International Journal of Pediatrics最新文献

{"title":"NeoNatalie Versus NeoNatalie Live Simulation for Training Undergraduate Students in Neonatal Resuscitation-A Randomized Control Trial.","authors":"Anish Sinha, Somashekhar Nimbalkar, Dipti Shah, Purvi Patel, Jaimin Patel, Qury Nagadia, Mayur Shinde, Reshma Pujara, Dipen Patel","doi":"10.1155/ijpe/3159205","DOIUrl":"10.1155/ijpe/3159205","url":null,"abstract":"<p><p><b>Background:</b> The most used manikin for neonatal resuscitation training is NeoNatalie (N), a low-fidelity manikin. A new manikin, NeoNatalie Live (NL), has been developed with more fidelity. We completed a noninferiority RCT to evaluate skill acquisition and to assess retention after 4 months of using these manikins. <b>Methodology:</b> Performance evaluation test (PET), a 14-item checklist, was used to assess students' skills before and after training and after 4 months. The maximum score was 100, and the noninferiority limit was 5. One hundred forty-three medical students were assigned randomly into two groups: N (<i>n</i> = 72) and NL (<i>n</i> = 71). Half of each group was evaluated on a simulator different from the one they were trained on. <b>Results:</b> Mean (SD) pretest PET scores (before training) for the NL and N groups were comparable across groups (39.5 [18.15] vs. 34.8 [19.10]; <i>p</i> = 0.13). The PET score was comparable between NL and N after training (82.46 [10.28] vs. 80.52 [13.07], absolute difference 1.93; 95% CI [-1.956343, 5.830363]; <i>p</i> = 0.83 [1-sided]). NL was statistically noninferior to N as the lower bound of 95% CI of absolute difference is greater than the noninferiority margin (-1.95 > -5). A similar finding was observed in retention after 4 months (76.09 [15.80] vs. 73.33 [18.42]; absolute difference 2.75; 95% CI [-2.92457, 8.43271], <i>p</i> = 0.83 [1-sided]). The mean gain of PET score within the group (posttest minus pretest) for NL and N was comparable (42.97 [17.11] vs. 45.73 [19.51]; absolute difference 2.76; 95% CI [-8.835228, 3.306668], <i>p</i> = 0.81 [1-sided]). <b>Conclusion:</b> There was an improvement in scores in the posttest for both manikins. The NL was noninferior as compared to N.</p>","PeriodicalId":51591,"journal":{"name":"International Journal of Pediatrics","volume":"2025 ","pages":"3159205"},"PeriodicalIF":1.3,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges in Education for Visually Impaired Children in Ghana: A Path to Inclusion.","authors":"Sylvester Kyei-Gyamfi, Frank Kyei-Arthur, Theophilus Kwabena Abutima, Ada Adoley Allotey, Henry Afrifa, Evans Sakyi-Boadu, Kwame S Sakyi","doi":"10.1155/ijpe/6653071","DOIUrl":"https://doi.org/10.1155/ijpe/6653071","url":null,"abstract":"<p><p>This study examined children with visual impairments (CwVI) satisfaction with school facilities, CwVIs' reasons for their satisfaction or dissatisfaction with school facilities, and steps to enhance their inclusion in teaching and learning. Grounded in Bronfenbrenner's ecological systems theory (EST) (1979), the study employed a mixed-methods approach, including a survey of 288 CwVIs, 73 key informant interviews (KIIs), 14 focus group discussions (FGDs), observations, and documentary reviews to complement the findings. The results revealed that 60.8% of CwVIs were satisfied with their school facilities, while 39.1% were dissatisfied. Key factors contributing to satisfaction included the suitability of the school compound and classroom furniture arrangement, which minimized accidents. In contrast, unsafe compounds, overcrowded classrooms, and poorly arranged furniture disrupted navigation and participation, exposing vulnerabilities in their learning environment. The findings highlighted the vital role of family and community involvement in fostering inclusive attitudes and advocating for infrastructure and resource improvements. Families actively supporting these efforts can significantly enhance support systems for CwVIs. The study underscores the need for collaboration between families and schools to build cohesive support networks that address the academic and social needs of CwVIs, fostering an inclusive learning environment.