International Journal of Pediatrics最新文献

{"title":"Natural disease history and characterization of SUMF1 molecular defects in multiple sulfatase deficiency: a case report","authors":"Shokoufeh Khanzadeh, Meisam Babaei, Parvin Imanpour, Shahram Sadeghvand","doi":"10.22038/IJP.2021.57775.4532","DOIUrl":"https://doi.org/10.22038/IJP.2021.57775.4532","url":null,"abstract":"Multiple sulfatase deficiency (MSD) is a very rare lysosomal storage disease(LSD) caused by mutations in the SUMF1 gene. So far, about 143 patients with MSD have been reported in previous studies, although this figure is likely an underestimation due to under-reporting and under-recognition. This report showed the genetic and clinical aspects of a patient with MSD compared with previously reported patients.","PeriodicalId":51591,"journal":{"name":"International Journal of Pediatrics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2021-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45640362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Endoscopic Esophageal Dilatation in Pediatric Patients with Esophageal Strictures.","authors":"Hasan M A Isa,&nbsp;Khadija A Hasan,&nbsp;Husain Y Ahmed,&nbsp;Afaf M Mohamed","doi":"10.1155/2021/1277530","DOIUrl":"https://doi.org/10.1155/2021/1277530","url":null,"abstract":"<p><strong>Materials and methods: </strong>In this retrospective cross-sectional single center study, records of patients with esophageal strictures presented to the pediatric department, Salmaniya Medical Complex, Bahrain, in the period between 1995 and 2019 were reviewed. Demographic data, indications of endoscopic dilatations, the procedure success rate, and possible complications were assessed.</p><p><strong>Results: </strong>Forty-six children were found to have esophageal strictures. Twenty-five (54.3%) patients were males. Most patients presented during infancy (86.5%, 32/37 patients). Twenty-six (56.5%) patients required 88 dilatation sessions, while the remaining 20 (43.5%) patients did not require dilatations. The median number of dilatation sessions per patient was three (interquartile range = 2-5). Savary-Gilliard bougienages were the main dilators used (80.8%, 21/26 patients). Anastomotic stricture (post esophageal atresia/tracheoesophageal fistula repair) was the main cause of esophageal strictures and was found in 35 (76.1%) patients. Patients with nonanastomotic strictures had more frequent dilatations compared to those with anastomotic strictures (<i>P</i> = 0.007). The procedure success rate was 98.8%. Yet, it was operator dependent (<i>P</i> = 0.047). Complete response to dilatation was found in 18 (69.2%) patients, satisfactory in seven (26.9%), and an inadequate response in one (3.9%). Those with satisfactory responses still require ongoing dilatations based on their symptoms and radiological and endoscopic findings. No perforation or mortality was reported. Patients with dilatations had more recurrent hospitalization (<i>P</i> < 0.0001), more dysphagia (<i>P</i> = 0.001), but shorter hospital stay (<i>P</i> = 0.046) compared to those without dilatations. Surgical intervention was required in one patient with caustic strictures. The median follow-up period was six years (interquartile range = 2.25-9.0).</p><p><strong>Conclusions: </strong>Endoscopic esophageal dilatation in children with esophageal strictures is effective and safe. Yet, it was operator dependent. Nonanastomotic strictures require more dilatations compared to anastomotic strictures. Findings of this study are comparable to those reported worldwide.</p>","PeriodicalId":51591,"journal":{"name":"International Journal of Pediatrics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2021-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8487364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39485441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of glucocorticoid therapy on bone mineral density in children and adolescents with congenital adrenal hyperplasia","authors":"N. Ghaemi, A. Malek, Sade Hal Setare, Z. Shaye","doi":"10.22038/IJP.2021.54310.4294","DOIUrl":"https://doi.org/10.22038/IJP.2021.54310.4294","url":null,"abstract":"Background: Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive diseases caused by a deficiency in adrenal enzymes that lead to changes in cortisol and aldosterone levels. \u0000\u0000Objective: This study aimed to assess the bone mineral density of the spine and femoral head in children and adolescents aged 5 and 20 years, suffering from different types of congenital adrenal hyperplasia and treated with corticosteroids and to study the associated factors. \u0000\u0000Materials and method: We studies 44 patients, 26 girls and 18 boys, who were treated with corticosteroids with a physiological dose of 15-20 mg/m2 since infancy. A questionnaire was completed by patients and their parents admitted to the Endocrinology Clinic of Imam Reza Hospital of Mashhad. The patients' bone density was then measured, and the association with different factors, such as age, gender, height, weight, type of CAH, type and duration of receiving corticosteroids, the 17-hydroxyprogesterone level, bone activity markers, vitamin D level, and puberty stage, was analyzed, using SPSS software. \u0000\u0000Result: No significant correlation between the bone density level and variables such as the duration and dose of corticosteroid consumption, age, sex, time of diagnosis, 17-hydroxyprogesterone level, calcium, and phosphorus, was found. Other variables such as height, weight, puberty stage, and vitamin D levels were found to play a significant role in determining the bone density level.