Veterinary Quarterly最新文献

筛选
英文 中文
Functional characterization of UL50 gene reveals its essential role in duck enteritis virus replication and pathogenesis. UL50基因的功能特征揭示了其在鸭肠炎病毒复制和发病过程中的重要作用。
IF 3.9 2区 农林科学
Veterinary Quarterly Pub Date : 2026-12-31 Epub Date: 2026-03-24 DOI: 10.1080/01652176.2026.2649575
Su-Xin Huo, Liu Chen, En-Dong Bao, Zheng Ni, Wei-Cheng Ye, Jiong-Gang Hua, Tao Yun, Yuan Fu, Yue Wu, Fang-Zhou Ding, Xu Gao, Rui Zhong, Zong-Xiao Wang, Cun Zhang, Yin-Chu Zhu
{"title":"Functional characterization of <i>UL50</i> gene reveals its essential role in duck enteritis virus replication and pathogenesis.","authors":"Su-Xin Huo, Liu Chen, En-Dong Bao, Zheng Ni, Wei-Cheng Ye, Jiong-Gang Hua, Tao Yun, Yuan Fu, Yue Wu, Fang-Zhou Ding, Xu Gao, Rui Zhong, Zong-Xiao Wang, Cun Zhang, Yin-Chu Zhu","doi":"10.1080/01652176.2026.2649575","DOIUrl":"10.1080/01652176.2026.2649575","url":null,"abstract":"<p><p>Duck plague, caused by a highly contagious <i>α</i>-herpesvirus, poses a major threat to waterfowl farming. Although <i>UL50</i> homologs have been studied in mammalian <i>α</i>-herpesviruses such as HSV-1 and PRV, their role in avian herpesviruses remains unknown. Here, we investigated the function of the DEV <i>UL50</i> gene, which encodes a conserved viral dUTPase, using bioinformatics, molecular biology, and virological approaches. Sequence analysis confirmed that DEV <i>UL50</i> retains conserved catalytic motifs and structural features characteristic of <i>α</i>-herpesvirus homologs. A <i>UL50</i>-deleted mutant (ΔUL50) was constructed using the Red recombination system. <i>In vitro</i>, ΔUL50 exhibited reduced replication efficiency in DEFs, characterized by smaller plaques and lower viral titers, although overall growth kinetics were broadly similar to the WT. Notably, in duck DRG neurons, ΔUL50 replication was nearly abolished. GFP-reporter BAC viruses further confirmed that ΔUL50 failed to spread in DRG neurons but retained propagation in DEFs, indicating a cell-type-dependent replication defect. <i>In vivo</i>, ΔUL50 displayed markedly reduced viral loads and attenuated virulence, with no mortality and milder clinical and histopathological changes. These findings demonstrate that <i>UL50</i> is dispensable but replication-supportive, particularly in non-dividing neuronal cells, highlighting its role in DEV pathogenicity and extending understanding of <i>α</i>-herpesvirus biology beyond mammalian systems.</p>","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"46 1","pages":"2649575"},"PeriodicalIF":3.9,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13015092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147516289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Jejunal mucosal immune response in goats ten months after Mycobacterium avium subsp. paratuberculosis challenge is primarily determined by lesion severity rather than vaccination route. 鸟分枝杆菌亚群感染10个月后山羊空肠黏膜免疫反应的研究。副结核挑战主要取决于病变严重程度,而不是疫苗接种途径。
IF 3.9 2区 农林科学
Veterinary Quarterly Pub Date : 2026-12-31 Epub Date: 2026-07-23 DOI: 10.1080/01652176.2026.2707278
Miguel Criado, Marta Silva, Pedro Mendívil, David Zapico, Victoria Pérez-Rojo, Julio Benavides, José Espinosa, Natalia Elguezabal, Daniel Gutiérrez-Expósito
{"title":"Jejunal mucosal immune response in goats ten months after <i>Mycobacterium avium</i> subsp. <i>paratuberculosis</i> challenge is primarily determined by lesion severity rather than vaccination route.","authors":"Miguel Criado, Marta Silva, Pedro Mendívil, David Zapico, Victoria Pérez-Rojo, Julio Benavides, José Espinosa, Natalia Elguezabal, Daniel Gutiérrez-Expósito","doi":"10.1080/01652176.2026.2707278","DOIUrl":"10.1080/01652176.2026.2707278","url":null,"abstract":"<p><p>Current vaccines against <i>paratuberculosis</i> offer incomplete and variable protection that raises questions on the ruminant immune responses to <i>Mycobacterium avium</i> subspecies <i>paratuberculosis</i> (<i>Map</i>) infection, particularly at the mucosal level. Thus, this study examined the immune responses established in the jejunum of goats vaccinated with oral, intradermal, or subcutaneous inactivated vaccines 11 months post-vaccination and 10 months after experimental <i>Map</i> challenge. In general terms, the mucosal response of non-challenged animals was not affected by vaccination. However, the quantification of immune cell populations, cytokine expression, recall responses of tissue-isolated mononuclear leukocytes, and secretory IgA levels in vaccinated and challenged animals with focal lesions suggested a local Th1 polarization. In contrast, those with diffuse lesions exhibited features compatible with the early development of a more Th2-biased response. The vaccination route played a lesser role in the immune response than lesion severity. Orally vaccinated and challenged goats, showed reduced local IL-1β and IL-17A expression, which may explain the milder lesions observed in these animals, despite their high bacterial burden, as these cytokines participate in macrophage recruitment, granuloma formation, and bacterial clearance. Nevertheless, owing to the high variability among challenged animals, larger sample sizes would allow robust conclusions to be drawn in further studies.