</p>","PeriodicalId":51591,"journal":{"name":"International Journal of Pediatrics","volume":"2025 ","pages":"6653071"},"PeriodicalIF":1.3,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Neonatal Mortality (< 24 h) in Ecuador: A Population-Based Study on the Impact of Apgar Score, Gestational Age, Birth Weight, Delivery Type, and Healthcare Level.","authors":"Iván Dueñas-Espín, María Alejandra Montaluisa, Andrea Aguilar-Molina, Fernando Aguinaga, Luciana Armijos-Acurio, Ruth Jimbo-Sotomayor, Ángela León Cáceres, María F Rivadeneira, Silvana Rivera-Guerra, Xavier Sánchez, Betzabé Tello","doi":"10.1155/ijpe/4225987","DOIUrl":"10.1155/ijpe/4225987","url":null,"abstract":"<p><p><b>Background:</b> We examined the relationship between the 5-min Apgar score and other individual and contextual neonatal characteristics with early neonatal mortality (before 24 h) in Ecuadorian neonates. <b>Methods:</b> We conducted a retrospective case-control study using data from the Ecuadorian National Surveillance System for Neonatal Mortality, covering January 2014 to September 2017. We analyzed data for neonates who died within 28 days of birth, focusing on mortality before 24 h (early death). Multilevel multivariate logistic regression was used to calculate crude and adjusted odds ratios (aORs) for early death based on 5-min Apgar scores and other neonatal factors. The random effects variable in this model was altitude at which neonates were attended; this component of the model allows the intercept estimates to vary randomly among the groups of altitude, suggesting that there are differences between these groups that could influence the study results at which the neonates were attended. <b>Results:</b> Of 2144 neonates analyzed, 53.2% were male, with an average gestational age of 30.8 weeks and a mean birth weight of 1525.2 g. More than half (56.0%) were delivered by caesarean section. Common comorbidities included prematurity (39.4%), asphyxia (31.2%), and infections (24.7%). Also, 17.4% had Apgar scores of ≤ 3. After adjustment, Apgar scores of ≤ 3 were linked to significantly increased odds of death before 24 h, with an aOR of 20.65 (95% CI: 5.99-71.28, <i>p</i> < 0.001). <b>Conclusions:</b> This study demonstrated that the Apgar score, among other determinants, was significantly associated with early neonatal mortality (before the first 24 h). This association was independent of type of delivery, comorbidities, disorders related to asphyxia, prematurity, infections, and other medical disorders, as well as varying levels of care from primary to tertiary. These findings underscore the importance of Apgar evaluation in neonates and suggest a predictive value of the score for early neonatal mortality.</p>","PeriodicalId":51591,"journal":{"name":"International Journal of Pediatrics","volume":"2025 ","pages":"4225987"},"PeriodicalIF":1.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105887/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric Cervical Lymphadenitis: Etiology, Clinical Presentation, and Antimicrobial Resistance.","authors":"Mahmoud Khodabandeh, Zahra Jam, Aryan Banai Shahani, Mahsa Soti Khiabani","doi":"10.1155/ijpe/5154191","DOIUrl":"10.1155/ijpe/5154191","url":null,"abstract":"<p><p><b>Background:</b> Cervical lymphadenitis is prevalent in children. Several viruses and bacteria can cause cervical lymphadenitis. <i>Staphylococcus aureus</i> and <i>Streptococcus pyogenes</i> are known to predominate as bacterial causes. Choosing the effective antibiotic regimen to treat cervical lymphadenitis is difficult because of temporal and geographical variations in its etiologies and antibiotic resistance. We aim to elucidate the etiologies, treatment, and outcomes of cervical lymphadenitis in children in Iran. <b>Methods:</b> A total of 113 patients admitted to the Children's Medical Center in Iran were included in this retrospective cross-sectional study. Patients under 18 years in medical records were evaluated for demographics, signs and symptoms, lymph node aspiration or surgical drainage culture and antibiogram results, type