Maria Del Carmen Caballero-Guzmán, Laura Teresa Rodríguez Hernández, Raquel Tierno Patiño, Juan José Fernández Muñoz
{"title":"Neuropsychological profiles in long-term schizophrenia: A cluster analysis.","authors":"Maria Del Carmen Caballero-Guzmán, Laura Teresa Rodríguez Hernández, Raquel Tierno Patiño, Juan José Fernández Muñoz","doi":"10.1080/23279095.2026.2695322","DOIUrl":"https://doi.org/10.1080/23279095.2026.2695322","url":null,"abstract":"<p><p>This study examines neurocognitive heterogeneity in a large, predominantly chronic and institutionalized sample of individuals with schizophrenia (N = 184). Using hierarchical and iterative clustering on composite neuropsychological scores, four distinct cognitive profiles emerged: Severe Cognitive Impairment, Cognitive Impairment, Preserved Cognition, and a small High Functioning subgroup. Impaired profiles were the most prevalent, reflecting the long illness duration and institutional context of the sample. Despite this, a subset of participants demonstrated above average performance, suggesting the presence of resilience related factors such as cognitive reserve. Robust differences across clusters were observed in all cognitive domains, supporting the existence of discrete neurocognitive subtypes rather than a single severity continuum. These findings highlight the relevance of cognitive stratification in chronic schizophrenia and underscore the need for individualized interventions tailored to specific cognitive profiles within institutionalized settings.</p>","PeriodicalId":51308,"journal":{"name":"Applied Neuropsychology-Adult","volume":" ","pages":"1-9"},"PeriodicalIF":1.6,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148609931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Efficacy of combined transcranial direct current stimulation and computer-based cognitive rehabilitation on cognition in patients with traumatic brain injury: A systematic review.","authors":"Anas R Alashram","doi":"10.1080/23279095.2026.2702490","DOIUrl":"https://doi.org/10.1080/23279095.2026.2702490","url":null,"abstract":"<p><p>Patients with traumatic brain injury (TBI) frequently experience cognitive deficits. Transcranial direct current stimulation (tDCS) and computer-based cognitive rehabilitation (CBCR) have been used in cognitive rehabilitation patients with TBI. This review aims to explore the effects of integrating tDCS and CBCR on cognition post-TBI. \"PsycINFO, PubMed, EMBASE, MEDLINE, SCOPUS, Web of Science, PEDro, and CINAHL\" were explored until March 2026. Randomized studies that integrated tDCS and CBCR and included at least one outcome measure evaluating cognitive function in patients with TBI were included. The Cochrane Risk of Bias 2 (RoB 2) instrument was employed to assess the risk of bias. Four studies involving 115 participants met the inclusion criteria. Two studies reported significant improvements in executive function and working memory after combining tDCS and CBCR compared with no-intervention controls. The other two studies found no significant differences between groups in memory, attention, or executive function outcomes after combining tDCS and CBCR compared with combining tDCS and CBCR. Overall, evidence on the effects of combining tDCS and CBCR is limited. Additional high-quality studies with consistent treatment protocols and long-term follow-up are strongly warranted to understand the effects of the intervention on cognition in individuals with TBI.</p>","PeriodicalId":51308,"journal":{"name":"Applied Neuropsychology-Adult","volume":" ","pages":"1-10"},"PeriodicalIF":1.6,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148563755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ashley Heywood, Anthony D Robinson, Nikita Maniar, Fang Zhu, Jason R Soble, Matthew S Phillips
{"title":"When neurodegenerative disease masquerades as psychiatric illness: A clinical case study of early-onset frontotemporal dementia.","authors":"Ashley Heywood, Anthony D Robinson, Nikita Maniar, Fang Zhu, Jason R Soble, Matthew S Phillips","doi":"10.1080/23279095.2026.2705384","DOIUrl":"https://doi.org/10.1080/23279095.2026.2705384","url":null,"abstract":"<p><p>Behavioral variant frontotemporal dementia is characterized by significant changes in personality and behavior with typical age of onset between the fifth and sixth decade of life. The following case study describes a 44-year-old female patient with a significant psychiatric history and distant mild traumatic brain injury who began to behaviorally decompensate in her mid-to-late 30s. She was referred for neuropsychological evaluation due to report of memory problems and progressive neuropsychiatric and neurobehavioral decline. Neuropsychological testing revealed diffuse cognitive impairment mediated by pronounced neurobehavioral executive dysfunction. Laboratory and genetic testing were unremarkable. Neuroimaging revealed statistically significant asymmetric hypometabolism in the bilateral frontotemporal region, more pronounced on the left. Taken together, results were suggestive of a primary underlying frontotemporal lobar degenerative process with secondary exacerbation due to chronic psychiatric distress. This case report highlights the importance of thorough differential diagnosis of a neurodegenerative process in a young adult with an overlay of longstanding psychiatric illness, especially when the etiology in question falls outside the typical age of onset.</p>","PeriodicalId":51308,"journal":{"name":"Applied Neuropsychology-Adult","volume":" ","pages":"1-6"},"PeriodicalIF":1.6,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148551350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A P Porrselvi, C R Sneha, M G Nurul Mehnaz, Samyuktha Ravi, Ragaviveka Gopalan
