Infection and Chemotherapy最新文献

{"title":"Reply: Genomic Insights and Antimicrobial Resistance: Addressing the Burden of Neonatal Sepsis in Africa.","authors":"Abiodun Tola Seriki, Chioma Obi, Amusa Azeez Olashile, Utibeima Udo Essiet, Desmond Wemimo Akingboye, Abraham Ajayi, Tenny Obiageli Gladys Egwuatu, Stella Smith","doi":"10.3947/ic.2025.0119","DOIUrl":"10.3947/ic.2025.0119","url":null,"abstract":"","PeriodicalId":51616,"journal":{"name":"Infection and Chemotherapy","volume":"57 4","pages":"627-628"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12802041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145901506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-Income Status and Opportunistic Infections as Factors for Unsuppressed Viral Load in Timor-Leste.","authors":"John Patrick C Toledo","doi":"10.3947/ic.2025.0104","DOIUrl":"10.3947/ic.2025.0104","url":null,"abstract":"","PeriodicalId":51616,"journal":{"name":"Infection and Chemotherapy","volume":"57 4","pages":"629-630"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12802017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145901505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply: Exploring a More Accessible and Affordable Live Attenuated Herpes Zoster Vaccine (SKYZoster®) in the Philippines.","authors":"Sun Heom Baik, Hye Young Kim","doi":"10.3947/ic.2025.0138","DOIUrl":"10.3947/ic.2025.0138","url":null,"abstract":"","PeriodicalId":51616,"journal":{"name":"Infection and Chemotherapy","volume":"57 4","pages":"623-624"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12802014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145901533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Herpes Zoster Reactivation in Patients with Coronary Artery Disease.","authors":"Hyo-Ju Son, Seung-Beom Kim, Ji-Soo Kwon, Kyung Hwa Jung, Sang-Oh Lee, In Tae Moon, Sung-Han Kim","doi":"10.3947/ic.2025.0056","DOIUrl":"10.3947/ic.2025.0056","url":null,"abstract":"<p><p>The association between varicella-zoster virus (VZV) reactivation and coronary artery disease (CAD) remains uncertain. We enrolled 107 patients (mean age 66.5±10.8 years; 72% male) who underwent coronary angiography due to suspected CAD and assessed subclinical VZV reactivation via salivary VZV PCR. Patients were divided into three groups: acute coronary syndrome, chronic coronary syndrome, and insignificant CAD. VZV DNA was detected in three patients (3%) -one in the acute group and two in the chronic group (<i>P</i>=0.469). Although not statistically significant, these findings warrant further investigation into the potential link between VZV reactivation and CAD.</p>","PeriodicalId":51616,"journal":{"name":"Infection and Chemotherapy","volume":"57 4","pages":"596-601"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12802046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145901487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjunctive Role of Pulmonary Angiography in Differentiating Invasive Mold Pneumonia from Bacterial Pneumonia.","authors":"Yeon-Joo Choi, So Yun Lim, Euijin Chang, Seongman Bae, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sang-Ho Choi, Sang-Oh Lee, Yang Soo Kim, Mi Young Kim, Sung-Han Kim","doi":"10.3947/ic.2025.0064","DOIUrl":"10.3947/ic.2025.0064","url":null,"abstract":"<p><p>In this retrospective study over eight years involving 25 immunocompromised adults, computed tomography pulmonary angiography (CTPA) demonstrated vascular invasion sign in 80% of proven or probable invasive mold pneumonia (IMP) cases (12/15), while absent in all bacterial pneumonia cases (0/10). These findings suggest that angioinvasion-related features on CTPA may serve as a valuable diagnostic adjunct in differentiating IMP from bacterial pneumonia in high-risk population.</p>","PeriodicalId":51616,"journal":{"name":"Infection and Chemotherapy","volume":"57 4","pages":"602-607"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12802037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145901414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial Stewardship at the End of Life: From Overtreatment to Responsible Practice.","authors":"Andre Piccolo Pereira, Marcelo Carneiro, Rochele Mosmann Menezes, Eduarda Michelin, Juliano Rathke, Suelen Machado de Freitas","doi":"10.3947/ic.2025.0085","DOIUrl":"10.3947/ic.2025.0085","url":null,"abstract":"","PeriodicalId":51616,"journal":{"name":"Infection and Chemotherapy","volume":"57 4","pages":"617-618"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12802051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145901442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Morganella morganii</i> Urinary Tract Infection in Jordanian Children: Case Series from a Tertiary Hospital.","authors":"Eyad Altamimi, Rola Saqan, Maria A Alshurman, Tala Al Shalakhti, Haneen Tashtoush","doi":"10.3947/ic.2025.0066","DOIUrl":"10.3947/ic.2025.0066","url":null,"abstract":"<p><strong>Background: </strong>Urinary tract infections (UTIs) pose significant risks to children's health, with potential for kidney damage if untreated. <i>Morganella morganii</i> is an uncommon but important pathogen in pediatric UTIs. We aimed to describe the clinical characteristics, risk factors, and antibiotic susceptibility patterns of <i>M. morganii</i> UTIs in Jordanian children.