International Journal of Pediatrics最新文献_第8页

Long-Term Outcomes of Cochlear Implantation on Language Skills and Speech Intelligibility in Early-implanted versus Late-implanted Deaf Children 人工耳蜗植入对早期和晚期聋儿语言技能和言语清晰度的长期影响

IF 2.1

International Journal of Pediatrics Pub Date : 2021-09-21 DOI: 10.22038/IJP.2021.57919.4546

S. Hassanzadeh, M. Ajalloueyan, Azam Mirdeharbab, A. Arjmandnia, Mahdieh Hasanalifard, M. Saeedi, Alireza Aghaz

{"title":"Long-Term Outcomes of Cochlear Implantation on Language Skills and Speech Intelligibility in Early-implanted versus Late-implanted Deaf Children","authors":"S. Hassanzadeh, M. Ajalloueyan, Azam Mirdeharbab, A. Arjmandnia, Mahdieh Hasanalifard, M. Saeedi, Alireza Aghaz","doi":"10.22038/IJP.2021.57919.4546","DOIUrl":"https://doi.org/10.22038/IJP.2021.57919.4546","url":null,"abstract":"Background: Hearing loss may affect many aspects of a person's life. The age of cochlear implantation (CI) is often considered an important predictor of language skills of children with CI, but little is known about the benefits of early CI on speech intelligibility development in these children. This study aimed to compare language skills as well as intelligibility of speech in prelingual deaf patients who received CI before the age of six years and those who received CI after the age of six years with an 8-year follow-up.\u0000Materials and Methods: This 8-year longitudinal, retrospective case–control study was conducted in 2021 at a cochlear implant center in Tehran, Iran. Thirty-one patients were included in two groups: late cochlear implant (n = 15), and early cochlear implant (n =16). The Test of Language Development- Primary (TOLD-P3) was used to assess the participants 'language skills. The intelligibility of the participants' speech was assessed through the Persian version of the Intelligibility Context Scale (ICS) and the speech intelligibility rating (SIR).\u0000Results: These two groups did not show a significantly difference in terms of the language scores (P>0.05) but had a significantly difference in terms of the SIR and the ICS scores (P<0.05). Speech intelligibility had a significantly negative correlation with the age of CI (P<0.001), and had a significant positive correlation with language skills (P<0.001).\u0000Conclusion: The long-term outcomes of early and late CI were similar in terms of the development of language skills but too different in terms of the intelligibility of speech. The age of CI had no effect on the language development but had a significant effect on speech intelligibility.","PeriodicalId":51591,"journal":{"name":"International Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2021-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47821422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Passive Smoking with Dental Caries and Cotinine Biomarker among 8-12 Years Old Children of Semnan, Iran 伊朗塞姆南8-12岁儿童被动吸烟与龋齿和可替宁生物标志物的关系

IF 2.1

International Journal of Pediatrics Pub Date : 2021-09-21 DOI: 10.22038/IJP.2021.59254.4615

Shabnam Sohanian, R. Ghorbani, O. Mirmohammadkhani, Homa Delavari, Kamyar Mansori

{"title":"Association Passive Smoking with Dental Caries and Cotinine Biomarker among 8-12 Years Old Children of Semnan, Iran","authors":"Shabnam Sohanian, R. Ghorbani, O. Mirmohammadkhani, Homa Delavari, Kamyar Mansori","doi":"10.22038/IJP.2021.59254.4615","DOIUrl":"https://doi.org/10.22038/IJP.2021.59254.4615","url":null,"abstract":"Background: The present study was designed to determine association passive smoking with dental caries and cotinine biomarker among 8-12 years old children of Semnan, Iran. Materials and Methods: This cross sectional study was concocted on two groups of 8-12 years old children exposed (n=100) and non-exposed to passive smoking (n=100) in of Semnan (Iran). The sampling method was two-stage cluster sampling design. The data collection tool a standard checklist consisted of demographic, laboratory and dental characteristics. Examination was performed by a dentist on a dental unit and the dental indicators were measured for two groups. Also, salivary cotinine was measured and recorded using ELISA method by special cotinine kit (De salimetrics medi tec, USA). Univariate and Multivariable Logistic Regression model and area under the ROC curve were used to data analysis by STATA 14 software. Results: Univariate logistic regression model showed a statistically significant difference between the exposed and unexposed groups with passive smoking in term of the salivary cotinine level, age , sex , decayed, missing, and filled teeth (dmft) index, decayed, and filled teeth (dft) index and missing teeth (mt) (P-Value ≤0.20). However, multiple logistic regression model showed a statistically significant relationship between the decayed, missing, and filled teeth (dmft) index and passive smoking (OR=1.28; 95% CI: 1.05 – 1.38). Conclusion: This study showed that the risk of decay of deciduous teeth is higher in children exposed to passive smoking, therefore, passive smoking should be considered in the implementation of programs to prevent tooth decay in children.","PeriodicalId":51591,"journal":{"name":"International Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2021-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42407460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the Ventricular Function based on Echocardiographic Findings in Asthmatic Children Referred to Rasoul Akram and Firoozabadi Hospitals of Tehran 根据超声心动图结果评估转诊至德黑兰Rasoul Akram和Firoozabadi医院的哮喘儿童的心室功能

