Monaldi Archives for Chest Disease最新文献

{"title":"Prevalence of human metapneumovirus infection among children suffering from acute respiratory illness in India: a systematic review and meta-analysis.","authors":"Aninda Debnath, Pritam Halder, Thejas Achary, Raunak Bir, Anubhav Mondal, Pranav Ish","doi":"10.4081/monaldi.2025.3383","DOIUrl":"https://doi.org/10.4081/monaldi.2025.3383","url":null,"abstract":"<p><p>Acute respiratory infections (ARI) are a leading cause of pediatric morbidity and mortality worldwide, with India bearing a significant burden. Human metapneumovirus (HMPV), an under-recognized respiratory pathogen, has been implicated in ARI, yet its prevalence in India remains inadequately characterized. The objective of this study was to estimate the prevalence of HMPV among children with ARI in India and assess regional, temporal, and demographic trends to guide public health interventions. This systematic review and meta-analysis was conducted following PRISMA guidelines. Data were extracted from 30 studies encompassing 12,534 children with ARI across India from 2004 to 2024. A random-effects model was used to calculate pooled prevalence, with subgroup and sensitivity analyses to explore heterogeneity. Publication bias was assessed using Egger's test and funnel plots. The pooled prevalence of HMPV was 5% (95% confidence interval: 4-6%), with significant heterogeneity (I²=95%). Subgroup analyses revealed higher prevalence in the northeast region (7%) and among children under 5 years (6%), compared to older age groups (2%). No significant differences were observed in prevalence pre- and post-COVID-19. Sensitivity analyses confirmed the robustness of findings, with minimal impact of publication bias. HMPV is a significant contributor to pediatric ARI in India, particularly among children under 5 years, highlighting its public health importance. The lack of a post-COVID-19 surge in prevalence suggests sustained circulation and widespread immunity. These findings underscore the need for enhanced diagnostic capacities, routine surveillance, and targeted interventions to mitigate the burden of HMPV-related ARI in vulnerable populations.</p>","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic yield and complications of thoracic ultrasound-guided biopsy performed by pulmonologists.","authors":"Rahul Kumar, Dipti Gothi, Nipun Malhotra, Umesh Chandra Ojha, Sunil Kumar, Anshul Jain, Mahismita Patro, Ramesh Pal","doi":"10.4081/monaldi.2025.3406","DOIUrl":"https://doi.org/10.4081/monaldi.2025.3406","url":null,"abstract":"<p><p>Interventional pulmonology is a growing field in India, and adding thoracic ultrasound (TUS)-guided lung biopsy can be useful for interventional pulmonologists. This study evaluated whether TUS-guided lung biopsy performed by pulmonologists, without the help of radiologists, can accurately diagnose pulmonary disease. A single-center prospective study was conducted with patients with pulmonary lesions requiring transthoracic biopsy. The primary objective was to find out the time taken by an experienced pulmonologist for the procedure without the aid of a radiologist. The secondary objective included the diagnostic yield of TUS-guided lung biopsy performed by a pulmonologist and the complication rate of the procedure. The study included 88 patients aged 18 to 86 years with a mean age of 62.7±12.9 years. The mean time taken for biopsy was 13±2.42 minutes. A total of 68 (77.2%) cases were biopsied in 11-15 minutes. Diagnosis could be established in 88.5% of cases. Pain at the biopsy site was the most common complication seen in 11 (12.5%) cases. Hemoptysis and bleeding at the biopsy site were seen in 7 (7.95%) cases. Pneumothorax was seen in 2 (2.27%) cases. Air embolism, post-procedure intubation, and malfunctioning of the forceps were seen in 1 (1.14%) case. TUS-guided lung biopsy performed by a pulmonologist without the help of a radiologist has a diagnostic yield similar to that performed by radiologists but can take a shorter time. The complications are also similar but can be addressed quickly.</p>","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of the COVID-19 pandemic on the profile of interstitial lung disease presenting to the pulmonary medicine department of a tertiary care center in western India.","authors":"Unnati Desai, Ketaki Utpat, Aravind Raj","doi":"10.4081/monaldi.2025.3220","DOIUrl":"https://doi.org/10.4081/monaldi.2025.3220","url":null,"abstract":"<p><p>The COVID-19 pandemic impacted the etiological pattern of interstitial lung diseases (ILDs). This study aimed to analyze the profile of ILDs presenting to our department during the pandemic. Specifically, this cross-sectional observational study was conducted with the institute's ethics committee approval in the year 2021-2022. The clinical profile and history of COVID-19 illness in ILDs were noted. Data was analyzed in percentages and means. Of the 136 cases included, 85 (62.5%) were men and 51 (37.5%) women. The average age was 55.1±12.01 