Life and Science最新文献

{"title":"Variant Analysis of XDR Salmonella Typhi Strains Using Global Alignment Tool Kit in South Asian Region","authors":"Maham Niazi, Zilwa Mumtaz, Maqsood Ahmed, Saeed Ahmed, Ashaq Ali, Muhammad Zubair Yousaf","doi":"10.37185/lns.1.1.432","DOIUrl":"https://doi.org/10.37185/lns.1.1.432","url":null,"abstract":"Objective: To concisely compare genomic profiles of XDR Salmonella Typhi isolates from Lahore withantimicrobial-resistant Salmonella Typhi isolates from other developing nations.Study Design: Comparative analysis of whole genome sequences.Place and Duration of Study: The study was conducted from December 2020 to September 2021 at KauserAbdulla Malik (KAM) School Life Sciences, Forman Christian College University, Lahore, Pakistan.Methods: The Galaxy pipeline was run to obtain detailed information at the nucleotide level regardingmutations that lead to the emergence of XDR strains. Whole genome sequences were analyzed to compare thegenomes of selected three developing nations.Results: The Pakistani isolates had a significantly higher mutation rate, higher proportion of modifiers, andsilent mutations as compared to isolates of Bangladesh and India.Conclusion: Cases of Salmonella Typhi XDR are rapidly rising in Asian countries such as Pakistan, Bangladesh,and India emphasizing the need to analyze and compare its genome with relevant strains. Our study highlightsthe unique profile of the Lahore (Pakistan) isolate with the highest mutation rate suggesting the potentialregional differences in selective pressure. Further spotlights the necessity to elucidate the functionalconsequences of the identified mutations in S. Typhi isolates. \u0000How to cite this: Niaz M, Mumtaz Z, Ahmed M, Ahmad S, Ali A, Yousaf MZ. Variant Analysis of XDR Salmonella Typhi Strains Using Global Alignment Tool Kit in South Asian Region. Life and Science. 2024; 5(2): 244-250. doi: http://doi.org/10.37185/LnS.1.1.432","PeriodicalId":516717,"journal":{"name":"Life and Science","volume":" 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141129680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Obesity with its Associated Modifiable Risk Factors among Adolescents of Aged 17-24 Years: Cross-Sectional Study","authors":"Shah Zaib, Tahira Raza, Afnan Ahmad, Shahzaib Anwar, Syed Muhammad Haroon Tariq, Tahir Mubashar","doi":"10.37185/lns.1.1.362","DOIUrl":"https://doi.org/10.37185/lns.1.1.362","url":null,"abstract":"Objective: This study aims to point out the association of modifiable risk factors and the prevalence and riskfactors of overweight and obesity among adolescents aged 17-24 years.Study Design: Cross-sectional descriptive study.Place and Duration of Study: The study was conducted at the Department of Community Medicine, CombinedMilitary Hospital (CMH) College Lahore, Pakistan from April 2022 to May 2022.Methods: A cross-sectional study was performed on a sample size of 108 adult males through nonprobabilityconvenient sampling in CMH Lahore Medical College, Lahore, Pakistan. HbA1c tests were conducted to checkblood sugar. A questionnaire was distributed to collect data. SPSS software was used for the analysis of datausing the Chi-square test.Results: A total of 108 male cadets participated in the study. Mean age was 20.20 years ±1.4 SD. The majority ofparticipants were involved in physical activity and had healthy eating habits. Eighty-nine percent ofrespondents fall in the category of normal body mass index & 6.5% in the category of overweight & obese & 3.7% were underweight. Forty-seven percent of subjects were physically active for ≤ 3 days/week & 57.4% wereengaged for > 3 days/week. Fifty-seven percent of respondents had a screen time of 5-7 hours/day & 11.1% has> 7 hours/day. Among 108 respondents, 37% had snacking habits in between meals 1-2 times/week & 20.4%has 3-4 times/week.Conclusion: This study concludes that apart from non-modifiable risk factors, modifiable risk factors also have a major influence on the prevalence of overweight & obesity. Those who exercise & eat healthy have less risk ofdeveloping obesity as compared to those who have poor physical activity & unhealthy eating habits. \u0000How to cite this: Zaib S, Raza T, Ahmad A, Anwar S, Tariq SMH, Mubashar T. Prevalence of Obesity with its Associated Modifiable Risk Factors Among Adolescents of Aged 17-24 Years: Cross Sectional Study. Life and Science. 