Inpatient vs. outpatient management of uncomplicated preterm premature rupture of membranes: a clinical trial

Introduction: Preterm premature rupture of membranes (PPROM) is spontaneous rupture of fetal membranes before 37 weeks of gestation. PPROM cases who are clinically stable with no sign or symptom of intrauterine infection and normal fetal assessment are usually managed expectantly in hospital setting or at home. This study was performed with aim to compare the inpatient and outpatient management among women with uncomplicated PPROM.Methods: This non-randomized clinical trial was performed in an academic hospital, Mashhad University of Medical Sciences in 2017-2018. Women with confirmed PPROM who received initial treatments during primary 72-hour hospitalization were assigned into inpatient (n=45) or outpatient (n=35) management groups according to the patient's decision. The outcomes included latency period, gestational age at delivery, delivery route, delivery reason, WBC and neutrophil count, neonates’ weight, Apgar score, NICU admission, and death in the first 28 days after delivery. Data were analyzed by Statistical Package for Social Science (IBM SPSS) version 23. P 0.05). Neonatal Apgar score, death, and NICU admission rate or period were not significantly different between two groups(p>0.05).Conclusion: Homecare in selected PPROM women could be a suitable expectant strategy without compromising neonatal or maternal outcomes.