and duration of treatment, complications, treatment failure, and patient discharge instructions. <b>Results:</b> Patients' mean age was 3.5 years (SD: 2.9; range: 3 months to 13 years), and 70 (62%) were male. Of 113 patients, 38 (34%) had a prior history of upper respiratory tract infection (URI), 2 (1.7%) had dental caries, 1 (0.9%) had Hodgkin's lymphoma, and 72 (64.1%) patients did not have any accompanying illnesses in presentation. The most common clinical manifestation was neck swelling or erythema (99.1%), followed by fever (73%), neck pain (30%), and torticollis (9%). Twenty-one (18.5%) patients underwent cervical lymph node aspiration, and 7 (6%) underwent surgical incision and drainage, of which 17 (61%) had a positive culture. <i>Staphylococcus aureus</i> was isolated in 16 (94%) cases. No positive culture was reported regarding fungi and acid-fast bacilli. Regarding their antibiogram reports, the lowest resistance rates were to vancomycin, cotrimoxazole, and oxacillin (6% each), followed by clindamycin and erythromycin (12% each) and penicillin (94%). The mean duration of hospitalization was 6 days (SD: 3.2; range: 2-22 days). Thirty-three (29%) patients underwent surgical drainage along with antibiotic therapy. <b>Conclusion:</b> Cervical lymphadenitis was prevalently accompanied by URI. Swelling and erythema in the neck were the most common clinical manifestations. The most common isolated organism was <i>Staphylococcus aureus</i>. We did not find Streptococci, which might be due to the beta-lactam usage before hospital admission. Most of the patients were treated with clindamycin during hospitalization. However, resistance to clindamycin was higher than that of other antibiotics effective against Staphylococci and Streptococci, like oxacillin. We recommend considering this resistance pattern in choosing antibiotics to prevent treatment failure and reduce the need for surgery.</p>","PeriodicalId":51591,"journal":{"name":"International Journal of Pediatrics","volume":"2025 ","pages":"5154191"},"PeriodicalIF":1.3,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Scoping Review of the Social Determinants of Pediatric and Adolescent Obesity.","authors":"Deepali K Ernest, Elizabeth A Onugha, Bipin Singh, Shreela V Sharma, Jayna M Dave","doi":"10.1155/ijpe/8871022","DOIUrl":"https://doi.org/10.1155/ijpe/8871022","url":null,"abstract":"<p><p><b>Context:</b> Social determinants of health (SDOH) play a large role in pediatric and adolescent metabolic health worldwide. <b>Objective:</b> The study is aimed at exploring key SDOH related to childhood obesity, worldwide. <b>Methods:</b> Primary research articles from PubMed, Embase, and Medline databases published between 2013 and 2023, had a study population of 0-19-year-olds, and examined the association between WHO-defined SDOH and childhood obesity were included. Non-English papers and those outside WHO-defined SDOHs were excluded. Two reviewers independently performed a blinded screening of titles and abstracts, followed by a full-text assessment of selected articles. <b>Results:</b> Of the 703 initial articles, 22 duplicates were excluded, leaving 681 unique articles from PubMed (<i>N</i> = 274), Medline (<i>N</i> = 43), and Embase (<i>N</i> = 364). Initial screening excluded 579 articles, and full-text screening excluded 61 more, resulting in 41 final articles. Reasons for exclusion primarily involve missing SDOH exposure or weight-related outcomes and articles being reviews, editorial/opinion pieces, or interventional studies. Most included studies were cross-sectional (<i>N</i> = 25) and conducted in North America (<i>N</i> = 22). The average study sample size was 43,640 participants. These studies focus on socioeconomic determinants, neighborhood characteristics, food environment, healthcare access, educational determinants, and immigration-related factors. Obesity-related outcomes included general obesity, severe obesity, abdominal obesity, weight gain, BMI/weight categories, and continuous BMI measures. <b>Conclusion:</b> Key SDOHs of childhood obesity include socioeconomic status, neighborhood characteristics, food environment, healthcare access, immigration, and culture. Despite diverse regional studies, there is a notable gap in US-specific data on SDOH of childhood obesity, especially by race and ethnicity. Further research is needed to better understand these determinants and their impact on pediatric metabolic health.