</p>","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"46 1","pages":"2707278"},"PeriodicalIF":3.9,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13403457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148580908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Equine genital and ocular squamous cell carcinomas: clinical, histopathological, molecular and viral characterization with proposed histopathological classification system. 马生殖器和眼部鳞状细胞癌:临床,组织病理学,分子和病毒特征与提出的组织病理学分类系统。
IF 3.9 2区 农林科学
Veterinary Quarterly Pub Date : 2026-12-31 Epub Date: 2026-03-24 DOI: 10.1080/01652176.2026.2648939
Kevin O'Brien, Tim Mair, Hardeep S Mudhar, Patricia Pesavento, Henry Miller, Simon L Priestnall, Alejandro Suárez-Bonnet
{"title":"Equine genital and ocular squamous cell carcinomas: clinical, histopathological, molecular and viral characterization with proposed histopathological classification system.","authors":"Kevin O'Brien, Tim Mair, Hardeep S Mudhar, Patricia Pesavento, Henry Miller, Simon L Priestnall, Alejandro Suárez-Bonnet","doi":"10.1080/01652176.2026.2648939","DOIUrl":"10.1080/01652176.2026.2648939","url":null,"abstract":"<p><p>Equine squamous cell carcinomas (eSCCs) are common, and a proportion are likely induced by <i>Equus caballus</i> papillomavirus 2 (EcPV-2). Accurate prediction of clinical outcomes is challenging with no recognized prognostic criteria or consistent histopathological classification scheme for eSCC. The aims of this study were to histopathologically subtype a large case series of eSCCs (genital and ocular) and correlate them with p16 and HER-2 expression, equine papillomavirus infection status, and various clinical and histopathological parameters to predict tumour behavior and prognosis. One hundred and eighty-five samples were examined and subtyped histologically. HER-2 and p16 immunohistochemistry (IHC) and <i>in situ</i> hybridization (ISH) for the EcPV-2 E6/E7 oncogenes were performed on a subset of cases, and follow-up survival data were analyzed. The results were compared and correlated with published guidelines on the categorization of human SCC. Six histopathological subtypes of SCC, according to the WHO, were identified for the first time in horses: usual/invasive (most common), verrucous, pseudoglandular, papillary, warty, and basaloid, with different histological subtypes demonstrating prognostic significance. HER-2 and EcPV-2 statuses were not associated with prognosis in horses with SCC. p16 expression is not associated with EcPV-2 status but could be a potential prognostic factor. ISH demonstrated EcPV-2 genetic material in the majority of eSCCs, except for the papillary subtype, which includes mature, not just pre-cancerous, eSCCs. Widespread HER-2 expression in eSCCs could suggest a role for this cell receptor as a potential therapeutic target.</p>","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"46 1","pages":"2648939"},"PeriodicalIF":3.9,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13015116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147505432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial intelligence and laboratory biomarkers in veterinary medicine: an update about machine learning applications. 兽医学中的人工智能和实验室生物标志物:关于机器学习应用的最新进展。
IF 3.9 2区 农林科学
Veterinary Quarterly Pub Date : 2026-12-31 Epub Date: 2026-09-17 DOI: 10.1080/01652176.2026.2715555
Fernando Tecles, Julian J Arense-Gonzalo, Alberto Muñoz-Prieto, Asta Tvarijonaviciute, Silvia Martínez-Subiela, Edgar G Manzanilla, José J Cerón
