Brett M Montelaro, Travis M Wilson, Noah Newman, Edward Trey Woods, Muzamil Khawaja, Hafeez Hassan Virk, Johao Escobar, Mahboob Alam, Hani Jneid, Samin K Sharma, Chayakrit Krittanawong
{"title":"Calcium modification techniques in complex percutaneous coronary intervention: State-of-the-art review.","authors":"Brett M Montelaro, Travis M Wilson, Noah Newman, Edward Trey Woods, Muzamil Khawaja, Hafeez Hassan Virk, Johao Escobar, Mahboob Alam, Hani Jneid, Samin K Sharma, Chayakrit Krittanawong","doi":"10.1016/j.tcm.2025.04.004","DOIUrl":"https://doi.org/10.1016/j.tcm.2025.04.004","url":null,"abstract":"<p><p>As patients increase in age and medical complexity, coronary artery calcification is frequently encountered and its presence portends worse outcomes following percutaneous coronary intervention (PCI) - negatively impacting procedural success and long-term outcomes. This review paper explores available imaging techniques and calcium modification technique that can identify, characterize and modify these lesions to facilitate stent implantation. The data supporting these techniques are explored and an algorithm for decision-making during lesion modification is presented. Current barriers and future directions are additionally discussed.</p>","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S D Haas, A E van der Hulst, C Adel, A Malekzadeh, N A Blom, M Königs, J G van den Aardweg, I M Kuipers, J Oosterlaan
{"title":"Cardiorespiratory fitness in children with surgically corrected congenital heart disease: A meta-analysis and meta-regression.","authors":"S D Haas, A E van der Hulst, C Adel, A Malekzadeh, N A Blom, M Königs, J G van den Aardweg, I M Kuipers, J Oosterlaan","doi":"10.1016/j.tcm.2025.04.005","DOIUrl":"https://doi.org/10.1016/j.tcm.2025.04.005","url":null,"abstract":"<p><p>Congenital heart disease (CHD) is the most common birth defect, and despite advancements in medical care, children with surgically corrected CHD often experience reduced cardiorespiratory fitness, which is associated with negative long-term health outcomes. This meta-analysis aimed to quantify peak oxygen consumption (̇VO<sub>2peak</sub>) impairments in children with surgically corrected CHD, examine isolated diagnosis-specific impairments, and explore the relationship between clinical variables and cardiorespiratory fitness. A total of 45 studies encompassing 2,536 children with CHD and 3,108 healthy controls were included in the meta-analysis, revealing that children with CHD had significantly lower ̇VO<sub>2peak</sub> (standardized mean difference = 1.13, 95 % CI 0.98 to 1.28), with those having univentricular hearts being most affected (standardized mean difference = 1.61, 95 % CI 1.34 to 1.87). Reduced saturation during exercise, chronotropic impairment and early onset of anaerobic threshold are likely to play a role in this impairment.</p>","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Editorial Commentary: Spotlight on ATTR cardiomyopathy: the unexpected journey of a once considered “orphan disease”","authors":"Selim R. Krim","doi":"10.1016/j.tcm.2025.04.003","DOIUrl":"10.1016/j.tcm.2025.04.003","url":null,"abstract":"","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":"35 6","pages":"Pages 363-364"},"PeriodicalIF":7.3,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Victoria Catalán , Javier Gómez-Ambrosi , Gema Frühbeck
{"title":"Editorial Commentary: Medical versus surgically-induced weight loss differences on cardiovascular outcomes","authors":"Victoria Catalán , Javier Gómez-Ambrosi , Gema Frühbeck","doi":"10.1016/j.tcm.2025.04.002","DOIUrl":"10.1016/j.tcm.2025.04.002","url":null,"abstract":"","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":"35 6","pages":"Pages 382-383"},"PeriodicalIF":7.3,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Enhanced cardiac PET: Illuminating the path to better CAD care-18F labeled myocardial perfusion PET.","authors":"Anna Koulova, David H Hsi","doi":"10.1016/j.tcm.2025.04.001","DOIUrl":"https://doi.org/10.1016/j.tcm.2025.04.001","url":null,"abstract":"","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Takahiro Higuchi, Xinyu Chen, Maximilian Scheifele, Maximilian Fischer, Sebastian Clauss, Konrad Klimek, Rudolf A Werner
{"title":"<sup>18</sup>F labeled myocardial perfusion PET: New precision in cardiac imaging.","authors":"Takahiro Higuchi, Xinyu Chen, Maximilian Scheifele, Maximilian Fischer, Sebastian Clauss, Konrad Klimek, Rudolf A Werner","doi":"10.1016/j.tcm.2025.03.008","DOIUrl":"https://doi.org/10.1016/j.tcm.2025.03.008","url":null,"abstract":"<p><p>The rising global burden of coronary artery disease (CAD) underscores the need for advanced diagnostic tools. While single-photon emission computed tomography (SPECT) has been the cornerstone for myocardial perfusion imaging (MPI), it is increasingly being supplemented by positron emission tomography (PET) due to superior spatial resolution, sensitivity, and the ability to quantify myocardial blood flow. However, current PET tracers, including Rubidium-82, <sup>13</sup>N-Ammonia, and <sup>15</sup>O-Water, face limitations due to their short half-lives and logistical challenges. The advent of <sup>18</sup>F labeled PET tracers, such as Flurpiridaz F18, promises a new era in cardiac imaging by offering a longer half-life (110 minutes), compatibility with exercise stress testing, and high diagnostic accuracy. This review explores the current landscape of MPI, evaluates the clinical performance of novel <sup>18</sup>F tracers, and discusses their transformative potential in expanding access to PET imaging and improving CAD diagnostics.</p>","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Editorial Commentary: Transvenous leads’ last stand: Non-transvenous defibrillators and a leadless future","authors":"David J. Sanders , Alexander Mazur","doi":"10.1016/j.tcm.2025.03.007","DOIUrl":"10.1016/j.tcm.2025.03.007","url":null,"abstract":"","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":"35 6","pages":"Pages 372-373"},"PeriodicalIF":7.3,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ashley Slingerland , Muhammad Moolla , Kevin John , Liz Dennett , Jeevan Nagendran , Anoop Mathew
