Monaldi Archives for Chest Disease最新文献

Characterizing non-cystic fibrosis bronchiectasis: spirometry indices and disease burden by FACED score. 非囊性纤维化支气管扩张的特征：肺活量测定指标和疾病负担。

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Monaldi Archives for Chest Disease Pub Date : 2026-05-07 DOI: 10.4081/monaldi.2026.3920

Amna Irfan Ansari, Muhammad Tayyab Ihsan, Shayan Shahid, Akbar Shoukat Ali, Muhammad Irfan

{"title":"Characterizing non-cystic fibrosis bronchiectasis: spirometry indices and disease burden by FACED score.","authors":"Amna Irfan Ansari, Muhammad Tayyab Ihsan, Shayan Shahid, Akbar Shoukat Ali, Muhammad Irfan","doi":"10.4081/monaldi.2026.3920","DOIUrl":"https://doi.org/10.4081/monaldi.2026.3920","url":null,"abstract":"This study aimed to characterize the clinical, radiological, and severity profile by spirometry indices and evaluate the clinical and structural disease burden stratified by FACED [FEV1% predicted (F), age (A), chronic colonization by Pseudomonas aeruginosa (C), extension of the disease by radiological assessment (E), and dyspnea (D)] severity in patients with non-cystic fibrosis (CF) bronchiectasis. A retrospective review of 125 patients with non-CF bronchiectasis who underwent a pulmonary lung function test at the Aga Khan University Hospital (Karachi, Pakistan) was conducted. Spirometry patterns were normal, obstructive, restrictive, and mixed. FACED classifications were mild (0-2) and moderate-severe disease (≥3). Pseudomonas aeruginosa was found in 26.40%. Obstructive ventilatory disorder (54.40%) was the most frequent finding. Symptom duration of >10 years was relatively frequent in the obstructive group (34.69%; p=0.012). Moderate-to-severe disease (FACED≥3) was most prevalent in the obstructive pattern (60.29%; p=0.012). Patients with moderate-to-severe disease more frequently reported longer symptom duration compared with those with mild disease (p=0.015). Non-CF bronchiectasis patients with obstructive ventilatory disease may present with a longer duration of symptoms and disease severity. Patients with moderate-severe disease had longer symptom duration, with trends towards higher lung parenchymal injury (residual fibrosis on high-resolution computed tomography) and hospitalization due to respiratory infection.","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radiological manifestations of allergic bronchopulmonary aspergillosis in adult asthmatic patients. 成人哮喘患者变应性支气管肺曲菌病的影像学表现。

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Monaldi Archives for Chest Disease Pub Date : 2026-05-07 DOI: 10.4081/monaldi.2026.3648

Fatima Wahab, Taimur Hussain Babar, Syed Farrukh Nadeem, Zafar Amin, Sajjad Sarwar, Sara Ahmad, Ammara Wahab, Saba Mukhtar

{"title":"Radiological manifestations of allergic bronchopulmonary aspergillosis in adult asthmatic patients.","authors":"Fatima Wahab, Taimur Hussain Babar, Syed Farrukh Nadeem, Zafar Amin, Sajjad Sarwar, Sara Ahmad, Ammara Wahab, Saba Mukhtar","doi":"10.4081/monaldi.2026.3648","DOIUrl":"https://doi.org/10.4081/monaldi.2026.3648","url":null,"abstract":"Allergic bronchopulmonary aspergillosis (ABPA) develops in patients through type I or type III hypersensitivity reactions to the filamentous fungi Aspergillus. There is a wide spectrum of radiological presentations of ABPA, including fleeting alveolar opacities, centrilobular nodules, bronchiectasis, mucoid impaction resulting in bronchocele, cavitation, and pulmonary fibrosis. This study aims to identify the pattern of radiological presentation in our community and its implications in the clinical diagnosis of the disease. We conducted a descriptive, cross-sectional study. The study was conducted at the Department of Radiology, Combined Military Hospital, Bahawalpur, between 4th April 2021 and 3rd October 2021. A total of 85 asthmatic patients between the ages of 18 and 60 years with a clinical diagnosis of ABPA reporting for high-resolution computed tomography (HRCT) were included. Patients with bronchiectasis other than ABPA, such as tuberculosis, foreign body, recurrent aspiration, and malignancy, were excluded. All the patients underwent an HRCT scan of the chest. In this study, the frequency of different radiological presentations of ABPA in adult asthmatic patients was as follows: mucus plug in 47 (55.29%) patients, centrilobular nodules in 49 (57.65%) patients, central bronchiectasis in 35 (41.18%) patients, and patchy air space consolidation in 37 (43.53%) patients. This study concluded that centrilobular nodules are the most common radiological presentation of ABPA in adult asthmatic patients, followed by the mucus plug, patchy air space consolidation, and central bronchiectasis.","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of sepsis subphenotypes: current methods and clinical implications in critical care practice. A structured narrative review. 鉴定脓毒症亚表型：目前的方法和临床意义在重症监护实践。结构化的叙述性评论

