Monaldi Archives for Chest Disease最新文献

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Utility of chest ultrasound and intrapleural fibrinolytics with gentamicin following failed pleurodesis. 胸膜切除术失败后胸部超声和庆大霉素胸膜内纤溶的应用。
IF 1.1
Monaldi Archives for Chest Disease Pub Date : 2025-05-26 DOI: 10.4081/monaldi.2025.3224
Aldo Pezzuto, Ferdinando Cozzolino, Giosuè Amoroso, Evohe Adone, Elisa Desideri, Alberto Ricci
{"title":"Utility of chest ultrasound and intrapleural fibrinolytics with gentamicin following failed pleurodesis.","authors":"Aldo Pezzuto, Ferdinando Cozzolino, Giosuè Amoroso, Evohe Adone, Elisa Desideri, Alberto Ricci","doi":"10.4081/monaldi.2025.3224","DOIUrl":"https://doi.org/10.4081/monaldi.2025.3224","url":null,"abstract":"<p><p>This is a case of a 65-year-old male patient who presented to our institution due to worsening dyspnea and respiratory failure development. The patient was admitted due to dyspnea at rest and chest pain. He had a recent medical history of lung cancer with malignant pleural effusion. The patient had already undergone pleural talc poudrage by thoracoscopy, which had not been effective. Indeed, the patient was found to have residual septate pleural effusion on ultrasound examination. A placement of transthoracic pleural drainage followed by intrapleural instillation of urokinase (100,000 units) and gentamicin (80 mg) was performed within 30 days of chemical pleurodesis, achieving re-expansion of the lung by preventing recurrence of the effusion and leading to rapid clinical improvement. The novelty of the present case concerns the effectiveness of a combined treatment of fibrinolytic and intrapleural antibiotic through a pleural drainage after failure of chemical pleurodesis.</p>","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determinants of treatment outcome in children with multidrug-resistant tuberculosis: a tertiary care hospital experience. 儿童耐多药结核病治疗结果的决定因素:三级保健医院经验
IF 1.1
Monaldi Archives for Chest Disease Pub Date : 2025-05-22 DOI: 10.4081/monaldi.2025.3367
Sajjad Sarwar, Muhammad Sajid, Saba Mukhtar, Rabbiya Ahmad, Sana Sarwar, Madiha Mukhtar, Muhammad Atif
{"title":"Determinants of treatment outcome in children with multidrug-resistant tuberculosis: a tertiary care hospital experience.","authors":"Sajjad Sarwar, Muhammad Sajid, Saba Mukhtar, Rabbiya Ahmad, Sana Sarwar, Madiha Mukhtar, Muhammad Atif","doi":"10.4081/monaldi.2025.3367","DOIUrl":"https://doi.org/10.4081/monaldi.2025.3367","url":null,"abstract":"<p><p>This study aimed to analyze the significant factors associated with unsuccessful treatment outcomes among multidrug-resistant tuberculosis in children under 18. This observational study was conducted at the Bahawal Victoria Hospital, Bahawalpur, Pakistan, at the Programmatic Management Unit of the National Tuberculosis Control Program of Pakistan. The data were collected retrospectively using the Electronic Nominal Recording Reporting System records for all the eligible drug-resistant tuberculosis patients registered at the study sites between June 2014 and September 2022. Multivariate binary logistic regression analysis was used to analyze the factors significantly associated with unsuccessful treatment outcomes. This study included 88 children. Of the 88 patients, 64 (72.8%) completed their treatment successfully. A total of 13 patients (14.8%) died, 2 (2.3%) had treatment failure, and 9 (10.2%) were lost to follow-up. Factors significantly associated with unsuccessful treatment outcomes included a history of use of second-line drugs and those with favorable interim treatment outcomes (negative association). The overall treatment success rate among the children was 72.8%, which can be further improved by reducing loss to follow-up and rational use of second-line drugs in treating drug-sensitive tuberculosis. This can be done by devising a careful, targeted treatment regimen and patient education.</p>","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Compression-only or standard cardiopulmonary resuscitation for out-of-hospital cardiac arrest: a systematic review and meta-analysis of randomized controlled trials. 院外心脏骤停的单压迫或标准心肺复苏:随机对照试验的系统回顾和荟萃分析