2024; 5(2): 210-215. doi: http://doi.org/10.37185/LnS.1.1.362","PeriodicalId":516717,"journal":{"name":"Life and Science","volume":" 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141129615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Awareness of the Green Dentistry Concept among Dental Professionals in Tertiary Care Dental Hospital, Rawalpindi","authors":"Vasiqa Bano, Erum Amin, Samar Maqbool, Syed Ali Hassan, Abeer Baber, Raabia Urooj","doi":"10.37185/lns.1.1.418","DOIUrl":"https://doi.org/10.37185/lns.1.1.418","url":null,"abstract":"Objective: To assess awareness of green dentistry among graduates, postgraduates and general dentistsStudy Design: Descriptive Cross-sectional.Place and Duration of Study: The study was conducted at Armed Forces Institute of Dentistry (AFID)Rawalpindi, Pakistan from August 2022 to October 2022.Methods: Based on a pre-validated survey questionnaire comprising of 20 close-ended questions assessing theawareness regarding green dentistry. Male and female respondents consisting of General dentists, graduates,postgraduate and house officers, and practitioners of AFID who gave consent were included in the study. Thesample size was calculated using the WHO calculator and 332 respondents were recruited and thequestionnaire was distributed, responses were then analyzed using SPSS version 22 and the p-value < 0.05 wasconsidered significant.Results: Out of the 332 participants 148 were post-graduates, 109 were Graduates, 35 were consultants and 40were general dentists with the age range of 25 to 50 years. 248 participants were females and 84 were malesand 100% response rate was observed. Postgraduates (47%) were more aware of the eco-friendly dentistryconcept the difference was found statistically significant (p-value <0.000).Conclusion: Most of the respondents were aware of the green dentistry concept, those who had littleknowledge were accepting the concept and were enthusiastic to inculcate these practices in their practices. \u0000How to cite this: Bano V, Amin E, Maqbool S, Hassan SA, Baber A, Urooj R. Awareness of Green Dentistry Concept among Dental Professionals. Life and Science. 2024; 5(2): 251-258. doi: http://doi.org/10.37185/LnS.1.1.418","PeriodicalId":516717,"journal":{"name":"Life and Science","volume":" 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141129608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review of High-Resolution Computed Tomography Chest Incidental Findings in COVID and Post-COVID Era in PIMS Hospital Islamabad","authors":"Sara Shahid, Ayesha Isani, Hyder Wajid Abbasi, Ana Rizvi, Hafiza Habiba Mubarik","doi":"10.37185/lns.1.1.417","DOIUrl":"https://doi.org/10.37185/lns.1.1.417","url":null,"abstract":"Objective: To scrutinize the frequency of alternative pulmonary infectious diseases, and incidental findings ofthe High resolution CT scan chest in COVID-19 screening trials during peak and late COVID era.Study Design: A cross-sectional study.Place and Duration of Study: The study was carried out at the Department of Radiology, Pakistan Institute ofMedical Sciences (PIMS), Islamabad, Pakistan from June 2021 to June 2022.Methods: High-resolution computed tomography (HRCT) scan chest reports of 191 patients were analyzedfrom the Peak COVID period from May 2020 to May 2021 and 191 reports of patients in the late COVID periodfrom June 2021 to June 2022. Reports were evaluated for any alternative disease process or incidental findings,further classified according to their clinical significance.Results: Incidental findings were seen in 60% of scans in the Peak period of SARS-CoV-2 infection and 75% in the late COVID era. The mean age group of patients in the peak period was 50.76 years and in the late COVID period was 56.65 years, with significant male predominance (76%) in the peak period. Around 30.5% and 56.7% of “major\" incidental findings in each peak and late COVID period were recorded, respectively, with Pulmonarynodule being the most frequent incidental finding in the peak period and Tuberculosis often repeatedlyencountered incidental finding in the late COVID period.Conclusion: Incidental findings appear in more than half of the High-resolution CT chest scans in suspectedCOVID-19 patients, with a substantial number requiring further workup. \u0000How to cite this: Shahid S, Isani A, Abbasi HW, Rizvi A, Mubarik HH. Review of High-Resolution Computed Tomography Chest Incidental Findings in COVID and Past COVID Era. Life and Science. 2024; 5(2): 237-243. doi: http://doi.org/10.37185/LnS.1.1.417","PeriodicalId":516717,"journal":{"name":"Life and Science","volume":" 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141129670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency of Self Medication Among Health Science Students in Foundation University Medical College, Islamabad, Pakistan","authors":"Sana Kiran Tahir, Nosheen Zaidi, Mahnoor Shabbir, Sarah Eman, Azqa Batool, Muhammad Hammad Qureshi, Muhammad Daoud Tariq","doi":"10.37185/lns.1.1.505","DOIUrl":"https://doi.org/10.37185/lns.1.1.505","url":null,"abstract":"Objective: This study aimed to assess the level of knowledge and practices of self-medication among healthscience students. The