Veterinary Quarterly最新文献_第7页

Correlation between change in serum creatinine concentration and renal cortical anisotropic backscattering artifact in azotemic cats during hospitalization. 氮质血症猫住院期间血清肌酐浓度变化与肾皮质各向异性反向散射伪影之间的相关性。

IF 7.9 2区农林科学

Veterinary Quarterly Pub Date : 2024-12-01 Epub Date: 2024-07-31 DOI: 10.1080/01652176.2024.2384910

Ming-Jen Kang, Pin-Chen Liu, Hock Gan Heng, Kuan-Sheng Chen

{"title":"Correlation between change in serum creatinine concentration and renal cortical anisotropic backscattering artifact in azotemic cats during hospitalization.","authors":"Ming-Jen Kang, Pin-Chen Liu, Hock Gan Heng, Kuan-Sheng Chen","doi":"10.1080/01652176.2024.2384910","DOIUrl":"10.1080/01652176.2024.2384910","url":null,"abstract":"Information on the clinical outcomes of feline azotemia using ultrasound examinations is limited. This study aimed to understand the correlation between cortical anisotropy backscattering artifact (CABA) and serum creatinine (sCr) changes in feline azotemia after hospitalization and to investigate whether CABA is useful for predicting the clinical outcome of feline azotemia. Sixty-five hospitalized cats with azotemia, including 49 cats with moderate or severe azotemia (severe group) and 16 cats with mild azotemia (mild group). This retrospective study reviewed the CABA using ultrasound images of cats hospitalized with azotemia between 2016 and 2021. The correlation between CABA and the clinical outcomes of cats with azotemia was investigated using the chi-squared or Fisher's exact test, and the intra- and inter-observer agreements in CABA were assessed using McNemar's and Cohen's kappa tests. The presence of CABA was significantly positively correlated with the clinical outcomes of cats with azotemia only in the severe group (p = 0.0034, odds ratio = 8.57). There was no association between CABA and clinical outcomes in cats with mild azotemia (p = 0.75). CABA can be used for clinical outcome prediction in moderate and severe feline azotemia, with a sensitivity of 80.8% and a specificity of 73.9%. Also, satisfactory intra- and inter-observer agreements were revealed in the detection of CABA during ultrasound image review. Our study demonstrated that cats with moderate and severe azotemia with CABA observed during ultrasonography might have better clinical outcomes. These findings provide additional information on the prognosis and treatment of feline azotemia.","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"44 1","pages":"1-8"},"PeriodicalIF":7.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11293257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141857086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The global seroprevalence of Toxoplasma gondii infection in workers occupationally exposed to animals (1972-2023): a systematic review and meta-analysis. 全球职业接触动物工人的弓形虫感染血清流行率（1972-2023 年）：系统回顾和荟萃分析。

IF 7.9 2区农林科学

Veterinary Quarterly Pub Date : 2024-12-01 Epub Date: 2024-08-29 DOI: 10.1080/01652176.2024.2396577

Abdullah Mohammed, Musa Ahmed, Nasir Ibrahim

{"title":"The global seroprevalence of Toxoplasma gondii infection in workers occupationally exposed to animals (1972-2023): a systematic review and meta-analysis.","authors":"Abdullah Mohammed, Musa Ahmed, Nasir Ibrahim","doi":"10.1080/01652176.2024.2396577","DOIUrl":"10.1080/01652176.2024.2396577","url":null,"abstract":"Toxoplasma gondii, a ubiquitous zoonotic parasite infecting warm-blooded animals, poses a significant health threat to workers with occupational animal exposure (WOEA) due to their frequent contact with potential reservoirs. Existing data on T. gondii seroprevalence in the WOEA exhibits substantial global variation. This systematic review and meta-analysis, adhering to PRISMA guidelines, aimed to quantify the global seroprevalence of T. gondii infection among WOEA over the past five decades (1972-2023). We identified 66 eligible studies through a comprehensive search strategy encompassing English publications, with a total sample size of 15,279. A random-effects model with the Freeman-Tukey transformation in STATA v16.0 accounted for the high heterogeneity observed. We estimated the pooled global seroprevalence of T. gondii infection in WOEA at 41% (95% CI: 36-47%). Subgroup analyses revealed significant variations by gender: males (63%) vs. females (37%) (p < 0.05), occupation: non-livestock workers (54%), livestock workers (47%), slaughterhouse workers (44%), and veterinary personnel (27%) (p < 0.05). Geographic trends showed the highest prevalence in Africa (51%), followed by South America (49%), Europe (47%), Australia (43%), Asia (36%), and North America (23%; p < 0.05). Lower prevalence was observed in high-income (39%) and upper-middle-income (38%) countries compared to lower-middle-income (44%) and low-income (48%) countries (p < 0.05). This analysis underscores the high global seroprevalence of T. gondii in the WOEA, highlighting the need for targeted interventions in this high-risk population.","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"44 1","pages":"1-18"},"PeriodicalIF":7.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11363739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142114542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beclin-1 and LC3B expression in canine mast cell tumours: an immuno-ultrastructural and immunohistochemical study of autophagy. 犬肥大细胞瘤中 Beclin-1 和 LC3B 的表达：自噬的免疫超微结构和免疫组织化学研究。