\u0000\u0000Conclusion: It is highly recommended to consider the side effects and complications when starting treatment with corticosteroids in patients with CAH. Bone densitometry should regularly be done, osteoporosis prophylaxis should be considered using weight-bearing exercises and calcium and vitamin D supplements, and the level of vitamin D should be monitored.","PeriodicalId":51591,"journal":{"name":"International Journal of Pediatrics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2021-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41274980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Outcomes of Cochlear Implantation on Language Skills and Speech Intelligibility in Early-implanted versus Late-implanted Deaf Children","authors":"S. Hassanzadeh, M. Ajalloueyan, Azam Mirdeharbab, A. Arjmandnia, Mahdieh Hasanalifard, M. Saeedi, Alireza Aghaz","doi":"10.22038/IJP.2021.57919.4546","DOIUrl":"https://doi.org/10.22038/IJP.2021.57919.4546","url":null,"abstract":"Background: Hearing loss may affect many aspects of a person's life. The age of cochlear implantation (CI) is often considered an important predictor of language skills of children with CI, but little is known about the benefits of early CI on speech intelligibility development in these children. This study aimed to compare language skills as well as intelligibility of speech in prelingual deaf patients who received CI before the age of six years and those who received CI after the age of six years with an 8-year follow-up.\u0000Materials and Methods: This 8-year longitudinal, retrospective case–control study was conducted in 2021 at a cochlear implant center in Tehran, Iran. Thirty-one patients were included in two groups: late cochlear implant (n = 15), and early cochlear implant (n =16). The Test of Language Development- Primary (TOLD-P3) was used to assess the participants 'language skills. The intelligibility of the participants' speech was assessed through the Persian version of the Intelligibility Context Scale (ICS) and the speech intelligibility rating (SIR).\u0000Results: These two groups did not show a significantly difference in terms of the language scores (P>0.05) but had a significantly difference in terms of the SIR and the ICS scores (P<0.05). Speech intelligibility had a significantly negative correlation with the age of CI (P<0.001), and had a significant positive correlation with language skills (P<0.001).\u0000Conclusion: The long-term outcomes of early and late CI were similar in terms of the development of language skills but too different in terms of the intelligibility of speech. The age of CI had no effect on the language development but had a significant effect on speech intelligibility.","PeriodicalId":51591,"journal":{"name":"International Journal of Pediatrics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2021-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47821422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Passive Smoking with Dental Caries and Cotinine Biomarker among 8-12 Years Old Children of Semnan, Iran","authors":"Shabnam Sohanian, R. Ghorbani, O. Mirmohammadkhani, Homa Delavari, Kamyar Mansori","doi":"10.22038/IJP.2021.59254.4615","DOIUrl":"https://doi.org/10.22038/IJP.2021.59254.4615","url":null,"abstract":"Background: The present study was designed to determine association passive smoking with dental caries and cotinine biomarker among 8-12 years old children of Semnan, Iran. Materials and Methods: This cross sectional study was concocted on two groups of 8-12 years old children exposed (n=100) and non-exposed to passive smoking (n=100) in of Semnan (Iran). The sampling method was two-stage cluster sampling design. The data collection tool a standard checklist consisted of demographic, laboratory and dental characteristics. Examination was performed by a dentist on a dental unit and the dental indicators were measured for two groups. Also, salivary cotinine was measured and recorded using ELISA method by special cotinine kit (De salimetrics medi tec, USA). Univariate and Multivariable Logistic Regression model and area under the ROC curve were used to data analysis by STATA 14 software. Results: Univariate logistic regression model showed a statistically significant difference between the exposed and unexposed groups with passive smoking in term of the salivary cotinine level, age , sex , decayed, missing, and filled teeth (dmft) index, decayed, and filled teeth (dft) index and missing teeth (mt) (P-Value ≤0.20). However, multiple logistic regression model showed a statistically significant relationship between the decayed, missing, and filled teeth (dmft) index and passive smoking (OR=1.28; 95% CI: 1.05 – 1.38). Conclusion: This study showed that the risk of decay of deciduous teeth is higher in children exposed to passive smoking, therefore, passive smoking should be considered in the implementation of programs to prevent tooth decay in children.","PeriodicalId":51591,"journal":{"name":"International Journal of Pediatrics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2021-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42407460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Ventricular