years. Cough and breathlessness were the predominant symptoms. A total of 20 (15%) participants gave a past history of COVID-19, of whom 2 (10%) had mild, 2 (10%) had moderate, and 16 (80%) had severe COVID-19 illness. Among them, 9 (45%) cases had pre-existing ILD. Thus, 11 (55%) had new-onset ILD attributed to severe COVID-19. This contributed to 8% of the ILD caseload. Predominant ILD patterns on high-resolution computed tomography thorax were usual interstitial pneumonia, hypersensitivity pneumonitis (HP), and non-specific interstitial pneumonia. The ILD diagnosis with multidisciplinary discussion was idiopathic interstitial pneumonitis in 44 cases, HP in 36, connective tissue disease-ILD in 35, post-COVID-19 ILD in 11, sarcoidosis in 8, and silicosis in 2. COVID-19 was attributed to only 8% of the caseload and was the fourth most common cause of ILD. Generally, ILD cases were younger patients and had severe disease.</p>","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing respiratory care: clinical pharmacist interventions in respiratory tract infection management at a tertiary teaching hospital.","authors":"Chandrashekhar Mallikarjun Patil, Princy Domnic Dsouza, Sai Phalguna Prakash Chitralu, Vinod Ashok Koujalagi, Agadi Hiremath Viswanatha Swamy, Sanatkumar Bharamu Nyamagoud","doi":"10.4081/monaldi.2025.3337","DOIUrl":"https://doi.org/10.4081/monaldi.2025.3337","url":null,"abstract":"<p><p>Respiratory tract infections (RTIs) are prevalent in India, affecting approximately 11.3% of the population. India leads globally in lung disease mortality, including chronic obstructive pulmonary disease and asthma, contributing significantly to disability-adjusted life years and mortality rates. The role of clinical pharmacist interventions (CPIs) in optimizing antibiotic use and managing RTIs is increasingly recognized as vital for improving patient outcomes and reducing healthcare costs. This study aimed to evaluate the effectiveness of CPIs in managing RTIs among inpatients at Vivekananda General Hospital, Hubballi, and to identify common drug-related problems (DRPs) using the Hepler-Strand classification system. A cross-sectional study was conducted over 6 months, including 200 inpatients diagnosed with RTIs. Data was collected through patient profiles, treatment charts, and medical case sheets. The study employed descriptive and inferential statistical analyses to evaluate the impact of CPIs on antibiotic therapy and the prevalence of DRPs. The study identified drug-drug interactions as the most frequent DRP (38.30%), followed by drug duplication (31.49%) and improper drug selection (9.79%). Other issues included adverse drug reactions (4.68%), overdosage (5.53%), untreated indications (6.38%), subtherapeutic dosage (2.13%), and drug use without indication (1.70%). CPIs, including prospective audits, prescription feedback, and healthcare professional education, effectively addressed these issues, improved antibiotic appropriateness, and optimized patient outcomes. CPIs significantly enhance the management of RTIs by addressing various DRPs and optimizing antibiotic use. The study underscores the importance of incorporating pharmacists into antimicrobial stewardship programs to improve medication safety, efficacy, and overall patient care in managing RTIs. Continued emphasis on pharmacist-led interventions and adherence to best practices in antimicrobial stewardship is essential for reducing the burden of respiratory diseases in India.</p>","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of medical thoracoscopy in the diagnosis of exudative lymphocytic pleural effusions: an observational study.","authors":"Pradeep Naik G, Swathi Karanth Mp, Aravind Ram, Akshata Js, Raghu Bp, Nagaraja C","doi":"10.4081/monaldi.2025.3233","DOIUrl":"https://doi.org/10.4081/monaldi.2025.3233","url":null,"abstract":"<p><p>Diagnosis of pleural effusion remains challenging despite extensive microbiological and radiological investigations. Pleural histopathological examination (HPE) is often needed to ascertain the etiology. Medical thoracoscopy (MT) is surpassing the other modalities of pleural biopsy on account of its high diagnostic yield. We aim to estimate the yield of MT in undiagnosed exudative lymphocytic pleural effusion and also intend to correlate gross thoracoscopy findings with HPE results. This retrospective observational study was conducted in a tertiary respiratory care center. Medical records of undiagnosed exudative lymphocytic predominant pleural effusion patients who underwent MT during the study period of 24 months were retrieved from the Medical Records Department. The clinico-demographic profile, radiological images, gross thoracoscopy findings, HPE reports, and post-procedure complications were recorded and analyzed using analysis of variance and chi-square test. The study comprised 62 patients with a mean age of 52 years at presentation. HPE of MT-guided biopsy confirmed tuberculosis in 22 (35.3%), malignancy in 18 (29%) cases, and 22 (35.5%) cases had chronic nonspecific inflammation. The most commonly observed MT finding in malignancy was pleural nodules (14.70%), followed by thickened pleura (10.50%) and growth (2.10%). In tuberculosis, the most common MT finding was adhesions in all, followed by nodules (5.28%). We also diagnosed a case of pleural amoebiasis and ependymoma, which are rare. Macroscopic findings had a significant correlation with the final histopathologic diagnosis, with a diagnostic yield of 66.1%. Gross thoracoscopic findings correlate well with the histopathological diagnosis of pleural effusion etiology, with a correlation coefficient of 0.73. Pleural nodules were the most common finding in malignancy, while adhesions were common in benign pathology like tuberculosis. A good diagnostic yield underscores the utility of MT in undiagnosed exudative lymphocytic pleural effusions.</p>","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic yield of rapid on-site cytology evaluation on fluoroscopic-guided transbronchial biopsy in a private hospital in Jakarta: a one-year retrospective study.","authors":"Mohamad Fahmi Alatas, Bernadina Chyntia, Andika Chandra Putra, Wiwien Heru Wiyono, Renaningtyas Tambun","doi":"10.4081/monaldi.2025.2997","DOIUrl":"https://doi.org/10.4081/monaldi.2025.2997","url":null,"abstract":"<p><p>Rapid on-site cytology examination (ROSE) with a fluoroscopic-guided transbronchial biopsy (TBLB) involves the immediate evaluation of cytological specimens during a diagnostic procedure. This research aims to investigate the potential yield of this diagnostic technique, shedding light on its benefits, limitations, and the evidence supporting its efficacy. A retrospective analysis of the data was conducted on 26 patients who underwent ROSE and TBLB procedures in the hospital between July 2022 and August 2023. A total of 21 patients met the requirements for the inclusion criteria: patients with peripheral pulmonary lesions found by chest X-rays or chest computed tomography scans consented to have a bronchoscopy with both ROSE and TBLB examination. A total of 5 patients were excluded because of the exclusion criteria: patients who only took either ROSE or TBLB examination and were noncompliance with bronchoscopy. The statistical software SPSS 29.0 was used for the analyses. The chi-square test was employed to evaluate differences between two groups of categorical variables and was considered significant when the p-value was under 0.05. ROSE evaluated 21 lesions and followed up with the final pathological biopsy. Malignant tumors were identified in 12 cases by ROSE and TBLB procedures. One case was benign by the biopsy results but was malignant by ROSE examination. Similarly, 8 cases were benign, as determined by ROSE examination and TBLB. Between ROSE and TBLB, there was a statistical difference with p<0.001. The sensitivity is 100%, and the specificity is 11.1%. However, high sensitivity was proven by ROSE compared to biopsy, which is the gold standard in this study. No significant complications were observed after the procedure. According to this study, ROSE has a high diagnostic value with high sensitivity values for real-time diagnosis but still has not been able to replace the biopsy function as the gold standard. ROSE should only be considered for screening and sample adequacy in the bronchoscopy suite.</p>","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative study between ultrasound-guided closed pleural biopsy and thoracoscopic pleural biopsy in undiagnosed exudative pleural effusions.","authors":"Sreyas Sharma, Nitesh Gupta, Pranav Ish, Rajnish Kaushik, Neeraj Kumar Gupta, Tanmaya Talukdar, Rohit Kumar","doi":"10.4081/monaldi.2025.3361","DOIUrl":"https://doi.org/10.4081/monaldi.2025.3361","url":null,"abstract":"<p><p>Pleural biopsies are often required to establish a diagnosis in exudative pleural effusions, which remain undiagnosed after initial pleural fluid analysis. Medical thoracoscopy offers a high diagnostic yield but has limited availability in resource-constrained settings. This prospective comparative study evaluated the diagnostic yield between ultrasound-guided closed pleural biopsy and medical thoracoscopy among patients with undiagnosed exudative pleural effusions with pleural-based lesions at least 10 mm in size. Both groups achieved an equal diagnostic yield of 92% despite fewer biopsy specimens being taken in the ultrasound-guided biopsy group (4.52±0.65) compared to the thoracoscopic group (7.8±1) (p<0.0001). In conclusion, ultrasound-guided closed pleural biopsy is a suitable alternative to medical thoracoscopy in patients with undiagnosed exudative pleural effusion having pleural thickening or nodularity of at least 10 mm in size in terms of having similar diagnostic yield as compared to medical thoracoscopy.