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Monaldi Archives for Chest Disease Pub Date : 2026-05-07 DOI: 10.4081/monaldi.2026.3866

Divya Chinta, Vigneswaran Jeyasekaran, Ravi Nagilla, Sai Jaswanth Dasaganipalli

{"title":"Identification of sepsis subphenotypes: current methods and clinical implications in critical care practice. A structured narrative review.","authors":"Divya Chinta, Vigneswaran Jeyasekaran, Ravi Nagilla, Sai Jaswanth Dasaganipalli","doi":"10.4081/monaldi.2026.3866","DOIUrl":"https://doi.org/10.4081/monaldi.2026.3866","url":null,"abstract":"Sepsis demonstrates high variability in clinical manifestations, and patients with similar manifestations at the moment of diagnosis usually develop in very different ways. Such differences are explained by the difference in the immune response and organ reactions to infection. To counter this diversity, scientists have started to classify the patients into subphenotypes to determine whether the treatment can be planned in an individualized way. The objective of this review is to determine the methods of determining sepsis subphenotypes and their role in clinical practice. To conduct this review, a search in PubMed was conducted on studies published between 2015 and 2025. Papers that provided explicit information about the process of subphenotype identification were included. Articles that lacked the complete text, publications that were not published in English, and those that lacked the necessary methodological information were filtered out. In the chosen studies, there were several methods used, based on routinely available clinical variables; others were based on biomarkers, machine-learning techniques, time-varying trends in the dysfunction of organs, and transcriptomic data. Even though the methods are different, they have found many groups of patients who have significant differences in terms of inflammation, organ failure patterns, and response to treatment. According to the available evidence, there is no one such condition that sepsis represents, but rather a series of biologically different conditions. Subphenotyping can improve initial diagnosis and treatment, but most current methods are complex for clinical use. More efforts should be made to establish less complex tools, which may be implemented consistently at the bedside.","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of positive expiratory pressure in the prevention and treatment of postoperative pulmonary complications following thoracic and abdominal surgery. A systematic review and meta-analysis. 呼气正压在防治胸腹外科术后肺部并发症中的作用。系统回顾和荟萃分析。

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Monaldi Archives for Chest Disease Pub Date : 2026-05-07 Epub Date: 2026-02-04 DOI: 10.4081/monaldi.2026.3735

Darko Dolic, Simone Salvitti

{"title":"Efficacy of positive expiratory pressure in the prevention and treatment of postoperative pulmonary complications following thoracic and abdominal surgery. A systematic review and meta-analysis.","authors":"Darko Dolic, Simone Salvitti","doi":"10.4081/monaldi.2026.3735","DOIUrl":"10.4081/monaldi.2026.3735","url":null,"abstract":"Postoperative pulmonary complications (PPCs), including atelectasis, pneumonia, and respiratory failure, are common after thoracic and upper abdominal surgery and are associated with increased morbidity, longer hospital stays, and higher costs. This systematic review and meta-analysis investigated whether positive expiratory pressure (PEP) devices reduce PPCs after thoracic or upper abdominal surgery compared with continuous positive airway pressure (CPAP), usual care/no intervention, or other non-CPAP respiratory treatments. We searched major databases and included randomized controlled trials. A total of 12 studies were included, and 7 contributed to the meta-analysis. Across comparator-stratified analyses, PEP did not demonstrate a consistent reduction in PPCs. Compared with usual care/no intervention, pooled estimates showed no significant benefit, and results were similarly inconclusive when PEP was compared with other non-CPAP treatments; evidence vs. CPAP was limited to a single small trial. The overall certainty of evidence was low due to methodological limitations and heterogeneity in outcome definitions and intervention protocols. Overall, current evidence does not support routine use of PEP devices as a primary strategy to prevent PPCs after thoracic or upper abdominal surgery. Further well-designed trials are needed to clarify whether specific patient subgroups or standardized protocols may benefit.","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146126926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding adverse drug reactions in respiratory care: a prospective predictive and severity-based analysis at a tertiary care hospital in India. 解码呼吸系统护理中的药物不良反应：印度一家三级护理医院的前瞻性预测和基于严重程度的分析。

