Trends in Cardiovascular Medicine最新文献

Atrial Fibrosis and Post-Operative Atrial Fibrillation - Substrate, Signal or Spectator? 心房纤维化和术后心房颤动：基底、信号还是旁观者？

IF 9 2区医学

Trends in Cardiovascular Medicine Pub Date : 2026-04-28 DOI: 10.1016/j.tcm.2026.04.006

Mark T Mills

引用次数: 0

Reconsidering anticoagulation strategies around cardioversion of atrial fibrillation: time to move beyond the dogma? 重新考虑房颤转复前后的抗凝策略：是时候超越教条了？

IF 9 2区医学

Trends in Cardiovascular Medicine Pub Date : 2026-04-20 DOI: 10.1016/j.tcm.2026.04.003

Anil K Gehi

引用次数: 0

Cardiogenic shock: Beyond pump failure. 心源性休克：超出泵衰竭。

IF 9 2区医学

Trends in Cardiovascular Medicine Pub Date : 2026-04-20 DOI: 10.1016/j.tcm.2026.04.004

Aldo Bonaventura, Simon Kraler, Luca Liberale, Antonio Abbate

引用次数: 0

Rescuing the heart from the tornadoes of sudden cardiac death. 将心脏从心源性猝死的龙卷风中拯救出来。

IF 9 2区医学

Trends in Cardiovascular Medicine Pub Date : 2026-04-20 DOI: 10.1016/j.tcm.2026.04.005

Francisco M Cruz, José Jalife

{"title":"Rescuing the heart from the tornadoes of sudden cardiac death.","authors":"Francisco M Cruz, José Jalife","doi":"10.1016/j.tcm.2026.04.005","DOIUrl":"https://doi.org/10.1016/j.tcm.2026.04.005","url":null,"abstract":"<p><p>Sudden cardiac death (SCD) causes 4 to 5 million deaths each year globally. Electrical vortices (tornadoes or rotors) are the origin of ventricular fibrillation (VF), which often causes SCD. Cardiac electrical vortices have complex dynamics and have been shown in many mammalian species. During VF, the heart fails to contract suitably and is unable to pump blood. Once VF is initiated, drug treatments are ineffective and even make things worse. The only effective treatment is electrical shock to the ventricles. Our current understanding of VF mechanisms is fragmentary, hindering the development of personalized therapies. Yet recent insights into the roles of the most critical sarcolemmal ion channels in VF in controlling the excitation-recovery process provide hope. Substantial evidence indicates that the molecular interplay between the main cardiac sodium channel (Na<sub>V</sub>1.5) and the strong inward-rectifier potassium current (Kir2.1) controls cardiac excitability, wave propagation velocity, and rotor formation, as well as rotor stability and frequency during VF. Studies at the cellular, molecular, and ion channel levels are helping us understand how rotors generate the turbulence that characterizes VF, providing insights into how to prevent their initiation and identifying new therapeutic targets to avert premature death.</p>","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":" ","pages":""},"PeriodicalIF":9.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147788475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The link between atrial fibrosis and postoperative atrial fibrillation after cardiac surgery: A systematic review. 心脏手术后心房纤维化与房颤的关系：一项系统综述。

IF 9 2区医学

Trends in Cardiovascular Medicine Pub Date : 2026-04-19 DOI: 10.1016/j.tcm.2026.04.002

Abdul Nawaz, Amrinpreet Sohpal, Rishit Mitra, Yasir Abu-Omar, Abdelrahman Elsebaie, Mohammad El-Diasty

{"title":"The link between atrial fibrosis and postoperative atrial fibrillation after cardiac surgery: A systematic review.","authors":"Abdul Nawaz, Amrinpreet Sohpal, Rishit Mitra, Yasir Abu-Omar, Abdelrahman Elsebaie, Mohammad El-Diasty","doi":"10.1016/j.tcm.2026.04.002","DOIUrl":"10.1016/j.tcm.2026.04.002","url":null,"abstract":"<p><p>Postoperative atrial fibrillation (POAF) is a common complication that can affect up to 20-44% of patients undergoing cardiac surgery. Evidence suggests that atrial fibrosis is a key factor in the development of POAF due to the disruption of the myocardial electric properties. This systematic review examines the correlation between pre-existing atrial fibrosis and the development of POAF after cardiac surgery. A systematic literature search was conducted in MEDLINE, Embase, and Google Scholar (2000 to March 2025) to identify studies that conducted comparative analysis of atrial fibrosis levels between those who did and did not develop POAF, using histological assessment methods. Extracted data, included study characteristics, histopathological staining methods and analysis findings, fibrosis quantification methods, and overall POAF incidence. Thirteen studies met the inclusion criteria, resulting in a total of 1222 patients, primarily undergoing coronary artery bypass surgery. The incidence of POAF ranged from 14%-42.4% (median 31.6%). In more than half of the studies (7/13), patients who developed POAF demonstrated statistically significant higher degrees of atrial fibrosis compared to those that remained in sinus rhythm postoperatively (four exhibited p < 0.001). Of the eight studies that conducted multivariate analyses, three identified atrial fibrosis as an independent POAF predictor. High heterogeneity precluded pooling of results into a meta-analysis. The current evidence examining the link between pre-existing atrial fibrosis and the development of POAF is restricted by methodological heterogeneity and inconsistent findings. Further efforts to standardize fibrosis quantification methods and POAF definitions are warranted before histopathological assessments can reliably inform POAF risk before cardiac surgery.</p>","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":" ","pages":""},"PeriodicalIF":9.0,"publicationDate":"2026-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147788528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Importance of the surgical myectomy option in the changing landscape of management for symptomatic obstructive hypertrophic cardiomyopathy. 手术切除肌瘤在症状性梗阻性肥厚性心肌病治疗方案变化中的重要性。