IF 2.1

International Journal of Pediatrics Pub Date : 2021-09-21 DOI: 10.22038/IJP.2021.59039.4602

M. Fallahpour, M. Radgoudarzi, Mojtaba Didar Shetaban, Mohammad Bagher Didarshetaban

{"title":"Evaluation of the Ventricular Function based on Echocardiographic Findings in Asthmatic Children Referred to Rasoul Akram and Firoozabadi Hospitals of Tehran","authors":"M. Fallahpour, M. Radgoudarzi, Mojtaba Didar Shetaban, Mohammad Bagher Didarshetaban","doi":"10.22038/IJP.2021.59039.4602","DOIUrl":"https://doi.org/10.22038/IJP.2021.59039.4602","url":null,"abstract":"Objective: Asthma is a chronic inflammatory disease of the lead to hypertrophy and dilatation of the right ventricle. Aim of study to evaluate and compare left and right ventricular systolic and diastolic function of the heart based on echocardiographic criteria in children with moderate to severe asthma and non-asthmatic children referred to Hazrat Rasouland Firoozabadi Hospitals of Tehranin 2019. Methods: In this case-control study, 50 patients with a definite diagnosis of moderate to severe asthma(case group) and 50 healthy individuals (control group) were studied and compared in terms of clinical and echocardiographic measures. Blood pressure, heart rate, body height and weight of all children were recorded. The patients who were >6 years underwent pulmonary function tests using spirometry. Conventional and TDI echocardiography was performed bya single experienced pediatric cardiologist on two groups blindly and echocardiographic data was collected.Results: The results showed that the left ventricular stroke volume was significantly lower in patients with asthma. Also, in the right ventricular SV, significantly lower values were found in the group of patients under study than healthy individuals (P=0.01). The E/A ratio in both groups was higher than one with a mean and standard deviation of 1.72±0.26 in the case group compared to 1.92±0.32 which was not significantly different.Conclusion: The results of this study showed that asthma can affect ventricular contraction in children. Contrary to previous studies and despite the observation of cardiac systolic dysfunction in patients with asthma, diastolic dysfunction in these patients was not observed even by tissue Doppler echocardiography.Keywords: Asthma, Cardiac function, Echocardiography","PeriodicalId":51591,"journal":{"name":"International Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2021-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46388132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Efficiency of Epiphysiodesis for Growth Modulation in Patients with Congenital Scoliosis: A Systematic Review 体表成形术对先天性脊柱侧凸患者生长调节的效果:一项系统综述

IF 2.1

International Journal of Pediatrics Pub Date : 2021-09-12 DOI: 10.22038/IJP.2021.56414.4434

E. Keykhosravi, H. Rezaee, Amin Tavallaii, Mohammad Abouei Mehrizi, A. Pourbagher-Shahri, Vahid Khajereza Shahri, Ahmad Abdul Sater Abdul Sater