{"title":"Artificial intelligence and laboratory biomarkers in veterinary medicine: an update about machine learning applications.","authors":"Fernando Tecles, Julian J Arense-Gonzalo, Alberto Muñoz-Prieto, Asta Tvarijonaviciute, Silvia Martínez-Subiela, Edgar G Manzanilla, José J Cerón","doi":"10.1080/01652176.2026.2715555","DOIUrl":"10.1080/01652176.2026.2715555","url":null,"abstract":"<p><p>The use of artificial intelligence has been a revolution in human medicine in the last years. Machine learning (ML), a subset of artificial intelligence, has allowed the use of a large amount of data to search for associations of clinical significance. Although the use of ML with laboratory biomarkers in veterinary medicine is limited in comparison with the human side, the number of studies published in this field is increasing in recent years. This review addresses some basic concepts and gives a general overview of the use of ML in the area of biomarkers in veterinary medicine. It is especially focused on two species of each companion (dogs and cats) and farm (bovine and porcine) animals, and provides information about the advances made in the last years, indicating how ML using laboratory data can contribute to the diagnosis and monitoring of selected diseases and, in case of farm animals, also to better control and improve their productive performance. In addition, possible new applications such as optimizing laboratory management, refining diagnostics or improving treatment monitoring based on the experience in humans are outlined. This narrative review can contribute to a better knowledge about the possible use of ML in laboratory biomarkers in veterinary and animal sciences for current and future applications.</p>","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"46 1","pages":"2715555"},"PeriodicalIF":3.9,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13587570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148992265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Apoptosis inhibitor of macrophage (AIM/CD5L) as a potential immunomodulator in feline injection-site sarcoma: a hypothesis on tumor-macrophage interactions. 巨噬细胞凋亡抑制剂(AIM/CD5L)作为猫注射部位肉瘤的潜在免疫调节剂:肿瘤-巨噬细胞相互作用的假设
IF 3.9 2区 农林科学
Veterinary Quarterly Pub Date : 2026-12-31 Epub Date: 2026-08-02 DOI: 10.1080/01652176.2026.2706036
Julia Gilbert, Gyula Balka, Míra Mándoki, Anna Szilasi
{"title":"Apoptosis inhibitor of macrophage (AIM/CD5L) as a potential immunomodulator in feline injection-site sarcoma: a hypothesis on tumor-macrophage interactions.","authors":"Julia Gilbert, Gyula Balka, Míra Mándoki, Anna Szilasi","doi":"10.1080/01652176.2026.2706036","DOIUrl":"10.1080/01652176.2026.2706036","url":null,"abstract":"<p><p>AIM (apoptosis inhibitor of macrophage), also known as CD5L, is a macrophage-derived scavenger protein with broad immunomodulatory roles in mammals. Secreted by tissue macrophages, AIM circulates bound to IgM pentamers, which stabilize the protein in blood; free AIM is released during inflammation to influence immune signaling and cellular homeostasis. (Yang et al. 2023). In cats, AIM exhibits distinctive structural and biochemical properties, existing as both a three-domain (37 kDa) and a four-domain (45 kDa) variant generated through exon 3 duplication (Evangelista et al. 2025), and binding IgM approximately 1000-fold more tightly than murine AIM due to a species-specific positively charged cluster in its third SRCR domain (Miyazaki et al., 2018). These differences suggest feline AIM may function distinctly from human/mouse AIM. Feline injection-site sarcomas (FISS) arise in the context of chronic inflammation and frequently contain abundant tumor-associated macrophages (TAMs)associated with tumor aggressiveness and progression (Gomes et al., 2025). Given AIM's macrophage origin and its established roles in inflammatory regulation, autophagy signaling, and complement-mediated tumor targeting, we propose a directional hypothesis: that the high-affinity IgM-binding of feline AIM constrains free AIM availability in vivo, shifting the functional balance away from complement-mediated tumor cytotoxicity and toward macrophage-intrinsic M2-polarizing pathways, thereby promoting an immunosuppressive tumor microenvironment that contributes to FISS progression. Exploring AIM in this context may provide new perspectives for investigation in feline tumor immunology.</p>","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"46 1","pages":"2706036"},"PeriodicalIF":3.9,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13435276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148664940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
LNC_003296 regulates the proliferation and differentiation of ovine myoblasts by modulating the stability of Hsp70. LNC_003296通过调节Hsp70的稳定性调控绵羊成肌细胞的增殖和分化。
IF 3.9 2区 农林科学
Veterinary Quarterly Pub Date : 2026-12-31 Epub Date: 2026-08-25 DOI: 10.1080/01652176.2026.2720646
Yize Song, Xiaofei Guo, Xiaosheng Zhang, Jinlong Zhang, Hui Sheng, Mingxing Chu
