Monaldi Archives for Chest Disease最新文献

{"title":"Trajectory of the response to bronchodilator and respiratory outcomes in adults with asthma-like symptoms.","authors":"Daniel Gimenez da Rocha, Monique Olivia Burch, Luciana Aparecida Teixeira Soares, Jessica Regina Bertolino, Ana Lúcia Bergamasco Galastri, Daniel Antunes, Ronei Luciano Mamoni, Eduardo Vieira Ponte","doi":"10.4081/monaldi.2025.3116","DOIUrl":"https://doi.org/10.4081/monaldi.2025.3116","url":null,"abstract":"<p><p>In the real world, health professionals need to care for individuals with asthma-like symptoms who have a persistently negative bronchodilator response (BDR). Little is known about the evolution of symptoms and lung function of these individuals because they are usually excluded from studies on asthma. The aim of this study was to evaluate whether individuals with asthma-like symptoms but with a persistently negative BDR have a different evolution of symptoms and lung function compared to individuals with asthma proven by positive BDR. This prospective cohort study included adults with asthma-like symptoms. Individuals participated in two visits 12 months apart. They responded to questionnaires and underwent a spirometry test. In individuals without airway obstruction in the first visit, those with asthma-like symptoms and persistently negative BDR were less likely to lose forced expiratory volume in the first second during follow-up or progress to airway obstruction at the final visit compared to individuals with asthma proven by positive BDR. Among individuals with airway obstruction at baseline, those with asthma-like symptoms and persistently negative BDR were less likely to resolve the airway obstruction during follow-up compared to individuals with asthma proven by positive BDR. In individuals with proven asthma, the emergence or persistence of positive BDR during follow-up was accompanied by a worsening of asthma outcomes compared to the remission of positive BDR. Thus, BRD is an accessible marker of disease progression in individuals with asthma-like symptoms. In individuals with asthma proven by positive BDR, the trend in BDR was associated with the evolution of symptoms and lung function.</p>","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authors' Response.","authors":"Branko Beronja, Aleksandra Karan, Biljana Lukic, Ivana Milosevic, Jelena Dotlic, Tatjana Gazibara","doi":"10.4081/monaldi.2025.3462","DOIUrl":"https://doi.org/10.4081/monaldi.2025.3462","url":null,"abstract":"<p><p>Dear Editor, We read the comments by Rossato and Di Vincenzo with enthusiasm and appreciate their interest in our study, which helps deepen the discussion on smoking and COVID-19. Indeed, smoking is a major health issue worldwide, as it is associated with a variety of poor outcomes, including COVID-19...</p>","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute effects of heated tobacco smoking: a single-center study.","authors":"Naglaa B Ahmed, Ayman E Salem, Eman A AbdulGawad, Hebatallah H Ahmed, Menna H Mohamed Abdel Gawad","doi":"10.4081/monaldi.2025.3316","DOIUrl":"https://doi.org/10.4081/monaldi.2025.3316","url":null,"abstract":"<p><p>The idea of heated tobacco products (HTPs) is to deliver nicotine to the consumer by heating the tobacco rather than burning it, possibly causing less release of many harmful and potentially harmful chemical constituents (HPHCs), including carbon monoxide (CO). This prospective observational study targets studying the acute effects of HTPs regarding exhaled CO, serum cotinine level, and pulmonary function. A total of 91 participants were included; 46 current traditional cigarette smokers were instructed not to smoke for a minimum of 12 hours before the study (not following the smoking cessation program) and then divided into two groups. Group 1 contained 23 participants who smoked their usual cigarette brands, and Group 2 consisted of 23 participants who smoked the I-Quit-Ordinary-Smoking tobacco sticks. Group 3 is the control group, including 45 normal healthy non-smoker participants. All participants were subjected to the subsequent thorough medical history and clinical examination, followed by assessment of the following parameters before smoking as well as 5 minutes after smoking (either heated tobacco or traditional cigarettes according to their groups): oxygen saturation (SpO₂), heart rate (HR), measurement of exhaled CO, spirometry, and blood sample for serum cotinine level (which was assessed 5 minutes as well as 30 minutes after smoking). The study's findings showed that after smoking cigarettes, the amount of CO in the air was higher (mean 32.83±16.73 standard deviation) than after smoking heated tobacco, which was statistically significant. Serum cotinine levels also went up after smoking in both groups, but they were slightly higher after HTPs than after conventional cigarettes (CCs). Spirometry and SpO2 levels went down after smoking in groups 1 and 2, while HR levels went up after smoking in both groups, with a p-value of less than 0.001. We concluded that the HTPs have acute respiratory and cardiovascular effects similar to CCs but with less exhaled CO.