Infection and Chemotherapy最新文献

{"title":"Development of a Prediction Model for the Risk of Infection in Patients with Aplastic Anemia: Survival Analysis in Recurrent Events.","authors":"Pirun Saelue, Thitichaya Penthinapong","doi":"10.3947/ic.2024.0045","DOIUrl":"10.3947/ic.2024.0045","url":null,"abstract":"<p><strong>Background: </strong>In patients with aplastic anemia (AA), infection-related complications are the leading cause of mortality. However, limited knowledge about the predictive factors for infection in these patients exists. Thus, this study aimed to evaluate risk factors for infection and develop a risk prediction model for the occurrence of infection in patients with AA.</p><p><strong>Materials and methods: </strong>Between January 2004 and December 2020, 206 patients with AA ≥15 years of age were included in this study. Survival analysis using recurrent event methodologies was conducted to identify predictive factors associated with infection, including the Anderson and Gill model; Prentice, Williams, and Peterson (PWP) Total Time model; PWP Gap Time model; marginal model; and frailty models. The best model was determined using backward stepwise regression, and internal validation was performed using the bootstrapping method with 500 re-samplings.</p><p><strong>Results: </strong>With a median follow-up of 2.95 years, the incidence rate of infection among patients with AA was 32.8 events per 100 person-years. The PWP Total Time model revealed that cirrhosis comorbidity, lymphocytes ≥80%, and previous infection increased the risk of infection, while bone marrow cellularity ≥20% offered protection. The bone marrow cellularity, lymphocyte percentage, previous infection, cirrhosis, and hematocrit (BLICH) model was generated to predict the risk of infection. The internal validation showed a good calibration of this model.</p><p><strong>Conclusion: </strong>Cirrhosis, lymphocytes ≥80%, previous infection, and bone marrow cellularity <20% are risk factors for infection in patients with AA. The BLICH model can predict the risk of infection in these patients.</p>","PeriodicalId":51616,"journal":{"name":"Infection and Chemotherapy","volume":" ","pages":"483-491"},"PeriodicalIF":2.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11704865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142480454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review of Human Papillomavirus Vaccination and Associated Ethical Concerns.","authors":"Eric Fu, Ozdemir Erdemir, Khalil Pathan, Meaghan Brophy, Aidan Pettit","doi":"10.3947/ic.2024.0070","DOIUrl":"10.3947/ic.2024.0070","url":null,"abstract":"<p><p>Since its Fast-Track approval by the Federal Drug Administration, the human papillomavirus (HPV) vaccine has been marked by controversies. Unconfirmed reports of adverse events in both Japan and Denmark led to suspensions of national vaccination programs, which setback the fight against cervical cancer and associated mortality and morbidity. Despite follow-up studies of vaccine adverse reports, additional randomized control trials, and review reports from both the World Health Organization and the European Commission, there is still a great deal of hesitancy around the vaccine. While all three version of the HPV vaccine have been shown to be efficacious and safe, additional ethical dilemmas deserve to be considered as well.</p>","PeriodicalId":51616,"journal":{"name":"Infection and Chemotherapy","volume":" ","pages":"432-439"},"PeriodicalIF":2.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11704856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Antimicrobial Resistance Trends among Lower Respiratory Tract Pathogens in Crete, Greece, 2017-2022.","authors":"Sofia Maraki, Viktoria Eirini Mavromanolaki, Anna Kasimati, Evangelia Iliaki-Giannakoudaki, Dimitra Stafylaki","doi":"10.3947/ic.2024.0060","DOIUrl":"https://doi.org/10.3947/ic.2024.0060","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Lower respiratory tract infections (LRTIs) are the most common infections in humans accounting for significant morbidity and mortality. Management of LRTIs is complicated due to increasing antimicrobial resistance. This study investigated the prevalence and trends of antimicrobial resistance for bacteria isolated from respiratory samples of patients with LRTIs.