{"title":"LNC_003296 regulates the proliferation and differentiation of ovine myoblasts by modulating the stability of Hsp70.","authors":"Yize Song, Xiaofei Guo, Xiaosheng Zhang, Jinlong Zhang, Hui Sheng, Mingxing Chu","doi":"10.1080/01652176.2026.2720646","DOIUrl":"10.1080/01652176.2026.2720646","url":null,"abstract":"<p><p>Long non-coding RNAs (lncRNAs) are involved in various regulatory processes during muscle development. Our previous RNA-seq study identified LNC_003296 as being significantly differentially expressed between ovariectomized Small-tailed Han sheep (OR-STH) and their non-ovariectomized counterparts (STH). Through biotinylated RNA pull-down assays and RNA immunoprecipitation (RIP), we further demonstrated that LNC_003296 directly interacts with Hsp70. Protein stability and degradation experiments revealed that LNC_003296 enhances the protein stability of Hsp70. Overexpression of either LNC_003296 or Hsp70 promoted myoblast proliferation, facilitated differentiation, and contributed to skeletal muscle fiber formation. Conversely, their knockdown suppressed cell proliferation and inhibited differentiation. In summary, these data indicate that LNC_003296 can bind to Hsp70 and enhance its protein stability, thereby influencing the proliferation and differentiation of myoblasts.</p>","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"46 1","pages":"2720646"},"PeriodicalIF":3.9,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13520862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148820186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic relevance of short-term changes in body weight, renal indices, and echocardiographic variables after intravenous diuretic therapy in dogs with myxomatous mitral valve disease hospitalized for pulmonary edema. 因肺水肿住院的二尖瓣黏液瘤病犬在静脉利尿剂治疗后体重、肾脏指数和超声心动图变量的短期变化与预后的相关性
IF 3.9 2区 农林科学
Veterinary Quarterly Pub Date : 2026-12-31 Epub Date: 2026-03-24 DOI: 10.1080/01652176.2026.2648250
Sin-Wook Park, Kyung-Ho You, Keon Kim, Woong-Bin Ro, Chang-Min Lee
{"title":"Prognostic relevance of short-term changes in body weight, renal indices, and echocardiographic variables after intravenous diuretic therapy in dogs with myxomatous mitral valve disease hospitalized for pulmonary edema.","authors":"Sin-Wook Park, Kyung-Ho You, Keon Kim, Woong-Bin Ro, Chang-Min Lee","doi":"10.1080/01652176.2026.2648250","DOIUrl":"10.1080/01652176.2026.2648250","url":null,"abstract":"<p><p>Congestive heart failure (CHF) secondary to myxomatous mitral valve disease (MMVD) is managed with diuretics, yet the prognostic value of short-term hemodynamic responses remains unclear. This retrospective study evaluated 50 dogs with ACVIM stage C or D MMVD hospitalized for CHF. We assessed changes in body weight, echocardiographic parameters, and renal values before and after intravenous (IV) diuretic therapy to determine their association with survival. IV diuretic therapy led to significant reductions in body weight and echocardiographic indices, including the left atrium-to-aortic root ratio (LA/Ao), normalized left ventricular internal diameter in diastole (LVIDDN), and early diastolic transmitral flow velocity (all <i>P </i>< 0.005). Conversely, blood urea nitrogen and creatinine concentrations significantly increased (<i>P</i> < 0.001). However, neither short-term changes in these variables nor post-treatment values were associated with long-term survival. Baseline LA/Ao and LVIDDN were related to survival in univariable analysis, while prior oral diuretic therapy was the only independent predictor in the multivariable model (Hazard Ratio 4.21; <i>P</i> < 0.001). Dogs with prior diuretic use had shorter median survival (194 days) than those without (459 days). Thus, short-term echocardiographic improvements reflect effective decongestion rather than long-term prognosis. Prognostic evaluation should prioritize baseline assessments and treatment history.</p>","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"46 1","pages":"2648250"},"PeriodicalIF":3.9,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13015027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147505445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phenol-soluble modulin alpha (PSMα) mediates autophagy induction and intracellular survival of Staphylococcus Aureus in bovine mammary epithelial cells. 酚溶性调节素α (PSMα)介导金黄色葡萄球菌在牛乳腺上皮细胞中的自噬诱导和细胞内存活。
IF 3.9 2区 农林科学
Veterinary Quarterly Pub Date : 2026-12-31 Epub Date: 2026-04-09 DOI: 10.1080/01652176.2026.2657289
Huahua Chen, Jieyuan Wang, Zhiyuan Lu, Guodong Cheng, Muzi Li, Yongxia Liu, Xiaozhou Wang, Jianzhu Liu
