Life and Science最新文献

{"title":"Role of Prophylactic Antibiotics in Preventing Stroke-Associated Pneumonia in Patients with Ischemic Stroke","authors":"Muhamad Jawad Aslam, Muhammad Amir, Tahir Mukhtar Sayed, Asif Hashmat, Maryam Hussain, Minahil Fatima","doi":"10.37185/lns.1.1.465","DOIUrl":"https://doi.org/10.37185/lns.1.1.465","url":null,"abstract":"Objective: To compare the frequency of stroke-associated pneumonia in patients given prophylactic antibiotics versus those not given prophylactic antibiotics.Study Design: Comparative Cross-sectional study.Place and Duration of Study: The study was carried out at the Department of Internal Medicine, Combined st st Military Hospital (CMH), Peshawar, Pakistan from 1 August 2022 to 31 January 2023.Methods: We included 250 ischemic stroke patients and divided them into groups A, “Prophylactic group,” and B, “no prophylactic antibiotics group.” Patients were assessed at 7 days after admission for presence of “stroke associated pneumonia (SAP)” through clinical examination and chest X-rays. Data were analyzed using a statistical package for social sciences 22. For qualitative variables, frequency and percentages were used, whereas for quantitative data, the median (IQR) was used as the data were not normally distributed and contained outliers; using the median and IQR can be more appropriate for describing the central tendency and spread of the data compared to the mean and standard deviation.Results: In our study, the median age of the patients was 68(46-83) years. 61 (24.40%) of the patients were male while 189(75.60%) were female. The median BMI was 31 (19-44) kg/m2. Diabetes was present in 123 (49.20%) patients and 96(38.40%) had hypertension. We found that in the the “prophylactic antibiotics” group (A), 9 (7.20%) patients developed SAP, while in the “no prophylactic antibiotics” group (B) frequency of SAP was 34 (27.20%) (p< 0.001).Conclusion: Prophylactic antibiotics used in “ischemic stroke” patients provide better outcomes by reducing the incidence of “stroke-associated pneumonia”. Therefore, it should be given to all patients admitted to the hospital with ischemic CVA. \u0000How to cite this: Aslam MJ, Amir M, Sayed TM, Hashmat A, Hussain M, Fatima M.Role of Prophylactic Antibiotics in Preventing Stroke Associated Pneumonia in Patients with Ischemic Stroke. Life and Science. 2024; 5(1): 82-88. doi: http://doi.org/10.37185/LnS.1.1.465","PeriodicalId":516717,"journal":{"name":"Life and Science","volume":"27 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140508214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Alpha Lipoic Acid on Oxidative Stress, Lipid Profile, and Blood Glucose Levels in Type 2 Diabetic Male Sprague Dawley Rats","authors":"Barkat Ullah Khan, Sidra Arshad, Faiza Ikram, Iftekhar Yousef, Inam Naizi, Muhammad Ismaeel","doi":"10.37185/405","DOIUrl":"https://doi.org/10.37185/405","url":null,"abstract":"Objective: To determine the effect of Alpha Lipoic Acid (ALA) on blood glucose, lipid profile, and oxidative stress in streptozotocin-induced type II diabetic male Sprague Dawley rats.Study Design: Laboratory-based experimental study.Place and Duration of the Study: The study was carried out at the Physiology Research Lab, Army Medical College, Rawalpindi, Pakistan, from 20th  January 2021 to 24th June 2021.Methods: Thirty Sprague Dawley (SD) rats were divided into three equal groups. Group I was given a normal standard rat diet. In Groups II and III after feeding a diet rich in fat and calories for 2 weeks, after feeding a diet rich in fat and calories for 2 weeks, a single low dose of streptozotocin was injected for Type 2 Diabetes Mellitus (T2DM) induction. Alpha Lipoic Acid 30 mg/kg body weight/day was administered intraperitoneally in Group III for 01 weeks after the development of T2DM.Results: The blood glucose, lipid profile, and serum Malondialdehyde levels were deranged in the diabetic group. After Alpha