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Materials and methods: &lt;/strong&gt;Sputum and bronchial washings were collected from patients of all ages hospitalized with LRTIs and were analyzed by the microbiological laboratory in the University Hospital of Heraklion, Crete, Greece, from January 2017 to December 2022. Identification of the bacterial isolates was performed by matrix-assisted laser desorption ionization-time of flight mass spectrometry and antimicrobial susceptibility testing by Vitek 2 system.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 4,008 strains were isolated from 3,427 respiratory samples. &lt;i&gt;Acinetobacter baumannii&lt;/i&gt; was the most frequently isolated pathogen (23.1%), followed by &lt;i&gt;Pseudomonas aeruginosa&lt;/i&gt; (20.0%), &lt;i&gt;Staphylococcus aureus&lt;/i&gt; (10.6%) and &lt;i&gt;Klebsiella pneumoniae&lt;/i&gt; (6.8%). The isolation rate of &lt;i&gt;A. baumannii&lt;/i&gt; significantly increased during the study period, while there were lower increases in the isolation rates of &lt;i&gt;P. aeruginosa&lt;/i&gt;, &lt;i&gt;K. pneumoniae&lt;/i&gt; and &lt;i&gt;S. aureus. A. baumannii&lt;/i&gt; and &lt;i&gt;P. aeruginosa&lt;/i&gt; were more prevalent during summer, &lt;i&gt;K. pneumoniae&lt;/i&gt; was more common during autumn, while for &lt;i&gt;S. aureus&lt;/i&gt; higher incidence was noted during winter. &lt;i&gt;A. baumannii&lt;/i&gt; exhibited high resistance rates (≥90.0%) to most of the antimicrobial agents tested, and extremely high multidrug-resistance (91.0%). &lt;i&gt;P. aeruginosa&lt;/i&gt; showed the lowest rate of resistance for colistin (1.4%). Among β-lactams, resistance rates to piperacillin/tazobactam, ceftazidime, cefepime, imipenem and meropenem were 26.2%, 27%, 25.8%, 29.2% and 29.9%, respectively. A total of 162 (68.1%) meropenem-resistant &lt;i&gt;P. aeruginosa&lt;/i&gt; were simultaneously resistant to ceftazidime and piperacillin/tazobactam. Regarding &lt;i&gt;K. pneumoniae&lt;/i&gt;, high rates of resistance were observed for the third and fourth generation cephalosporins, namely cefotaxime, ceftriaxone, ceftazidime, and cefepime and the carbapenems, imipenem and meropenem ranging from 46.2% to 53.8%. Carbapenem-resistance was detected among 46.2% of the isolates. Among the 126 carbapenem-resistant &lt;i&gt;K. pneumoniae&lt;/i&gt; isolates, 83 (65.9%), 30 (23.8%), 9 (7.2%), and 4 (4.2%) were positive for &lt;i&gt;Klebsiella pneumoniae&lt;/i&gt; carbapenemase, New Delhi Metallo-β-lactamase, Verona Integron-Mediated Metallo-β-lactamase and OXA-48 carbapenemase, respectively. Of the total number of &lt;i&gt;S. aureus&lt;/i&gt;, 37.2% were methicillin resistant. Low rates of resistance were detected in trimethoprim/sulfamethoxazole (3.3%), gentamicin (2.8%), and rifampicin (0.9%). All isolates were susceptible to linezolid, daptomycin, tigecy","PeriodicalId":51616,"journal":{"name":"Infection and Chemotherapy","volume":"56 4","pages":"492-501"},"PeriodicalIF":2.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11704854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Antimicrobial Susceptibility of Wound Pathogens in a Tertiary Care Hospital in Kashmir: A Cross-sectional Study.","authors":"Tabeen Mansoor, Dekyong Angmo, Nahid Nehvi","doi":"10.3947/ic.2024.0083","DOIUrl":"https://doi.org/10.3947/ic.2024.0083","url":null,"abstract":"<p><strong>Background: </strong>Wound infections significantly impact morbidity, mortality, and healthcare costs globally. The Kashmir Valley's unique geographical and climatic conditions, coupled with resource constraints and antibiotic misuse, complicate managing these infections effectively. This study aimed to identify predominant bacterial pathogens in wound infections at a tertiary care hospital in Kashmir, determine their antibiotic susceptibility profiles, and estimate the prevalence of multidrug-resistant (MDR) strains.