</p><p><strong>Materials and methods: </strong>We conducted a retrospective review of pediatric patients (aged 0-18 years) diagnosed with <i>M. morganii</i> UTIs at King Abdullah University Hospital from 2017 to 2022. Data collected included demographics, clinical presentation, laboratory findings, imaging studies, antimicrobial susceptibility profiles, and treatment offered.</p><p><strong>Results: </strong>Nine patients were identified, 77.8% of whom were female, with a median age of 3.35 years (interquartile range, 2-14.5). The most common symptoms were fever (55.6%), malodorous urine (44.4%), and vomiting (22.2%). A high prevalence of underlying urological abnormalities, particularly neurogenic bladder and myelomeningocele (44% each), was noted. Eight cases involved lower UTIs. <i>M. morganii</i> isolates were uniformly sensitive to amikacin, cefepime, and piperacillin-tazobactam but resistant to amoxicillin-clavulanate and nitrofurantoin.</p><p><strong>Conclusion: </strong><i>M. morganii</i> should be considered in pediatric UTIs, especially among children with urinary tract anomalies or catheter use. Awareness of its distinct resistance profile is critical for selecting appropriate empiric therapy.</p>","PeriodicalId":51616,"journal":{"name":"Infection and Chemotherapy","volume":" ","pages":"522-530"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12802043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145656302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Link between Mental Health and Treatment Adherence in People Living with HIV: A Structured Questionnaire-Based Study.","authors":"Yae Jee Baek, Jongyae Yoon, Eunjung Lee, Hyo Kyoung Kim, Hyo Hyun Hong, Min Seo Kang, Jongtak Jung, Tae Hyong Kim","doi":"10.3947/ic.2025.0096","DOIUrl":"10.3947/ic.2025.0096","url":null,"abstract":"<p><strong>Background: </strong>People living with human immunodeficiency virus (PLHIV) commonly experience psychological issues, including anxiety disorders and depression, which may affect their adherence to antiretroviral therapy. This study aimed to explore the mental health status of PLHIV and identify the factors associated with poor compliance (PC) with antiretroviral therapy.</p><p><strong>Materials and methods: </strong>A structured questionnaire survey was administered to PLHIV who were regularly followed up at a university hospital from September 19 to 20, 2020. The survey encompassed assessments of depression (by using the Patient Health Questionnaire-9), anxiety (by using the Beck Anxiety Inventory-Primary Care), suicidality, and meaning in life (by using the Meaning in Life Questionnaire). For participants who provided consent for identification, demographic information was merged to facilitate the analysis. PC was determined based on whether individuals made themselves available for routine clinical visits.</p><p><strong>Results: </strong>Among 327 eligible PLHIV, 150 individuals (45.9%) completed the survey. Forty-one out of the 150 individuals (27.3%) screened positive for depression, while 52 (34.7%) screened positive for anxiety disorders. Thirty-two participants (21.3%) presented with symptoms indicative of both depression and anxiety. The most prevalent depressive symptom was trouble sleeping, accounting for 29.3% of respondents, followed by fatigue (26.0%). Over nervousness was the most commonly reported anxiety symptom (22.7%). Furthermore, 32 individuals (21.3%) reported experiencing suicidal ideation or engaging in self-injury. Among the 123 participants who agreed to identify themselves, suicide attempts and low CD4 counts were positively correlated with PC (adjusted odds ratio [aOR], 3.34; 95% confidence interval [CI], 1.29-8.91 and OR, 5.46; 95% CI, 1.27-24.78, respectively), and younger age was found to be associated with PC (aOR, 0.93; 95% CI, 0.88-0.97; <i>P</i>=0.004). When measures of anxiety disorder and depression were incorporated into the analysis, depression exhibited an OR of 14 for PC (aOR, 13.98; 95% CI, 3.29-98.65; <i>P</i>=0.001). Anxiety disorders were found to be inversely associated with PC. History of opportunistic infection and Meaning in Life Questionnaire scores were not significantly associated with PC.