{"title":"Linguistic and cultural adaptation of the Montreal Cognitive Assessment (MoCA) version 8 for the Tamil-speaking population in India.","authors":"A P Porrselvi, C R Sneha, M G Nurul Mehnaz, Samyuktha Ravi, Ragaviveka Gopalan","doi":"10.1080/23279095.2026.2703255","DOIUrl":"https://doi.org/10.1080/23279095.2026.2703255","url":null,"abstract":"<p><strong>Background: </strong>Cognitive screening for Tamil-speaking populations is constrained by a shortage of linguistically appropriate tools. The previously available Montreal Cognitive Assessment (MoCA) version 7 did not account for Tamil diglossia, limiting its use among Indian Tamil speakers. This study aimed to linguistically and culturally adapt the parallel forms MoCA 8.1, 8.2, and 8.3 into Indian Tamil and conduct pilot testing.</p><p><strong>Methods: </strong>Three phases were conducted: forward and back translation with MoCA Institute approval; pilot testing for linguistic clarity; and secondary pilot testing with 139 participants (106 healthy controls and 33 with clinician-diagnosed Mild Cognitive Impairment or Dementia).</p><p><strong>Results: </strong>Cultural and linguistic modifications to the tests and manual were approved by the MoCA Institute, and all three versions were made available. MoCA scores declined with age (<i>p</i> < .001) and were higher among individuals with >12 years of education (<i>p</i> = .002). Unadjusted analyses showed lower clinical group scores; however, after controlling for age, most differences were non-significant, except in the Language domain. Several tasks appeared education-sensitive, indicating misclassification risk.</p><p><strong>Conclusions: </strong>The adapted Tamil MoCA versions demonstrate preliminary feasibility and cultural relevance, but validation with larger, age-matched samples is needed to establish normative data, education-based stratification, and other psychometric properties.</p>","PeriodicalId":51308,"journal":{"name":"Applied Neuropsychology-Adult","volume":" ","pages":"1-11"},"PeriodicalIF":1.6,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148551380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cross-validation of verbal fluency measures as embedded performance validity tests in a clinical sample.","authors":"Keith Johnson, Lee Ashendorf","doi":"10.1080/23279095.2026.2704636","DOIUrl":"https://doi.org/10.1080/23279095.2026.2704636","url":null,"abstract":"<p><p>This study evaluated the utility of the Controlled Oral Word Association Test (COWAT-FAS) and Animal Naming as embedded performance validity tests (PVTs) in a mixed clinical sample of 165 military veterans referred for neuropsychological evaluation. Participants had either a self-reported history of mild TBI or were referred for evaluation of possible ADHD. Participants were classified as credible (0 PVT failures; <i>n</i> = 92) or non-credible (≥2 PVT failures; <i>n</i> = 73). Classification accuracy was examined for COWAT and Animal Naming raw scores, demographically adjusted T-scores, and two previously published logistic regression models. Both verbal fluency measures significantly differentiated credible from non-credible groups. Optimal indices utilized COWAT raw scores, either alone or when embedded within the logistic regression formula. Findings support verbal fluency measures as efficient embedded, non-memory-based PVTs.</p>","PeriodicalId":51308,"journal":{"name":"Applied Neuropsychology-Adult","volume":" ","pages":"1-6"},"PeriodicalIF":1.6,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148498254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mesut Sari, Canan Ayvat, Mustafa Çobaner, Yasemin İmrek, Onur Koçhan, Ali Evren Tufan
