BioMedicine-Taiwan最新文献_第6页

Changing trends in blood component utilisation during COVID time: Analysis of 1096 COVID-19 in patients COVID期间血液成分利用的变化趋势:1096例COVID-19患者分析

IF 1.7

BioMedicine-Taiwan Pub Date : 2023-07-01 DOI: 10.51248/.v43i3.1334

Christy K. Jose, K. Pailoor

{"title":"Changing trends in blood component utilisation during COVID time: Analysis of 1096 COVID-19 in patients","authors":"Christy K. Jose, K. Pailoor","doi":"10.51248/.v43i3.1334","DOIUrl":"https://doi.org/10.51248/.v43i3.1334","url":null,"abstract":"Introduction and Aim: In the global pandemic caused by Covid-19, older individuals and those with comorbidities have been shown to be more susceptible to serious diseases. The purpose of our research is to estimate the proportion of Covid-19 inpatients requiring blood transfusions over a period of 3 months.\u0000 \u0000Materials and Methods: A retrospective observational analysis of blood product consumption in Covid-19 inpatients at our center from April to June 2021 was conducted by reviewing monthly transfusion records archived in our blood bank. Each blood component administered in Covid-19 wards during the prescribed period was noted.\u0000 \u0000Results: Out of 1096 Covid-19 inpatients, only 66 (6.02%) patients received transfusions. As compared to non-Covid wards, Covid-19 wards had substantially lower transfusion rates for packed cell units (84 vs. 1074 units), FFP (33 vs. 691 units), and platelets (46 vs. 595 units). A total of 163 units of blood components were given to 66 Covid-19 inpatients, the majority of which were packed cell units (51.5%).\u0000 \u0000Conclusion: In comparison to hospitalized non Covid patients, Covid-19 inpatients required fewer transfusions. In our institute, only the Covid 19 patients who were critically sick received blood transfusions; the rest received conservative therapy for their mild to moderate illnesses. This information will be beneficial for our department as it helps us plan and prepare for the use of blood supplies while the pandemic is still going strong.","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43293580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of the role of zinc finger protein-804a (znf804a) (rs1344706) gene polymorphism in schizophrenia and methamphetamine addiction patients 锌指蛋白804a (znf804a) (rs1344706)基因多态性在精神分裂症和甲基苯丙胺成瘾患者中的作用

IF 1.7

BioMedicine-Taiwan Pub Date : 2023-07-01 DOI: 10.51248/.v43i3.2819

Saja Mahir Mohammed, Zainab Hassan Hashim, Qasim Sh. Al-Mayah, Mahir Mohammed Hussein

{"title":"Assessment of the role of zinc finger protein-804a (znf804a) (rs1344706) gene polymorphism in schizophrenia and methamphetamine addiction patients","authors":"Saja Mahir Mohammed, Zainab Hassan Hashim, Qasim Sh. Al-Mayah, Mahir Mohammed Hussein","doi":"10.51248/.v43i3.2819","DOIUrl":"https://doi.org/10.51248/.v43i3.2819","url":null,"abstract":"Introduction and Aim: The zinc finger protein 804A (ZNF804A) gene has garnered significant interest as a gene associated with an increased risk of psychosis. This interest stems from the strong association observed between a specific single nucleotide polymorphism (SNP), namely rs1344706, within the ZNF804A gene, and various psychosis phenotypes, including schizophrenia and bipolar disorder. In this study, we aimed to assess the functional impact of ZNF804A gene polymorphism in individuals diagnosed with schizophrenia and methamphetamine addiction.\u0000 \u0000Materials and Methods: This nested case control research included 50 individuals with schizophrenia and 50 methamphetamine (crystal) users recruited from Ibn-Rushed Psychiatric Teaching Hospital in Baghdad. 50 healthy subjects were also recruited as a control group. All participants were subjected to thorough physical examination. The serum concentration of Zinc Finger Protein-804A (ZNF804A) was determined using a sandwich enzyme-linked immunosorbent assay. Genomic DNA was isolated from whole blood samples, and the Taqman allelic discrimination method was used to genotype the ZNF804A gene rs1344706 polymorphism.\u0000 \u0000Results: Patients with schizophrenia had a significantly higher median level of ZNF804A (48.67 ng/L) than controls (25.56 ng/L) or methamphetamine users (35.62 ng/L). The SNP rs1344706 homozygous (AA) genotype was more common in schizophrenia patients (36% vs. 16%) and methamphetamine addiction patients (4%), with significant differences (OR= 1.32, 95%CI= 1.32-11.75, p=0.014 and OR= 11.7, 95%CI=02.43-56.4, p=0.002, respectively).\u0000 \u0000Conclusion: The AA genotype of rs1344706 polymorphism could be considered a risk factor for schizophrenia but has a protective role against methamphetamine addiction. Serum level of ZNF804A could be used to confirm the diagnosis of schizophrenia in young individuals with subtle clinical features. ","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48721861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of reactive oxygen species on the progression of human diseases by damaging biomolecules 活性氧通过破坏生物分子对人类疾病进展的影响