IF 7.9 2区农林科学

Veterinary Quarterly Pub Date : 2024-12-01 Epub Date: 2024-11-01 DOI: 10.1080/01652176.2024.2419585

Giovanna P Vicente, Leonardo Della Salda, Ricardo F Strefezzi

{"title":"Beclin-1 and LC3B expression in canine mast cell tumours: an immuno-ultrastructural and immunohistochemical study of autophagy.","authors":"Giovanna P Vicente, Leonardo Della Salda, Ricardo F Strefezzi","doi":"10.1080/01652176.2024.2419585","DOIUrl":"10.1080/01652176.2024.2419585","url":null,"abstract":"Mast cell tumours (MCTs) are common malignant neoplasms in dogs, for which prognosis and therapeutic decisions are based on histological features and proliferation markers. Autophagy is a cellular catabolic process responsible for degrading cytoplasmic components to maintain homeostasis, alterations in which are frequently linked to tumour growth and progression. This study was conducted to investigate the occurrence of autophagy in canine MCTs and to verify its value as a prognostic indicator for dogs with the disease. Beclin-1 and LC3B expressions were investigated using immunohistochemistry, and autophagy was ultrastructurally characterised. The autophagic phenomenon was successfully visualised in neoplastic mast cells under transmission electron and immunoelectron microscopy. MCTs from dogs that died due to the disease showed higher positivity for Beclin-1 and dogs with MCTs presenting a LC3B granular immunohistochemical pattern had a significantly shorter post-surgical survival. The occurrence of autophagy is an indicator of poor prognosis. Future studies are needed to elucidate the specific mechanisms and open new opportunities to treatments targeting this cancer cell advantage.","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"44 1","pages":"1-15"},"PeriodicalIF":7.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11536674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular characterization of the meq oncogene of Marek's disease virus in vaccinated Brazilian poultry farms reveals selective pressure on prevalent strains. 接种疫苗的巴西家禽养殖场马立克氏病病毒 meq 肿瘤基因的分子特征揭示了流行毒株的选择性压力。

IF 6.4 2区农林科学

Veterinary Quarterly Pub Date : 2024-12-01 Epub Date: 2024-03-11 DOI: 10.1080/01652176.2024.2318198

Ruy D Chacón, Christian J Sánchez-Llatas, Sarah L Pajuelo, Andrea J Diaz Forero, Victor Jimenez-Vasquez, Jack A Médico, Luis F Soto-Ugaldi, Claudete S Astolfi-Ferreira, Antonio J Piantino Ferreira

{"title":"Molecular characterization of the meq oncogene of Marek's disease virus in vaccinated Brazilian poultry farms reveals selective pressure on prevalent strains.","authors":"Ruy D Chacón, Christian J Sánchez-Llatas, Sarah L Pajuelo, Andrea J Diaz Forero, Victor Jimenez-Vasquez, Jack A Médico, Luis F Soto-Ugaldi, Claudete S Astolfi-Ferreira, Antonio J Piantino Ferreira","doi":"10.1080/01652176.2024.2318198","DOIUrl":"10.1080/01652176.2024.2318198","url":null,"abstract":"Marek's disease virus (MDV) has become an increasingly virulent pathogen in the poultry industry despite vaccination efforts to control it. Brazil has experienced a significant rise of Marek's disease (MD) outbreaks in recent years. Our study aimed to analyze the complete meq gene sequences to understand the molecular epidemiological basis of MD outbreaks in Brazilian vaccinated layer farms. We detected a high incidence rate of visceral MD (67.74%) and multiple circulating MDV strains. The most prevalent and geographically widespread genotype presented several clinical and molecular characteristics of a highly virulent strain and evolving under positive selective pressure. Phylogenetic and phylogeographic analysis revealed a closer relationship with strains from the USA and Japan. This study sheds light on the circulation of MDV strains capable of infecting vaccinated birds. We emphasize the urgency of adopting preventive measures to manage MDV outbreaks threatening the poultry farming industry.","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"44 1","pages":"1-13"},"PeriodicalIF":6.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10930104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140095006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of different dietary levels of iron and zinc for the enrichment of eggs in laying hens. 比较不同日粮中铁和锌的含量对蛋鸡鸡蛋的富集作用。