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Monaldi Archives for Chest Disease Pub Date : 2026-05-07 Epub Date: 2025-05-15 DOI: 10.4081/monaldi.2025.3464

Vaishnavi V Gaonkar, Vinay V Shanbhag, Mandati Santhosh Reddy, M S Ganachari

{"title":"Decoding adverse drug reactions in respiratory care: a prospective predictive and severity-based analysis at a tertiary care hospital in India.","authors":"Vaishnavi V Gaonkar, Vinay V Shanbhag, Mandati Santhosh Reddy, M S Ganachari","doi":"10.4081/monaldi.2025.3464","DOIUrl":"10.4081/monaldi.2025.3464","url":null,"abstract":"Adverse drug reactions (ADRs) are a major concern in healthcare, including morbidity, longer hospitalization, and increased healthcare expenses. Despite the necessity of ADR monitoring, reporting is poor, particularly in developing countries such as India. This study assessed the severity, predictability, and causality of ADRs in a tertiary care hospital's respiratory department. A prospective observational study was conducted at KLE's Dr. Prabhakar Kore Hospital, Belagavi, Karnataka, from September 2023 to January 2025. Patients aged 45 years and above with chronic respiratory conditions were included. ADRs were assessed using validated scales, including the World Health Organization-Uppsala Monitoring Center Scale, the Modified Hartwig and Siegel Scale, and the Predictability Assessment. Descriptive statistics were applied to analyze ADR patterns. Among the 107 patients enrolled, 63.5% were elderly and 59.8% were female. Mild ADRs accounted for 60.7% of cases, while serious responses were reported in 3.7%. Predictability analysis revealed that 77.5% of ADRs were foreseeable. Causality assessment revealed ADRs as probable (51.4%), possible (37.3%), and certain (10.2%). Drug withdrawal was the most popular intervention (55.1%). The most commonly reported ADRs were gastrointestinal disorders (33.6%), followed by respiratory (18.6%) and cardiovascular disorders (16.8%). The study highlighted the need for improved pharmacovigilance programs to reduce ADR-related hazards in respiratory patients. Improving ADR reporting methods and predictive assessments can enhance patient safety and maximize therapeutic outcomes.","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of urinary incontinence in patients with chronic cough: a systematic review. 慢性咳嗽患者尿失禁的患病率：一项系统综述。

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Monaldi Archives for Chest Disease Pub Date : 2026-05-07 Epub Date: 2026-02-12 DOI: 10.4081/monaldi.2026.3767

Ludovica Scotti, Simone Salvitti

{"title":"Prevalence of urinary incontinence in patients with chronic cough: a systematic review.","authors":"Ludovica Scotti, Simone Salvitti","doi":"10.4081/monaldi.2026.3767","DOIUrl":"10.4081/monaldi.2026.3767","url":null,"abstract":"Chronic cough-related diseases increase the risk of urinary incontinence (UI) due to repeated intra-abdominal pressure affecting the pelvic floor. Existing studies focus on specific diseases rather than UI as a broader consequence. To determine the prevalence of UI in patients with chronic cough-related diseases and compare it with the prevalence in healthy populations. A systematic review was conducted using Medline, Embase, Cochrane, OVID, Scopus, ProQuest, PEDro, and EBSCO. Two independent reviewers screened studies using predefined criteria in a Microsoft Excel spreadsheet. Only prevalence studies were included. Data were extracted, synthesized, and assessed using the GRADE approach for evidence quality and the STROBE checklist for reporting quality. Prevalence estimates varied widely based on demographic characteristics. UI prevalence ranged from 2.2% to 45% in pediatric patients, 30.4% to 74% in adult women, and 2.4% to 39% in adult men. The quality of evidence was low, while reporting quality was acceptable. UI is a common complication in patients with chronic cough, with a higher prevalence than in healthy populations. Due to the stigma surrounding urogenital disorders, clinicians should actively inquire about UI during patient history-taking and refer affected individuals for appropriate treatment.","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146183291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mapping the nexus: tracing blood pressure changes in patients with psoriasis. 绘制关系图：追踪银屑病患者的血压变化。