{"title":"Phenol-soluble modulin alpha (PSMα) mediates autophagy induction and intracellular survival of <i>Staphylococcus Aureus</i> in bovine mammary epithelial cells.","authors":"Huahua Chen, Jieyuan Wang, Zhiyuan Lu, Guodong Cheng, Muzi Li, Yongxia Liu, Xiaozhou Wang, Jianzhu Liu","doi":"10.1080/01652176.2026.2657289","DOIUrl":"10.1080/01652176.2026.2657289","url":null,"abstract":"<p><p><i>Staphylococcus aureus</i> (<i>S. aureus</i>) is a Gram-positive bacterium that serves as a major pathogen causing bovine mastitis. One of the key intracellular survival mechanisms of <i>S. aureus</i> involves the induction of autophagy. The capacity of <i>S. aureus</i> to subvert autophagy for intracellular survival and replication is strongly linked to its broad array of virulence determinants, which play pivotal roles in infection establishment and immune evasion. One of these virulence factors is phenol-soluble modulin alpha (PSMα), an amphipathic small peptide that plays a key role in the pathogenesis of <i>S. aureus</i>. Utilizing gene-edited <i>S. aureus</i> strain and bovine mammary epithelial cells (BMECs, MAC-T), this study elucidates the involvement of PSMα in autophagy induction during <i>S. aureus</i> infection. The results demonstrated that PSMα knockout attenuated <i>S. aureus</i>-induced autophagy, weakened the activation of the PI3K/Akt/mTOR pathway, and reduced intracellular bacterial load. Our findings elucidate a PSMα-dependent autophagy induction mechanism in <i>S. aureus</i> infection, which is associated with the intracellular survival of <i>S. aureus</i>.</p>","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"46 1","pages":"2657289"},"PeriodicalIF":3.9,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147640315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic interaction between clinical stage and left atrial remodeling in dogs with myxomatous mitral valve disease. 二尖瓣黏液瘤病犬临床分期与左房重构预后的相互作用。
IF 3.9 2区 农林科学
Veterinary Quarterly Pub Date : 2026-12-31 Epub Date: 2026-05-06 DOI: 10.1080/01652176.2026.2668790
Sin-Wook Park, Keon Kim, Kyung-Ho You, Woong-Bin Ro, Chang-Min Lee
{"title":"Prognostic interaction between clinical stage and left atrial remodeling in dogs with myxomatous mitral valve disease.","authors":"Sin-Wook Park, Keon Kim, Kyung-Ho You, Woong-Bin Ro, Chang-Min Lee","doi":"10.1080/01652176.2026.2668790","DOIUrl":"10.1080/01652176.2026.2668790","url":null,"abstract":"<p><p>Myxomatous mitral valve disease (MMVD) is leading cause of acquired heart failure in small-breed dogs. Although the American College of Veterinary Internal Medicine (ACVIM) staging is widely used in practice, how each stage and the degree of cardiac remodeling affect survival has not been clearly defined. We aimed to determine whether severe remodeling in dogs with preclinical (stage B2) disease is associated with survival differences compared with dogs with congestive heart failure (CHF; stage C) and less severe remodeling. This retrospective study analyzed 270 dogs with MMVD, stratified by the left atrium-to-aortic root ratio as having mild (<1.9), moderate (1.9-2.2), and severe (≥2.2) left atrial enlargement. Survival for dogs with stage B2 disease with severe LA enlargement did not differ significantly from dogs with stage C disease with mild-to-moderate enlargement. However, within the subgroup with severe LA enlargement, dogs that developed CHF had significantly shorter survival than those that remained in stage B2 (360 vs. 654 days; <i>P</i> = 0.032). Severe LA enlargement in dogs with preclinical disease contributes to a poor prognosis comparable to that of CHF with mild-to-moderate enlargement, indicating that stage alone may be insufficient for determining prognosis and that LA remodeling should also be considered.</p>","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"46 1","pages":"2668790"},"PeriodicalIF":3.9,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13151762/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction. 修正。
IF 3.9 2区 农林科学
Veterinary Quarterly Pub Date : 2026-12-31 Epub Date: 2026-08-26 DOI: 10.1080/01652176.2026.2723620
{"title":"Correction.","authors":"","doi":"10.1080/01652176.2026.2723620","DOIUrl":"10.1080/01652176.2026.2723620","url":null,"abstract":"","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"46 1","pages":"2723620"},"PeriodicalIF":3.9,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13523112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148834480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信
小红书