IF 1.7

BioMedicine-Taiwan Pub Date : 2023-07-01 DOI: 10.51248/.v43i3.2439

V. Pathak, R. Kant, Navneeta R. Kumar

引用次数: 0

Effects of silver nanoparticles on multiple drug-resistant strains of Staphylococcus aureus from periodontal infection: An alternative approach for antimicrobial therapy 纳米银对牙周感染引起的多株金黄色葡萄球菌耐药性的影响：一种抗菌治疗的替代方法

IF 1.7

BioMedicine-Taiwan Pub Date : 2023-07-01 DOI: 10.51248/.v43i3.2822

Shaimaa Noori Mahal, Ahmed Mohammed Turki, Elham Hazeim Abdulkareem

{"title":"Effects of silver nanoparticles on multiple drug-resistant strains of Staphylococcus aureus from periodontal infection: An alternative approach for antimicrobial therapy","authors":"Shaimaa Noori Mahal, Ahmed Mohammed Turki, Elham Hazeim Abdulkareem","doi":"10.51248/.v43i3.2822","DOIUrl":"https://doi.org/10.51248/.v43i3.2822","url":null,"abstract":"Introduction and Aim: Most cases of periodontitis are associated with microorganisms. The Gram positive bacteria Staphylococcus aureus is considered as one of the important organisms associated with periodontal infections. This study investigated the effect of silver nanoparticles as well as the antiseptic agent chlorhexidine on multi-drug resistant S. aureus isolated from periodontal infections.\u0000 \u0000Materials and Methods: In this study, with help from dentists, 266 clinical samples were collected from dental patients who had periodontal infection. S. aureus isolated from samples was tested for their antibiotic susceptibility profiles. Silver nanoparticles and chlorhexidine were evaluated for their antibacterial activity against these S. aureus isolates.\u0000 \u0000Results: S. aureus strains isolated from periodontal infection patients in this study were found to be multidrug resistant. AgNPs obtained using E. coli showed high inhibition of S. aureus growth when used in different concentrations (5, 10, 15, 20, 25mM). Chlorhexidine also exhibited antibacterial activity against S. aureus. Combination of AgNPs with penicillin and ciprofloxacin had an increasing significant effect on the sensitivity of S. aureus. Similarly, chlorhexidine in combination with penicillin and ciprofloxacin also showed an inhibitory effect on the growth of S. aureus.\u0000 \u0000Conclusion: AgNPs and chlorhexidine combined with antibiotics used in treatment of S. aureus isolated from periodontal disease showed a good antibacterial effect which suggests its use as an antibacterial agent against periodontitis associated bacteria.","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43672611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Do miR-146a plasma levels alter in Alzheimer’s patients and impact their cognitive functions? 阿尔茨海默病患者血浆中miR-146a水平是否改变并影响其认知功能?

IF 1.7

BioMedicine-Taiwan Pub Date : 2023-07-01 DOI: 10.51248/.v43i3.2817

Sadiruldeen Sami Abed, Farqad Bader Hamdan, Qasim Sharhan Al-Mayah, Mahir Mohammed Hussein

{"title":"Do miR-146a plasma levels alter in Alzheimer’s patients and impact their cognitive functions?","authors":"Sadiruldeen Sami Abed, Farqad Bader Hamdan, Qasim Sharhan Al-Mayah, Mahir Mohammed Hussein","doi":"10.51248/.v43i3.2817","DOIUrl":"https://doi.org/10.51248/.v43i3.2817","url":null,"abstract":"Introduction and Aim: The miR-146a is a short non-coding RNA molecule that has both therapeutic and biomarker potential. Abnormal miR-146a expression has been linked to several disorders. The target of the study is to investigate the possible link between miRNA-146a expression and the deterioration of cognitive function in Alzheimer's patients.\u0000 \u0000Materials and Methods: The research comprised 40 individuals from Iraq, spanning both genders and ranging in age from 60 to 85 years. They were segregated into two distinct groups. The first group included 40 subjects (age of 75±6.6 years) who displayed no signs of cognitive or functional impairment. The second group consisted of 40 patients diagnosed with Alzheimer's disease (with an average age of 74.98±5.03 years), as per the DSM-5 criteria. To assess the mir-146 gene expression, quantitative polymerase chain reaction (qPCR) was employed.\u0000 \u0000Results: The median expression of miR-146a in Alzheimer's disease was 0.97-fold greater than in control, with no statistically significant difference. There were no significant differences in the means between Alzheimer's females and Alzheimer's males. Female control subjects had considerably higher mean ADAS-cog scores than male control subjects. In Alzheimer's disease patients, age was observed to be strongly associated with ADAS-Cog scores, showing that age plays a role in disease development.\u0000 \u0000Conclusion: Serum miR-146a is not related to the development of Alzheimer disease and does not affect disease progression","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42668445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of in vitro antioxidant potential of Anisomeles indica Kuntze and exploration of its bioactive phytoconstituents 山莨菪碱体外抗氧化能力的评价及其生物活性成分的探索