Function based on Echocardiographic Findings in Asthmatic Children Referred to Rasoul Akram and Firoozabadi Hospitals of Tehran","authors":"M. Fallahpour, M. Radgoudarzi, Mojtaba Didar Shetaban, Mohammad Bagher Didarshetaban","doi":"10.22038/IJP.2021.59039.4602","DOIUrl":"https://doi.org/10.22038/IJP.2021.59039.4602","url":null,"abstract":"Objective: Asthma is a chronic inflammatory disease of the lead to hypertrophy and dilatation of the right ventricle. Aim of study to evaluate and compare left and right ventricular systolic and diastolic function of the heart based on echocardiographic criteria in children with moderate to severe asthma and non-asthmatic children referred to Hazrat Rasouland Firoozabadi Hospitals of Tehranin 2019. Methods: In this case-control study, 50 patients with a definite diagnosis of moderate to severe asthma(case group) and 50 healthy individuals (control group) were studied and compared in terms of clinical and echocardiographic measures. Blood pressure, heart rate, body height and weight of all children were recorded. The patients who were >6 years underwent pulmonary function tests using spirometry. Conventional and TDI echocardiography was performed bya single experienced pediatric cardiologist on two groups blindly and echocardiographic data was collected.Results: The results showed that the left ventricular stroke volume was significantly lower in patients with asthma. Also, in the right ventricular SV, significantly lower values were found in the group of patients under study than healthy individuals (P=0.01). The E/A ratio in both groups was higher than one with a mean and standard deviation of 1.72±0.26 in the case group compared to 1.92±0.32 which was not significantly different.Conclusion: The results of this study showed that asthma can affect ventricular contraction in children. Contrary to previous studies and despite the observation of cardiac systolic dysfunction in patients with asthma, diastolic dysfunction in these patients was not observed even by tissue Doppler echocardiography.Keywords: Asthma, Cardiac function, Echocardiography","PeriodicalId":51591,"journal":{"name":"International Journal of Pediatrics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2021-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46388132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Efficiency of Epiphysiodesis for Growth Modulation in Patients with Congenital Scoliosis: A Systematic Review","authors":"E. Keykhosravi, H. Rezaee, Amin Tavallaii, Mohammad Abouei Mehrizi, A. Pourbagher-Shahri, Vahid Khajereza Shahri, Ahmad Abdul Sater Abdul Sater","doi":"10.22038/IJP.2021.56414.4434","DOIUrl":"https://doi.org/10.22038/IJP.2021.56414.4434","url":null,"abstract":"Purpose: Congenital scoliosis (CS) is a challenging entity in spinal surgery. Convex growth arrest (CGA) is a therapeutic method aiming at inhibiting growth on the curve convexity while remained growth of concavity corrects the scoliotic curve over time. In the view of controversies in current clinical studies for efficiency of CGA in CS patients, we performed a systematic review of the literature to clarify the debate. Methods: A comprehensive literature search was performed to identify studies assessing CGA outcome in CS patients, in following databases and search engines: Ovid MEDLINE, PubMed, Scopus, Cochrane Central Register of Controlled Trials (CCTR), EMBASE, Google Scholar, and Web of Science. Two authors screened the search results and selected the studies by the supervision of senior authors.Results: In 19 studies, enrolling 363 patients, age at surgery was 58.76 months ranging from 4 to 216 months. Anterior and posterior hemiepiphysiodesis was the most common approach. Eight studies added instrumentation to CGA. Follow-up mean was 64.57 months. Nine studies reported true epiphysiodesis effect (postoperative and final follow-up CCA difference): of 162 patients, 69 improved, 59 stabilized, and 34 progressed. Other studies reported preoperative and final follow-up CCA difference: of 88 patients, 49 improved, 32 stabilized, and 7 progressed. Preoperative curve magnitude, sagittal plane deformities, age <5 years, and type of spinal anomalies did not affect CGA outcome. Instrumentation was preferred in complicated spinal anomalies and older ages.Conclusion: CGA alone or with instrumentation is a feasible CS treatment, however criteria for choosing suitable candidates need reconsideration.","PeriodicalId":51591,"journal":{"name":"International Journal of Pediatrics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2021-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45625485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inpatient vs. outpatient management of uncomplicated preterm premature rupture of membranes: a clinical trial","authors":"L. Pourali, Masoumeh Mirteimouri, Samaneh Akbarzadeh, Habibullah Esmayili, Elahe Hasanzadeh","doi":"10.22038/IJP.2021.57629.4522","DOIUrl":"https://doi.org/10.22038/IJP.2021.57629.4522","url":null,"abstract":"Introduction: Preterm premature rupture of membranes (PPROM) is spontaneous rupture of fetal membranes before 37 weeks of gestation. PPROM cases who are clinically stable with no sign or symptom of intrauterine infection and normal fetal assessment are usually managed expectantly in hospital setting or at home. This study was performed with aim to compare the inpatient and outpatient management