IF 7.9 2区农林科学

Veterinary Quarterly Pub Date : 2024-12-01 Epub Date: 2024-11-21 DOI: 10.1080/01652176.2024.2431035

Zooheb Ullah, Sarzamin Khan, Muhammad Shuaib, Obaid Ullah, Shahrood Ahmed Siddiqui, Anthony Pokoo-Aikins, Majid S Jabir, Ayman A Swelum

{"title":"Comparison of different dietary levels of iron and zinc for the enrichment of eggs in laying hens.","authors":"Zooheb Ullah, Sarzamin Khan, Muhammad Shuaib, Obaid Ullah, Shahrood Ahmed Siddiqui, Anthony Pokoo-Aikins, Majid S Jabir, Ayman A Swelum","doi":"10.1080/01652176.2024.2431035","DOIUrl":"10.1080/01652176.2024.2431035","url":null,"abstract":"Zinc (Zn) and iron (Fe) are necessary for structural and metabolic functions of the body like, immune competence, physical growth, reproductive function, and neurobehavioral development. The deficiency of micronutrients is a severe public health distress in nearly all developing countries which leads to the syndrome of malnutrition mostly in children and women. The present study was conducted to compare the effect of different levels of Fe and Zn on feed intake (FI), feed conversion ratio (FCR), daily egg production, and Fe and Zn depositions in the egg yolk of laying hens. For this purpose, 80 commercial laying birds were allocated into four groups consisting of four replicates each (n = 5). The basal ration was provided to the control group (C) while three different levels (100, 200, and 300 mg/kg diet/element) of Fe and Zn (1:1) were provided to the FZ100, FZ200, and FZ300 groups, respectively. Overall FI, hen day egg production, and FCR were not affected (p > 0.05). The Fe and Zn content in egg yolk were significantly increased in the FZ300 group after 4 weeks of supplementation. The cost per egg produced in response to different levels of Fe and Zn supplementation was not affected however a numerical increase in cost/egg was found in the FZ300 group. In conclusion, Fe and Zn supplementation (300 mg/kg diet/element) significantly enhanced the egg Fe and Zn contents without adversely affecting production parameters including FI, egg production, and FCR of laying hens.","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"44 1","pages":"1-7"},"PeriodicalIF":7.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11583324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of hempseed (Cannabis sativa L.) in diet on growth, gut health, and immunity in broilers. 日粮中的大麻籽（Cannabis sativa L.）对肉鸡生长、肠道健康和免疫力的影响。

IF 7.9 2区农林科学

Veterinary Quarterly Pub Date : 2024-12-01 Epub Date: 2024-06-18 DOI: 10.1080/01652176.2024.2367214

Bushra Sana, Naila Chand, Shabana Naz, Ibrahim A Alhidary, Rifat Ullah Khan, Shamsuddin Shamsi, Caterina Losacco, Vincenzo Tufarelli