{"title":"The Efficiency of Epiphysiodesis for Growth Modulation in Patients with Congenital Scoliosis: A Systematic Review","authors":"E. Keykhosravi, H. Rezaee, Amin Tavallaii, Mohammad Abouei Mehrizi, A. Pourbagher-Shahri, Vahid Khajereza Shahri, Ahmad Abdul Sater Abdul Sater","doi":"10.22038/IJP.2021.56414.4434","DOIUrl":"https://doi.org/10.22038/IJP.2021.56414.4434","url":null,"abstract":"Purpose: Congenital scoliosis (CS) is a challenging entity in spinal surgery. Convex growth arrest (CGA) is a therapeutic method aiming at inhibiting growth on the curve convexity while remained growth of concavity corrects the scoliotic curve over time. In the view of controversies in current clinical studies for efficiency of CGA in CS patients, we performed a systematic review of the literature to clarify the debate. Methods: A comprehensive literature search was performed to identify studies assessing CGA outcome in CS patients, in following databases and search engines: Ovid MEDLINE, PubMed, Scopus, Cochrane Central Register of Controlled Trials (CCTR), EMBASE, Google Scholar, and Web of Science. Two authors screened the search results and selected the studies by the supervision of senior authors.Results: In 19 studies, enrolling 363 patients, age at surgery was 58.76 months ranging from 4 to 216 months. Anterior and posterior hemiepiphysiodesis was the most common approach. Eight studies added instrumentation to CGA. Follow-up mean was 64.57 months. Nine studies reported true epiphysiodesis effect (postoperative and final follow-up CCA difference): of 162 patients, 69 improved, 59 stabilized, and 34 progressed. Other studies reported preoperative and final follow-up CCA difference: of 88 patients, 49 improved, 32 stabilized, and 7 progressed. Preoperative curve magnitude, sagittal plane deformities, age <5 years, and type of spinal anomalies did not affect CGA outcome. Instrumentation was preferred in complicated spinal anomalies and older ages.Conclusion: CGA alone or with instrumentation is a feasible CS treatment, however criteria for choosing suitable candidates need reconsideration.","PeriodicalId":51591,"journal":{"name":"International Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2021-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45625485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inpatient vs. outpatient management of uncomplicated preterm premature rupture of membranes: a clinical trial 无并发症早产胎膜早破的住院与门诊治疗：一项临床试验

IF 2.1

International Journal of Pediatrics Pub Date : 2021-09-11 DOI: 10.22038/IJP.2021.57629.4522

L. Pourali, Masoumeh Mirteimouri, Samaneh Akbarzadeh, Habibullah Esmayili, Elahe Hasanzadeh

{"title":"Inpatient vs. outpatient management of uncomplicated preterm premature rupture of membranes: a clinical trial","authors":"L. Pourali, Masoumeh Mirteimouri, Samaneh Akbarzadeh, Habibullah Esmayili, Elahe Hasanzadeh","doi":"10.22038/IJP.2021.57629.4522","DOIUrl":"https://doi.org/10.22038/IJP.2021.57629.4522","url":null,"abstract":"Introduction: Preterm premature rupture of membranes (PPROM) is spontaneous rupture of fetal membranes before 37 weeks of gestation. PPROM cases who are clinically stable with no sign or symptom of intrauterine infection and normal fetal assessment are usually managed expectantly in hospital setting or at home. This study was performed with aim to compare the inpatient and outpatient management among women with uncomplicated PPROM.Methods: This non-randomized clinical trial was performed in an academic hospital, Mashhad University of Medical Sciences in 2017-2018. Women with confirmed PPROM who received initial treatments during primary 72-hour hospitalization were assigned into inpatient (n=45) or outpatient (n=35) management groups according to the patient's decision. The outcomes included latency period, gestational age at delivery, delivery route, delivery reason, WBC and neutrophil count, neonates’ weight, Apgar score, NICU admission, and death in the first 28 days after delivery. Data were analyzed by Statistical Package for Social Science (IBM SPSS) version 23. P 0.05). Neonatal Apgar score, death, and NICU admission rate or period were not significantly different between two groups(p>0.05).Conclusion: Homecare in selected PPROM women could be a suitable expectant strategy without compromising neonatal or maternal outcomes.","PeriodicalId":51591,"journal":{"name":"International Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2021-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41737834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison the analgesic effect of oral acetaminophen vs ibuprofen in children with supracondylar fractures: A Triple-blind Randomized Clinical Trial 口服对乙酰氨基酚与布洛芬对儿童髁上骨折的镇痛效果比较:一项三盲随机临床试验

IF 2.1

International Journal of Pediatrics Pub Date : 2021-09-11 DOI: 10.22038/IJP.2021.58555.4576

Morteza Talebi Deluee, Somaye Bagherian, B. Kakhki, A. Mousavian, H. Miri, E. Moradi