IF 1.1
Monaldi Archives for Chest Disease Pub Date : 2025-05-22 DOI: 10.4081/monaldi.2025.3362
Arshbeer Singh Sandhu, Muhammad Arslan Arif Maan, Ogechukwu Obi, Oliver Hervir, Mark Abdelnour, Nayan Gandhi, Mansoureh Fatahi, Abuelgasim Mohamed, Ratan Pal Yadav, Jassim Zaheen Shah, Muhammad Ehsan, Wajeeh Ur Rehman
{"title":"Compression-only or standard cardiopulmonary resuscitation for out-of-hospital cardiac arrest: a systematic review and meta-analysis of randomized controlled trials.","authors":"Arshbeer Singh Sandhu, Muhammad Arslan Arif Maan, Ogechukwu Obi, Oliver Hervir, Mark Abdelnour, Nayan Gandhi, Mansoureh Fatahi, Abuelgasim Mohamed, Ratan Pal Yadav, Jassim Zaheen Shah, Muhammad Ehsan, Wajeeh Ur Rehman","doi":"10.4081/monaldi.2025.3362","DOIUrl":"https://doi.org/10.4081/monaldi.2025.3362","url":null,"abstract":"<p><p>This meta-analysis aims to compare chest compression-only cardiopulmonary resuscitation (CO-CPR) with standard CPR (sCPR), which includes mouth-to-mouth ventilation, as potential strategies for managing out-of-hospital cardiac arrest (OHCA). We systematically searched various databases and registries such as MEDLINE, Embase, The Cochrane Library, and Clinicaltrials.gov to retrieve relevant studies. We used the revised Cochrane \"Risk of Bias\" tool for randomized trials (RoB 2.0) to assess the risk of bias in included studies. Revman 5.4 was used to pool dichotomous outcomes under a random effects model. A total of 4 randomized controlled trials were included in our meta-analysis. Our results indicate that CO-CPR was associated with a significantly increased survival to hospital discharge compared to sCPR [relative risk (RR) 1.22, 95% confidence interval (CI): 1.01 to 1.46] with minimal heterogeneity (I2=0%). No significant difference was observed between the two groups regarding 1-day survival (RR 1.07, 95% CI: 0.94 to 1.23), survival to hospital admission with a good neurological outcome (cerebral performance category 1 or 2) (RR 1.10, 95% CI: 0.80 to 1.51), return of spontaneous circulation (RR 1.05, 95% CI: 0.95 to 1.17), and survival to hospital admission (RR 1.08, 95% CI: 0.93 to 1.25). This meta-analysis found that chest CO-CPR significantly improves survival to hospital discharge compared to sCPR for managing OHCA, while yielding comparable results for other resuscitation outcomes.</p>","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship between the level of asthma control, lung function and bronchodilator response in asthmatic children on inhaled corticosteroids. 吸入糖皮质激素哮喘患儿哮喘控制水平、肺功能和支气管扩张剂反应的关系。
IF 1.1
Monaldi Archives for Chest Disease Pub Date : 2025-05-20 DOI: 10.4081/monaldi.2025.3257
Javier Mallol, Viviana Aguirre-Camposano, Alejandro Gallardo, Pablo Córdova