</p>","PeriodicalId":51591,"journal":{"name":"International Journal of Pediatrics","volume":"2025 ","pages":"8871022"},"PeriodicalIF":1.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterising the Human Milk Microbiota of Indian Mothers: Prospects for Probiotic Discoveries and Antimicrobial Peptides.","authors":"H Anil, Somashekhar M Nimbalkar, Chaitanya Joshi, Anju Kunjadiya, Axil Patel, Reshma Pujara, Krutarth Raval, Satyamitra Shekh, Priyanka Dalwadi, Dipen V Patel","doi":"10.1155/ijpe/4819511","DOIUrl":"https://doi.org/10.1155/ijpe/4819511","url":null,"abstract":"<p><p><b>Background:</b> The human milk microbiome is vital in the formation of the newborn microbiome and affects various health outcomes. Probiotics prevent severe necrotizing enterocolitis in neonates, but uncertainty about their safety is the obstacle to their use. Probiotic organisms and antimicrobial peptides derived from probiotic strains in human milk can offer safer options. <b>Aim:</b> This study is aimed at determining the probiotic properties in the human breastmilk microbiome and their potential antimicrobial activity. <b>Methods:</b> Study Design: We conducted a prospective longitudinal study. Participants: The study included 30 mothers, equally divided among gestational ages of < 32 weeks, 32-36 6/7 weeks, and above 37 weeks at the time of delivery. Milk samples were collected and analyzed at three different time points, that is, colostrum, transition milk (7-9 days), and mature milk (after 14 days). <b>Outcome:</b> The microbiome isolated was tested for probiotic and antimicrobial properties. <b>Results:</b> Three hundred and eighty-one bacterial colonies were isolated, of which 38 different species were identified. Of these, <i>Gemella haemolysans</i>, <i>Micrococcus luteus</i> and <i>lylae</i>, and <i>Staphylococcus hominis</i> and <i>warneri</i> were selected. Few showed bile salt, phenol, and NaCl tolerance, but none showed tolerance to pH. Antimicrobial activity was not seen when isolates or protein extracts were tested against the pathogen. Enhancement in the zone of clearance was seen when a combination of protein and antimicrobial agents was tested compared to antimicrobial alone. The zone of clearance was seen even at one-tenth of the standard concentration of amphotericin B when combined with protein extract. <b>Conclusion:</b> The non-<i>Lactobacillus</i> strains tested showed few probiotic properties. Though the isolates did not exhibit antimicrobial properties, the protein extracted from them enhanced the potency of antimicrobial agents.</p>","PeriodicalId":51591,"journal":{"name":"International Journal of Pediatrics","volume":"2025 ","pages":"4819511"},"PeriodicalIF":1.3,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12021482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Impact of Food Allergies Among Jordanian Schoolchildren: A Comprehensive Analysis of Parent-Reported Data and Associated Atopic Conditions.","authors":"Nour Yousef, Raghda O'leimat, Mohammad Abdelraheem, Eyad Altamimi","doi":"10.1155/ijpe/8255384","DOIUrl":"https://doi.org/10.1155/ijpe/8255384","url":null,"abstract":"<p><p><b>Background:</b> Food allergies, characterized by immune reactions to food proteins, have emerged as an increasing global concern, impacting over 10% of the population. This study investigates the prevalence of food allergies among schoolchildren aged 5-14 years in northern and central Jordan. <b>Methods:</b> A randomized cross-sectional online questionnaire was administered to students aged 5-14 years residing in the central and northern regions of Jordan. Parents of these students (<i>n</i> = 1629) completed the questionnaire, which comprised information on demographics, dietary habits, food allergies, and allergy