Alejandra Marroig, Fernando Massa, Ángela Gutiérrez, Adil Supiyev, Barış Sevi, Graciela Muniz-Terrera
{"title":"Longitudinal norms of frailty measured by the frailty index: A cross-national comparison using data from the survey of health, aging, and retirement in Europe (SHARE).","authors":"Alejandra Marroig, Fernando Massa, Ángela Gutiérrez, Adil Supiyev, Barış Sevi, Graciela Muniz-Terrera","doi":"10.1016/j.tjfa.2026.100144","DOIUrl":"10.1016/j.tjfa.2026.100144","url":null,"abstract":"<p><strong>Background: </strong>Frailty, a geriatric syndrome commonly used to identify vulnerable older adults, is a public health priority. However, the lack of cross-national comparisons of frailty trajectories and their distribution constrains current understanding of normative changes in frailty for residents across different countries.</p><p><strong>Objective: </strong>To derive longitudinal percentiles of frailty using a consistent cross-country approach.</p><p><strong>Design: </strong>Observational study using longitudinal data from the Survey of Health, Ageing and Retirement in Europe (SHARE) between 2004 and 2020.</p><p><strong>Setting: </strong>We fit the distribution of the FI by Generalized Additive Models for Location, Scale, and Shape (GAMLSS), assessed the role of sex (male/female), education (in years), and migration status (migrant/non-migrant), and estimated the longitudinal percentiles of frailty using a consistent cross-country approach for 16 countries.</p><p><strong>Participants: </strong>Individuals aged ≥65 years (N = 42,951) at study entry.</p><p><strong>Measurements: </strong>Frailty index (FI) based on the accumulation of deficits in 40 items.</p><p><strong>Results: </strong>The results show that education is protective against frailty in all countries (a decrease of 1.1 pp. in Switzerland to 5.7 pp. in Slovenia, all p < 0.001). In most countries, women are frailer than men and migrant individuals have higher levels of frailty than non-migrants. FI trajectories showed heterogeneity across countries. The quantiles for women and migrants suggest frailer trajectories than men and non-migrants respectively.</p><p><strong>Conclusions: </strong>Findings from this cross-national comparison provide a framework within which the longitudinal norms of frailty trajectories from different countries can be interpreted.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"15 3","pages":"100144"},"PeriodicalIF":3.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13019775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147500692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Declining kidney function and frailty progression: a 7-year cohort study of Chinese middle-aged and older adults.","authors":"Fan Zhang, Yan Bai, Liuyan Huang, Yifei Zhong","doi":"10.1016/j.tjfa.2026.100151","DOIUrl":"10.1016/j.tjfa.2026.100151","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate the association between baseline kidney function and frailty trajectories in middle-aged and older adults.</p><p><strong>Methods: </strong>Data were derived from the China Health and Retirement Longitudinal Study (2011-2018), including 5364 participants aged ≥45 years at baseline with up to four assessment waves over approximately 7 years. Kidney function was evaluated using estimated glomerular filtration rate based on serum creatinine and cystatin C (eGFR<sub>scr-cysc</sub>) and categorized as normal (≥90), mildly reduced (60-89) and moderately-to-severely reduced (<60 ml/min/1.73m²). Frailty was assessed using a 30‑item frailty index (0-100 scale). Linear mixed-effects models with random intercepts were used to examine the effects of baseline kidney function and its interaction with time on frailty index trajectories.</p><p><strong>Results: </strong>At baseline, the mean frailty index was higher in participants with mildly (β=2.28, 95% CI: 1.63-2.94) and moderately-to-severely (β=3.70, 95% CI: 2.41-4.99) reduced kidney function compared to normal kidney function, where β represents the adjusted difference in frailty index relative to the reference group. Frailty index increased over time in all groups; in participants with normal kidney function, it rose by 0.83 points per year (95% CI: 0.77-0.90). The annual increase was 0.26 points greater (95% CI: 0.18-0.35) in the mildly reduced and 0.70 points greater (95% CI: 0.54-0.87) in the moderately-to-severely reduced group. Over approximately 7 years, predicted mean frailty index increased from 15.1 to 20.9, 17.4 to 25.0, and 18.8 to 29.5 in the normal, mildly reduced and moderately-to-severely reduced groups, respectively.</p><p><strong>Conclusions: </strong>Middle-aged and older adults with lower kidney function exhibited higher frailty index levels at baseline and faster frailty progression over time.