{"title":"Effects of hempseed (Cannabis sativa L.) in diet on growth, gut health, and immunity in broilers.","authors":"Bushra Sana, Naila Chand, Shabana Naz, Ibrahim A Alhidary, Rifat Ullah Khan, Shamsuddin Shamsi, Caterina Losacco, Vincenzo Tufarelli","doi":"10.1080/01652176.2024.2367214","DOIUrl":"10.1080/01652176.2024.2367214","url":null,"abstract":"The aim of the present study was to assess the effects of different levels of hempseed (HS) on growth performance, immunity and gut health in broiler chickens. A total of 192 Hubbard broiler chicks were divided into four groups and fed HS as follow: control (HS0), HS 10% (HS-10), HS 15% (HS-15) and HS 20% (HS-20). The study on HS supplementation in broilers revealed no significant impacts on feed intake during the starter (p = .2294) and finisher phases (p = .2294), or overall (p = .0944), though numerical increases were noted with higher HS levels. Body weight gain showed no significant influence in the starter and finisher phases, with overall weight gain also not significantly different (p = .0944), but numerically higher with increased HS. Feed conversion ratio was unaffected in the starter (p = .6986) and finisher phases (p = .6425), and overall (p = .2218). Dressing percentage (p = .1062) and mortality (p = .1631) were not significantly altered, but HS-20 had the highest dressing percentage and lowest mortality numerically. White blood cell counts increased significantly (p = .0377), especially in HS-15 and HS-20 groups. IgM and IgG production was higher in HS-20 on day 28 (p = .021). Gut pH (p > .05) and intestinal histomorphology (p > .05) were not significantly affected, although villus height increased numerically with higher HS levels. These results suggest potential benefits of HS, especially at higher inclusion levels. In conclusion, the obtained results indicated that HS incorporation into the diet of broilers did not affect the growth performance and gut health; however, the immune responses were significantly higher at 15 and 20% levels.","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"44 1","pages":"1-10"},"PeriodicalIF":7.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11188954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141421779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathological, immunological and molecular epidemiological analysis of lumpy skin disease virus in Indian cattle during a high-mortality epidemic. 高死亡率流行病期间印度牛身上块状皮肤病病毒的病理学、免疫学和分子流行病学分析。

IF 7.9 2区农林科学

Veterinary Quarterly Pub Date : 2024-12-01 Epub Date: 2024-09-05 DOI: 10.1080/01652176.2024.2398211

Gundallhalli Bayyappa Manjunathareddy, Mani Saminathan, Lalasangi Sanjeevakumar, Sugana Rao, Murali Dinesh, Kuldeep Dhama, Karam Pal Singh, Bhupendra Nath Tripathi

{"title":"Pathological, immunological and molecular epidemiological analysis of lumpy skin disease virus in Indian cattle during a high-mortality epidemic.","authors":"Gundallhalli Bayyappa Manjunathareddy, Mani Saminathan, Lalasangi Sanjeevakumar, Sugana Rao, Murali Dinesh, Kuldeep Dhama, Karam Pal Singh, Bhupendra Nath Tripathi","doi":"10.1080/01652176.2024.2398211","DOIUrl":"10.1080/01652176.2024.2398211","url":null,"abstract":"Lumpy skin disease (LSD) is an economically significant, emerging viral disease of Cattle and Buffaloes. This study aimed to investigate the causes of high mortality in a recent LSD epidemic in India. We examined 1618 animals across seventy outbreaks and conducted post-mortem on 48 cattle out of 513 clinically suspected LSD cases. The morbidity, mortality and case fatality rates recorded were 31.70%, 2.97 and 9.37% respectively. Disease stages were categorized as early (20.81%), mid (42.02%), and late (37.17%) and the distribution of skin lesions was classified as mild (34.14%), moderate (39.39%), and severe (26.47%). Post-mortem findings revealed systemic infection with necrotic and ulcerative nodules on multiple internal organs. Histologically, necrotizing vasculitis and mononuclear cell infiltration with intracytoplasmic inclusions were observed in various organs. The highest viral load was found in skin nodules/scabs, trachea, tongue, and lymph nodes. The viral load was significantly higher in mid- and late-stages of skin nodules and internal organs; whereas, blood from early-stage showed high viral load. The expression of Th1-type and Th2-type cytokines varied significantly across different stages of the disease. The downregulation of the apoptotic intrinsic and upregulation of the extrinsic pathway genes, suggesting that the latter plays a role in LSDV infection. Genetic analysis revealed that the LSD virus (LSDV) isolates were derived from a Kenyan ancestral strain with unique nucleotide changes in RPO30 and P32 gene. In conclusion, the high mortality in the recent Indian LSD epidemic can be attributed to a newly identified, highly virulent strain of LSDV causing systemic infection.","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"44 1","pages":"1-22"},"PeriodicalIF":7.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11378666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of clopidogrel, hypercoagulability, and platelet count in dogs undergoing splenectomy for splenic masses. 对因脾脏肿块接受脾脏切除术的狗进行氯吡格雷、高凝状态和血小板计数评估。