{"title":"Comparison the analgesic effect of oral acetaminophen vs ibuprofen in children with supracondylar fractures: A Triple-blind Randomized Clinical Trial","authors":"Morteza Talebi Deluee, Somaye Bagherian, B. Kakhki, A. Mousavian, H. Miri, E. Moradi","doi":"10.22038/IJP.2021.58555.4576","DOIUrl":"https://doi.org/10.22038/IJP.2021.58555.4576","url":null,"abstract":"Introduction: A supracondylar fracture are common in children with the average age of is 5-8 years. It is especially important to pay attention to pain control in these children because of lots of pain. This study was design to compare the analgesic effect of oral ibuprofen vs acetaminophen in children with supracondylar fractures who undergoing non-surgical treatment.Material & Methods: This triple-blind clinical trial was conducted on children with supracondylar fracture referred to the Emergency Department of Emam Reza and Hosheminejad Hospital. Children’s pain were assessed 2, 4 and 12 hours after taking the drug by VAS (Visual Analog Scale) criteria, which was explained by researcher to their parents. Results: In this study, 64 children with a mean age of 5.7±1.7 years were studied. 31 children in the acetaminophen group and 33 children in the ibuprofen group were evaluated. The mean pain score reduction within 12 hours of drug administration showed no difference between the two groups (P = 0.710). After 12 hours of drug administration, 5 and 7 children being painless in the acetaminophen and ibuprofen, respectively, with no difference between the two groups.Conclusion: During the 12 hours after ibuprofen and acetaminophen, children had similar analgesia and there was no significant difference between the two drugs in terms of pain relief and side effects, and both drugs are safe and effective for pain-control in children.","PeriodicalId":51591,"journal":{"name":"International Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2021-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43989590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Helicobacter Pylori Infection in Children with Idiopathic Thrombocytopenic Purpura 儿童特发性血小板减少性紫癜幽门螺杆菌感染

IF 2.1

International Journal of Pediatrics Pub Date : 2021-09-01 DOI: 10.22038/IJP.2021.51270.4077

M. Golpayegani, Mina Hayati, G. Yousefi

{"title":"Helicobacter Pylori Infection in Children with Idiopathic Thrombocytopenic Purpura","authors":"M. Golpayegani, Mina Hayati, G. Yousefi","doi":"10.22038/IJP.2021.51270.4077","DOIUrl":"https://doi.org/10.22038/IJP.2021.51270.4077","url":null,"abstract":"Background: Today Helicobacter pylori is the most common bacterial infection worldwide and is associated with some extra-gastrointestinal diseases such as blood disorders including idiopathic thrombocytopenic purpura (ITP). Therefore, this study was designed and performed to determine the status of Helicobacter pylori infection in children with idiopathic thrombocytopenic purpura referred to Dr. Mohammad Kermanshahi Hospital in 2019. Materials and Methods: In this cross-sectional study, 68 children with ITP were evaluated for Helicobacter pylori infection using stool antigen test. Information on Helicobacter pylori was collected using a checklist along with data on gender, age, type of ITP (acute / chronic), primary platelet counts, duration of ITP, and history of receiving treatment for H. pylori infection. Data were analyzed by SPSS-20 using descriptive statistics and the Chi-square test. Results: The mean age of all subjects was 6.35 ± 3.44 years with an age range of 1 to 13 years. The mean duration of the disease was 9.73. ± 9.04 months. Among patients, 63.24% (43 patients) were boys. Regarding the type of ITP, the highest percentage was the Acute type of disease (72/06%). Also, based on the analytical results, there was no significant relationship between Helicobacter pylori infection and gender, mean duration of infection and type of ITP (p <0.05). Conclusion: According to the results of this study, half of the ITP patients had Helicobacter pylori infection, but there was no significant relationship between the type of ITP and its duration with Helicobacter pylori infection. Therefore, it is recommended to conduct similar studies with a larger sample size and perform follow-ups to achieve more accurate results","PeriodicalId":51591,"journal":{"name":"International Journal of Pediatrics","volume":"9 1","pages":"14355-14361"},"PeriodicalIF":2.1,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42211673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intelligent Resilience of Pediatric Burn Nurses: A Qualitative Study 儿科烧伤护士的智能恢复力：定性研究

IF 2.1

International Journal of Pediatrics Pub Date : 2021-09-01 DOI: 10.22038/IJP.2021.59646.4645

Kolsoum Deldar, R. Froutan

引用次数: 0

The Correlation between the Mothers’ and their Daughters’ Ages of Menarche: A Systematic Review and Meta-analysis 母亲和女儿初潮年龄的相关性：系统综述和Meta分析

IF 2.1

International Journal of Pediatrics Pub Date : 2021-09-01 DOI: 10.22038/IJP.2021.58319.4564