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"15 3","pages":"100151"},"PeriodicalIF":3.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13188088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147870340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Strengthening healthy ageing in the Caribbean through regional capacity building and ICOPE implementation.","authors":"Nadine Simo, Moustapha Dramé, Denis Boucaud-Maitre, Maturin Tabue-Teguo","doi":"10.1016/j.tjfa.2026.100160","DOIUrl":"10.1016/j.tjfa.2026.100160","url":null,"abstract":"","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"15 3","pages":"100160"},"PeriodicalIF":3.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13226892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148018742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M Inzitari, E Vela, C Martín Pardina, E Vallés, L Viale, G Valls, M A Gil, M Llonch, K Covinsky, J Deardorff
{"title":"A new simplified minimum data set better predicts outcomes for individuals admitted to intermediate care functional recovery units in catalonia.","authors":"M Inzitari, E Vela, C Martín Pardina, E Vallés, L Viale, G Valls, M A Gil, M Llonch, K Covinsky, J Deardorff","doi":"10.1016/j.tjfa.2026.100158","DOIUrl":"10.1016/j.tjfa.2026.100158","url":null,"abstract":"<p><p>Background Intermediate care functional recovery (ICFR) units in Catalonia, Spain, provide post acute care and geriatric rehabilitation. Providers report a Minimum Data Set (MDS), initially developed to classify patients into resource utilization groups (RUG), to adjust public reimbursement. The MDS, completed by health professionals, is time consuming and diverges from routine clinical assessment. Objectives We developed new intermediate care case-mix indexes (ICMI), based on admission diagnosis and function, and tested whether ICMIs better predict length of stay (LOS) and discharge destination, compared to RUG. Methods We developed the ICMIs using 122,754 ICFRs admissions (years 2017-18-19-22): we categorized individuals by diagnosis and four levels of activities of daily living (ADL). To obtain ICMIs, each category was assigned a weight based on associations with ICFR LOS and \"unsuccessful discharge\" (death or other service versus home). Then, in the 2023 cohort, we compared the performance of four models (base model (age, sex, income), base+RUG, base+ADL, base+ICMIs) to predict LOS >57 days and unsuccessful discharge. Results The 2023 cohort included 31,640 patients (median age [IQR]=82.0 [75.0;88.0], 57% women). When predicting dichotomous LOS, the area under the ROC curve (AUC) increased from 0.56 [95% CI=0.544-0.57] to 0.56 [95% CI=0.55-0.56] (base+RUG), 0.59 [95% CI=0.58-0.61] (base+ADL), and 0.63 [95% CI=0.62-0.65] (base+ICMI). AUC to predict discharge destination showed similar improvements (0.55 [95% CI=0.54 0.55], 0.59 [95% CI=0.58-0.59], 0.64 [95% CI=0.63-0.64], 0.66 [95% CI=0.65-0.66], respectively). Conclusions In Catalan ICFRs, new, simplified, case-mix indicators improved prediction of LOS and discharge destination, compared to existing tools. This study can inform new policies for intermediate care, adding a validated instrument to improve evaluation and reimbursing systems.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"15 3","pages":"100158"},"PeriodicalIF":3.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13188075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147876620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Matteo Cesari, Jotheeswaran Amuthavalli Thiyagarajan, Antonio Cherubini, Theresa Diaz, Marina Kotsani, Teena Kunjumen, Tahir Masud, John W Rowe, Ritu Sadana, Mirko Petrovic
{"title":"Geriatric medicine across countries: Specialised workforce, training and system integration challenges.","authors":"Matteo Cesari, Jotheeswaran Amuthavalli Thiyagarajan, Antonio Cherubini, Theresa Diaz, Marina Kotsani, Teena Kunjumen, Tahir Masud, John W Rowe, Ritu Sadana, Mirko Petrovic","doi":"10.1016/j.tjfa.2026.100152","DOIUrl":"10.1016/j.tjfa.2026.100152","url":null,"abstract":"<p><strong>Background: </strong>The development and integration of geriatric medicine into national health care systems vary widely across countries. While a robust care workforce requires providers from several disciplines, including nursing, social sector, rehabilitation, psychiatry, neurology, and others, a strong core of highly qualified geriatricians is essential to delivering older person-centred and integrated care. The number and professional profile of geriatricians, along with the status of the specialty, are important to informing efforts to reshape health care systems in response to the global ageing scenario.