Complications of Therapeutic Plasmapheresis in Patients with Neurologic Diseases at A Tertiary Care Hospital

Life and Science Pub Date : 2024-05-05 DOI:10.37185/lns.1.1.538

Naveed Ahmed, Imran Ahmad, F. A. Siddiqi, K. Nawaz, Jahanzeb Liaqat, Fawad Ahmad

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Abstract

Objective: To determine the complications of therapeutic plasmapheresis in patients with neurologicaldiseases at a tertiary care hospital.Study Design: Cross-sectional study.Place and Duration of Study: The study was carried out at Department of Neurology, Pak Emirates MilitaryHospital (PEMH) Rawalpindi, Pakistan from August 2021 to July 2022.Methods: This study was carried out on patients diagnosed with various neurologic diseases where therapeuticplasmapheresis was performed which involves the replacement of patient plasma with donor plasma. A totalof 680 therapeutic plasmapheresis treatments were performed on patients with a variety of neurologicdiseases. Ppatients with hemodynamic instability, active sepsis, coagulopathy, and known allergies to freshfrozen plasma were excluded from the study. Data was recorded from consenting patients on a pre-designedproforma recording various parameters.Results: Among 680 treatments,76.2% were carried out in males and 23.8% in females.Guillain Barre Syndrome (42.06%) was the most common disease followed by chronic inflammatorydemyelinating polyneuropathy (13.82%), neuromyelitis optical spectrum disorders (10.29%), and myastheniagravis (7.94%) being the most common ones. In total 157 (23%) adverse events were noted, with fever (2.9%),pruritis (2.8%), urticaria and mild hypotension (2.5% each), tachycardia (2.2%), and DVT (1.3%) beingcommonly encountered complications. Anaphylaxis was recorded in 0.1%. The majority of the reactions weremild 118 (17.3%), some moderate 21 (3%), and few were severe 11 (1.6%). Serious, life-threatening events wereseen in 0.1% and none had a fatal outcome. Prophylactic use of calcium resulted in lower electrolyte imbalancerelatedcomplications.Conclusion: Therapeutic plasmapheresis is a safer treatment option for various neurologic diseases whenperformed by trained staff. How to cite this: Ahmed N, Ahmad I, Siddiqi FA, Nawaz KH, Liaqat J, Ahmad F. Complications of Therapeutic Plasmapheresis in Patients with Neurologic Diseases at A Tertiary Care Hospital. Life and Science. 2024; 5(2): 259-265. doi: http://doi.org/10.37185/LnS.1.1.538

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一家三级医院神经系统疾病患者的治疗性浆膜穿刺并发症

研究目的研究设计：横断面研究：横断面研究：研究于 2021 年 8 月至 2022 年 7 月在巴基斯坦拉瓦尔品第 Pak Emirates MilitaryHospital (PEMH) 神经科进行：本研究针对被诊断患有各种神经系统疾病的患者进行治疗性血浆置换，即用捐献者血浆置换患者血浆。对患有各种神经系统疾病的患者共进行了 680 次治疗性血浆置换。血流动力学不稳定、活动性败血症、凝血病和已知对新鲜冷冻血浆过敏的患者被排除在研究之外。在事先设计好的记录各种参数的表格上记录同意患者的数据：吉兰巴雷综合征（42.06%）是最常见的疾病，其次是慢性炎症性脱髓鞘性多发性神经病（13.82%）、神经脊髓炎光学谱系障碍（10.29%）和肌萎缩（7.94%）。共发现 157 例（23%）不良反应，其中发热（2.9%）、瘙痒（2.8%）、荨麻疹和轻度低血压（各占 2.5%）、心动过速（2.2%）和深静脉血栓（1.3%）是常见的并发症。过敏性休克的发生率为 0.1%。大多数反应为轻度 118 例（17.3%），中度 21 例（3%），重度 11 例（1.6%）。有 0.1%的患者出现了严重的、危及生命的反应，没有人死亡。预防性使用钙剂可降低与电解质失衡相关的并发症：结论：如果由受过培训的人员操作，治疗性浆穿刺是治疗各种神经系统疾病的一种更安全的方法。如何引用本文：Ahmed N、Ahmad I、Siddiqi FA、Nawaz KH、Liaqat J、Ahmad F. 一家三级医院神经系统疾病患者的治疗性浆膜穿刺并发症。生命与科学2024; 5(2):259-265. DOI: http://doi.org/10.37185/LnS.1.1.538

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Life and Science

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