among women with uncomplicated PPROM.Methods: This non-randomized clinical trial was performed in an academic hospital, Mashhad University of Medical Sciences in 2017-2018. Women with confirmed PPROM who received initial treatments during primary 72-hour hospitalization were assigned into inpatient (n=45) or outpatient (n=35) management groups according to the patient's decision. The outcomes included latency period, gestational age at delivery, delivery route, delivery reason, WBC and neutrophil count, neonates’ weight, Apgar score, NICU admission, and death in the first 28 days after delivery. Data were analyzed by Statistical Package for Social Science (IBM SPSS) version 23. P 0.05). Neonatal Apgar score, death, and NICU admission rate or period were not significantly different between two groups(p>0.05).Conclusion: Homecare in selected PPROM women could be a suitable expectant strategy without compromising neonatal or maternal outcomes.","PeriodicalId":51591,"journal":{"name":"International Journal of Pediatrics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2021-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41737834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison the analgesic effect of oral acetaminophen vs ibuprofen in children with supracondylar fractures: A Triple-blind Randomized Clinical Trial","authors":"Morteza Talebi Deluee, Somaye Bagherian, B. Kakhki, A. Mousavian, H. Miri, E. Moradi","doi":"10.22038/IJP.2021.58555.4576","DOIUrl":"https://doi.org/10.22038/IJP.2021.58555.4576","url":null,"abstract":"Introduction: A supracondylar fracture are common in children with the average age of is 5-8 years. It is especially important to pay attention to pain control in these children because of lots of pain. This study was design to compare the analgesic effect of oral ibuprofen vs acetaminophen in children with supracondylar fractures who undergoing non-surgical treatment.Material & Methods: This triple-blind clinical trial was conducted on children with supracondylar fracture referred to the Emergency Department of Emam Reza and Hosheminejad Hospital. Children’s pain were assessed 2, 4 and 12 hours after taking the drug by VAS (Visual Analog Scale) criteria, which was explained by researcher to their parents. Results: In this study, 64 children with a mean age of 5.7±1.7 years were studied. 31 children in the acetaminophen group and 33 children in the ibuprofen group were evaluated. The mean pain score reduction within 12 hours of drug administration showed no difference between the two groups (P = 0.710). After 12 hours of drug administration, 5 and 7 children being painless in the acetaminophen and ibuprofen, respectively, with no difference between the two groups.Conclusion: During the 12 hours after ibuprofen and acetaminophen, children had similar analgesia and there was no significant difference between the two drugs in terms of pain relief and side effects, and both drugs are safe and effective for pain-control in children.","PeriodicalId":51591,"journal":{"name":"International Journal of Pediatrics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2021-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43989590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Helicobacter Pylori Infection in Children with Idiopathic Thrombocytopenic Purpura","authors":"M. Golpayegani, Mina Hayati, G. Yousefi","doi":"10.22038/IJP.2021.51270.4077","DOIUrl":"https://doi.org/10.22038/IJP.2021.51270.4077","url":null,"abstract":"Background: Today Helicobacter pylori is the most common bacterial infection worldwide and is associated with some extra-gastrointestinal diseases such as blood disorders including idiopathic thrombocytopenic purpura (ITP). Therefore, this study was designed and performed to determine the status of Helicobacter pylori infection in children with idiopathic thrombocytopenic purpura referred to Dr. Mohammad Kermanshahi Hospital in 2019. Materials and Methods: In this cross-sectional study, 68 children with ITP were evaluated for Helicobacter pylori infection using stool antigen test. Information on Helicobacter pylori was collected using a checklist along with data on gender, age, type of ITP (acute / chronic), primary platelet counts, duration of ITP, and history of receiving treatment for H. pylori infection. Data were analyzed by SPSS-20 using descriptive statistics and the Chi-square test. Results: The mean age of all subjects was 6.35 ± 3.44 years with an age range of 1 to 13 years. The mean duration of the disease was 9.73. ± 9.04 months. Among patients, 63.24% (43 patients) were boys. Regarding the type of ITP, the highest percentage was the Acute type of disease (72/06%). Also, based on the analytical results, there was no significant relationship between Helicobacter pylori infection and gender, mean duration of infection and type of ITP (p <0.05). Conclusion: According to the results of this study, half of the ITP patients had Helicobacter pylori infection, but there was no significant relationship between the type of ITP and its duration with Helicobacter pylori infection. Therefore, it is recommended to conduct similar studies with a larger sample size and perform follow-ups to achieve more accurate results","PeriodicalId":51591,"journal":{"name":"International Journal of Pediatrics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42211673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}