Lipoic Acid supplementation, the blood glucose levels, Serum MDA, and levels of triglycerides, cholesterol, and Low Density Lipoproteins decreased, whereas High Density Lipoproteins level were significantly raised (p <0.001) in group III as compared to the diabetic group II. Conclusion: Treatment with Alpha Lipoic Acid reduces oxidative stress and improve reduces oxidative stress and improves glycemic and lipid profiles in T2DM rats. \u0000How to cite this: khan BU, Arshad S, Ikram F, Yousef I, Naizi I, Ismaeel M. The Effects of Alpha Lipoic Acid on Oxidative Stress, Lipid Profile and Blood Glucose Levels in Type 2 Diabetic Male Sprague Dawley Rats. Life and Science. 2024; 5(1): 89-94. doi: http://doi.org/10.37185/LnS.1.1.405","PeriodicalId":516717,"journal":{"name":"Life and Science","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140507954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Early and Delayed Feeding after Elective Gut Anastomosis","authors":"Ghazanfar Jabbar, Mirza Sijeel Ahmed, Arsalan Sharif Malik, Shahzad Akhtar, F. Minhas, Muhammad Talha Makshoof, Zoha Shahid","doi":"10.37185/lns.1.1.411","DOIUrl":"https://doi.org/10.37185/lns.1.1.411","url":null,"abstract":"Objective: To compare the effects of early and delayed feeding after elective gut anastomosis in relation to a mean number of days of audible bowel sounds.Study Design: A cross-sectional study.Place and Duration of Study: The study was conducted at the Department of Surgery, Combined Military th th Hospital (CMH), Rawalpindi, Pakistan, from 11th May 2019 to 10th November 2019.Methods: A total of 60 individuals undergoing gut anastomosis were divided into two groups. In group A, the NG tube was removed within 6 to 24 hours of surgery, and clear oral liquids (30ml/hour) were started. Oral fluids, including juices and soups on the other day after surgery, tailed by semisolid food at 3rd day, then regular food at 4 day and finally discharge at the 5 day. In group B, the NG tube was detached three to five days after the procedure, observing NG tube output <30-50cc daily. Then, patients were followed up in post-surgical wards for 48 hours. Patients were noted and informed of the time when bowel sounds were audible, the first flatus passed, and the first stool passed. Results: The mean age in group A was 40.23 ± 15.66 years, and in group B was 37.93 ± 15.23 years. Most of the patients, 31 (51.67%), were between 16 to 30 years of age. Out of 60 patients, 36 (60.0%) were males and 24 (40.0%) were females, with male to female ratio of 1.5:1. The mean number of days of audible bowel sounds in Group A (early feeding) was 1.57 ± 0.63 days while in Group B (delayed feeding) was 3.90 ± 0.76 days (p-value = 0.0001). Conclusion: This research established that the outcome of early feeding is better than the outcome of delayed feeding after elective gut anastomosis. \u0000How to cite this: Jabbar G, Ahmed MS, Malik AS, Akhtar S, Minhas FS, Makshoof MT, Shahid Z. Comparison of Early and Delayed Feeding After Elective Gut Anastomosis. Life and Science. 2024; 5(1): 101-106. doi: http://doi.org/10.37185/LnS.1.1.411","PeriodicalId":516717,"journal":{"name":"Life and Science","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140508626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dengue Fever Perception and Knowledge for Endemicity Control among University Students of Karachi","authors":"Farhan M Qureshi, S. Bari, Saima Masood, Masood Wazir, Sehrish Zehra, A. Khalid","doi":"10.37185/lns.1.1.373","DOIUrl":"https://doi.org/10.37185/lns.1.1.373","url":null,"abstract":"Objective: To determine the knowledge and the risk perception regarding dengue fever among the educated population along with their behaviors towards prevention in the backdrop of rising cases of dengue at the national level.Study Design: Cross-sectional study.Place and Duration of Study: The study was carried out at the Departments of Electrical, Software