</p>","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Promoting effective teamwork in the cardiothoracic surgery department: strategies for success.","authors":"Firas Aljanadi","doi":"10.4081/monaldi.2025.2977","DOIUrl":"https://doi.org/10.4081/monaldi.2025.2977","url":null,"abstract":"<p><p>In daily practice, teamwork is of paramount importance within the healthcare settings, particularly in specialized fields such as cardiothoracic surgery. This is due to the fact that collaboration, communication, and synchronization play a vital role in ensuring successful patient outcomes. The aim of this paper is to propose strategies to promote effective teamwork within a cardiothoracic surgical setting, elaborating general teamwork principles and applicable concepts from healthcare.</p>","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the role of cartridge-based nucleic acid amplification test in extrapulmonary tuberculosis diagnosis: insights from a cross-sectional study.","authors":"Anil Sontakke, Rajasi Bundale, Sagar Kolte, Nidhi Girdhar, Hrishikesh Gaikwad, Harshal Ital","doi":"10.4081/monaldi.2025.3238","DOIUrl":"https://doi.org/10.4081/monaldi.2025.3238","url":null,"abstract":"<p><p>Extrapulmonary tuberculosis (EPTB) is a multifaceted disease that could potentially impact nearly all organs. Current global data indicate a significant variation in the proportion of EPTB among all tuberculosis cases, ranging from 15% to 53%. Clinicians in India express concerns about the efficacy of the cartridge-based nucleic acid amplification test (CBNAAT) in EPTB, as its yield frequently does not align with the findings of the World Health Organization meta-analysis. Hence, the present study was conducted to evaluate the diagnostic yield of CBNAAT in EPTB at a tertiary care hospital. Specifically, the present hospital-based observational cross-sectional study was conducted at the Department of Respiratory Medicine at a tertiary care hospital from February 2024 to April 2024. A total of 52 patients with presumptive EPTB were enrolled. Demographic information, clinical history, and clinical examination findings were recorded with the help of a standard, semi-structured, pre-validated case record proforma. A composite reference standard (CRS), which was defined by clinical, radiological, laboratory, and histopathological findings and treatment response to antitubercular therapy along the course, was considered. The statistical software, namely SPSS 22.0, was used for the analysis of the data. Among a total of 52 patients, the mean age of patients was 37.42±16.18 years, with the proportion of males being 59.62%. The majority of patients had tuberculosis pleural effusion (63.46%). The pooled diagnostic yield of CBNAAT showed sensitivity and specificity of CBNAAT compared to CRS of 22.22% and 100%, respectively. Culture had the highest sensitivity in diagnosing EPTB in the study population, as compared to CBNAAT, thereby emphasizing the importance of diagnosis by culture method.</p>","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bronchoscopic valve therapy for tuberculosis: a scoping review.","authors":"Kshitij Agarwal, Adam T Gray, Tudor P Toma, Valentina Luzzi, Lorenzo Corbetta","doi":"10.4081/monaldi.2025.3281","DOIUrl":"https://doi.org/10.4081/monaldi.2025.3281","url":null,"abstract":"<p><p>The management of tuberculosis (TB) presents significant challenges, particularly in the context of multidrug-resistant TB (MDR-TB) and TB-HIV co-infection. Traditional surgical interventions, such as lung resection and pneumothorax induction, have largely been phased out with the advent of modern antibiotic regimens. However, emerging evidence suggests that endobronchial interventions, specifically the use of unidirectional valves, have potential in supporting the treatment of MDR-TB. The objective of this review is to demonstrate the feasibility of closure of tubercular cavities using endobronchial valves, resulting in improved clinical outcomes and sputum smear conversion. PubMed was searched from inception to September 2024. The small studies reviewed here demonstrate the feasibility of tubercular cavity closure using endobronchial valves, resulting in improved clinical outcomes and sputum smear conversion. Yet, limited access to Food and Drug Administration-approved valves and funding challenges hinders large-scale trials. To address these limitations, further evidence is needed within improved international collaboration. We suggest that international prospective trials and innovation are needed. Such collaborative efforts would clarify the role of valves in TB treatment and hopefully lead to the development of simpler and more affordable occlusive devices that would benefit patients with MDR-TB, particularly in low-income countries.