IJTLD OPEN最新文献_第2页

Mapping TB incidence across districts in Uganda to inform health program activities 绘制乌干达各地区结核病发病率图，为卫生计划活动提供信息

IJTLD OPEN Pub Date : 2024-05-01 DOI: 10.5588/ijtldopen.23.0624

N.J. Henry, S. Zawedde-Muyanja, R.K. Majwala, S. Turyahabwe, R.V. Barnabas, R.C. Reiner, Jr, C.E. Moore, J.M. Ross

{"title":"Mapping TB incidence across districts in Uganda to inform health program activities","authors":"N.J. Henry, S. Zawedde-Muyanja, R.K. Majwala, S. Turyahabwe, R.V. Barnabas, R.C. Reiner, Jr, C.E. Moore, J.M. Ross","doi":"10.5588/ijtldopen.23.0624","DOIUrl":"https://doi.org/10.5588/ijtldopen.23.0624","url":null,"abstract":"BACKGROUNDIdentifying spatial variation in TB burden can help national TB programs effectively allocate resources to reach and treat all people with TB. However, data limitations pose challenges for subnational TB burden estimation.METHODSWe\u0000 developed a small-area modeling approach using geo-positioned prevalence survey data, case notifications, and geospatial covariates to simultaneously estimate spatial variation in TB incidence and case notification completeness across districts in Uganda from 2016–2019. TB incidence\u0000 was estimated using 1) cluster-level data from the national 2014–2015 TB prevalence survey transformed to incidence, and 2) case notifications adjusted for geospatial covariates of health system access. The case notification completeness surface was fit jointly using observed case notifications\u0000 and estimated incidence.RESULTSEstimated pulmonary TB incidence among adults varied >10-fold across Ugandan districts in 2019. Case detection increased nationwide from 2016 to 2019, and the number of districts with case detection\u0000 rates >70% quadrupled. District-level estimates of TB incidence were five times more precise than a model using TB prevalence survey data alone.CONCLUSIONA joint spatial modeling approach provides useful insights for TB program operation,\u0000 outlining areas where TB incidence estimates are highest and health programs should concentrate their efforts. This approach can be applied in many countries with high TB burden.","PeriodicalId":516613,"journal":{"name":"IJTLD OPEN","volume":"14 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141047272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive care for people affected by TB: addressing TB-associated disabilities 对结核病患者的全面关怀：解决与结核病相关的残疾问题

IJTLD OPEN Pub Date : 2024-05-01 DOI: 10.5588/ijtldopen.24.0167

M. Calvi, D. Boccia, E. Jaramillo, F. Mavhunga, J. Reeder, T. Kasaeva

引用次数: 0

Disability, comorbidities and risk determinants at end of TB treatment in Kenya, Uganda, Zambia and Zimbabwe 肯尼亚、乌干达、赞比亚和津巴布韦结核病治疗结束时的残疾、并发症和风险决定因素

IJTLD OPEN Pub Date : 2024-05-01 DOI: 10.5588/ijtldopen.24.0082

S.A. Adakun, F.M. Banda, A. Bloom, M. Bochnowicz, J. Chakaya, A. Chansa, H. Chiguvare, R. Chimzizi, C. Colvin, J. Dongo, A. Durena, C. Duri, R. Edmund, A. Harries, I. Kathure, F. Kavenga, Y. Lin, H. Luzze, I. Mbithi, M. Mputu, A. Mubanga, D. Nair, M. Ngwenya, B. Okotu, P. Owiti, A. Owuor, P. Thekkur, C. Timire, S. Turyahabwe, E. Tweyongyere, M. YaDiul, R. Zachariah, K. Zimba