Engineering, Computer Sciences and Geophysics of Bahria University, Karachi Campus, Pakistan, from October 2021 to March 2022.Methods: With an observational analytical study design, 333 students were recruited through convenient sampling. Data were collected using a structured questionnaire. The socio-demographic traits and general information about dengue fever spread and prevention were presented in frequencies and percentages while dengue fever knowledge, risk perception, and behavior of respondents were compared using a chi-square test with the significance level set at 0.05. Results: It was found that 79.8% of the students recognized that transmission of dengue is through mosquitoes, whereas only 17.4% identified the correct species of dengue infection. Twenty-two percent knew that dengue is a viral illness. Sixty-eight percent marked contaminated water as a mosquito breeding site, while 52.8% believed it to be trash/garbage. Eighty-nine, sixty-nine and fifty-two percent reported the use of window screens, bed nets/mesh, and insect repellents as protective measures, respectively. Fifty-seven percent of participants considered dengue a fatal illness. Eighty-eight and seventy-five percent recognized dengue as a preventable and curable disease, respectively. Conclusion: Educated participants in this study were misapprehensive that they had satisfactory knowledge, risk perception, and behavior toward dengue fever. Very few had the correct knowledge regarding transmission mode and spread and protective and preventive strategies. Information regarding transmission mode and spread, as well as protective and preventive strategies, were insufficient. \u0000How to cite this: Qureshi FM, Bari SF, Wazir SM, Wazir M, Zehra S, Khalid A. Dengue Fever Perception and Knowledge for Endemicity Control among University Students of Karachi Life and Science. 2024; 5(1): 75-82. doi: http://doi.org/10.37185/LnS.1.1.373","PeriodicalId":516717,"journal":{"name":"Life and Science","volume":"51 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140507730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Restless Leg Syndrome in Patients with Non-Dialysis Dependent Chronic Kidney Disease at Fatima Memorial Hospital Lahore: A Cross-sectional Study","authors":"Bilal Basit, Omer Sabir, Adnan Hussain Shahid, Andleeb Kanwal, Ghulam Abass Qadri, Nabiha Rizvi","doi":"10.37185/lns.1.1.516","DOIUrl":"https://doi.org/10.37185/lns.1.1.516","url":null,"abstract":"Objective: To determine the occurrence of restless leg syndrome in individuals with non-dialysis-dependent chronic kidney disease.Study Design: A descriptive cross-sectional study.Place and Duration of Study: The study was carried out at the Outpatient Department (OPD) of Fatima Memorial Hospital, Lahore, Pakistan, from March 2020 to August 2020.Methods: A total of 280 CKD patients not dependent on dialysis were included in the study. The data were collected through interviews containing questions from international restless leg syndrome study group (IRLSSG). Patients were stratified into different stages according to the estimated glomerular filtration rate (eGFR). Restless leg syndrome was diagnosed by analyzing the responses of the interview marked by the examiner. Results: Among 280 patients, 15.7% (n=44) of chronic kidney disease patients were noted to have restless leg syndrome. The syndrome was significantly more frequent in females and was associated with higher CKD stages (Stage V > Stage III and IV). There was no association with either age or BMI.Conclusion: Restless leg syndrome is more common in chronic kidney disease stage V as compared to lower chronic kidney disease stages (III & IV). If untreated, it can affect patients' quality of life and increase the risk of cardiovascular activities. \u0000How to cite this: Basit MB, Sabir O, Shahid AH, Kanwal A, Qadri GA, Rizvi N. Evaluation of Restless Leg Syndrome in Patients with NonDialysis Dependent Chronic Kidney Disease at Fatima Memorial Hospital Lahore: A Cross-sectional study. Life and Science. 