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Monaldi Archives for Chest Disease Pub Date : 2026-05-06 DOI: 10.4081/monaldi.2026.3230

Sharang Gupta, Raina Arora, Anjana Rajenesh, Dimple Chopra, Shivali Aggarwal, Rupinder Walia

{"title":"Mapping the nexus: tracing blood pressure changes in patients with psoriasis.","authors":"Sharang Gupta, Raina Arora, Anjana Rajenesh, Dimple Chopra, Shivali Aggarwal, Rupinder Walia","doi":"10.4081/monaldi.2026.3230","DOIUrl":"https://doi.org/10.4081/monaldi.2026.3230","url":null,"abstract":"Psoriasis is a chronic condition driven by genetics, immune dysfunction, and environmental factors, impacting the skin, nails, joints, and potentially more. Understanding the correlation between psoriasis severity and blood pressure is crucial for mitigating the risk of cardiovascular comorbidities in affected patients. The aim of the study was to analyze the correlation between blood pressure and the duration and severity of psoriasis in affected patients. This is a cross-sectional study that included 150 subjects (100 psoriasis patients and 50 controls). After thorough history taking and complete general physical and dermatological examinations, the patients were divided into various grades of severity of the disease based on the Psoriasis Area Severity Index. Blood pressure of all subjects was measured. Patients with psoriasis have significantly higher levels of both systolic blood pressure and diastolic blood pressure than the controls (p=0.003 and p<0.001, respectively). A linear positive correlation was found between the systolic blood pressure (R²=0.768) and diastolic blood pressure (R²=0.550) and the duration of the disease. Similarly, a significant linear positive correlation was found between the severity of the disease and systolic blood pressure (R²=0.196) and also the diastolic blood pressure (R²=0.119). Multivariate regression analysis confirmed that disease severity and duration independently predict elevated blood pressure (p<0.05). This study establishes the association of psoriasis with increased blood pressure and its correlation with severity and duration, shedding light on the complex relationship between the disease and cardiovascular health.","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A pilot animal study of a novel nanocomposite silicone airway stent: biocompatibility and performance in a sheep model. 一种新型纳米复合硅酮气道支架的动物实验：在绵羊模型中的生物相容性和性能。

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Monaldi Archives for Chest Disease Pub Date : 2026-04-29 DOI: 10.4081/monaldi.2026.3840

Gita Manzari Tavakoli, Maryam Mazraehei Farahani, Zahra Moradhaseli, Arda Kiani, Hossein Kazemizadeh, Abdol-Mohammad Kajbafzadeh

{"title":"A pilot animal study of a novel nanocomposite silicone airway stent: biocompatibility and performance in a sheep model.","authors":"Gita Manzari Tavakoli, Maryam Mazraehei Farahani, Zahra Moradhaseli, Arda Kiani, Hossein Kazemizadeh, Abdol-Mohammad Kajbafzadeh","doi":"10.4081/monaldi.2026.3840","DOIUrl":"https://doi.org/10.4081/monaldi.2026.3840","url":null,"abstract":"Airway obstruction resulting from both malignant and non-malignant etiologies is a growing challenge in pulmonary diseases and critical care medicine, particularly after the COVID-19 pandemic. Conventional silicone and metallic airway stents may be indicated in airway obstructions that lead to palliative relief, but they may lead to complications such as migration, inflammatory reaction to the adjacent tissue, and granulation tissue overgrowth. We conducted this animal pilot study to investigate the biocompatibility of a next-generation nanocomposite silicone airway stent, engineered with 3wt% hydrophobic nano-silica reinforcement. Innovative characteristics of the stent include improved biocompatibility and reduced mucus adhesion due to its hydrophobic properties. A refined stenting technique was applied to implant the stent in the trachea of two sheep models by assembling two endotracheal tubes, Ambu, and the stent. After a two-month follow-up, high-resolution computed tomography imaging, 3D virtual bronchoscopy, bronchoscopy, and biopsy of the tracheal wall were done. Histopathologic assessment demonstrated an inflammatory infiltrate dominated by lymphocytes, without stromal reactions, mucosal and submucosal thickening, or granulation, confirming a favorable tissue tolerance. These preliminary outcomes emphasize the stent's potential as a transformative therapeutic option; however, the study's limited sample size and absence of comparative controls highlight the necessity for further preclinical trials with quantitative airflow parameters to elucidate the clinical translatability of this innovative biomaterial solution for airway obstructions. Additionally, the findings of this study can address the unmet needs in managing complex airway obstructions, particularly for patients refractory to current therapeutic options in the future.","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147788885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lung autopsy findings in 44 COVID-19 deceased patients:pathological and radiological insights. 44例COVID-19死亡患者肺尸检结果：病理和放射学见解