{"title":"Disability, comorbidities and risk determinants at end of TB treatment in Kenya, Uganda, Zambia and Zimbabwe","authors":"S.A. Adakun, F.M. Banda, A. Bloom, M. Bochnowicz, J. Chakaya, A. Chansa, H. Chiguvare, R. Chimzizi, C. Colvin, J. Dongo, A. Durena, C. Duri, R. Edmund, A. Harries, I. Kathure, F. Kavenga, Y. Lin, H. Luzze, I. Mbithi, M. Mputu, A. Mubanga, D. Nair, M. Ngwenya, B. Okotu, P. Owiti, A. Owuor, P. Thekkur, C. Timire, S. Turyahabwe, E. Tweyongyere, M. YaDiul, R. Zachariah, K. Zimba","doi":"10.5588/ijtldopen.24.0082","DOIUrl":"https://doi.org/10.5588/ijtldopen.24.0082","url":null,"abstract":"BACKGROUNDWe examined the feasibility of assessing and referring adults successfully completing TB treatment for comorbidities, risk determinants and disability in health facilities in Kenya, Uganda, Zambia and Zimbabwe.METHODSThis\u0000 was a cross-sectional study within national TB programmes.RESULTSHealth workers assessed 1,063 patients (78% of eligible) in a median of 22 min [IQR 16–35] and found it useful and feasible to accomplish in addition to other responsibilities.\u0000 For comorbidities, 476 (44%) had HIV co-infection, 172 (16%) had high blood pressure (newly detected in 124), 43 (4%) had mental health disorders (newly detected in 33) and 36 (3%) had diabetes mellitus. The most common risk determinants were ‘probable alcohol dependence’ (15%)\u0000 and malnutrition (14%). Disability, defined as walking <400 m in 6 min, was found in 151/882 (17%). Overall, 763 (72%) patients had at least one comorbidity, risk determinant and/or disability. At least two-thirds of eligible patients were referred for care, although 80% of those with disability\u0000 needed referral outside their original health facility.CONCLUSIONSSeven in 10 patients completing TB treatment had at least one comorbidity, risk determinant and/or disability. This emphasises the need for offering early patient-centred\u0000 care, including pulmonary rehabilitation, to improve quality of life, reduce TB recurrence and increase long-term survival.","PeriodicalId":516613,"journal":{"name":"IJTLD OPEN","volume":"19 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141037663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-communicable airway disease and air pollution in three African Countries: Benin, Cameroon and The Gambia 非洲三国的非传染性呼吸道疾病和空气污染：贝宁、喀麦隆和冈比亚

IJTLD OPEN Pub Date : 2024-04-01 DOI: 10.5588/ijtldopen.23.0490

B. Awokola, H. Lawin, O. Johnson, A. Humphrey, D. Nzogo, L. Zubar, G. Okello, S. Semple, E. Awokola, G. Amusa, N. Mohammed, C. Jewell, A. Erhart, K. Mortimer, G. Devereux, B. H. Mbatchou-Ngahane

{"title":"Non-communicable airway disease and air pollution in three African Countries: Benin, Cameroon and The Gambia","authors":"B. Awokola, H. Lawin, O. Johnson, A. Humphrey, D. Nzogo, L. Zubar, G. Okello, S. Semple, E. Awokola, G. Amusa, N. Mohammed, C. Jewell, A. Erhart, K. Mortimer, G. Devereux, B. H. Mbatchou-Ngahane","doi":"10.5588/ijtldopen.23.0490","DOIUrl":"https://doi.org/10.5588/ijtldopen.23.0490","url":null,"abstract":"BACKGROUNDAir pollution exposure can increase the risk of development and exacerbation of chronic airway disease (CAD). We set out to assess CAD patients in Benin, Cameroon and The Gambia and to compare their measured exposures to air\u0000 pollution.METHODOLOGYWe recruited patients with a diagnosis of CAD from four clinics in the three countries. We collected epidemiological, spirometric and home air pollution data.RESULTSOf\u0000 the 98 adults recruited, 56 were men; the mean age was 51.6 years (standard deviation ±17.5). Most (69%) patients resided in cities and ever smoking was highest in Cameroon (23.0%). Cough, wheeze and shortness of breath were reported across the countries. A diagnosis of asthma was present\u0000 in 74.0%; 16.3% had chronic obstructive pulmonary disease and 4.1% had chronic bronchitis. Prevalence of airflow obstruction was respectively 77.1%, 54.0% and 64.0% in Benin, Cameroon, and Gambia. Across the sites, 18.0% reported >5 exacerbations. The median home particulate matter less\u0000 than 2.5 μm in diameter (PM2.5) was respectively 13.0 μg/m3, 5.0 μg/m3 and 4.4 μg/m3. The median home carbon monoxide (CO) exposures were respectively 1.6 parts per million (ppm), 0.3 ppm and 0.4 ppm. Home PM2.5 differed significantly\u0000 between the three countries (P < 0.001) while home CO did not.CONCLUSIONBased on these results, preventive programmes should focus on ensuring proper spirometric diagnosis, good disease control and reduction in air pollution\u0000 exposure.","PeriodicalId":516613,"journal":{"name":"IJTLD OPEN","volume":"123 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140770239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A pilot cross-sectional study of non-communicable diseases in TB household contacts 结核病家庭接触者非传染性疾病横断面试点研究