</p><p><strong>Conclusion: </strong>The prevalence of depression and anxiety disorders was high in PLHIV. Depression and low CD4 counts under regular follow-up were associated with PC. Thus, screening for depression can be effective in reducing non-adherence to antiretroviral therapy.</p>","PeriodicalId":51616,"journal":{"name":"Infection and Chemotherapy","volume":"57 4","pages":"569-577"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12802036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145901529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Treatment with Remdesivir on the Early Readmission of Patients Affected by Nosocomial Coronavirus Disease 2019.","authors":"Lucio Boglione, Valentina Dodaro, Roberto Rostagno, Roberta Moglia, Marco Cantone, Younes Harouny, Federica Poletti","doi":"10.3947/ic.2025.0115","DOIUrl":"10.3947/ic.2025.0115","url":null,"abstract":"<p><strong>Background: </strong>The patients affected by hospital-acquired coronavirus disease 2019 (HA-COVID-19) who were readmitted in hospital within 60 days had worse prognosis and mortality. In this study the aim was the assessment of early readmission rate in HA-COVID-19 and the role of remdesivir treatment.</p><p><strong>Materials and methods: </strong>This observational retrospective study included patients with HA-COVID-19 hospitalized in different wards between Jan 2021 and Mar 2022. Early readmission rate was determined. A multivariate logistic regression was made to determine the predictive factors for re-hospitalization.</p><p><strong>Results: </strong>A total of 190 patients with a confirmed diagnosis of HA-COVID-19 were included. Early readmission was documented in 22 patients (11.6%) with a consequent mortality rate of 22.7%. In multivariate analysis, the following factors were predictive of readmission: chronic pulmonary disease (odds ratio [OR], 3.187; 95% confidence interval [CI], 2.145-11.228; <i>P</i><0.001), hospitalization time ≥11 days (OR, 3.556; 95% CI, 1.442-8.417; <i>P</i>=0.008), intensive care unit support (OR, 7.449; 95% CI, 3.901-14.782; <i>P</i><0.001), and remdesivir use (OR, 0.729; 95% CI, 0.512-0.884; <i>P</i>=0.001).</p><p><strong>Conclusion: </strong>Readmission cumulative rate was about one tenth with higher mortality. The remdesivir use in the first hospitalization leads to significant reduction in the odds of readmission.</p>","PeriodicalId":51616,"journal":{"name":"Infection and Chemotherapy","volume":"57 4","pages":"587-595"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12802054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145901448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Usefulness and Limitations of Radiologic Findings for Diagnosis of Infectious Diseases: A Call for Antimicrobial Stewardship.","authors":"Juseong Gang, Bongyoung Kim","doi":"10.3947/ic.2025.0092","DOIUrl":"10.3947/ic.2025.0092","url":null,"abstract":"<p><p>Radiological evaluation is pivotal in diagnosing infectious diseases, but its inherent limitations can lead to diagnostic uncertainty and inappropriate antibiotic use, exacerbating the global challenge of antimicrobial resistance (AMR). This review examines the utility and constraints of imaging studies-computed tomography (CT), magnetic resonance imaging (MRI), and ultrasonography (US)-in common infectious diseases, including pneumonia, acute pyelonephritis (APN), infectious colitis, and skin and soft tissue infections (SSTI). For pneumonia, CT and lung US offer higher sensitivity than chest X-rays, but distinguishing between bacterial and viral pathogens remains challenging. In APN, contrast-enhanced CT is the standard, but routine imaging is not recommended for uncomplicated cases. CT findings in infectious colitis are often nonspecific, necessitating a comprehensive clinical assessment. For SSTIs, particularly in differentiating necrotizing fasciitis, MRI and CT demonstrate high negative predictive value, but positive findings require careful clinical correlation. Furthermore, inter-reader variability exists in interpreting subtle imaging findings. This review highlights the gap between radiological findings and definitive diagnoses, underscoring that imaging is a powerful adjunct but cannot replace comprehensive clinical judgment. A multidisciplinary approach integrating clinical data with imaging findings is essential for accurate diagnosis, responsible antimicrobial stewardship, and effective patient management in the era of AMR.</p>","PeriodicalId":51616,"journal":{"name":"Infection and Chemotherapy","volume":"57 4","pages":"449-461"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12802030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145901467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}