IF 6.4 2区农林科学

Veterinary Quarterly Pub Date : 2024-12-01 Epub Date: 2024-06-01 DOI: 10.1080/01652176.2024.2347926

Guk-Il Joung, Jeong-Yeol Bae, Jung-Il Kim, Jin-Young Kim, Joong-Hyun Song

{"title":"Evaluation of clopidogrel, hypercoagulability, and platelet count in dogs undergoing splenectomy for splenic masses.","authors":"Guk-Il Joung, Jeong-Yeol Bae, Jung-Il Kim, Jin-Young Kim, Joong-Hyun Song","doi":"10.1080/01652176.2024.2347926","DOIUrl":"10.1080/01652176.2024.2347926","url":null,"abstract":"Dogs that had splenectomy are predisposed to fatal thrombotic conditions, and thrombocytosis is a risk factor for post-splenectomy hypercoagulability. However, in veterinary medicine, there are no specific therapeutic approaches for managing this hypercoagulability. This study aimed to determine the preventive effect of clopidogrel on post-operative hypercoagulability during the first 2 weeks post-splenectomy in dogs with splenic masses. This study included 12 dogs that had splenectomy. Seven dogs received no treatment (group A), and five were treated with clopidogrel (group B). Clopidogrel was loaded at 10 mg/kg on day 2 and continued at 2 mg/kg until day 14. Blood samples were collected on the day of surgery and 2, 7, and 14 days after splenectomy in both groups. In group B, thromboelastography (TEG) was performed on the same days. In group A, there was significant elevation of platelet counts on days 7 (p = 0.007) and 14 (p = 0.001) compared to day 0. In group B, the platelet counts were significantly elevated on day 7 (p = 0.032) but no significant difference was found on day 14 compared to day 0. Platelet counts on day 14 were significantly higher in group A than in group B (p = 0.03). The lower platelet counts were correlated with alterations in TEG parameters, and no significant differences were found in the K and α-angle values at all postoperative assessment points compared to day 0. Our study suggests that clopidogrel may reduce post-operative thrombocytosis and hypercoagulability in dogs that undergo splenectomy for splenic masses.","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"44 1","pages":"1-8"},"PeriodicalIF":6.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11146242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141186643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polyomavirus surveillance in cetaceans of Brazil: first detection of polyomavirus in Guiana dolphins (Sotalia guianensis). 巴西鲸目动物多瘤病毒监测：首次在圭亚那海豚（Sotalia guianensis）中发现多瘤病毒。

IF 7.9 2区农林科学

Veterinary Quarterly Pub Date : 2024-12-01 Epub Date: 2024-10-20 DOI: 10.1080/01652176.2024.2413185

Aricia Duarte-Benvenuto, Josué Díaz-Delgado, Ana Carolina Ewbank, Kátia R Groch, Vanessa Dal Bianco, Samira Costa-Silva, Roberta Zamana-Ramblas, Cíntia Favero, Adriana Castaldo Colosio, Hernani da Cunha Gomes Ramos, Elitieri Santos-Neto, Jose Lailson-Brito, Vitor L Carvalho, Vanessa L Ribeiro, Carolina Pacheco Bertozzi, Caroline F Pessi, Irene Sacristán, José Luiz Catão-Dias, Carlos Sacristán