</p><p><strong>Materials and methods: </strong>A prospective cross-sectional study was conducted from January to June 2023 at the Government Medical College, Srinagar. Pus samples from wound infections were aseptically collected and processed following standard microbiological protocols. Antibiotic susceptibility testing utilized the Kirby-Bauer disk diffusion method, adhering to Clinical and Laboratory Standards Institute guidelines. Data were analyzed using IBM SPSS statistics.</p><p><strong>Results: </strong>Out of 4,378 samples analyzed, bacterial growth was observed in 1,921 samples, representing 43.9% of the total. Among the bacterial isolates, Gram-negative bacilli accounted for 73.5%, with <i>Escherichia coli</i> being the most prevalent at 27.9%. Among Gram-positive cocci, <i>Staphylococcus aureus</i> predominated, comprising 25.9% of the isolates. Methicillin-resistant <i>S. aureus</i> exhibited 100% susceptibility to linezolid but low susceptibility to erythromycin (27.0%) and clindamycin (24.0%). <i>E. coli</i> demonstrated high susceptibility to tigecycline (97.4%) and amikacin (75.0%), but lower susceptibility to imipenem (45.0%) and piperacillin-tazobactam (57.8%).</p><p><strong>Conclusion: </strong>The substantial wound infection burden and high MDR prevalence in Kashmir necessitate comprehensive antimicrobial stewardship and infection control programs. Regular surveillance, education, and research are crucial to address antibiotic resistance and ensure effective wound infection management in the region.</p>","PeriodicalId":51616,"journal":{"name":"Infection and Chemotherapy","volume":"56 4","pages":"502-509"},"PeriodicalIF":2.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11704860/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How Can Chronic COVID (Long-COVID Syndrome) Be Diagnosed and Treated?","authors":"Josef Finsterer","doi":"10.3947/ic.2024.0115","DOIUrl":"https://doi.org/10.3947/ic.2024.0115","url":null,"abstract":"","PeriodicalId":51616,"journal":{"name":"Infection and Chemotherapy","volume":"56 4","pages":"559-560"},"PeriodicalIF":2.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11704858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aging with HIV: The Burden of Comorbidities, Polypharmacy, and Drug Interactions in Korean People Living with HIV Aged ≥50 Years.","authors":"Jin Kim, Hyun-Ju Nam, Ji-Yeon Kim, Mi-Kyung Heo, Sung Un Shin, Uh Jin Kim, Seong Eun Kim, Seung-Ji Kang, Jihwan Bang, Jin-Soo Lee, Mi-Ok Jang, Kyung-Hwa Park","doi":"10.3947/ic.2024.0132","DOIUrl":"https://doi.org/10.3947/ic.2024.0132","url":null,"abstract":"<p><strong>Background: </strong>The life expectancy of people living with human immunodeficiency virus (PLWH) has significantly improved with advancements in antiretroviral therapy (ART). However, aging PLWH face a growing burden of non-communicable diseases (NCDs), polypharmacy, and drug-drug interactions (DDIs), which pose challenges in their management. This study investigates the prevalence of NCDs, polypharmacy, and DDIs among PLWH aged ≥50 years in Korea and their impact on quality of life (QOL).</p><p><strong>Materials and methods: </strong>A cross-sectional study was conducted among 243 PLWH aged ≥50 years receiving ART for at least three months at three university hospitals in Korea between January and July 2022. Data were collected through electronic medical records and personal interviews, assessing demographics, comorbidities, polypharmacy, ART adherence, and QOL using the Korean version of WHOQOL-HIV BREF scale. Potential DDIs were analyzed using the University of Liverpool HIV Drug Interaction Database, and potentially inappropriate medications (PIMs) were identified using the 2023 American Geriatrics Society Beers Criteria. We classified participants into three age groups: 50-<65 years, 65-<75 years, and ≥75 years.</p><p><strong>Results: </strong>The prevalence of comorbidities was 71.6%, with older participants (≥75 years) showing a significantly higher burden, including bone diseases, osteoarthritis, and dementia (<i>P</i><0.001). Polypharmacy was observed in 28.4% of participants and increased with age, with 53.3% of those aged ≥75 years taking ≥10 pills daily. Polypharmacy was associated with poorer QOL (71.6 <i>vs.