IF 1.7

BioMedicine-Taiwan Pub Date : 2023-07-01 DOI: 10.51248/.v43i3.2541

M. T, Kumar Vadlapudi, Prathap H.M., Poornima D.V., R. F., V. E., S. M., Anuradha Cm

{"title":"Evaluation of in vitro antioxidant potential of Anisomeles indica Kuntze and exploration of its bioactive phytoconstituents","authors":"M. T, Kumar Vadlapudi, Prathap H.M., Poornima D.V., R. F., V. E., S. M., Anuradha Cm","doi":"10.51248/.v43i3.2541","DOIUrl":"https://doi.org/10.51248/.v43i3.2541","url":null,"abstract":"Introduction and Aim: Anisomeles indica Kuntze (A. indica) is employed to treat a wide range of illnesses. The Present study was aimed at establishing preliminary phytochemical screening, UV-Visible spectrophotometric, FT-IR analysis, and evaluation of biological activities of A. indica extracts. \u0000 \u0000Materials and Methods: A. indica leaves were employed for the Soxhlet extraction. Furthermore, the crude extracts were utilized for phytochemical analysis and quantitative estimations of phenolics and flavonoids. UV-Vis spectrophotometric, and FT-IR analysis provided further evidence for the existence of bioactive constituents in A. indica extracts. The A. indica extracts were assessed for antioxidant potential by DPPH and metal chelation activity. \u0000 \u0000Results: The findings illustrated that A. indica methanol extract was found to possess the highest yield. The preliminary phytochemical screening, UV-Vis spectrophotometric, and FT-IR fingerprint analysis provided evidence for the existence of significant bioactive constituents. A.indica methanol extract has significant total phenol, flavonoid content, and TAC (total antioxidant capacity) among all extracts. These characteristics are attributed to substantial antioxidant activity and metal-chelating activity. \u0000 \u0000Conclusion: The findings of this study imply that A. indica extract possess antioxidant activity as evaluated by the potential DPPH radical scavenging and chelate metal ions. These characteristics are interconnected to the high flavonoid and phenol content, and distinctive secondary metabolites. The finding indicates that A.indica is abundant in active phytoconstituents, which also offer a vital source for effective therapeutic management.","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47313786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A study on virulence determinants and antimicrobial resistance among Enterococci isolates 肠球菌分离株毒力决定因素及耐药性的研究

IF 1.7

BioMedicine-Taiwan Pub Date : 2023-07-01 DOI: 10.51248/.v43i3.1160

Reena Rajan, K. Dhandapani

{"title":"A study on virulence determinants and antimicrobial resistance among Enterococci isolates","authors":"Reena Rajan, K. Dhandapani","doi":"10.51248/.v43i3.1160","DOIUrl":"https://doi.org/10.51248/.v43i3.1160","url":null,"abstract":"Introduction and Aim: Presence of virulence factors may cause increased persistence of Enterococci in the healthcare environment, increase ability to colonise inpatients and thereby result in the transmission of infection. The present study was performed to detect the presence of virulence traits among the clinical strains of Enterococci and to determine its association between virulence factors and susceptibility to various antibiotics.\u0000 \u0000Materials and Methods: Clinical isolates of Enterococci were identified to species level by conventional method and Vitek 2 automated method and subjected to antibiotic susceptibility testing using disk diffusion and Minimum Inhibitory Concentration (MIC) method. Presence of hemolysin, gelatinase and biofilm was detected by phenotypic method.\u0000 \u0000Results: Out of 708 isolates from urine 39 (5.51%) Enterococcus faecalis, and 3 isolates each of Enterococcus faecium (0.42 %) and Enterococcus durans (0.42 %) were biofilm producers. Beta hemolysin production was detected in 342 (48.30%) E. faecalis obtained from urine and 9/48 (18.75 %) from pus. Out of the isolates studied, 9/774 (1.16 %) isolates were found to be positive for beta-hemolysin production, gelatinase and biofilm production. All the 9 (100.00 %) isolates were resistant to penicillin, high level gentamicin, ciprofloxacin and levofloxacin.\u0000 \u0000Conclusion: Virulence factors described in Enterococci enable these organisms to colonise patient tissue, increase resistance to antimicrobial agents and aggravate infection outcome.","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48602113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of conventional management and Carica papaya on influencing wound healing: A systematic review and meta-analysis 常规治疗和木瓜对伤口愈合的影响:系统回顾和荟萃分析