{"title":"Polyomavirus surveillance in cetaceans of Brazil: first detection of polyomavirus in Guiana dolphins (Sotalia guianensis).","authors":"Aricia Duarte-Benvenuto, Josué Díaz-Delgado, Ana Carolina Ewbank, Kátia R Groch, Vanessa Dal Bianco, Samira Costa-Silva, Roberta Zamana-Ramblas, Cíntia Favero, Adriana Castaldo Colosio, Hernani da Cunha Gomes Ramos, Elitieri Santos-Neto, Jose Lailson-Brito, Vitor L Carvalho, Vanessa L Ribeiro, Carolina Pacheco Bertozzi, Caroline F Pessi, Irene Sacristán, José Luiz Catão-Dias, Carlos Sacristán","doi":"10.1080/01652176.2024.2413185","DOIUrl":"10.1080/01652176.2024.2413185","url":null,"abstract":"Polyomaviruses (PyVs) are small double-stranded DNA viruses able to infect species across all vertebrate taxa. In cetaceans, PyVs have been reported only in short-beaked common dolphin (Delphinus delphis), common bottlenose dolphin (Tursiops truncatus) and killer whale (Orcinus orca). Herein, we surveyed PyV in 119 cetaceans (29 mysticetes and 90 odontocetes) stranded along the Brazilian coast, from 2002 to 2022, comprising 18 species. DNA extracted from the lungs was tested using a nested PCR targeting the major capsid protein gene of PyV. Polyomavirus was detected in lung samples of 1.7% (2/119) cetaceans: two juvenile female Guiana dolphins (Sotalia guianensis) stranded in Rio de Janeiro (Rio de Janeiro state) and Guriri (Espírito Santo state), in 2018. Both retrieved sequences were identical and presented 93.3% amino acid identity with Zetapolyomavirus delphini, suggesting a novel species. On histopathology, one of the PyV-positive individuals presented basophilic intranuclear inclusion bodies morphologically consistent with polyomavirus in the lungs. Other available tissues from both cases were PyV-PCR-negative; however, both individuals tested positive for Guiana dolphin morbillivirus. To our knowledge, this is the first report of PyV infection in cetaceans of the Southern Hemisphere and the first description of a co-infection with morbillivirus.","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"44 1","pages":"1-7"},"PeriodicalIF":7.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11492386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142480146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of QLNC-3A6 in canine plasma by UHPLC-MS/MS and its application in pharmacokinetic studies. UHPLC-MS/MS测定犬血浆中QLNC-3A6的含量及其在药动学研究中的应用。

IF 7.9 2区农林科学

Veterinary Quarterly Pub Date : 2024-12-01 Epub Date: 2024-10-10 DOI: 10.1080/01652176.2024.2407174

Sumeng Chen, Yu Liu, Yue Wang, Zeyu Wen, Jinyan Meng, Yuxin Yang, Yang Zhang, Mei Kong, Gang Chen, Xingyuan Cao

{"title":"Determination of QLNC-3A6 in canine plasma by UHPLC-MS/MS and its application in pharmacokinetic studies.","authors":"Sumeng Chen, Yu Liu, Yue Wang, Zeyu Wen, Jinyan Meng, Yuxin Yang, Yang Zhang, Mei Kong, Gang Chen, Xingyuan Cao","doi":"10.1080/01652176.2024.2407174","DOIUrl":"10.1080/01652176.2024.2407174","url":null,"abstract":"Multi-targeted tyrosine kinase inhibitor QLNC-3A6 Di-maleate, a structurally novel small molecule compound, has therapeutic efficacy for the treatment of canine cutaneous mast cell tumor (CMCT) caused by mutations in the c-Kit gene. Since pharmacokinetic (PK) information plays an important role in the development and application of new drugs, etc., a rapid, highly sensitive and selective UHPLC-MS/MS analytical method was developed and validated for the first time in this study for the quantitative detection of QLNC-3A6 in canine plasma. 100 µL of plasma was precipitated using 350 µL of acetonitrile, and Chromatographic separation was performed on a Phenomenex Kinetex C18 column (50 × 2.1 mm, 2.6 µm) at a flow rate of 0.4 mL/min, the mobile phases were set to 0.1% formic acid aqueous solution (A) and 0.1% formic acid acetonitrile (B). The calibration curve linear range was 0.5-100 ng/mL (R2>0.99). The intraday and interday precision values (relative standard deviation, RSD) were 2.06-13.57% and 6.90-9.14%. Intraday and interday accuracies were -10.73 to 9.54% and -3.86 to 0.70% respectively. The dilution integrity RSD value and stability RSD value were less than 3.77 and 7.45%, respectively. Subsequently, the pharmacokinetics were investigated in canine after oral administration of QLNC-3A6 Di-maleate tablets at a dose of 3 mg/kg BW using this method. The results showed that QLNC-3A6 showed fast absorption rate, rapid distribution and slow metabolic elimination in canine plasma. The results of the main PK parameters including λz, T1/2λz, Cmax, Tmax and AUClast were 0.07 ± 0.01/h, 11.00 ± 2.57 h, 50.88 ± 31.94 ng/mL, 9.08 ± 11.57 h and 836.48 ± 230.53 ng h/mL, respectively.","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"44 1","pages":"1-11"},"PeriodicalIF":7.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11469437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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