</i> 76.6, <i>P</i>=0.010). Amber-flag DDIs were found in 81 participants (33.3%), most commonly involving metformin and divalent cations. No red-flag DDIs were identified. PIMs were observed in 6.6% of participants aged ≥65 years.</p><p><strong>Conclusion: </strong>Aging PLWH in Korea face significant challenges from comorbidities, polypharmacy, and DDIs, which negatively impact QOL. Integrated, age-specific, and multidisciplinary care strategies are urgently needed to improve outcomes and ensure the well-being of older PLWH.</p>","PeriodicalId":51616,"journal":{"name":"Infection and Chemotherapy","volume":"56 4","pages":"534-543"},"PeriodicalIF":2.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11704864/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Antimicrobial Wipes on Hospital-Associated Bacterial and Fungal Strains.","authors":"Hye-Sun Chun, Chulmin Park, Dukhee Nho, Raeseok Lee, Sung-Yeon Cho, Chang-Joo Kim, Dong-Gun Lee","doi":"10.3947/ic.2024.0097","DOIUrl":"https://doi.org/10.3947/ic.2024.0097","url":null,"abstract":"<p><strong>Background: </strong>Healthcare-associated infections (HAI) caused by multidrug-resistant organisms have emerged as a significant global issue, posing substantial challenges to healthcare systems. Low- and intermediate-level disinfectants are extensively utilized for cleaning and disinfecting surfaces in hospitals to mitigate environmental transmission of HAI. Therefore, the need for more effective and environmentally safe disinfectants is increasing. This study aimed to assess the effect of antimicrobial wipes used for surface cleaning and disinfection in healthcare environments.</p><p><strong>Materials and methods: </strong>A microbe library comprising 188 bacterial and fungal isolates, including multidrug-resistant strains, was established and used to evaluate the antimicrobial effect of three types of antimicrobial wipes: A (didecyldimethylammonium chloride [DDAC] 0.31% and 3-(trimethoxysilyl)-propyldimethyloctadecyl ammonium chloride [Si-QAC] 0.45%); B (benzalkonium chloride [BAK] 0.63%); and C (DDAC 0.5% and BAK 0.9%). The antimicrobial effect of the wipes was assessed and compared in three assays: rapid bactericidal effect assay of the three wipes, minimum inhibitory concentration (MIC) assay of DDAC and BAK, and a time-kill assay of the DDAC and Si-QAC combination.</p><p><strong>Results: </strong>The rapid antimicrobial effect evaluation showed that both wipes A and C, which contain a combination of two quaternary ammonium compounds (QACs), exhibited similar antimicrobial effect (<i>P</i>=0.8234). Antimicrobial wipe A demonstrated better effect against Gram-positive bacteria and fungi than wipe C (<i>P</i> <0.05). The antimicrobial efficacy of the A wipe against <i>Mycobacterium</i> strains was superior to that of both the B and C wipes. Moreover, DDAC exhibited MIC₅₀ values that were 2 to 3-fold lower than those of BAK for Gram-negative bacteria and fungi. The time-kill assay results for the DDAC and Si-QAC combination exhibited a growth reduction of >3 logs for <i>Staphylococcus aureus</i> and <i>Enterococcus faecium,</i> whereas approximately 2 logs of reduction was observed for <i>Escherichia coli</i> and <i>Pseudomonas aeruginosa</i> at 3 hour.</p><p><strong>Conclusion: </strong>The results suggest that antimicrobial wipes containing relatively lower concentrations of QAC (wipe A) achieve similar rapid bactericidal effect as that of those with higher concentrations (wipe C). For Gram-negative bacteria, including multidrug-resistant strains and fungal isolates, DDAC presented lower MICs compared with BAK. Furthermore, the combination therapy with DDAC and Si-QAC demonstrated enhanced efficacy compared to treatment with either agent alone, except in the case of <i>Klebsiella</i> strains. Further research is needed to develop antimicrobial wipes that minimize the environmental impact while ensuring effective disinfection.</p>","PeriodicalId":51616,"journal":{"name":"Infection and Chemotherapy","volume":"56 4","pages":"522-533"},"PeriodicalIF":2.