</p><p><strong>Methods: </strong>WHO developed and distributed a structured questionnaire to representatives of national geriatrics and gerontology societies beginning in March 2025. The survey collected data on the status of the geriatric medicine specialty, including its formal recognition at the country level, the estimated number of practising geriatricians, and information on training curricula, professional environments, and systemic challenges.</p><p><strong>Results: </strong>A total of 48 national societies completed the survey. Recognition of geriatric medicine ranged widely, from full specialty status in some countries to subspecialty or non-recognition in others. The number of practicing geriatricians per 100,000 persons aged 60 years and older ranged from <0.1 to >30 across countries, illustrating marked workforce disparities and some severe shortages. Where the geriatric medicine specialty is formally available, pre-service training durations ranged from 24 to 96 months. Geriatricians worked in diverse settings, though integration into primary care and public health was limited. Training in and exposure to geriatric medicine principles during undergraduate and postgraduate medical training were minimal in many countries. Key challenges included workforce shortages, fragmentation of care, and undervaluation of the speciality's role in informing health care for older people. Strategic priorities reported by respondents included investment in training, policy development, and institutional support.</p><p><strong>Conclusions: </strong>The survey highlights disparities in geriatric medicine across countries and identifies several challenges and priorities. Strengthening education, policy, and workforce development is essential to meet the needs of ageing populations and support healthy ageing worldwide. At the same time, countries should also think of innovative approaches and building capacity of existing other health occupations to improve geriatric care. Future updates of this survey will provide longitudinal insights into workforce evolution. These findings provide a global evidence base to guide workforce planning and policy under the United Nations Decade of Healthy Ageing (2021-2030).</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"15 3","pages":"100152"},"PeriodicalIF":3.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13188073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147876611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Robinson Ramírez-Vélez, Miguel Germán Borda, Juan Carlos Calderón-González, Albeiro Dávila-Grisales, Gonzalo Romero-Martínez, Mikel Izquierdo, Miguel A Pérez-Sousa
{"title":"Low relative sit-to-stand power in Colombian older adults: Cut-off points and associations with frailty and functional decline.","authors":"Robinson Ramírez-Vélez, Miguel Germán Borda, Juan Carlos Calderón-González, Albeiro Dávila-Grisales, Gonzalo Romero-Martínez, Mikel Izquierdo, Miguel A Pérez-Sousa","doi":"10.1016/j.tjfa.2026.100141","DOIUrl":"10.1016/j.tjfa.2026.100141","url":null,"abstract":"<p><strong>Objectives: </strong>To examine the association between relative sit-to-stand (STS) power and age, establish sex-specific cut-off points, and evaluate their associations with adverse outcomes in Colombian older adults.</p><p><strong>Design: </strong>Cross-sectional, population-based study.</p><p><strong>Setting: </strong>Health, Well-being, and Aging Study (SABE-Colombia, 2014-2015).</p><p><strong>Participants: </strong>3051 community-dwelling adults aged ≥60 years (56.6 % women; mean age 68.6 ± 6.4 years).</p><p><strong>Measurements: </strong>Relative STS power (W·kg⁻¹) was estimated using a validated equation. Quantile regression examined age-related changes across percentiles (Q10-Q90). Receiver operating characteristic (ROC) curves with the Youden index determined cut-off points. Age-adjusted logistic regression tested associations with frailty, functionality as gait speed and handgrip strength (HGS), and depression.</p><p><strong>Results: </strong>Optimal cut-offs for low relative STS power were 2.11 W·kg⁻¹ for men and 1.63 W·kg⁻¹ for women. Prevalence of low STS power was 34.3 % in men and 34.8 % in women, increasing with age in both sexes. Quantile regression revealed steeper age-related declines at higher percentiles, particularly among men. Low relative STS power was significantly associated with frailty and low functionality.</p><p><strong>Conclusion: </strong>Relative STS power is a simple, clinically feasible biomarker to identify functional impairment in older adults. The sex-specific thresholds reported for Colombian populations reflect demographic differences in muscle physiology and decline. Their integration into geriatric practice may enhance early detection, guide preventive interventions, and ultimately improve health outcomes in aging populations.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"15 3","pages":"100141"},"PeriodicalIF":3.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13019548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147492240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carlos de Mestral, Saman Khalatbari-Soltani, Patrick Bodenmann, Yves Henchoz, Mauricio Avendano