{"title":"Relationship between the level of asthma control, lung function and bronchodilator response in asthmatic children on inhaled corticosteroids.","authors":"Javier Mallol, Viviana Aguirre-Camposano, Alejandro Gallardo, Pablo Córdova","doi":"10.4081/monaldi.2025.3257","DOIUrl":"https://doi.org/10.4081/monaldi.2025.3257","url":null,"abstract":"<p><p>This study evaluated tools for assessing asthma control in 149 children on inhaled corticosteroids, focusing on the Asthma Control Test (ACT) and the Global Initiative for Asthma criteria (GINAc). It also explored the role of lung function (LF) tests, including spirometry and bronchodilator response (BDR), in identifying uncontrolled asthma. The GINAc identified 65.8% of children as having uncontrolled asthma, compared to 25.9% by the ACT (p<0.001). Spirometry and BDR results did not differ significantly between controlled and uncontrolled asthma groups. However, abnormal LF was more frequent in children with uncontrolled asthma identified by GINAc (18.4%) than in those controlled (5.9%; p = 0.038). In ACT-identified uncontrolled cases, 18.2% had abnormal LF compared to 12.4% with controlled asthma (p=0.360). Similarly, BDR appeared in 17.3% of uncontrolled cases by GINAc and 11.8% in controlled cases, with 25% of ACT-identified uncontrolled cases showing BDR vs. 11.4% in controlled (p=0.037). Findings suggest GINAc detects more cases of uncontrolled asthma than ACT and highlights the potential value of including spirometry and BDR to complement asthma control questionnaires, mainly aiding in identifying controlled asthma cases with underlying abnormal LF or BDR.</p>","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrasound-guided diaphragm evaluation and outcomes in severe acute exacerbation of chronic obstructive pulmonary disease (uDISCO Study): an observational study. 慢性阻塞性肺疾病严重急性加重期超声引导膈膜评估和预后(uDISCO研究):一项观察性研究。
IF 1.1
Monaldi Archives for Chest Disease Pub Date : 2025-05-19 DOI: 10.4081/monaldi.2025.3483
Nipun Malhotra, Dipti Gothi, Rahul Kumar, Mahismita Patro, Sunil Kumar, Anshul Jain, Mohit Agarwal
{"title":"Ultrasound-guided diaphragm evaluation and outcomes in severe acute exacerbation of chronic obstructive pulmonary disease (uDISCO Study): an observational study.","authors":"Nipun Malhotra, Dipti Gothi, Rahul Kumar, Mahismita Patro, Sunil Kumar, Anshul Jain, Mohit Agarwal","doi":"10.4081/monaldi.2025.3483","DOIUrl":"https://doi.org/10.4081/monaldi.2025.3483","url":null,"abstract":"<p><p>Acute exacerbations of chronic obstructive pulmonary disease (COPD) are associated with compromised diaphragmatic function. This can be evaluated using point-of-care ultrasound. The association of diaphragm function with hospital length of stay or mortality has not been assessed earlier. This study aimed to evaluate the correlation of diaphragmatic function with length of hospital stay, mortality, and non-invasive ventilation (NIV) failure in severe acute exacerbation of COPD. Diaphragmatic excursion and thickening index (Tdi) were evaluated with ultrasound-guided assessment in individuals with severe acute exacerbation of COPD at the time of hospitalization. The individuals were evaluated for length of stay in survivors, NIV ventilation failure in those requiring NIV therapy, and mortality in non-survivors. A total of 110 individuals were screened, and 60 of these were enrolled. A total of 55 individuals survived, and 5 died. The length of stay had a negative correlation with excursion (R: -0.78, p<0.001) and Tdi (R: -0.96, p<0.001). The excursion and Tdi were smaller by 30% and 50%, respectively, in the event of NIV failure compared to NIV success. Excursion ≤1.96 cm [area under receiver-operating characteristic curve (AUROC): 0.958] or Tdi≤92% (AUROC: 0.974) were associated with length of stay ≥8 days. Excursion ≤1.48 cm (AUROC: 0.75) or Tdi≤51.2% (AUROC: 0.8) were associated with NIV failure. Tdi≤40% was associated with a high risk of mortality (RR: 22.67, p=0.035). Smaller diaphragmatic excursion, or Tdi, correlated with prolonged LoS, mortality, and NIV failure.</p>","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contribution of small airway disease to dynamic hyperinflation in patients with chronic obstructive pulmonary disease. 慢性阻塞性肺疾病患者小气道疾病对动态恶性充气的影响。