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11704855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Nationwide Analysis of Antimicrobial Prescription in Korean Hospitals between 2018 and 2021: The 2023 KONAS Report.","authors":"Himel Mondal","doi":"10.3947/ic.2024.0103","DOIUrl":"https://doi.org/10.3947/ic.2024.0103","url":null,"abstract":"","PeriodicalId":51616,"journal":{"name":"Infection and Chemotherapy","volume":"56 4","pages":"555-556"},"PeriodicalIF":2.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11704869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological Characteristics of HIV-Infected Individuals by the Registration for Special Exempted Calculation: A Nationwide Cohort Study.","authors":"Yunsu Choi, Kyoung Hwan Ahn, Soo Min Kim, Bo Youl Choi, Jungsoon Choi, Jung Ho Kim, Shin-Woo Kim, Youn Jeong Kim, Yoon Hee Jun, Bo Young Park","doi":"10.3947/ic.2024.0085","DOIUrl":"https://doi.org/10.3947/ic.2024.0085","url":null,"abstract":"<p><strong>Background: </strong>The Korean government is implementing policy to reduce medical costs and improve treatment related for human immunodeficiency virus (HIV) patients. The level of cost reduction and the benefits provided vary depending on how individuals with HIV utilize the system. This study aims to determine exact HIV prevalence by analyzing healthcare utilization patterns and examining differences in healthcare usage based on how individuals pay for their medical expenses.</p><p><strong>Materials and methods: </strong>We analyzed National Health Insurance Service (NHIS) claims data from 2002 to 2021. From a total of 106,675 individuals with at least one HIV-related claim, 22,779 participants were selected for this study.</p><p><strong>Results: </strong>Data from Korea Disease Control and Prevention Agency annual reports indicated that 93% of HIV patients were male, while NHIS data showed 84%. In the analysis of those exempted from registration, it was found that the registration rate for female patients is notably low, with adults between the ages of 20 and 40 making up 80% of the total. The registration rate in Gangwon State was lower than Seoul. The treatment experience rate was much higher in the registered group (93.0%) than the unregistered group (4.9%). Also, there was a big difference in treatment continuity rates: 76.2% for registered individuals and 2.8% for non-registered individuals.</p><p><strong>Conclusion: </strong>The exempt calculation system for health insurance improves HIV care. However, those diagnosed anonymously or with reduced medical costs may be less likely to continue HIV treatment, so a new policy is needed to ensure anonymity and treatment continuity.</p>","PeriodicalId":51616,"journal":{"name":"Infection and Chemotherapy","volume":"56 4","pages":"510-521"},"PeriodicalIF":2.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11704859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-World Status in the Treatment of Latent Tuberculosis Infection in People Living with HIV in Korea.","authors":"Hyun-Ha Chang, Hyun-Ju Nam, Hyun Sook Kim, Kyung-Hwa Park, Sohyun Bae, Yoonjung Kim, Shin-Woo Kim, Sook In Jung","doi":"10.3947/ic.2024.0126","DOIUrl":"https://doi.org/10.3947/ic.2024.0126","url":null,"abstract":"<p><p>This retrospective study analyzed medical records of 1,392 people living with HIV (PLWH) diagnosed with latent tuberculosis infection (LTBI) at two provincial central hospitals from 2011 to 2022. LTBI was diagnosed in 152 patients (10.9%) patients aged ≥18 years. Among the 113 patients who initiated treatment, 96 (85.0%) completed isoniazid therapy, while 17 (15.0%) discontinued due to patient refusal, liver function test abnormalities, and other reasons. During a mean follow-up period of 55.0±31.0 months, two cases of active tuberculosis were reported in both the treatment non-completion group (3.6%) and the completion group (2.1%). This study provides recent real-world insights into LTBI treatment among PLWH in Korea.</p>","PeriodicalId":51616,"journal":{"name":"Infection and Chemotherapy","volume":"56 4","pages":"551-554"},"PeriodicalIF":2.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11704868/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}