{"title":"Multidomain neurocognitive and attentional profile in adults with childhood-diagnosed specific learning disorder: An exploratory case-control study from Turkey.","authors":"Mesut Sari, Canan Ayvat, Mustafa Çobaner, Yasemin İmrek, Onur Koçhan, Ali Evren Tufan","doi":"10.1080/23279095.2026.2700776","DOIUrl":"https://doi.org/10.1080/23279095.2026.2700776","url":null,"abstract":"<p><strong>Objective: </strong>Adult outcomes of childhood-diagnosed specific learning disorder (SLD) remain insufficiently characterized, particularly in non-Western clinical samples. We examined the neuropsychological and attentional profile of Turkish adults with documented childhood SLD.</p><p><strong>Method: </strong>In this exploratory case-control study, 20 adults with childhood-diagnosed SLD and 20 age- and sex-comparable healthy controls completed a multimodal assessment including the Stroop Test-TBAG form, Digit Span, Adult Attention Deficit Hyperactivity Disorder (ADHD) Self-Report Scale, Adult Reading History Questionnaire, and Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition-Clinician Version (SCID-5-CV) diagnostic interview. The prespecified primary outcome was Stroop total completion time. Four prespecified secondary outcomes-Stroop interference, Digit Span total, Digit Span forward, and Adult ADHD Self-Report Scale (ASRS) Part A positive-item count-were corrected using Benjamini-Hochberg false discovery rate. Adjusted analyses used HC3 robust standard errors.</p><p><strong>Results: </strong>Adults with SLD showed substantially longer Stroop total completion time than controls, with a large adjusted group effect that remained robust after additional adjustment for education. All four secondary outcomes met the corrected significance threshold, indicating poorer interference control, lower verbal attention and working-memory performance, and higher adult ADHD symptom burden. Reading-history scores were also consistent with persistent self-reported difficulties.</p><p><strong>Conclusions: </strong>Adults with childhood-diagnosed SLD showed a measurable multidomain neuropsychological and attentional profile, supporting executive and attentional screening in adult SLD assessment.</p>","PeriodicalId":51308,"journal":{"name":"Applied Neuropsychology-Adult","volume":" ","pages":"1-10"},"PeriodicalIF":1.6,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148498225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ronald M Miller, Samuel Redd Johnston, Lillian Dove J Meyers
{"title":"Indicator-coded versus ordinal race/ethnicity variables in the Meyers neuropsychological battery: a proof-of-concept comparison.","authors":"Ronald M Miller, Samuel Redd Johnston, Lillian Dove J Meyers","doi":"10.1080/23279095.2026.2700665","DOIUrl":"10.1080/23279095.2026.2700665","url":null,"abstract":"<p><p>Demographic variables such as age, education, sex, and race/ethnicity influence performance on neuropsychological tests. We present a proof-of-concept comparison of two approaches to incorporating race/ethnicity in regression-based norms for the Meyers Neuropsychological Battery (MNB). Linear regression models were developed on a reference dataset (<i>N</i> = 1,840) to predict T-scores from demographic predictors and raw scores, using either the MNB's existing single ordinal race/ethnicity variable or four indicator-coded variables. Models were applied to an independent sample (<i>N</i> = 10,778) to generate predicted scores and correction factors (actual minus predicted T-score). After Benjamini-Hochberg correction across 34 measures, only 3 (Trails B, Token Test, and Boston Naming) showed significant improvement with indicator coding. Delta R-squared analyses indicated that race/ethnicity indicators contributed 0.29% to 0.45% of unique variance. Correction factors for certain test-by-group combinations approached one standard deviation, but bootstrap confidence intervals revealed substantial instability attributable to small minority cell sizes in the development sample (e.g., <i>N</i> = 22 African American). These results suggest that race/ethnicity is a weak overall predictor once other demographics are controlled, though systematic prediction biases may exist for specific measures. The indicator-coded framework can in principle accommodate mixed racial/ethnic backgrounds, though this was not tested here.</p>","PeriodicalId":51308,"journal":{"name":"Applied Neuropsychology-Adult","volume":" ","pages":"1-10"},"PeriodicalIF":1.6,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148450354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Joseph J Boscarino, Michelle Hua, K Brianalysse Nicolena Cedeño, Sean Tran, Emily N Vanderbleek, Ferdinand E Korneli, Yolanda C Leon, Selim R Benbadis, Yarema B Bezchlibnyk, Mike R Schoenberg
{"title":"Lateralizing value of memory recognition index difference scores (RIDS) in patients with right versus left temporal lobe epilepsy.","authors":"Joseph J Boscarino, Michelle Hua, K Brianalysse Nicolena Cedeño, Sean Tran, Emily N Vanderbleek, Ferdinand E Korneli, Yolanda C Leon, Selim R Benbadis, Yarema B Bezchlibnyk, Mike R Schoenberg","doi":"10.1080/23279095.2026.2703874","DOIUrl":"https://doi.org/10.1080/23279095.2026.2703874","url":null,"abstract":"<p><strong>Introduction: </strong>The lateralizing value of neuropsychological data remains an important topic. However, no research has examined the utility of Wechsler Memory Scale - Fourth Edition (WMS-IV) recognition memory composites and difference scores between these to assess their accuracy in differentiating patients with right temporal lobe epilepsy (RTLE) from left temporal lobe epilepsy (LTLE).