{"title":"Invasive management of unroofed coronary sinus: A systematic review","authors":"Ashley Slingerland , Muhammad Moolla , Kevin John , Liz Dennett , Jeevan Nagendran , Anoop Mathew","doi":"10.1016/j.tcm.2025.03.006","DOIUrl":"10.1016/j.tcm.2025.03.006","url":null,"abstract":"<div><div>Unroofed coronary sinus (UCS) is a rare congenital anomaly, constituting under 1 % of atrial septal defects. Caused by partial or complete deficiency of the coronary sinus roof, UCS is often difficult to diagnose. While surgery remains the standard treatment, transcatheter approaches are emerging. We conducted a systematic review to evaluate outcomes of surgical and transcatheter approaches to UCS repair. Studies from MEDLINE, Embase, SCOPUS, and Web of Science were screened and selected based on predefined criteria. We extracted data on patient demographics, operative techniques, associated defects, and outcomes. Thirteen studies involving 293 patients with UCS were included. Majority (66.4 %) were male, with a mean age of 17.5 ± 11.5 years. UCS type 1A, marked by the presence of a persistent left superior vena cava and absent coronary sinus, was the most common subtype (50.4 %). Surgical repair was performed in 95.2 % of patients, with intracardiac baffle (34.1 %) and patch repair (21.9 %) being the predominant techniques. The remaining 4.8 % of patients underwent transcatheter repair, typically using Amplatzer® Septal Occluder device, with no reported procedural complications. In-hospital mortality rate was 2.7 %, and 30-day mortality was 3.0 %. Postoperative complications were rare, including residual defects (0.42 %), atrial fibrillation (2.9 %), and complete heart block requiring pacemaker (1.2 %). There were no cases of ischemic stroke. Surgical repair of UCS is associated with low postoperative mortality and complication rates, affirming its status as the standard of care. Transcatheter techniques may be feasible for select patients, though further studies are needed to to assess long-term outcomes and optimize criteria for patient selection.</div></div>","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":"35 6","pages":"Pages 394-403"},"PeriodicalIF":7.3,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rachel L. Goldberg , Sindhu Prabakaran , Nandita S. Scott
{"title":"Cardio obstetrics: Bridging heart and pregnancy health","authors":"Rachel L. Goldberg , Sindhu Prabakaran , Nandita S. Scott","doi":"10.1016/j.tcm.2024.10.005","DOIUrl":"10.1016/j.tcm.2024.10.005","url":null,"abstract":"<div><div>Cardiovascular disease remains a major contributor to maternal morbidity and mortality in the United States. Cardio Obstetrics is a nascent field for which most cardiovascular clinicians have not received any formal training. This has resulted in knowledge and care gaps. In this review we provide principles to guide the care for the evaluation and management of pregnancy capable individuals, which should be considered the standard knowledge for all clinicians.</div></div>","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":"35 3","pages":"Pages 166-174"},"PeriodicalIF":7.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maya Guglin , Joshua R. Hirsch , Tanyanan Tanawuttiwat , Naveed Akhtar , Scott Silvestry , Onyedika J. Ilonze , R. Michelle Gehring , Emma J. Birks
{"title":"How to diagnose and manage emergency medical conditions in patients on left ventricular assist device support: A clinician's field guide","authors":"Maya Guglin , Joshua R. Hirsch , Tanyanan Tanawuttiwat , Naveed Akhtar , Scott Silvestry , Onyedika J. Ilonze , R. Michelle Gehring , Emma J. Birks","doi":"10.1016/j.tcm.2024.11.004","DOIUrl":"10.1016/j.tcm.2024.11.004","url":null,"abstract":"<div><div>Left ventricular assist devices (LVADs) have revolutionized the treatment of advanced heart failure, providing mechanical circulatory support for patients awaiting heart transplantation or as destination therapy. However, patients on LVAD support are susceptible to a range of emergency medical conditions that require prompt recognition, intervention, and multidisciplinary management. This review paper aims to provide an algorithmic approach and a field guide on the diagnosis and management of emergency medical conditions in LVAD patients, including LVAD alarms, gastrointestinal bleeding, cerebrovascular accidents, pump thrombosis and obstruction, unresponsiveness, and electrical shock by the defibrillator. By understanding the mechanisms, clinical presentation, diagnostic evaluation, and therapeutic strategies associated with these conditions, healthcare providers can improve patient outcomes and optimize LVAD care.</div></div>","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":"35 3","pages":"Pages 186-194"},"PeriodicalIF":7.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}