</p>","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trajectory of the response to bronchodilator and respiratory outcomes in adults with asthma-like symptoms.","authors":"Daniel Gimenez da Rocha, Monique Olivia Burch, Luciana Aparecida Teixeira Soares, Jessica Regina Bertolino, Ana Lúcia Bergamasco Galastri, Daniel Antunes, Ronei Luciano Mamoni, Eduardo Vieira Ponte","doi":"10.4081/monaldi.2025.3116","DOIUrl":"https://doi.org/10.4081/monaldi.2025.3116","url":null,"abstract":"<p><p>In the real world, health professionals need to care for individuals with asthma-like symptoms who have a persistently negative bronchodilator response (BDR). Little is known about the evolution of symptoms and lung function of these individuals because they are usually excluded from studies on asthma. The aim of this study was to evaluate whether individuals with asthma-like symptoms but with a persistently negative BDR have a different evolution of symptoms and lung function compared to individuals with asthma proven by positive BDR. This prospective cohort study included adults with asthma-like symptoms. Individuals participated in two visits 12 months apart. They responded to questionnaires and underwent a spirometry test. In individuals without airway obstruction in the first visit, those with asthma-like symptoms and persistently negative BDR were less likely to lose forced expiratory volume in the first second during follow-up or progress to airway obstruction at the final visit compared to individuals with asthma proven by positive BDR. Among individuals with airway obstruction at baseline, those with asthma-like symptoms and persistently negative BDR were less likely to resolve the airway obstruction during follow-up compared to individuals with asthma proven by positive BDR. In individuals with proven asthma, the emergence or persistence of positive BDR during follow-up was accompanied by a worsening of asthma outcomes compared to the remission of positive BDR. Thus, BRD is an accessible marker of disease progression in individuals with asthma-like symptoms. In individuals with asthma proven by positive BDR, the trend in BDR was associated with the evolution of symptoms and lung function.</p>","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authors' Response.","authors":"Branko Beronja, Aleksandra Karan, Biljana Lukic, Ivana Milosevic, Jelena Dotlic, Tatjana Gazibara","doi":"10.4081/monaldi.2025.3462","DOIUrl":"https://doi.org/10.4081/monaldi.2025.3462","url":null,"abstract":"<p><p>Dear Editor, We read the comments by Rossato and Di Vincenzo with enthusiasm and appreciate their interest in our study, which helps deepen the discussion on smoking and COVID-19. Indeed, smoking is a major health issue worldwide, as it is associated with a variety of poor outcomes, including COVID-19...</p>","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute effects of heated tobacco smoking: a single-center study.","authors":"Naglaa B Ahmed, Ayman E Salem, Eman A AbdulGawad, Hebatallah H Ahmed, Menna H Mohamed Abdel Gawad","doi":"10.4081/monaldi.2025.3316","DOIUrl":"https://doi.org/10.4081/monaldi.2025.3316","url":null,"abstract":"<p><p>The idea of heated tobacco products (HTPs) is to deliver nicotine to the consumer by heating the tobacco rather than burning it, possibly causing less release of many harmful and potentially harmful chemical constituents (HPHCs), including carbon monoxide (CO). This prospective observational study targets studying the acute effects of HTPs regarding exhaled CO, serum cotinine level, and pulmonary function. A total of 91 participants were included; 46 current traditional cigarette smokers were instructed not to smoke for a minimum of 12 hours before the study (not following the smoking cessation program) and then divided into two groups. Group 1 contained 23 participants who smoked their usual cigarette brands, and Group 2 consisted of 23 participants who smoked the I-Quit-Ordinary-Smoking tobacco sticks. Group 3 is the control group, including 45 normal healthy non-smoker participants. All participants were subjected to the subsequent thorough medical history and clinical examination, followed by assessment of the following parameters before smoking as well as 5 minutes after smoking (either heated tobacco or traditional cigarettes according to their groups): oxygen saturation (SpO₂), heart rate (HR), measurement of exhaled CO, spirometry, and blood sample for serum cotinine level (which was assessed 5 minutes as well as 30 minutes after smoking). The study's findings showed that after smoking cigarettes, the amount of CO in the air was higher (mean 32.83±16.73 standard deviation) than after smoking heated tobacco, which was statistically significant. Serum cotinine levels also went up after smoking in both groups, but they were slightly higher after HTPs than after conventional cigarettes (CCs). Spirometry and SpO2 levels went down after smoking in groups 1 and 2, while HR levels went up after smoking in both groups, with a p-value of less than 0.001. We concluded that the HTPs have acute respiratory and cardiovascular effects similar to CCs but with less exhaled CO.</p>","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}