S. Nasiri, M. Dolatian, F. Tehrani, A. Bagheri, H. A. Majd, R. Pakzad

{"title":"The Correlation between the Mothers’ and their Daughters’ Ages of Menarche: A Systematic Review and Meta-analysis","authors":"S. Nasiri, M. Dolatian, F. Tehrani, A. Bagheri, H. A. Majd, R. Pakzad","doi":"10.22038/IJP.2021.58319.4564","DOIUrl":"https://doi.org/10.22038/IJP.2021.58319.4564","url":null,"abstract":"Background: Due to the increased effect of environmental factors on the age of menarche and the correlation between the mothers’ and daughters’ age of menarche, we aimed at performing a meta-analysis to compare the mean age of menarche between the mothers and their daughters, examining the correlation between them. Objective: This systematic review was conducted to determine the heritability of daughters’ age of menarche. Materials and Methods: In this systematic review and meta-analysis, a complete search was carried out in PubMed, Scopus, Google Scholar, Web of Science, Science Direct, and CINAHL electronic databases in English with no time limitation. A meta-regression analysis was then performed to evaluate the effect of age and sample size. 13 studies with a total sample size of 9719 for calculating the standardized mean difference and 15 articles with a total sample size of 8840, related to the research objectives, were analyzed in this meta-analysis. Results: The pooled mean of the daughters’ age of menarche was 12.62 yrs. (95% CI: 12.37 – 12.87) and that of the mothers’ age of menarche was 13.58 yrs. (95% CI: 13.31 – 13.81). The standardized mean difference between the mothers’ and daughters’ ages of menarche was -0.72 (CI: -0.99 to -0.44). The results of the meta-analysis revealed that, overall, there is a significant positive correlation between the mothers’ and daughters’ ages of menarche (r=0.27 [CI 95%: 0.17-0.36]). Conclusion: The daughters’ ages of menarche were positively correlated to those of their mothers, but the other environmental factors that may affect this decreasing trend should also be taken into account. Health policy-makers should plan to identify strong predictors, which can be effective in reducing the age of menarche.","PeriodicalId":51591,"journal":{"name":"International Journal of Pediatrics","volume":"9 1","pages":"14481-14496"},"PeriodicalIF":2.1,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46941673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Serum Anti TTG Level as a Predictor for Severity of Intestinal Damage in Children with Celiac Disease 血清抗TTG水平作为乳糜泻患儿肠道损伤严重程度的预测因子

IF 2.1

International Journal of Pediatrics Pub Date : 2021-08-31 DOI: 10.22038/IJP.2021.59273.4619

S. Jafari, M. Khalesi, Hoda Shojaie, H. Kianifar, M. Kiani

{"title":"Serum Anti TTG Level as a Predictor for Severity of Intestinal Damage in Children with Celiac Disease","authors":"S. Jafari, M. Khalesi, Hoda Shojaie, H. Kianifar, M. Kiani","doi":"10.22038/IJP.2021.59273.4619","DOIUrl":"https://doi.org/10.22038/IJP.2021.59273.4619","url":null,"abstract":"AbstractIntroduction: This study aimed at evaluating how the patient’s clinical manifestations and his/her anti TTG level are correlated with the intensity of histological damage based on the classification of Marsh Oberhuber.Methods: This cross-sectional study was performed on 186 children suspected to celiac disease who referred to gastroenterology clinic between 2014 and 2015 and had Anti TTG >20. All patients underwent upper gastrointestinal endoscopy and multiple biopsies of duodenum were taken; histological classification was performed based on Marsh Oberhuber criteria. Finally, the relationship between serum levels of Anti TTG and histologic findings was assessed based on Marsh Oberhuber criteria.Results: There was a statistically significant difference between Anti TTG and different classes of grading March (P=0.01). Moreover, the intensity of intestinal damage based on Marsh Oberhuber criteria was significantly higher in children who referred with gastrointestinal complaints, the classic form of celiac disease and growth disorder. Anti TTG level of 148 IU/ml was the best positive cutoff point suggested by the ROC. For anti TTG level of 148 IU/ml, sensitivity, specificity, positive predictive value and negative predictive value were 46.8%, 82.4%, 91.7%, and 27.2%, respectively.Conclusion: Anti TTG level of 148 IU/ml has a high positive predictive value and a low negative predictive value for histologic changes more than grade 1 in Marsh classification.","PeriodicalId":51591,"journal":{"name":"International Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45525285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0