{"title":"The mediating role of chronic disease in socioeconomic inequalities in frailty: A longitudinal cohort study of older adults in Lausanne, Switzerland.","authors":"Carlos de Mestral, Saman Khalatbari-Soltani, Patrick Bodenmann, Yves Henchoz, Mauricio Avendano","doi":"10.1016/j.tjfa.2026.100134","DOIUrl":"10.1016/j.tjfa.2026.100134","url":null,"abstract":"<p><strong>Background: </strong>Frailty is a major public health concern in aging populations. Socioeconomic disadvantage increases the risk of frailty, yet the mechanisms underlying this association remain unclear.</p><p><strong>Objectives: </strong>To examine the mediating role of chronic diseases in the longitudinal association between socioeconomic disadvantage and frailty.</p><p><strong>Design: </strong>Population-based cohort study.</p><p><strong>Setting: </strong>Lausanne, Switzerland.</p><p><strong>Participants: </strong>4731 community-dwelling adults aged 65-70 years at recruitment (2004, 2010, and 2014), followed for up to 16 years, as part of the Lausanne Cohort 65+.</p><p><strong>Intervention: </strong>None.</p><p><strong>Measurements: </strong>Socioeconomic disadvantage was assessed using indicators of education, occupation, income, health insurance subsidy, and financial strain. Frailty was measured using the Fried phenotype (unintentional weight loss, exhaustion, low physical activity, weakness, and slow walking speed). Chronic conditions (obesity, diabetes, hypertension, cardiovascular and respiratory disease, and multimorbidity [≥2 conditions]) were assessed at baseline using standardized self-reported physician diagnoses. Counterfactual mediation using Cox proportional hazards models estimated the proportion of the socioeconomic disadvantage-frailty association mediated by each condition.</p><p><strong>Results: </strong>Socioeconomic disadvantage was associated with a 1.5-2.5-fold higher risk of incident frailty. Obesity mediated 13-55% of this association, diabetes 11-22%, and multimorbidity 21-39%, whereas hypertension, cardiovascular, and respiratory disease showed minimal or no mediation.</p><p><strong>Conclusions: </strong>Chronic diseases-particularly obesity and diabetes-partly explain the long-term impact of socioeconomic disadvantage on frailty, underscoring stark inequities in healthy aging. Early detection and management of these conditions in socioeconomically vulnerable older adults, alongside population-level prevention and efforts to address adverse socioeconomic conditions as root causes, could help reduce these inequalities.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"15 3","pages":"100134"},"PeriodicalIF":3.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13019564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147494337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Functional disability and cognition in relation to residential transitions in older adults: Evidence from three French cohorts, 1988-2018.","authors":"Jeanne Bardinet, Luc Letenneur, Alice Pellichero, Denis Boucaud-Maitre, Maturin Tabue-Teguo, Hélène Amieva, Karine Pérès","doi":"10.1016/j.tjfa.2026.100159","DOIUrl":"10.1016/j.tjfa.2026.100159","url":null,"abstract":"<p><strong>Background: </strong>Aging is often accompanied by increasing difficulties in daily living that may compromise aging in place. In France, three main housing types can be distinguished: ordinary home (OH), intermediate housing (IH) and nursing home (NH). This study aimed to explore the relationship between functional disability, cognition, and residential transitions in older adults.</p><p><strong>Methods: </strong>Participants aged 65 years and older living in OH at baseline were drawn from three French population-based cohorts (PAQUID, Three-City and AMI), followed for up to 30 years. A hierarchical indicator of functional disability was derived from mobility, IADL and ADL disabilities, while cognitive function was assessed using the Mini Mental State Examination (MMSE). A multi-state model was applied to investigate the associations between functional disability and cognition (as time-dependent variables) with housing transitions, adjusting for sex, cohort, marital status and education. We also examined the involvement of IADL disabilities on transitions from OH to IH or NH in sex-stratified models. Sensitivity analyses were performed using lagged measures.