IJTLD OPEN Pub Date : 2024-04-01 DOI: 10.5588/ijtldopen.23.0579

Y. Hamada, A. Lugendo, T. Ntshiqa, G. Kubeka, J.M. Lalashowi, S. Mwastaula, K. Ntshamane, I. Sabi, S. Wilson, A. Copas, K. Velen, N. Ntinginya, L. T. Minja, I. Abubakar, S. Charalambous, M.X. Rangaka

{"title":"A pilot cross-sectional study of non-communicable diseases in TB household contacts","authors":"Y. Hamada, A. Lugendo, T. Ntshiqa, G. Kubeka, J.M. Lalashowi, S. Mwastaula, K. Ntshamane, I. Sabi, S. Wilson, A. Copas, K. Velen, N. Ntinginya, L. T. Minja, I. Abubakar, S. Charalambous, M.X. Rangaka","doi":"10.5588/ijtldopen.23.0579","DOIUrl":"https://doi.org/10.5588/ijtldopen.23.0579","url":null,"abstract":"BACKGROUNDData on the prevalence of non-communicable diseases (NCDs) in TB household contacts (HHCs) are limited, yet important to inform integrated screening and care for NCD within contact investigations. It is also unclear if screening\u0000 these contacts reveals more people with NCDs than individuals in the same neighbourhood.METHODWe conducted a pilot cross-sectional study in South Africa and Tanzania, enrolling adult HHCs of TB and individuals in neighbourhood\u0000 households (controls). We inquired about known NCD and systematically measured blood pressure, and tested for spot blood glucose and haemoglobin A1c.RESULTSWe enrolled 203 adult contacts of 111 persons with TB and 160 controls.\u0000 Among contacts, respectively 12.2% (95% CI 8.3–17.6) and 39.7% (95% CI 33.1–46.7) had diabetes and hypertension, compared to 14.1% (95% CI 9.2–21.0) and 44.7% (95% CI 36.9–52.7) among controls. More than half of NCDs were newly identified. We did not find a significant\u0000 difference in the prevalence of at least one NCD between the two groups (OR 0.85, 95% CI 0.50–1.45, adjusted for age and sex).CONCLUSIONSWe found a high prevalence of undiagnosed NCDs among contacts, suggesting a potential\u0000 benefit of integrating NCD screening and care within contact investigations. Screening in the same community might similarly find undiagnosed NCDs.","PeriodicalId":516613,"journal":{"name":"IJTLD OPEN","volume":"60 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140759310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decentralised ECG monitoring for drug-resistant TB patients in ambulatory settings 对流动环境中的耐药结核病患者进行分散式心电图监测

IJTLD OPEN Pub Date : 2024-04-01 DOI: 10.5588/ijtldopen.23.0623

M. Mbenga, A. Slyzkyi, V. Mirtskhulava, S. Pak, A. Gebhard, G. Utepkalieva, A. Sagimbekova, M. Adenov, G. Ryskulov

引用次数: 0

TB and poverty: the effect of rifampicin-resistant TB on household income 结核病与贫困：耐利福平结核病对家庭收入的影响

