Journal of Dermatology Research最新文献

{"title":"Androgenetic Alopecia: A Study on The Efficacy of a Combined Protocol of Blue Light Photobiomodulation and Subcutaneous Infiltrations of Biomimetic Peptides","authors":"Adone Baroni","doi":"10.46889/jdr.2024.5206","DOIUrl":"https://doi.org/10.46889/jdr.2024.5206","url":null,"abstract":"Androgenetic Alopecia (AGA) is a common condition affecting men and women, characterized by progressive hair follicle miniaturization and consequent hair loss. Blue light Photobiomodulation (PBM) by LED (Light emitting diode) device and infiltrations of biomimetic peptides therapy are two emerging approaches for AGA treatment. The aim of this study was to evaluate the efficacy of a combined protocol of blue light PBM and infiltrations of biomimetic peptides on the scalp for AGA treatment. A total of 20 patients with AGA diagnosis, according to Hamilton-Norwood criteria, were enrolled in the study. All patients were treated at the same time, both with Blue light LED and with subcutaneous infiltrations of biomimetic peptides on the scalp. At 6 months follow-up, a significant increase in hair density was observed in 85% of the patients treated. The results of our study suggest that the combined protocol of blue light PBM and biomimetic PRP could be an effective treatment for AGA. Further clinical studies with a larger number of patients are needed to confirm these results and to evaluate the long-term efficacy of the treatment.","PeriodicalId":512642,"journal":{"name":"Journal of Dermatology Research","volume":"16 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141817131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Open-Label Crossover Oral Bioequivalence Pharmacokinetics Comparison of a Single Dose of Super-bioavailable Itraconazole 130 mg and Innovator SUBA®-Itraconazole Capsules 130 mg (2 x 65 mg) in Healthy Adults Under Fed Conditions","authors":"D. Dhoot","doi":"10.46889/jdr.2024.5204","DOIUrl":"https://doi.org/10.46889/jdr.2024.5204","url":null,"abstract":"Introduction: Itraconazole (ITZ), an antifungal agent taken orally, demonstrates intricate and variable absorption kinetics, significantly impacted by food intake. The invention of Super-Bioavailable Itraconazole (SITZ) has led to a surge in various brands offering different dosages of SB ITZ, overcoming barriers associated with conventional itraconazole. Hence, this study was planned to evaluate the bioequivalence of Itraconazole Capsules 130 mg (Test) of Glenmark Pharmaceuticals Ltd, India, with Innovator SITZ 130 mg (2× 65 mg; Reference) in healthy, adult, male, human subjects under fed condition in addition to safety and tolerability.\u0000\u0000Materials and methods: A total of 36 subjects were enrolled in an open-label, balanced, randomized, two-treatment, two-sequence, two-period, two-way crossover, single dose oral bioavailability study which was conducted in healthy, adult, human male subjects under fed conditions. Test and reference product were administered sequentially. 22 blood samples per subject were collected as pre and post dose within 2 hours of intake of food. The concentrations of ITZ and Hydroxy-itraconazole (OH-ITZ) in plasma were measured by High-Performance Liquid Chromatography-Tandem Mass Spectrometry (HPLC-MS/MS). Assessment of bioequivalence was done on the basis of the 90% CIs of the differences of least squares treatment means for Ln-transformed Cmax and AUC0-t of ITZ obtained after single-dose administration under fed conditions for Test (T) vs Reference (R)\u0000\u0000Results: The mean value of the area under curve (AUC0-t) of test drug (SITZ 130 mg) was 4604.98 ng.hr/mL whereas for reference drug (SITZ, 2 x 65 mg), it was 4812.04 ng.hr/mL which was statistically non-significant. The Pharmacokinetic parameters for OH-ITZ measured from both formulations followed a pattern in terms of bioavailability similar to that for the ITZ plasma blood levels for the test/reference ratios for Cmax (100.88%) and AUC0-t (97.44%). Subjects crossed over from one period of administration of either test or reference drugs to a second period with dosing with the opposite drug attained higher Cmax and AUC0-t values for ITZ, than the same subjects administered reference drug in this study. The administration of both the drugs were well tolerated by all the subjects with no added adverse events\u0000\u0000Conclusion: The pharmacokinetics activity was found to be comparable and bioequivalent between test product at 130 mg dose and innovator itraconazole 130 mg (2x 65 mg). Also, both the drugs were found to be safe and well tolerated with no adverse effects.","PeriodicalId":512642,"journal":{"name":"Journal of Dermatology Research","volume":" 646","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141364303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human Hair Care Using Products Containing Naturally Obtained Collagen from Salmon Skin Waste","authors":"Joanna Igielska-Kalwat","doi":"10.46889/jdr.2024.5202","DOIUrl":"https://doi.org/10.46889/jdr.2024.5202","url":null,"abstract":"The aim of the articles was to popularize the upcycling trend in the production of sustainable cosmetics and to confirm their effectiveness. For thousands of years, people have been looking for new ways to improve their appearance. To