</p><p><strong>Results: </strong>Among 5264 included participants (mean age 74.7 ± 6.0 years; 56.9% women), 832 relocated from OH during a median follow-up of 10.2 years, including 216 to IH and 616 to NH. Mild and moderate disability, as lower MMSE scores, were independently associated with higher risks of transitioning to IH or NH, while severe disability and cognitive impairment were only associated with NH transitions. In sex-stratified analyses, transportation difficulties were associated with IH and NH transitions among women, whereas only with NH admission in men. Difficulties with handling finances in women, with medications management in men, and difficulties with shopping in both sexes were also associated with transition to NH.</p><p><strong>Discussion: </strong>Intermediate housing was more frequently associated with mild or moderate disability, whereas transitions to long-term care were more often observed in participants with severe cognitive decline.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"15 3","pages":"100159"},"PeriodicalIF":3.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13224349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148018690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Joanne Boyce, Declan Patton, Chanel Watson, Tom O'Connor, Zena Moore, Linda Nugent
{"title":"The impact of integrated care on quality of life in community-dwelling older adults with frailty: A systematic review and mixed method synthesis.","authors":"Joanne Boyce, Declan Patton, Chanel Watson, Tom O'Connor, Zena Moore, Linda Nugent","doi":"10.1016/j.tjfa.2026.100150","DOIUrl":"10.1016/j.tjfa.2026.100150","url":null,"abstract":"<p><strong>Background: </strong>Frailty among older adults is an escalating public health challenge, often associated with poorer quality of life (QoL) and increased pressure on healthcare systems. Integrated care is proposed as a strategy to meet the complex needs of this population, though evidence of its effectiveness remains inconclusive.</p><p><strong>Objectives: </strong>To determine the impact of integrated care on the quality of life of frail, community-dwelling older adults.</p><p><strong>Design: </strong>Systematic review and mixed-methods synthesis, including meta-analysis and narrative synthesis.</p><p><strong>Setting: </strong>Community-based healthcare systems across six international studies.</p><p><strong>Participants: </strong>A total of 5498 frail, community-dwelling older adults across six studies: four randomised controlled trials and two quasi-experimental designs.</p><p><strong>Intervention: </strong>Integrated care interventions tailored to frailty, including person-centred, multidisciplinary, and value-based models.</p><p><strong>Measurements: </strong>Quality of Life was the primary outcome. Secondary outcomes included social functioning and healthcare costs. Standardised tools such as SF-12, SF-36, ICECAP-O, and EQ-5D were used across studies.</p><p><strong>Results: </strong>The meta-analysis showed a small, non-significant improvement in QoL (SMD = 0.13, 95 % CI: -0.09 to 0.35, p = 0.24) with high heterogeneity (I² = 91 %). Tailored, multidimensional models showed greater effects, particularly in preserving social functioning. Findings on cost-effectiveness were inconsistent; some studies reported reduced hospital use, while others found increased primary care visits without cost savings.</p><p><strong>Conclusions: </strong>. Integrated care may support social functioning but does not demonstrate a consistent improvement in overall QoL. Future trials should standardise QoL measurement, report intervention components clearly, include economic evaluations, and assess longer-term outcomes.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"15 3","pages":"100150"},"PeriodicalIF":3.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13254956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148158979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emanuele Marzetti, Anna Picca, Riccardo Calvani, Hélio José Coelho-Júnior
{"title":"Access to emerging health technologies in aging: from innovation to inclusion.","authors":"Emanuele Marzetti, Anna Picca, Riccardo Calvani, Hélio José Coelho-Júnior","doi":"10.1016/j.tjfa.2026.100161","DOIUrl":"10.1016/j.tjfa.2026.100161","url":null,"abstract":"","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"15 3","pages":"100161"},"PeriodicalIF":3.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13234716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148037352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}