2024; 5(1): 95-100.doi: http://doi.org/10.37185/LnS.1.1.516","PeriodicalId":516717,"journal":{"name":"Life and Science","volume":"95 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140507803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Accuracy of Serum Cystatin C for Early Detection of Kidney Damage in Patients with Type II Diabetes Mellitus: Bahawalpur, Pakistan","authors":"Iqra Sajid, Rabia Saeed, Arfa Goheer, Sameen Asghar, Sara Saqib, Fareeha Bashir","doi":"10.37185/lns.1.1.559","DOIUrl":"https://doi.org/10.37185/lns.1.1.559","url":null,"abstract":"Objective: To determine the diagnostic accuracy of serum Cystatin C for early detection of kidney damage taking albumin Creatinine Ratio as a reference standard among people of Bahawalpur having diabetes mellitus type 2.Study Design: A cross-sectional study.Place and Duration of Study: The Study was conducted at the Department of Pathology in collaboration with th th Kidney Center, Bahawalpur Victoria Hospital, Bahawalpur, Pakistan from 27 August 2021 to 26 February 2022.Methods: There was a total of 200 patients having diabetes mellitus type 2 with GFR between 60-90ml/min with an age range from 40-60 years were selected. Study participants with a history of steroid intake, hypothyroidism, chronic liver disease, AIDS, and hypertension were not included in the study. For assessment of diagnostic accuracy of Cystatin C to evaluate the renal damages in early stages, microalbuminuria was evaluated. As per the guidelines provided by the respective manufacturers, individuals exhibiting two albumin creatinine ratio (ACR) levels exceeding 30 mg/g were classified as having diabetic nephropathy (DN).Results: The overall sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of serum Cystatin C for the early detection of kidney damage, with albumin-to-creatinine ratio used as the reference standard among individuals with type 2 diabetes mellitus, were 90.98%, 78.21%, 86.72%, 84.72%, and 86.0%, respectively.Conclusion: The findings of this investigation indicate that serum cystatin C (CysC) exhibits a considerable level of diagnostic accuracy in the early detection of kidney damage among individuals with type 2 diabetes mellitus, utilizing the albumin-to-creatinine ratio as a reference standard.How to cite this: Sajid I, Saeed R, Goheer A, Asghar S, Saqib S, Bashir F. Diagnostic Accuracy of Serum Cystatin C for Early Detection of Kidney Damage in Patients with Type II Diabetes Mellitus: Bahawalpur, Pakistan. Life and Science. 2024; 5(1): 41-47. doi: http://doi.org/10.37185/LnS.1.1.559","PeriodicalId":516717,"journal":{"name":"Life and Science","volume":"50 3-4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140507832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Efficacy of Levofloxacin-Based Triple Therapy over Standard ClarithromycinBased Therapy for Eradication of Helicobacter Pylori","authors":"Haseeb Noor, Kazim Abbas Virk, Hyder Wajid Abbasi, S. Virk, Sara Shahid, Muhammad Erfan","doi":"10.37185/lns.1.1.462","DOIUrl":"https://doi.org/10.37185/lns.1.1.462","url":null,"abstract":"Objective: To compare a first-line Clarithromycin-based triple therapy to Levofloxacin-based triple therapy for eradicating H.Pylori.Study Design: Comparative analysis.Place and Duration of Study: The study was carried out at the Department of the Gastroenterology of Pakistan Institute of Medical Sciences (PIMS), Islamabad, Pakistan, from June 2021 to December 2021.Methods: A total of 200 patients were enrolled in this comparative study, conducted in the outpatient Department of Gastroenterology. A pretested questionnaire was used to gather the required information; a group was allocated to each patient, and a response was sent to each treatment group after random sampling. The primary outcome was a negative Urea Breath test 4 weeks after completion of