Tark Kim, Yoon-Kyoung Hong, Sunghee Park, Jongtak Jung, Oh-Hyun Cho, Hee Bong Shin, Tae Youn Choi, Young Jin Choi, Mi-Na Kim, Yong Pil Chong
{"title":"Genetic Epidemiology and Antimicrobial Susceptibilities of Carbapenem-Resistant <i>Pseudomonas aeruginosa</i> Isolates from a Multicenter Study in Korea.","authors":"Tark Kim, Yoon-Kyoung Hong, Sunghee Park, Jongtak Jung, Oh-Hyun Cho, Hee Bong Shin, Tae Youn Choi, Young Jin Choi, Mi-Na Kim, Yong Pil Chong","doi":"10.3947/ic.2025.0032","DOIUrl":null,"url":null,"abstract":"<p><p>Owing to concern that carbapenemase-producing strains among carbapenem-resistant <i>Pseudomonas aeruginosa</i> (CRPA) isolates is on the rise, we investigated the genetic epidemiology and antimicrobial susceptibilities of clinical CRPA isolates collected in four academic hospitals in Korea. Carbapenemase genes were detected in 46 of 63 CRPA isolates (73.0%) collected between 2021 and 2024, and <i>bla</i><sub>NDM</sub> ST773 was the most common genotype (27 isolates, 42.9%), followed by <i>bla</i><sub>NDM</sub> ST644 (9 isolates, 14.3%) and <i>bla</i><sub>IMP</sub> ST235 (7 isolates, 11.1%). Overall susceptibility to ceftazidime/avibactam was only 17.5%, and none of the carbapenemase-producing isolates were susceptible to it. All ST644 strains were also resistant to aztreonam.</p>","PeriodicalId":51616,"journal":{"name":"Infection and Chemotherapy","volume":" ","pages":"418-423"},"PeriodicalIF":2.9000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12511746/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infection and Chemotherapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3947/ic.2025.0032","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/16 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0
Abstract
Owing to concern that carbapenemase-producing strains among carbapenem-resistant Pseudomonas aeruginosa (CRPA) isolates is on the rise, we investigated the genetic epidemiology and antimicrobial susceptibilities of clinical CRPA isolates collected in four academic hospitals in Korea. Carbapenemase genes were detected in 46 of 63 CRPA isolates (73.0%) collected between 2021 and 2024, and blaNDM ST773 was the most common genotype (27 isolates, 42.9%), followed by blaNDM ST644 (9 isolates, 14.3%) and blaIMP ST235 (7 isolates, 11.1%). Overall susceptibility to ceftazidime/avibactam was only 17.5%, and none of the carbapenemase-producing isolates were susceptible to it. All ST644 strains were also resistant to aztreonam.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