</p>","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The distress thermometer: a promising tool to screen patients with chronic respiratory diseases for emotional distress.","authors":"Sherif Mohamed, Omar Abdelwahab, Ashraf M Elsherbiny, Nashwa Abd El-Aziz","doi":"10.4081/monaldi.2025.3018","DOIUrl":"https://doi.org/10.4081/monaldi.2025.3018","url":null,"abstract":"<p><p>Patients with chronic respiratory diseases have variable degrees of emotional distress (ED). Chronic illness-related ED has been shown to be an independent factor for inefficient self-management as well as an essential factor for clinical deterioration and the quality of life in patients with chronic respiratory diseases. The distress thermometer (DT) comprises two distinct components: a visual analog scale, which resembles a thermometer, and a 39-problem list (PL) composed of 5 different categories: family, emotional, practical, spiritual/religious, and physical problems. DT has been approved as very effective in screening patients for ED in oncological and non-oncological settings. The COVID-19 pandemic has stimulated investigators to develop a modified DT (m-DT) that can be implemented for patients with COVID-19. This m-DT proved effective in screening adults, adolescents, and pregnant women with COVID-19 for ED. DT has been utilized in patients with chronic medical conditions in the non-oncological context, yet it was underutilized in those with chronic respiratory diseases. We believe that DT, with its advantages, represents a handy tool for screening patients with chronic respiratory diseases. The DT-associated PL is relatively comprehensive and covers almost all social, spiritual, financial, and emotional aspects of the screened individual's life. Screening of patients with cancer using DT has revealed encouraging results. Similar results among patients with chronic respiratory diseases are expected. DT can be utilized efficiently to deal with mental health issues routinely as a part of rehabilitation programs for chronic respiratory disorders. Further studies are warranted.</p>","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on \"Smoking patterns and outcomes of severe SARS-CoV-2 infection: a retrospective cohort study\".","authors":"Marco Rossato, Angelo Di Vincenzo","doi":"10.4081/monaldi.2025.3430","DOIUrl":"https://doi.org/10.4081/monaldi.2025.3430","url":null,"abstract":"<p><p>Dear Editor, We have read with interest the recently published paper by Beronja et al. reporting the clinical outcomes in a group of patients hospitalized for COVID-19 being current smokers or not and concluding that a history of cigarette smoking (past or active) is an independent factor for negative prognosis in COVID-19 patients...</p>","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and impact of anxiety and depression in patients with chronic obstructive pulmonary disease: a comparative analysis of post-tuberculosis and non-tuberculosis chronic obstructive pulmonary disease cases.","authors":"Eshutosh Chandra, Shipra Anand, Amitesh Gupta, Roopam Jha, Irshad Ahmad","doi":"10.4081/monaldi.2025.3278","DOIUrl":"https://doi.org/10.4081/monaldi.2025.3278","url":null,"abstract":"<p><p>Chronic obstructive pulmonary disease (COPD) is a prevalent and debilitating condition, increasingly recognized for its complex interaction with psychiatric disorders such as anxiety and depression. This study assesses and compares the prevalence of anxiety and depression among COPD patients, including those with a history of pulmonary tuberculosis (TB), and examines their associations with COPD severity. This descriptive, cross-sectional study included 100 patients diagnosed with COPD, aged 40 to 80 years. Patients underwent comprehensive clinical evaluation, including spirometry and COPD assessment tests, and were assessed for anxiety and depression using the Hospital Anxiety and Depression Scale. Participants were classified based on their COPD status and history of TB. Data on sociodemographic and clinical characteristics was collected, and associations between psychiatric illnesses and COPD status were analyzed. The study population was predominantly male (73%), with a mean age of 56.33 years. The COPD assessment score was medium in 65% of participants, with 30% of patients exhibiting high levels. Anxiety was present in 21% of the cohort, while 30% had depression. Analysis revealed a significant association between high COPD scores and increased prevalence of both anxiety and depression (p<0.05). Additionally, patients with a history of pulmonary TB showed higher rates of psychiatric comorbidities. Specifically, anxiety was more prevalent among patients with severe COPD and a history of TB. These findings highlight a substantial burden of anxiety and depression among COPD patients, particularly those with severe disease and a history of TB. These results align with the existing literature, suggesting a strong link between COPD severity, psychiatric comorbidities, and the impact of historical TB on mental health. These insights underscore the need for integrated management strategies addressing both respiratory and psychiatric aspects of COPD care.</p>","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on \"Hematological and clinical profiling of chronic obstructive pulmonary disease: a comprehensive study\".","authors":"Hinpetch Daungsupawong, Viroj Wiwanitkit","doi":"10.4081/monaldi.2025.3226","DOIUrl":"https://doi.org/10.4081/monaldi.2025.3226","url":null,"abstract":"<p><p>Dear Editor, This is a response to the article \"Hematological and clinical profiling of chronic obstructive pulmonary disease: a comprehensive study\". This observational cross-sectional study of chronic obstructive pulmonary disease patients sheds light on the association between hematological profiles and clinical parameters; however, some elements and techniques warrant additional consideration...</p>","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}