research sought to identify factors influencing self-medication practices, includingdemographics, program of study, and access to medical facilities.Study Design: Descriptive cross-sectional study design.Place and Duration of Study: The study was carried out at Foundation University Medical College, Islamabad,Pakistan including the Departments of MBBS, BDS, Nursing, and DPT over six months, from February 2023 toJuly 2023.Methods: A descriptive cross-sectional study design was employed, involving students from a private universityin Islamabad, including those in MBBS, BDS, Nursing, and DPT programs. The study was conducted over sixmonths, from February to July 2023, using a non-probability convenience sampling technique. A validatedquestionnaire was utilized for data collection, pre-tested for clarity and relevance, and translated from Arabicto English. Data analysis was performed using SPSS version 23.0, involving descriptive and inferential statisticsto elucidate self-medication trends and associations.Results: Among the participants, 60.9% engaged in self-medication within the past six months. The most usedmedications were pain relievers (61.9%), antibiotics (39.1%), and cough syrups (35.8%). Motivations for selfmedication included perceiving the illness as non-serious (47%), saving time (46.4%), and relying on pastexperiences (36.4%). Access to personal knowledge (52.3%) and understanding the importance of prescribedmedicines (54.3%) were prevalent among the participants.Conclusion: The study concluded that a significant number of medical students practiced self-medication,primarily motivated by underestimating the severity of illnesses. Over-the-counter painkillers and antibiotics,despite requiring a physician's prescription, were the most commonly self-prescribed medications among thestudy population.       \u0000How to cite this: Tahi Sk, Zaidi N, Shabbir M, Eman S, Batool A, Qureshi MH, Tariq MD. Frequency of Self Medication Among Health Science Students in Foundation University Medical College, Islamabad, Pakistan. Life and Science. 2024; 5(2): 222-227. doi: http://doi.org/10.37185/LnS.1.1.505            ","PeriodicalId":516717,"journal":{"name":"Life and Science","volume":" 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141129621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pattern of Fast Food and Sugar-Sweetened Beverages Consumption among Students of Lahore Medical and Dental College, Lahore","authors":"Saadia Maqbool, Seema Daud, Khawaja Allah Ditta Saad, Mehr Salman Ahmad, Beya Idrees, Kainat Ejaz","doi":"10.37185/lns.1.1.621","DOIUrl":"https://doi.org/10.37185/lns.1.1.621","url":null,"abstract":"Objective: To assess fast food and sugar-sweetened beverages consumption patterns among medical studentsalong with associated factors and to determine the association between intake of these items and body massindex.Study Design: Cross-sectional study.Place and Duration of Study: This study was conducted at the Department of Community Medicine, LahoreMedical and Dental College, Lahore, Pakistan from May 2023 to September 2023.Methods: A convenience sampling technique was used to recruit 146 MBBS students. Using a structuredquestionnaire, information was obtained on the background of participants, fast food and sugar-sweetenedbeverages consumption, and their body mass index. Chi-square test was applied to find an association betweenvariables with p ≤ 0.05 taken as significant.Results: The study included 60% females and 52% boarders. Mothers of 6% of students and fathers of 12% ofstudents were doctors. The mean body mass index was 22.43±3.51. Frequent consumption of fast food was36% and of sugar-sweetened beverages was 12%. The most frequently consumed items were salty snacks (77%)and regular soda (67%). A significant relationship was found between fast food consumption with residence,the mother's profession, and awareness about nutritional information. Consumption of sugar-sweetenedbeverages was significantly related to gender and knowledge about the harmful effects of these beverages. Thebody mass index of students significantly increased with an increase in the use of sugar-sweetened beveragesand was inversely associated with fast food consumption.Conclusion: Consumption of fast food and sugar-sweetened beverages was high among study participants.Salty snacks and soda drinks were frequently consumed items. There is an immediate need for national policiesand strategies to create a healthy dietary environment among students. \u0000How to cite this: Maqbool S, Daud S, Saad KAD, Ahmad MS, Idress B, Ejaz K. Pattern of Fast Food and Sugar Sweetened Beverages Consumption Among Students of Lahore Medical and Dental College, Lahore. Life and Science. 