treatment. Results: Out of 200 patients, 58 % (n=116) were males, and 39% (n= 84) were females. The mean age was 40.02 ± 24.4 years. Predominant presenting complaints were Retrosternal burning in 41 % (n=82), and pain and/or discomfort in the upper abdomen 34% (n=68). The response rate in the Clarithromycin based therapy group was 84% (n=84) out of 100 patients, while the response rate was 94% (n= 94) out of 100 in the Levofloxacin-based therapy group. Conclusion: Levofloxacin-based therapy is superior to Clarithromycin-based therapy in every age group and gender.How to cite this: Noor H, Virk KA, Abbasi HW, Virk ST, Shahid S, Erfan M. The Efficacy of Levofloxacin Based Triple Therapy over Standard Clarithromycin Based Therapy for Eradication of Helicobacter Pylori. Life and Science. 2024; 5(1): 61-67. doi: http://doi.org/10.37185/LnS.1.1.462","PeriodicalId":516717,"journal":{"name":"Life and Science","volume":"21 3-4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140507710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal Nerve Fiber Layer Thickness (RNFLT) in Myopic & Hypermetropic Eyes in a Subset of Pakistani Population","authors":"Sahrish Mukhtar, Nuzhat Hassan, M. Lakhani, Urooj Fatima, S. Shaheen, Iffat Raza","doi":"10.37185/lns.1.1.480","DOIUrl":"https://doi.org/10.37185/lns.1.1.480","url":null,"abstract":"Objective: This study aimed to evaluate retinal nerve fiber layer (RNFL) thickness in healthy individuals with myopic and hypermetropic eyes, using optical coherence tomography (OCT).Study Design: A cross-sectional study. Place and Duration of Study: The study was carried out at the Department of Ophthalmology, Dr. Akil bin Abdul Qadir Institute of Ophthalmology, Karachi, Pakistan from January 2015 to June 2015.Methods: In this study, 300 eyes were included were examined using standard protocols by a single examiner. Subjects with a history of diabetic or hypertensive retinopathy, raised intraocular pressure (> 21mmHg), and previous intraocular or laser surgery were excluded from the study. The mean retinal nerve fiber layer thickness was calculated in both myopic and hypermetropic eyes. Results: The mean global retinal nerve fiber layer thickness (RNFLT) in myopic eyes was found to be 93.98 ± 8.57 μm. In hypermetropic eyes, it was found to be 101.00 ± 6.58. This variation was found to be statistically significant with p-value of 0.001.Conclusion: We concluded that individuals with myopic eyes had significantly reduced retinal nerve fiber layer thickness whereas those with hypermetropic eyes showed an insignificant increase in RNFLT compared to emmetropic eyes.How to cite this: Mukhtar S, Hassan N, Lakhani M, Fatima U, Shaheen S, Raza I. Retinal Nerve Fiber Layer Thickness (RNFLT) in Myopic & Hypermetropic Eyes in a Subset of Pakistani Population. Life and Science. 2024; 5(1): 54-60. doi: http://doi.org/10.37185/LnS.1.1.480","PeriodicalId":516717,"journal":{"name":"Life and Science","volume":" 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139640592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Sonological Evaluation of Borderline Amniotic Fluid Index and Oligohydramnios-Its Correlation with Perinatal Outcomes","authors":"Saira Jamsheed, Khadijah Abid","doi":"10.37185/lns.1.1.378","DOIUrl":"https://doi.org/10.37185/lns.1.1.378","url":null,"abstract":"Objective: To evaluate the correlation of low borderline amniotic fluid index and oligohydramnios with perinatal outcomes among pregnant females presenting at the tertiary care hospital of Karachi. Study Design: Cross-sectional study.Place and Duration of Study: The study was conducted at the Department of Obstetrics and Gynecology, Hamdard University, Karachi, Pakistan, from March 2021 to March 2022.Methods: Females aged 18-45 years, with a gestational age of 20-42 weeks assessed on the last menstrual period and a single fetus on ultrasound were enrolled. The final sample size for the study was determined to be 