IF 1.1
Monaldi Archives for Chest Disease Pub Date : 2025-05-15 DOI: 10.4081/monaldi.2025.3402
Cristiane Chaves Marcelino Da Costa, Hebert Olímpio Júnior, Paulo Victor Leandro Da Silva Pinto, Milena Alves Da Silva, Laura Franco Pessoa, Laura Lima Da Silva, Jannis Papathanasiou, Arthur De Sá Ferreira, Agnaldo José Lopes
{"title":"Contribution of small airway disease to dynamic hyperinflation in patients with chronic obstructive pulmonary disease.","authors":"Cristiane Chaves Marcelino Da Costa, Hebert Olímpio Júnior, Paulo Victor Leandro Da Silva Pinto, Milena Alves Da Silva, Laura Franco Pessoa, Laura Lima Da Silva, Jannis Papathanasiou, Arthur De Sá Ferreira, Agnaldo José Lopes","doi":"10.4081/monaldi.2025.3402","DOIUrl":"https://doi.org/10.4081/monaldi.2025.3402","url":null,"abstract":"<p><p>Lung hyperinflation is a treatable trait in chronic obstructive pulmonary disease (COPD) that can often only be detected on exertion. Air trapping in these patients results from the premature closure of the small airways. This study aimed to assess the association between small airway disease (SAD) and dynamic hyperinflation (DH) induced by the Glittre-daily life activities test (TGlittre) in COPD patients. This is a cross-sectional study in which 54 patients with COPD underwent TGlittre coupled with dynamic ventilation measurements. They also underwent the COPD Assessment Test (CAT) questionnaire, the St. George's Respiratory Questionnaire (SGRQ), spirometry, and respiratory oscillometry (RO). In the TGlittre, 30 (55.6%) participants presented DH (DH group), while 24 (44.4%) did not (NDH group). When comparing these two groups, we observed no statistical difference concerning the CAT score, SGRQ score, and spirometric parameters. Respectively, 27 (90%) and 9 (37.5%) participants in the DH and NDH groups presented changes in the RO, with the DH group showing higher values in reactance area [Ax, 24.7 (17-46) vs. 6.1 (4-9) cm H2O/L/s, p<0.0001] and resonance frequency [Fres, (8 (4.3-17.9) vs. 2.8 (2.3-4.7) Hz, p<0.0001]. DH correlated significantly with Fres (rs=-0.604, p<0.0001), Ax (rs=-0.652, p<0.0001), and several domains of the SGRQ and CAT scores. In the multivariate regression analysis, Fres and Ax explained 49% of the variability in DH. In conclusion, our results show that patients with COPD and DH have more altered RO. In these patients, the more pronounced the DH, the worse the RO parameters, the greater the symptom impact, and the more deteriorated the quality of life. Furthermore, SAD is a significant predictor of DH in this patient population.</p>","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decoding adverse drug reactions in respiratory care: a prospective predictive and severity-based analysis at a tertiary care hospital in India. 解码呼吸系统护理中的药物不良反应:印度一家三级护理医院的前瞻性预测和基于严重程度的分析。
IF 1.1
Monaldi Archives for Chest Disease Pub Date : 2025-05-15 DOI: 10.4081/monaldi.2025.3464
Vaishnavi V Gaonkar, Vinay V Shanbhag, Mandati Santhosh Reddy, M S Ganachari
{"title":"Decoding adverse drug reactions in respiratory care: a prospective predictive and severity-based analysis at a tertiary care hospital in India.","authors":"Vaishnavi V Gaonkar, Vinay V Shanbhag, Mandati Santhosh Reddy, M S Ganachari","doi":"10.4081/monaldi.2025.3464","DOIUrl":"https://doi.org/10.4081/monaldi.2025.3464","url":null,"abstract":"<p><p>Adverse drug reactions (ADRs) are a major concern in healthcare, including morbidity, longer hospitalization, and increased healthcare expenses. Despite the necessity of ADR monitoring, reporting is poor, particularly in developing countries such as India. This study assessed the severity, predictability, and causality of ADRs in a tertiary care hospital's