IF 1.7

BioMedicine-Taiwan Pub Date : 2023-07-01 DOI: 10.51248/.v43i3.2851

Sathya Siva, Madhanraj Sekar, Surya Prakash V., Titus J., Mohammed Arifullah Mohamed Fazulah, S. V

引用次数: 0

Contribution of platelet-rich plasma therapy in reproductive health science: A narrative review 富血小板血浆疗法在生殖健康科学中的贡献：叙述性综述

IF 1.7

BioMedicine-Taiwan Pub Date : 2023-07-01 DOI: 10.51248/.v43i3.2678

Shilpa Dutta, Akash More, Priti Karadbhajne, D. Shrivastava

{"title":"Contribution of platelet-rich plasma therapy in reproductive health science: A narrative review","authors":"Shilpa Dutta, Akash More, Priti Karadbhajne, D. Shrivastava","doi":"10.51248/.v43i3.2678","DOIUrl":"https://doi.org/10.51248/.v43i3.2678","url":null,"abstract":"Platelet-rich plasma therapy, also truncated as PRP, has been remarkably utilized for quite long in the domains of cardiovascular surgery, orthopaedic treatments, sports medicines etc. Being in the limelight for its remarkable wound healing and cell proliferating activities, it has caught the interest of researchers in the field of reproductive sciences. The chief domain of research has revolved around thin endometrial lining, diminished ovarian content, recurrent implantation failure ailments etc. This article has focused on reviewing existing articles till now on the aetiology of PRP along with methodologies and results in reproductive aberrational conditions. Restrictive research is conducted from Scopus and Web of Science indexed journals, PubMed focusing on the deployment of PRP in infertility science and categorized the result under 3 genres: PRP in refractory attenuated endometrium, PRP in female gonadal abnormalities and PRP in Asherman’s syndrome. Most literature has shown promising results in improvement of thin endometrium, along with increase in AMH (Anti-Mullerian Hormone) level along with decrement of FSH (Follicle Stimulating Hormone) level, thereby improving ovarian reserve. It also showed reduced adhesion in the uterus after hysteroscopy, along with improvement in the menstrual cycle in case of Asherman’s syndrome, thereby increasing chances of clinical pregnancy. However, lack of standardized protocol is a major con in variation of results. Thus, until conclusive RCTs with larger sample size are conducted, PRP should be restricted to the experimental stage for now.","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45501343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating network pharmacology and molecular docking for the identification of key genes and therapeutic targets of Nigella sativa in multiple sclerosis treatment 结合网络药理学和分子对接，鉴定黑草治疗多发性硬化症的关键基因和治疗靶点

IF 1.7

BioMedicine-Taiwan Pub Date : 2023-07-01 DOI: 10.51248/.v43i3.2867

Hardi Kapadia, Divya Vora, Dinesh S. Manjegowda, A. Nair, Sameer Sharma, Susha Dinesh

{"title":"Integrating network pharmacology and molecular docking for the identification of key genes and therapeutic targets of Nigella sativa in multiple sclerosis treatment","authors":"Hardi Kapadia, Divya Vora, Dinesh S. Manjegowda, A. Nair, Sameer Sharma, Susha Dinesh","doi":"10.51248/.v43i3.2867","DOIUrl":"https://doi.org/10.51248/.v43i3.2867","url":null,"abstract":"Introduction and Aim: Multiple sclerosis (MS) is a chronic neurodegenerative disease affecting around 2.8 million people worldwide. MS pathophysiology is not yet explained up to the mark, which is the cause of difficulty and complexity in treating the illness. Most present-day scenarios are engrossed in inhibiting central nervous system (CNS) inflammation. However, this is not enough, hence the present study aims at finding best neuroprotective treatment without adverse effects.\u0000 \u0000Materials and Methods: In silico attempt to validate the phytocompounds from Nigella sativa and showcase their use for targeting the neuroprotective mechanism involved in management of MS by finding the key potential genes which were derived from mRNA datasets of previous research. Various bioinformatics tools and software such as GEO, String, ShinyGO, PyRx were used to carry out the current study. The leading steps involve retrieval of targets from mRNA datasets, molecular docking of phytocompounds with the targets and pharmacological analysis.\u0000 \u0000Results: These phytocompounds from seeds of N. sativa showed promising results as therapeutic agents against target genes RPL27, RPS14 and FAU for management of MS during current in silico study, but any treatment prior its clinical practice should validate with large robust data, which lies as the future prospective here.\u0000 \u0000Conclusion: In summary notable progress in management of MS with better understanding of pathology has been made and many disease modifying therapies (DMT) are made available but the question of safety and efficacy is still challenging due to adverse effects associated with these therapies. Hence properties of N. sativa must be explored as a therapeutic agent that can reduce the neuronal degeneration.","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42991282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0