history. <b>Results:</b> The parent-reported food allergies exhibited a prevalence of 11.5% (95% confidence interval = 10-13%). Of these reported allergies, 10.1% (95% CI = 8.6-11.7%) were classified as convincing, while only 5.7% (95% CI = 4.5-6.8%) received a formal diagnosis from a healthcare professional. The most commonly reported allergens included eggs (17.8%), cow's milk (15.8%), peanuts (14.5%), and strawberries (13.8%). The majority of children (67.1%) had a single reported allergen, while 15.8% had two, and 17.2% had more than two allergens identified. Food allergies were significantly more prevalent among children with comorbid atopic conditions and those with a family history of allergies. Additionally, regional variations were observed, with high prevalence rates in metropolitan regions. <b>Conclusion:</b> This study emphasizes the significance of considering persuasive food allergy (FA) data in addition to parent-reported information. The findings highlight the considerable burden of food allergies and their relationship with other atopic disorders. Comprehensive management strategies and further research to elucidate the underlying causes of food allergies are necessary.</p>","PeriodicalId":51591,"journal":{"name":"International Journal of Pediatrics","volume":"2025 ","pages":"8255384"},"PeriodicalIF":1.3,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12017951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent Ileocolic Intussusception in Children: A Scoping Review.","authors":"Salvatore Arena, Fabiola Cassaro, Giulia Maisano, Pietro Impellizzeri, Carmelo Romeo","doi":"10.1155/ijpe/8860000","DOIUrl":"10.1155/ijpe/8860000","url":null,"abstract":"<p><p><b>Background:</b> Intussusception is the most common cause of acute intestinal obstruction in children. It can be initial idiopathic intussusception or a recurrent intussusception (RI), and in this latter case, there is not a validated algorithm for optimal treatment. The aim of the study is to review the international literature to evaluate the incidence of RI, to determine the rates of surgical intervention and pathological leading point (PLP), and to define the most appropriate management for children with RI. We included English-written papers with pediatric population, excluding case reports, papers with adult or mixed cases, studies focusing on ileo-ileal or colo-colic intussusception, meta-analysis studies, or papers with unclear or replaced data. <b>Results:</b> A total number of 23 articles were included for a total of 26,731 patients affected by intussusception and 3164 recurrent patients (11.8%). The number of attempts of nonsurgical reduction ranged from 3 to 10 (median 5). On 2965 RI, 358 underwent surgery (12.1%). A pathologic leading point was found in 99 patients (3.95%). <b>Conclusions:</b> The presence of a PLP does not seem to be associated with the recurrence of intussusception. More than 85% of RI underwent successful nonsurgical management. RI should be safely approached in the same way as primary intussusception, and surgery should be reserved to cases where a PLP has been suspected. In cases of multiple episodes, surgery can be considered an effective way to avoid recurrences, and this possibility should be discussed with parents.</p>","PeriodicalId":51591,"journal":{"name":"International Journal of Pediatrics","volume":"2025 ","pages":"8860000"},"PeriodicalIF":1.3,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11957851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Incidence and Risk Factors of Complicated Acute Appendicitis in Children: Evidence From a Tertiary Pediatric Center.","authors":"Sina Azadnajafabad, Faraha Zahra Awan, Bahar Ashjaei, Hosein Alimadadi, Mahsa Soti Khiabani","doi":"10.1155/ijpe/1230753","DOIUrl":"10.1155/ijpe/1230753","url":null,"abstract":"<p><p><b>Background:</b> Acute appendicitis (AA) is the most prevalent surgical emergency in the pediatric population, with the complicated form leading to various adverse outcomes. Our study is aimed at evaluating the incidence and associated risk factors of complicated AA among children presenting