take care of their beauty, women and men around the world, in addition to using the best cosmetics and treatments, want to introduce sustainable care to alleviate the negative impact of consumerism on the environment. One of the most noticeable trends is the development of pro-ecological solutions used in everyday life, but also in industry. Manufacturers emphasize the production of more environmentally friendly raw materials. Conscious consumers choose cosmetics whose production is based on sustainable development. Instead of using waste from various industries, we used it to produce active substances used in hair cosmetics. We created the production of the collagen series in accordance with the assumptions of upcycling, obtaining collagen water that is waste generated during the production of supplements. The main aim of the work was to create cosmetic recipes for styling, washing and conditioning hair based on collagen waste, as well as to compare the results of subjects using the product in question.","PeriodicalId":512642,"journal":{"name":"Journal of Dermatology Research","volume":"31 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140979448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epithelioid Hemangioma: Report of a Case Series of 4 Patients","authors":"E. G. Aldás","doi":"10.46889/jdr.2024.5201","DOIUrl":"https://doi.org/10.46889/jdr.2024.5201","url":null,"abstract":"Epithelioid hemangioma or Angiolymphoid Hyperplasia with Eosinophilia (ALHE) is a rare benign vascular disease, characterized by solitary or multiple angiomatous papules and nodules, which are usually located on the skin of scalp and face (mainly in the preauricular zone); these have characteristic histological and immunohistochemical patterns, in particular characterized by an important lymphocytic inflammatory infiltrated with many eosinophils and vascular proliferation of capillaries with endothelial cellular changes. In this paper, four cases of this disease are reported, in the first series of Ecuadorian cases described in the literature.","PeriodicalId":512642,"journal":{"name":"Journal of Dermatology Research","volume":"18 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140982382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-vivo Studies of Cosmetics with Ultraviolet Light Filter and Synergistic Antioxidant Care","authors":"Joanna Igielska-Kalwat","doi":"10.46889//jdr.2024.5115","DOIUrl":"https://doi.org/10.46889//jdr.2024.5115","url":null,"abstract":"The natural process of skin melanogenesis is an evolutionarily valuable mechanism that protects the human body against excessive exposure to solar radiation. Cosmetics with a filter are a very important invention of the cosmetics industry, which enable protection of the skin against excessive exposure to solar radiation, thanks to which people with dysfunction of natural photochromia or people traveling to distant parts of the world can support it by protecting the body against the destructive effects of UV radiation. Cosmetics with a filter effectively protect against premature photo-aging and the formation of skin cancer. With the development of cosmetic formula technology, the discovery of new safe sunscreen substances and the evolution of marketing labels declaring the degree of photoprotection, the role of solar radiation, in which we have evolved since the emergence of Homo sapiens, began to be demonized. Taking into account the benefits of additional photoprotection provided by cosmetics with a high SPF factor, the properties and secondary effects of a cosmetic emulsion having direct contact with the hydrolipid barrier and the possibility of interfering with the physiology of the epidermis should also be taken into account. Both the benefits and side effects caused by excessive application should be balanced in terms of interference with the pH value of the epidermis and the role of the natural melanogenesis process as an essential phenomenon of skin photoprotection. When developing the method of use of a given cosmetic with a filter, you should also take into account the SPF factor and its protection range, the pH value of the emulsion and additional functions – antioxidant. Generalizing the method of use and frequency of application of photoprotective cosmetics, without personalizing the recommendations, seems to be an abuse in today’s cosmetic product technology to the detriment of the cosmetics industry and dermatology. To sum up, the authors wanted to present both the advantages and disadvantages of excessive use of creams containing filters.","PeriodicalId":512642,"journal":{"name":"Journal of Dermatology Research","volume":"60 33","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140663903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eruptive Nevus Following Rituximab Treatment: Unusual Dermoscopic Presentation: A Case Report","authors":"Ghita Sqalli Houssini","doi":"10.46889/jdr.2024.5114","DOIUrl":"https://doi.org/10.46889/jdr.2024.5114","url":null,"abstract":"Background: Eruptive nevi can occur following various conditions, including the use of immunosuppressive and immunomodulatory drugs such as biologics. Dermoscopy typically reveals a pattern of brown globules arranged in a ring at the periphery. We report a case of eruptive