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Monaldi Archives for Chest Disease Pub Date : 2026-04-21 DOI: 10.4081/monaldi.2026.3412

Mohammad Samet, Fatemeh Alsadat Aghaei-Meybodi, Sina Hosseini, Abbas Meidany, Azadeh Fateh

{"title":"Lung autopsy findings in 44 COVID-19 deceased patients:pathological and radiological insights.","authors":"Mohammad Samet, Fatemeh Alsadat Aghaei-Meybodi, Sina Hosseini, Abbas Meidany, Azadeh Fateh","doi":"10.4081/monaldi.2026.3412","DOIUrl":"https://doi.org/10.4081/monaldi.2026.3412","url":null,"abstract":"This study presents a detailed histopathological analysis of lung tissue from 44 deceased COVID19 patients, aiming to elucidate the mechanisms driving severe disease progression. Postmortem biopsies were systematically examined, revealing diffuse alveolar damage in 95.5% of cases, predominantly in the acute/exudative phase. Characteristic features included extensive hyaline membrane formation, alveolar septal thickening, fibrin deposition, and red blood cell extravasation. Notably, advanced fibrosis, indicative of ongoing tissue remodeling, was observed in 86.4% of cases, highlighting the chronic pathological impact of the disease. Patient demographics showed a predominance of older males with comorbidities such as hypertension and diabetes, aligning with known high-risk profiles. The methodology involved meticulous autopsy procedures and standardized histopathological assessments to ensure the reliability of findings. This study provides key insight into histological changes in the lungs of COVID-19 patients, helping to clarify the disease's progression. It provides valuable insights that may contribute to a better understanding of long COVID and the potential long-term pulmonary complications in these patients. These findings may ultimately support improved management approaches and therapeutic strategies for COVID-19 care.","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147788858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prescription trends and antibiotic utilization in pneumonia: an observational study at a tertiary teaching hospital. 某三级教学医院肺炎处方趋势及抗生素使用观察性研究

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Monaldi Archives for Chest Disease Pub Date : 2026-04-21 DOI: 10.4081/monaldi.2026.3664

Sai Sowmya Bhupathiraju, Latha Maregouda Goudar, Srujan Manjunath, Subhojit Paul, Viswanatha Swamy Agadi Hiremath, Jayasheela Siddhalingayya Hiremath

{"title":"Prescription trends and antibiotic utilization in pneumonia: an observational study at a tertiary teaching hospital.","authors":"Sai Sowmya Bhupathiraju, Latha Maregouda Goudar, Srujan Manjunath, Subhojit Paul, Viswanatha Swamy Agadi Hiremath, Jayasheela Siddhalingayya Hiremath","doi":"10.4081/monaldi.2026.3664","DOIUrl":"https://doi.org/10.4081/monaldi.2026.3664","url":null,"abstract":"Pneumonia is a significant cause of morbidity and mortality, particularly among 5-year-olds, the elderly population, and those with comorbid conditions. As antibiotics are the most commonly used drugs, they need to be selected rationally to improve the therapeutic outcomes as well as to limit the emergence of antimicrobial resistance (AMR). This prospective observational study was carried out at Vivekananda Hospital, Hubballi, Karnataka, India, from October 2024 to March 2025. The data, such as demographics, laboratory values, patterns of prescription, and utilization trends from 200 study subjects, were collected, analyzed, and statistically tested using descriptive analysis. The World Health Organization core drug prescribing indicators revealed an average of 9775 drugs per prescription, of which antibiotics constitute 28.51%, with all prescriptions containing at least one antibiotic. Also, there is a high prevalence of polypharmacy, with the majority of prescriptions containing two or more antibiotics. The most commonly prescribed antibiotic was azithromycin, followed by ceftriaxone and piperacillin + tazobactam and the highest defined daily dose (DDD)/1000/days was observed in azithromycin (9.85), indicating potential overuse, whereas linezolid and cefixime had a prescriber daily dose value equal to DDD. The study emphasizes the need for improvement in generic prescribing, including the use of culture sensitivity tests for selection of appropriate antibiotics and implementation of an Antimicrobial Stewardship Program to optimize the antibiotic use and minimize the development of AMR.","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147788863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0