2024; 5(2): 172-180. doi: http://doi.org/10.37185/LnS.1.1.621","PeriodicalId":516717,"journal":{"name":"Life and Science","volume":" 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141129664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevention of Uterine Inversion by Using Ultrasonographic Confirmation During Placental Delivery in Dr. Ruth K.M Pfau Civil Hospital Karachi","authors":"Tahmina Shahid Abbasi, K. Kubra, Tabassum Zarrar, Maria Tasneem, Pashmina Gul","doi":"10.37185/lns.1.1.563","DOIUrl":"https://doi.org/10.37185/lns.1.1.563","url":null,"abstract":"Objective: To determine the prevention of uterine inversion by using ultrasonographic confirmation duringplacental delivery.Study Design: Cross-sectional study.Place and Duration of Study: The study was carried out at the Department of Gynecology Unit II, Dr. Ruth K.MPfau Civil Hospital Karachi, Pakistan from June 2022 to June 2023.Methods: In this research, the total of 180 patients were included with transvaginal deliveries. To preventuterine inversion during placental delivery, regular ultrasonographic was implemented. The placental deliverywas performed with ultrasonographic confirmed placental detachment. The frequency of uterine inversionduring placental delivery was compared before and after the introduction of ultrasonographic images. Inaddition, a comparison was made between the ultrasonographic group and the non-ultrasonographic groupregarding the amount of blood loss during transvaginal delivery and the length of the third stage of labor. TheDescriptive statistics were applied to all parameters Using SPSS Version 26.Results: A total of 180 patients who had transvaginal deliveries, mean age 29 ± 9 years. One hundred and eighty women had transvaginal deliveries before and after the introduction of ultrasonography. Following theultrasonographic confirmation, there was a significant decrease in the frequency of uterine inversion whencompared to the pre-introduction period (43.3% vs. 56.7%, p = 0.001). Due to a number of limitations, theactual rate of ultrasonography performed even after it was introduced ultrasonography was 46.1%.Conclusion: In our investigation, we concluded that with the help of ultrasonographic confirmation of placentaldetachment uterine inversion may be prevented. \u0000How to cite this: Abbasi TS, Kubra K, Zarrar T, Tasneem M, Gul P. Prevention of Uterine Inversion by Using Ultrasonographic Confirmation During Placental Delivery in Dr. Ruth K.M Pfau Civil Hospital Karachi. Life and Science. 2024; 5(2): 204-209. doi: http://doi.org/10.37185/LnS.1.1.563","PeriodicalId":516717,"journal":{"name":"Life and Science","volume":" 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141129673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Alpha Lipoic Acid Supplementation on Slow Skeletal Muscle Mass and Contractile Functions in Type 2 Diabetic Male Sprague Dawley Rats","authors":"Barkat Ullah Khan, Iftekhar Yousef, Sidra Arshad, Faiza Ikram, Amjad Ali, Ikram Ullah","doi":"10.37185/lns.1.1.408","DOIUrl":"https://doi.org/10.37185/lns.1.1.408","url":null,"abstract":"Objective: To see the Effects of Alpha-Lipoic Acid (ALA) supplementation on slow skeletal muscle mass andcontractile functions in type 2 diabetic male Sprague Dawley rats.Study Design: Quasi-experimental study.Place and Duration of Study: The study was carried out at the Physiology Research Lab, Army MedicalCollege, Rawalpindi, Pakistan from June 2019 to April 2021 in collaboration with the National Institute of Health(NIH) Islamabad, Pakistan.Methods: Sixty adult SD rats were divided into three equal groups. Rats were fed on a standard diet as per NIHprotocols. After 2 weeks type 2 Diabetes mellitus (T2DM) was induced in groups 2 and 3 by injecting low dose35mg of streptozotocin (STZ) in the abdomen intraperitoneally. T2DM was successfully developed andconfirmed by measuring glucose levels through a glucometer. Group 3 was injected with Alpha Lipoic acid30mg/kg/day at the lower abdomen for the next two weeks. After 04 weeks, soleus muscles were dissected.The animal data acquisition unit (iWorx) was used for assessing the contractile functions of soleus.Results: Alpha Lipoic acid group showed improvement in muscle mass, muscle tension strength, and recoveryfrom fatigue after applying fatigue protocol as compared to group 2.Conclusion: Alpha Lipoic acid supplementation improves contractile force and delays fatigue in the soleusmuscles of diabetic rats. \u0000How to cite this: Khan BU, Yousef I, Arshad S, Ikram F, Ali A, Ullah I. Effects of Alpha Lipoic Acid Supplementation on Slow Skeletal Muscle Mass and Contractile Functions in Type 2 Diabetic Male Sprague Dawley Rats. Life and Science. 