IJTLD OPEN Pub Date : 2024-04-01 DOI: 10.5588/ijtldopen.23.0607

A. Ciobanu, V. Plesca, S. Doltu, M. Manea, L. Domente, A. Dadu

{"title":"TB and poverty: the effect of rifampicin-resistant TB on household income","authors":"A. Ciobanu, V. Plesca, S. Doltu, M. Manea, L. Domente, A. Dadu","doi":"10.5588/ijtldopen.23.0607","DOIUrl":"https://doi.org/10.5588/ijtldopen.23.0607","url":null,"abstract":"<sec id=\"st1\"><title>SETTING</title>The Republic of Moldova, one of Europe's poorest countries, also bears one of the highest burdens of rifampicin-resistant TB (RR-TB).</sec><sec id=\"st2\"><title>OBJECTIVES</title>To trace the patients’\u0000 journey through TB in terms of the relationship with poverty and assess its determinants.</sec><sec id=\"st3\"><title>DESIGN</title>This cross-sectional study used secondary data from a survey assessing catastrophic costs in RR-TB-affected households.</sec><sec\u0000 id=\"st4\"><title>RESULTS</title>Data were obtained from 430 RR-TB patients. The percentage of poor TB-affected households rose from 65% prior to TB to 86% after TB treatment completion (P < 0.001). Social factors leading to poverty were identified for each stage:\u0000 diagnostic period (history of incarceration: cOR 2.3, 95% CI 1.1–5.2); treatment period (being unemployed or unofficially employed: cOR 6.7, 95% CI 4.3–10.0); and post-treatment (being married or cohabiting: cOR 5.7, 95% CI 2.9–11.0). Participants who had ≥3 members in\u0000 their households were more likely to be poor at all TB stages: diagnostic period (cOR 5.7, 95% CI 3.7–8.8), treatment period (cOR 3.8, 95% CI 2.5–5.6) and post-treatment (cOR 7.2, 95% CI 3.6–14.3).</sec><sec id=\"st5\"><title>CONCLUSION</title>The\u0000 study identified risk factors associated with poverty at each stage of TB. These findings outline that innovative social protection policies are required to protect TB patients against poverty.</sec>","PeriodicalId":516613,"journal":{"name":"IJTLD OPEN","volume":"1029 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140774360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics of and treatment outcomes in rifampicin-intolerant patients 利福平不耐受患者的特征和治疗结果

IJTLD OPEN Pub Date : 2024-04-01 DOI: 10.5588/ijtldopen.23.0466

R. Mangat, S.K. Brode, H.K. Mah, M.S. Brar, N.F. Sabur

{"title":"Characteristics of and treatment outcomes in rifampicin-intolerant patients","authors":"R. Mangat, S.K. Brode, H.K. Mah, M.S. Brar, N.F. Sabur","doi":"10.5588/ijtldopen.23.0466","DOIUrl":"https://doi.org/10.5588/ijtldopen.23.0466","url":null,"abstract":"BACKGROUNDRifampicin (RIF) is considered the backbone of TB treatment, but adverse effects often limit its use.METHODSThis retrospective cohort study examined patients treated\u0000 for TB disease at our institution, and compared those who received RIF to those who were intolerant to RIF.RESULTSA total of 829 patients were included. Seventy-six patients (9%) were intolerant to RIF. Patients with RIF intolerance\u0000 were significantly older (median age: 67 years, IQR 50–78 vs. 48 years, IQR 31–70; P < 0.0001), and were more likely to be female (57% vs. 41%; P = 0.01) and have concurrent diabetes mellitus (37.3% vs. 19%; P < 0.0001) compared to those who tolerated\u0000 RIF. RIF intolerance was most commonly due to transaminitis (25%), cytopenia (14.5%), rash (17.1%) and gastro-intestinal intolerance (7.8%). Twenty patients were subsequently challenged with rifabutin, and this was successful in 70%. The mean treatment duration was significantly longer in\u0000 patients who were intolerant to RIF (335 vs. 270 days; P < 0.001). There was no significant difference in treatment outcomes.CONCLUSIONRIF intolerance is more common in older patients, females, and those with concurrent\u0000 diabetes mellitus. Patients who could not tolerate RIF had a longer duration of therapy, but no difference in treatment outcomes. When attempted, rifabutin was well tolerated in most patients with a previous RIF-related adverse event.","PeriodicalId":516613,"journal":{"name":"IJTLD OPEN","volume":"157 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140760076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TB preventive therapy: uptake and time to initiation during implementation of ‘7-1-7’ 结核病预防疗法："7-1-7 "计划实施期间的接受率和开始时间

IJTLD OPEN Pub Date : 2024-04-01 DOI: 10.5588/ijtldopen.24.0101

A. Harries, D. Nair, P. Thekkur, R. Ananthakrishnan, R. Thiagesan, J. M. Chakaya, I. Mbithi, B. Jamil, R. Fatima, M. Khogali, R. Zachariah, S.D. Berger, S. Satyanarayana, A.M.V. Kumar, A. Bochner, A. McClelland

引用次数: 0

A publicly accessible global data repository – the WHO TB-IPD platform 可公开访问的全球数据储存库--世卫组织结核病-IPD 平台

IJTLD OPEN Pub Date : 2024-04-01 DOI: 10.5588/ijtldopen.24.0131

R.L. Goodall, S.M. Fabiane, A. Hakiman, A.M. Crook, F. Mirzayev, S. Schumacher, M.X. Rangaka

引用次数: 0