with this condition. <b>Methods:</b> Employing a cross-sectional design, we included all children suspected of having AA who were admitted to a tertiary pediatric center in Iran from 2020 to 2021. Pathologists examined all surgically removed appendices, and only cases with histopathological confirmation of AA were included. We classified AA into complicated and uncomplicated categories. We recorded and analyzed demographic, clinical, and laboratory data of patients admitted with AA. Analyzed laboratory parameters included white blood cell (WBC) count, neutrophil count and percentage, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP). <b>Results:</b> The study comprised 98 pediatric patients with AA, including 60 males (61.2%) and 38 females (38.8%), with a median age of 9.0 (interquartile range: 7.0-11.0) years. Eighteen (18.4%) cases were diagnosed with complicated AA. Mean WBC count, neutrophil count, and CRP levels were significantly higher in patients with complicated AA (<i>p</i> values: 0.048, 0.018, and 0.014, respectively). After adjusting for relevant clinical factors, CRP (odds ratio: 1.02 [95% CI: 1.00-1.04]), WBC count (1.18 [1.03-1.37]), and neutrophil count (1.23 [1.06-1.45)]) were significantly associated with complicated AA. Receiver operating characteristic (ROC) curve analysis indicated a CRP cut-off of 19.5 mg/dL, with an area under the curve of 0.687 (95% CI: 0.551-0.823), a sensitivity of 72.2%, and a specificity of 68.4% for predicting complicated AA. <b>Conclusions:</b> Laboratory parameters, specifically WBC count, neutrophil count, and CRP levels, are significant independent predictors of complicated AA in pediatric patients. These findings could assist in the timely diagnosis and management of children suspected of having AA in clinical practice.</p>","PeriodicalId":51591,"journal":{"name":"International Journal of Pediatrics","volume":"2025 ","pages":"1230753"},"PeriodicalIF":1.3,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955285/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Feasibility of a Nonelectric Bubble CPAP System in the NICU of a Philippine Regional Referral Hospital: A Qualitative Study.","authors":"Grace Katharine Meara, Ghassan Bou Saba, Navid Roodaki, Daisy Garcia, Agustin Conde-Agudelo, Paula Rauschendorf, Thomas F Burke","doi":"10.1155/ijpe/5529978","DOIUrl":"https://doi.org/10.1155/ijpe/5529978","url":null,"abstract":"<p><p><b>Aim:</b> Bubble continuous positive airway pressure (bCPAP) is recommended by WHO for the treatment of neonatal respiratory distress; however, considerable challenges hinder global access. The objective of this study was to evaluate the feasibility of the use and integration of Vayu bCPAP systems into the neonatal intensive care unit of a public regional referral hospital in the Philippines. <b>Methods:</b> We conducted a mixed-methods study from March 2021 to May 2022. Demographic and clinical characteristics of 150 consecutive neonates treated with a Vayu bCPAP system were collected and analyzed. Forty-seven healthcare workers participated in a survey, and 5-point Likert scales were used to assess the usability and integration of Vayu bCPAP systems into the hospital. <b>Results:</b> The mean duration of bCPAP treatment was 2.5 days (range, 1.0-7.0). Of the neonates treated with a Vayu bCPAP system, 89.3% survived to discharge. Most healthcare workers reported that Vayu bCPAP systems are easy to use. The main themes included positive perceptions of usability, accessibility of the devices, and improved neonatal outcomes. There were mixed perceptions about training on the use of the device, and improvements were suggested. <b>Conclusion:</b> Implementation of Vayu bCPAP systems at a regional referral hospital in the Philippines was feasible. Vayu bCPAP systems were perceived to be easy to use and to improve neonatal outcomes.</p>","PeriodicalId":51591,"journal":{"name":"International Journal of Pediatrics","volume":"2025 ","pages":"5529978"},"PeriodicalIF":1.3,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11985220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}