2024; 5(2): 216-221. doi: http://doi.org/10.37185/LnS.1.1.408","PeriodicalId":516717,"journal":{"name":"Life and Science","volume":" 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141129731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complications of Therapeutic Plasmapheresis in Patients with Neurologic Diseases at A Tertiary Care Hospital","authors":"Naveed Ahmed, Imran Ahmad, F. A. Siddiqi, K. Nawaz, Jahanzeb Liaqat, Fawad Ahmad","doi":"10.37185/lns.1.1.538","DOIUrl":"https://doi.org/10.37185/lns.1.1.538","url":null,"abstract":"Objective: To determine the complications of therapeutic plasmapheresis in patients with neurologicaldiseases at a tertiary care hospital.Study Design: Cross-sectional study.Place and Duration of Study: The study was carried out at Department of Neurology, Pak Emirates MilitaryHospital (PEMH) Rawalpindi, Pakistan from August 2021 to July 2022.Methods: This study was carried out on patients diagnosed with various neurologic diseases where therapeuticplasmapheresis was performed which involves the replacement of patient plasma with donor plasma. A totalof 680 therapeutic plasmapheresis treatments were performed on patients with a variety of neurologicdiseases. Ppatients with hemodynamic instability, active sepsis, coagulopathy, and known allergies to freshfrozen plasma were excluded from the study. Data was recorded from consenting patients on a pre-designedproforma recording various parameters.Results: Among 680 treatments,76.2% were carried out in males and 23.8% in females.Guillain Barre Syndrome (42.06%) was the most common disease followed by chronic inflammatorydemyelinating polyneuropathy (13.82%), neuromyelitis optical spectrum disorders (10.29%), and myastheniagravis (7.94%) being the most common ones. In total 157 (23%) adverse events were noted, with fever (2.9%),pruritis (2.8%), urticaria and mild hypotension (2.5% each), tachycardia (2.2%), and DVT (1.3%) beingcommonly encountered complications. Anaphylaxis was recorded in 0.1%. The majority of the reactions weremild 118 (17.3%), some moderate 21 (3%), and few were severe 11 (1.6%). Serious, life-threatening events wereseen in 0.1% and none had a fatal outcome. Prophylactic use of calcium resulted in lower electrolyte imbalancerelatedcomplications.Conclusion: Therapeutic plasmapheresis is a safer treatment option for various neurologic diseases whenperformed by trained staff. \u0000How to cite this: Ahmed N, Ahmad I, Siddiqi FA, Nawaz KH, Liaqat J, Ahmad F. Complications of Therapeutic Plasmapheresis in Patients with Neurologic Diseases at A Tertiary Care Hospital. Life and Science. 2024; 5(2): 259-265. doi: http://doi.org/10.37185/LnS.1.1.538","PeriodicalId":516717,"journal":{"name":"Life and Science","volume":" 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141129667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Role of Irbesartan in Elevating Serum High Density Lipoprotein in Hypercholesterolemic Animal Model","authors":"S. Shakir, Zunnera Rashid Chaudhry, Maliha Atif, Rabia Sadaf, Erum Rashid Chaudhry, Sana Rasheed Chaudhry","doi":"10.37185/lns.1.1.536","DOIUrl":"https://doi.org/10.37185/lns.1.1.536","url":null,"abstract":"Objective: To explore the HDL cholesterol-raising capacity of Irbesartan (an antihypertensive drug) in rabbit'sserum.Study Design: Laboratory-based experimental study.Place and Duration of Study: The study was carried out at the Animal House of the National Institute of Health(NIH) Islamabad, Pakistan from January 2023 to November 2023.Methods: This study was conducted on 18 rabbits divided into three groups with six rabbits in each. Leaving one group as a normal control, two out of three groups were made hypercholesterolemic by a high-cholesterol diet. Irbesartan was given to one of the hypercholesteremic groups for 30 days. Blood samples were taken for serum analysis of HDL cholesterol.Results: Results of blood serum levels of all three groups were compared and analyzed on three differentoccasions i.e., on day zero, day 120, and day 150 for HDL cholesterol. Their means were calculated using SPSSVersion 20. The irbesartan-treated group showed obvious elevation in serum HDL cholesterol in comparisonwith the hypercholesteremic control group.Conclusion: It is concluded that Irbesartan, an antihypertensive drug has an additional role of elevating serumhigh-density lipoproteins and can provide the supplementary benefit of improving the lipid profile inhypertension and Hypercholesterolemia. \u0000How to cite this: Shakir S, Chaudhry ZR, Atif M, Sadaf R, Chaudhry ER, Chaudhry SR. Novel Role of Irbesartan in Elevating Serum High Density Lipoprotein in Hypercholesterolemic Animal Model. Life and Science. 2024; 5(2): 199-203. doi: http://doi.org/10.37185/LnS.1.1.536","PeriodicalId":516717,"journal":{"name":"Life and Science","volume":" 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141129666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}