</p><p><strong>Methods: </strong>This observational study analyzed archival data among 41 presurgical patients with TLE to examine the predictive utility of memory recognition indices and the difference score between these composites derived from the WMS-IV in differentiating seizure laterality. Independent t-tests, chi-square, logistic regression, and receiver operating characteristic (ROC) curve analyses were conducted.</p><p><strong>Results: </strong>23 LTLE patients (mean age = 36.48 years, SD = 10.15) and 18 RTLE patients (mean age = 42.78 years, SD = 13.22) were selected after being diagnosed based on concordant semiology, long-term video EEG monitoring, and neuroimaging. WMS-IV recognition index difference scores (RIDS) were significantly higher in RTLE than LTLE (<i>p</i> = .006, <i>d</i> = -.909). The WMS-IV RIDS was a significant predictor of seizure laterality after controlling for sex and yielded adequate accuracy in differentiating right and left TLE cases (AUC = .742).</p><p><strong>Conclusions: </strong>The current findings support the utility and adequate accuracy of the WMS-IV RIDS in improving neuropsychological lateralization in patients with TLE.</p>","PeriodicalId":51308,"journal":{"name":"Applied Neuropsychology-Adult","volume":" ","pages":"1-8"},"PeriodicalIF":1.6,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148450408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The development of a normative data set for a number of classic tasks in neuropsychology assessing executive functions for use with young adults in Saudi Arabia.","authors":"Mohammed R Alzahrani","doi":"10.1080/23279095.2026.2702492","DOIUrl":"https://doi.org/10.1080/23279095.2026.2702492","url":null,"abstract":"<p><p>The present research aimed to validate and standardize classic tasks in neuropsychology for the evaluation of executive functions in young adults from Saudi Arabia: Arabic Wisconsin Card Sorting Test (WCST), Controlled Oral Word Association Test (COWAT) FAS, Stroop Color and Word Test (SCWT) and Trail Making Test Part B (TMT-B). The sample mirrored the demographics of target population (e.g., age, gender, and socioeconomic status) to prevent bias. The population is divided into specific subgroups (strata), and participants were drawn proportionally from each group. Accordingly, 512 healthy young adults were evaluated. The study population ranged in age from 18 to 22 years (20 ± 2.8 years), of which 60% were men. The conditions of sampling adequacy (KMO = .85) and sphericity (<i>p</i> < .001) were satisfactorily met, as the model explains 59.4% of the total variance. For all tests direct and statistically significant correlations (<i>p</i> < .05) were found between measurements taken at different times by the same evaluator. This study analyzes the psychometric properties of the executive function instruments. As the results indicates, all tasks showed adequate internal consistency and inter- and intra-rater reliability, except for the COWAT-FAS, which lacked reliability.</p>","PeriodicalId":51308,"journal":{"name":"Applied Neuropsychology-Adult","volume":" ","pages":"1-7"},"PeriodicalIF":1.6,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148450339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zachary C Merz, Alexander M Eisenstein, Charlotte Payne, Matthew Harris
{"title":"Concordance between the Saint Louis University Mental Status exam and the repeatable battery for the assessment of neuropsychological status.","authors":"Zachary C Merz, Alexander M Eisenstein, Charlotte Payne, Matthew Harris","doi":"10.1080/23279095.2026.2699353","DOIUrl":"https://doi.org/10.1080/23279095.2026.2699353","url":null,"abstract":"<p><p>A primary concern has long been understanding the construct validity of brief cognitive screening instruments, as well as item performance and the relationship to more established neuropsychological testing batteries. The current study sought to perform a more in-depth assessment of the construct validity one commonly utilized screening instrument (i.e., the Saint Louis University Mental Status examination or SLUMS) and its direct relationship with a more comprehensive neuropsychological testing battery (i.e., the Repeatable Battery for the Assessment of Neuropsychological Status or RBANS). Archival data was obtained from referrals for a comprehensive neuropsychological evaluation at a private, mid-Atlantic medical center in the United States of America between 2021 and 2025. The final sample included 544 individuals who met inclusion criteria. Factor analytic procedures yielded a five-factor solution: (1) Orientation & Retrieval Memory, (2) Complex Attention/Construction, (3) Verbal Fluency, (4) Receptive Language, and (5) Verbal Learning, accounting for 57% total variance. Current results provide support for the use of the SLUMS as a valid screener of neurocognitive functioning, especially in settings when clinicians require a reliable measure of cognition but are limited by time constraints.</p>","PeriodicalId":51308,"journal":{"name":"Applied Neuropsychology-Adult","volume":" ","pages":"1-8"},"PeriodicalIF":1.6,"publicationDate":"2026-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148426268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}