomes associated with high maternal total serum bile acids (TSBAs). The reported thresholds for non-fasting TSBA associated with the risk of stillbirth and spontaneous preterm birth can be used to identify pregnancies at risk of these adverse outcomes to decide on appropriate interventions and to give reassurance to women with lower concentrations of TSBA. Data also support the use of ursodeoxycholic acid to protect against the risk of spontaneous preterm birth. A previous history of ICP may be associated with higher rates of subsequent hepatobiliary disease: if there is a suspicion of underlying susceptibility, clinicians caring for women with ICP should screen for associated disorders or for genetic susceptibility and, where appropriate, refer for ongoing hepatology review.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":"17 3","pages":"138-143"},"PeriodicalIF":0.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11384812/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142300563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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