respiratory department. A prospective observational study was conducted at KLE's Dr. Prabhakar Kore Hospital, Belagavi, Karnataka, from September 2023 to January 2025. Patients aged 45 years and above with chronic respiratory conditions were included. ADRs were assessed using validated scales, including the World Health Organization-Uppsala Monitoring Centre Scale, Modified Hartwig and Siegel Scale, and Predictability Assessment. Descriptive statistics were applied to analyze ADR patterns. Among the 107 patients enrolled, 63.5% were elderly and 59.8% were female. Mild ADRs accounted for 60.7% of cases, while serious responses were reported in 3.7%. Predictability analysis revealed that 77.5% of ADRs were foreseeable. Causality assessment revealed ADRs as probable (51.4%), possible (37.3%), and certain (10.2%). Drug withdrawal was the most popular intervention (55.1%). The most commonly reported ADRs were gastrointestinal disorders (33.6%), followed by respiratory (18.6%) and cardiovascular disorders (16.8%). The study highlighted the need for improved pharmacovigilance programs to reduce ADR-related hazards in respiratory patients. Improving ADR reporting methods and predictive assessments can enhance patient safety and maximize therapeutic outcomes.</p>","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of herbal medicine related to anxiety and depression in the general population of southeast Iran during the COVID-19 pandemic. 在2019冠状病毒病大流行期间,伊朗东南部普通人群中与焦虑和抑郁相关的草药使用情况
IF 1.1
Monaldi Archives for Chest Disease Pub Date : 2025-05-12 DOI: 10.4081/monaldi.2025.3066
Hossein Yarmohammadi, Maryam Iranzadasl, Mohammad Mostafa Ansari Ramandi, Mohammad Gholami Fesharaki, Fereshteh Ghorat
{"title":"Use of herbal medicine related to anxiety and depression in the general population of southeast Iran during the COVID-19 pandemic.","authors":"Hossein Yarmohammadi, Maryam Iranzadasl, Mohammad Mostafa Ansari Ramandi, Mohammad Gholami Fesharaki, Fereshteh Ghorat","doi":"10.4081/monaldi.2025.3066","DOIUrl":"https://doi.org/10.4081/monaldi.2025.3066","url":null,"abstract":"<p><p>The COVID-19 pandemic has led to increased anxiety/depression and changes in people's health behaviors. This study aimed to investigate health beliefs regarding using herbal medicine and its associated factors among Iranians. A cross-sectional study on the general population in Birjand (southeast Iran) was conducted using a survey questionnaire (an online platform for creating questionnaires, available at https://porsline.ir/) consisting of demographic characteristics and beliefs toward herbal medicine use, as well as a telehealth and hospital anxiety and depression scale questionnaire to address anxiety and depression disorders. All statistical analysis was done with SPSS software version 18, and a p-value of 0.05 or less was considered significant. The study included 619 participants with a mean age of 36.58±10.74 and a female rate of 61%. The overall use of herbal medicine was 385 (62%), 170 (28%) for prevention, 12 (2%) for treatment, 170 (28%) for relaxation, and 191 (31%) for other reasons. Using herbal medicine for relaxation (p=0.010) and prevention (p=0.02) was significantly associated with less anxiety, while using herbs for the treatment of COVID-19 had an association with no family history of Coronavirus infection (p<0.001). The majority of participants used herbal medicine for different purposes for COVID-19, and this health behavior had a relationship with anxiety/depression and family history of COVID-19. This study's findings would be useful to researchers and policymakers in improving health beliefs and behaviors during the other pandemic in Iran.</p>","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Performance of conventional laboratory tests and Xpert MTB/RIF in the diagnosis of tuberculosis. 常规实验室检查和专家MTB/RIF在结核病诊断中的表现。