260 with 130 participants in each group, i.e., the females with Amniotic Fluid Value (AFI) value of ≤5 cm considered as oligohydramnios (group-1) and AFI value of 5.1 to 8 cm considered as borderline AFI (group-2)The amniotic fluid index value was determined in all the females using ultrasonographic reports by the consultant physicians. Females were classified as having oligohydramnios if their amniotic fluid index value was less than 5 cm and borderline amniotic fluid index between 5.1 and 8 cm. To evaluate the maternal and perinatal outcomes, all females were monitored up to birth. Data was analyzed using SPSS version 23.Results: The mean maternal age was 29.85±5.45 years, and the mean BMI was 29.78±5.62 kg/m . Most of the females had gravida ≥1. Females with oligohydramnios had higher rates of low birth weight (84.6% vs. 51.5%, p=0.001), IUGR (68.5% vs. 22.3%, p=0.001), meconium staining (42.3% vs 7.7%, p=0.001), low APGAR score (50.8% vs. 13.8%, p=0.001), respiratory distress syndrome (72.3% vs 27.7%, p=0.001), birth asphyxia (65.4% vs 23.1%, p=0.001), NICU admission (73.8% vs. 43.1%, p=0.001), and neonatal death (21.5% vs. 5.4%, p=0.001) than women with borderline amniotic fluid index.Conclusion: This observational study demonstrates a significant correlation between oligohydramnios and adverse perinatal outcomes, emphasizing the importance of vigilant monitoring and intervention in pregnancies with low amniotic fluid. How to cite this: Jamsheed S, Abid K. Clinical and Sonological Evaluation of Borderline Amniotic Fluid Index and Oligohydramnios-Its Correlation with Perinatal Outcomes. Life and Science. 2024; 5(1): 16-21. doi: http://doi.org/10.37185/LnS.1.1.378","PeriodicalId":516717,"journal":{"name":"Life and Science","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140506612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ameliorative Effect of Vitamin D on Articular Cartilage Thickness in Arthritic Rat Model","authors":"A. Shahid, Huma Beenish, Tooba Khurshid, Amber Rashid, Uzma Shahid, Maimoona Khan","doi":"10.37185/lns.1.1.570","DOIUrl":"https://doi.org/10.37185/lns.1.1.570","url":null,"abstract":"Objective: To determine the protective effect of vitamin D on the articular cartilage of formalin-induced arthritis in rats.Study Design: Lab–based Experimental study.Place and Duration of Study: The study was carried out at the Department of Anatomy, Islamic International Medical College from September 2020 to September 2021.Methods: We randomly split thirty adult male albino rats weighing between 250 and 300 grams into three groups. (10 in total). On days 1 and 3 of the experiment, formaldehyde was subcutaneously injected into the right paw of every animal, with the exception of those in group A. The usual rat food was given to the rats in Groups A and B. Throughout the trial, Rats in group C were given vitamin D 4000IU/kg orally by adding cholecalciferol (Vitamin D3) injection in a standard diet for 28 days. All of the animals were dissected after the experiment, and the right hind leg was taken out, processed, and stained with H&E for a microscopic assessment of the thickness of the unclarified cartilage. Version 21 of SPSS was used to analyze the results.Results: The oral administration of vitamin D exhibited a significant increase in unclarified cartilage thickness on intergroup comparison.Conclusion: Vitamin D is an effective antiarthritic agent in ameliorating the thickness of articular cartilage thickness in arthritic rat models. \u0000How to cite this: Shahid A, Beenish H, Khurshid T, Rashid A, Shahid U, Khan M. Ameliorative Effect of Vitamin D on Articular Cartilage Thickness in Arthritic Rat Model. Life and Science. 2024; 5(1): 107-112. doi: http://doi.org/10.37185/LnS.1.1.570","PeriodicalId":516717,"journal":{"name":"Life and Science","volume":"17 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140508023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}