IF 9 2区医学

Trends in Cardiovascular Medicine Pub Date : 2026-04-08 DOI: 10.1016/j.tcm.2026.04.001

Barry J Maron, Martin S Maron

引用次数: 0

Editorial commentary: The emerging paradigm of occlusion Myocardial infarction in acute coronary syndromes 编辑评论：急性冠状动脉综合征中闭塞性心肌梗死的新模式。

IF 9 2区医学

Trends in Cardiovascular Medicine Pub Date : 2026-04-01 Epub Date: 2025-10-27 DOI: 10.1016/j.tcm.2025.10.009

Mohammed Ayyad

引用次数: 0

Mind–heart links in ASCVD: Evidence for chronic risk, acute triggers, and clinical prevention ASCVD的心脑联系：慢性风险、急性诱因和临床预防的证据。

IF 9 2区医学

Trends in Cardiovascular Medicine Pub Date : 2026-04-01 Epub Date: 2025-10-17 DOI: 10.1016/j.tcm.2025.10.004

Emmanuel Eroume A Egom

{"title":"Mind–heart links in ASCVD: Evidence for chronic risk, acute triggers, and clinical prevention","authors":"Emmanuel Eroume A Egom","doi":"10.1016/j.tcm.2025.10.004","DOIUrl":"10.1016/j.tcm.2025.10.004","url":null,"abstract":"<div><div>The background for this review includes negative emotions—including anger, sadness, and chronic stress—that are biologically active contributors to atherothrombosis but remain under-integrated in prevention. The objective is to synthesize epidemiologic, mechanistic, and interventional evidence linking emotional dysregulation to the pathogenesis and acute expression of ASCVD, and to contextualize effect sizes alongside traditional risk factors. The methods include a narrative review of large cohorts and case-crossover studies, neural and immunologic mechanisms (amygdala–bone marrow–arterial axis), and trials of β-blockers, SSRIs, cognitive behavioral therapy (CBT), mindfulness, and endothelial function responses to provoked emotions. We found that depressive symptoms and trait anger confer ∼30–50 % higher incident MI risk; intense anger outbursts transiently raise MI risk up to ∼8–9 ×, and bereavement up to ∼20 × within 24 h. Stress-evoked amygdalar activity predicts myelopoiesis, arterial inflammation, and events. Mechanisms include HPA axis activation, IL-6/NLRP3 signaling, eNOS uncoupling, and catecholamine-driven platelet activation. Interventions such as β-blockers, SSRIs, CBT, and mindfulness improve vascular/inflammatory markers and may reduce event susceptibility. We conclude that emotions are causal drivers of atherothrombosis and acute coronary events. Incorporating emotion metrics, inflammatory biomarkers, and targeted behavioral/pharmacologic strategies into preventive cardiology can close residual risk gaps.</div></div>","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":"36 3","pages":"Pages 169-177"},"PeriodicalIF":9.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145330929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial commentary: Multimodality imaging in valvular heart disease controversies: Seeing is believing 多模态成像在瓣膜性心脏病中的争议：眼见为实。

IF 9 2区医学

Trends in Cardiovascular Medicine Pub Date : 2026-04-01 Epub Date: 2025-10-17 DOI: 10.1016/j.tcm.2025.10.005

Kimberly Chow , Bo Xu

引用次数: 0

Editorial commentary: Unanswered questions for an age-old problem: Rethinking left ventricular thrombus management 编辑评论：一个古老问题的未解之谜：重新思考左室血栓的处理。

IF 9 2区医学

Trends in Cardiovascular Medicine Pub Date : 2026-04-01 Epub Date: 2025-10-07 DOI: 10.1016/j.tcm.2025.09.010

Aloysius Sheng-Ting Leow , Ching-Hui Sia

引用次数: 0