IF 1.1
Monaldi Archives for Chest Disease Pub Date : 2025-05-06 DOI: 10.4081/monaldi.2025.3394
Natalia Zaporojan, Ramona Hodișan, Andreea Atena Zaha, Claudiu Zaporojan, Dana Carmen Zaha
{"title":"Performance of conventional laboratory tests and Xpert MTB/RIF in the diagnosis of tuberculosis.","authors":"Natalia Zaporojan, Ramona Hodișan, Andreea Atena Zaha, Claudiu Zaporojan, Dana Carmen Zaha","doi":"10.4081/monaldi.2025.3394","DOIUrl":"https://doi.org/10.4081/monaldi.2025.3394","url":null,"abstract":"<p><p>The laboratory diagnosis of tuberculosis (TB) represents a continuous challenge due to the variability and complexity of the required clinical samples. Although molecular technologies have considerably improved diagnostic accuracy, their combined use with traditional methods like microscopy and bacterial culture remains a subject of debate. This study aims to compare the performance of microscopy, bacterial culture on Löwenstein-Jensen medium, and the molecular Xpert MTB/RIF test in diagnosing pulmonary and extrapulmonary TB. In this retrospective study, conducted over a period from January 2016 to January 2023, data were collected from pulmonary TB and extrapulmonary TB samples of patients hospitalized in the pneumonology departments of the Bihor County Emergency Hospital. The study included 1796 patients, of whom 85.2% had samples collected from the respiratory tract. The variability of sensitivity and specificity depending on the type of sample indicates the need for a differentiated approach in diagnosis. The results show that the Xpert MTB/RIF test detected a higher number of positive cases (16%) compared to microscopy (9%) and bacterial culture (15%). Statistical analysis revealed a high sensitivity and specificity of Xpert MTB/RIF, suggesting superior accuracy compared to traditional methods. Our conclusions underline the importance of the Xpert MTB/RIF as a valuable tool in the diagnosis of TB, but it is recommended to use it in combination with other methods to ensure a complete and efficient diagnosis.</p>","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Skin prick test wheal size: a potential predictor of respiratory allergies? 皮肤点刺试验轮大小:呼吸道过敏的潜在预测指标?
IF 1.1
Monaldi Archives for Chest Disease Pub Date : 2025-04-29 DOI: 10.4081/monaldi.2025.3326
Gennaro Liccardi, Matteo Martini, Mauro Maniscalco, Maria Beatrice Bilò, Claudio Candia, Lorenzo Cecchi, Carmen Montera, Annaclaudia Giordano, Manlio Milanese, Fabio De Bartolomeis, Domenico Gargano, Mario Lo Schiavo, Francesco Madonna, Antonio Papa, Alfonso Pedicini, Alfonso Savoia, Paola Rogliani
{"title":"Skin prick test wheal size: a potential predictor of respiratory allergies?","authors":"Gennaro Liccardi, Matteo Martini, Mauro Maniscalco, Maria Beatrice Bilò, Claudio Candia, Lorenzo Cecchi, Carmen Montera, Annaclaudia Giordano, Manlio Milanese, Fabio De Bartolomeis, Domenico Gargano, Mario Lo Schiavo, Francesco Madonna, Antonio Papa, Alfonso Pedicini, Alfonso Savoia, Paola Rogliani","doi":"10.4081/monaldi.2025.3326","DOIUrl":"https://doi.org/10.4081/monaldi.2025.3326","url":null,"abstract":"<p><p>Dear Editor, The skin prick test is the most commonly used method for diagnosing IgE-mediated sensitizations in conditions like bronchial asthma, allergic rhinitis, and food allergies... ******************************** Promoted by the Italian Association of Hospital and Territorial Allergists and Immunologists (AAIITO - Campania region). *******************************.</p>","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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