nevus with an atypical dermoscopic pattern in a patient receiving Rituximab. Observation: A 37-year-old female patient, followed for acquired bullous epidermolysis, developed pigmented and extensive macules six months later. Dermoscopy of a lesion on the trunk, which was increasing in size, showed a homogeneous brown pattern with irregularly arranged brown globules and dots at the center and periphery. Biopsy revealed a junctional nevus. Conclusion: The atypical brown pattern on dermoscopy of eruptive nevi is described for the first time, particularly after rituximab therapy.","PeriodicalId":512642,"journal":{"name":"Journal of Dermatology Research","volume":"4 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140738545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral Facial Palsy in Geniculate Herpes Zoster Revealing HIV Infection: A Case Report","authors":"Toure Mariama Saliou","doi":"10.46889/jdr.2024.5113","DOIUrl":"https://doi.org/10.46889/jdr.2024.5113","url":null,"abstract":"Herpes zoster of the geniculate ganglion is characterized by severe paroxysmal ear pain accompanied by an erythematous vesicular rash involving the external auditory canal. Most people with herpes zoster have associated immunodepression of any type. We report a case of PFP in a patient living with HIV during geniculate herpes zoster.","PeriodicalId":512642,"journal":{"name":"Journal of Dermatology Research","volume":" 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140210019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HIV-Syphilis Coinfection: The Clinical Intersection of 02 Cases","authors":"El Boukili Hafsa","doi":"10.46889/jdr.2024.5112","DOIUrl":"https://doi.org/10.46889/jdr.2024.5112","url":null,"abstract":"Syphilis is a complex disease, which is sexually transmitted. The incidence of syphilis is rising all over the world, partly due to the increased transmission in HIV patients and other high-risk groups such as the homosexual population. Interestingly syphilis itself facilitates HIV infection in several ways. Great importance exists in recognition of both diseases and their complex interactions.","PeriodicalId":512642,"journal":{"name":"Journal of Dermatology Research","volume":" 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140210311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human Protothecosis: Case Report of a Rare Algal Infection","authors":"Freitas Acbp","doi":"10.46889/jdr.2024.5109","DOIUrl":"https://doi.org/10.46889/jdr.2024.5109","url":null,"abstract":"Protothecosis: is a rare disease caused by opportunistic algae infection of the genus Prototheca. An 84-year-old female patient has presented with an erythematous, infiltrated, papulopustular plaque with areas of central atrophy on the left forearm for the past 10 months. Histopathology revealed structures similar to morulae, corresponding to algae, and culture was positive for Prototheca spp. Itraconazole 200 mg/day was prescribed, resulting in improvement of cutaneous lesions. Protothecosis has a high potential for underreporting and misdiagnosis due to its rarity and linical similarities with other dermatoses. The patient in this study presented a lesion in a typical area due to the ease of trauma and entry point, with a good therapeutic response to oral antifungal monotherapy.","PeriodicalId":512642,"journal":{"name":"Journal of Dermatology Research","volume":"16 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140244844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wound Irrigation Using Normal Saline 0.9% Versus Tap Water: A Review for Street Medicine and Low-resource Providers","authors":"Samrah Mitha","doi":"10.46889/jdr.2024.5108","DOIUrl":"https://doi.org/10.46889/jdr.2024.5108","url":null,"abstract":"Patients experiencing homelessness are a vulnerable cohort who suffer from disproportionate skin disease burden. Acute and chronic wounds represent high morbidity conditions with severe consequences. Adequate management in the form of cleansing and irrigation is necessary for removing cellular debris, bacteria and contaminants. Providers in low-resource street medicine settings may be the first point of contact in the management of wounds encountered by unhoused patients. This review determines the feasibility of improvised irrigation techniques that can be used in street settings to irrigate wounds. A MEDLINE search was conducted and yielded randomized controlled trials, laboratory studies and case-control studies. No significant difference in wound infection and healing rates was found when normal saline 0.9% or tap water was used in wound irrigation. Improvised cleansing devices with suitable irrigation pressure included water bottles punctured with 14-18-gauge needles, 10-mL syringes and 50-syringes. Lower and upper extremity wounds were found to be at higher risk of infection, requiring judicious management and cleaning. Street medicine providers should consider weighing the benefits versus risks of on-site, improvised wound irrigation for acute soft tissue injuries, especially in the setting of limited resources.","PeriodicalId":512642,"journal":{"name":"Journal of Dermatology Research","volume":"82 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140080166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}