Trends in Cardiovascular Medicine最新文献

Impact of smoking from childhood associated with greater risk of cardiac damage. 儿童时期吸烟与心脏损伤风险增加有关。

IF 9 2区医学

Trends in Cardiovascular Medicine Pub Date : 2025-10-11 DOI: 10.1016/j.tcm.2025.10.002

Douglas R Corsi, Andrew O Agbaje

{"title":"Impact of smoking from childhood associated with greater risk of cardiac damage.","authors":"Douglas R Corsi, Andrew O Agbaje","doi":"10.1016/j.tcm.2025.10.002","DOIUrl":"https://doi.org/10.1016/j.tcm.2025.10.002","url":null,"abstract":"Active and passive tobacco exposure during childhood and adolescence represents a critical preventable risk factor for premature cardiovascular disease. Tobacco smoking in early life poses an elevated risk of endothelial dysfunction, vascular alteration, and irregular heart rhythm, which may lead to thrombosis. Smoking may temporarily raise cardiac output, enhance heart rate, augment cardiac contractility, and increase cardiac filling due to systemic venoconstriction. Emerging studies have shown that smoking is an independent driver of ventricular hypertrophy in the young population, as a crucial factor in cardiovascular risk progression. This narrative review provides up-to-date evidence regarding epidemiology, risk factors, and clinical implications of active and passive childhood tobacco exposure on a growing heart. Long-term prospective relationships between tobacco use and structural and functional heart alterations were discussed, and strategies to reduce smoking interest in the young population were also highlighted. Finally, this review re-engages interest in a sensational topic that cannot be wished away like a bad dream and recommends strategic actions to take to save the youth's heart.","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":" ","pages":""},"PeriodicalIF":9.0,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145287660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial commentary: Unanswered questions for an age-old problem: Rethinking left ventricular thrombus management. 编辑评论：一个古老问题的未解之谜：重新思考左室血栓的处理。

IF 9 2区医学

Trends in Cardiovascular Medicine Pub Date : 2025-10-06 DOI: 10.1016/j.tcm.2025.09.010

Aloysius Sheng-Ting Leow, Ching-Hui Sia

引用次数: 0

Managing implantable cardioverter-defibrillators at end-of-life: Towards peaceful and dignified death. 在生命末期管理植入式心律转复除颤器：走向和平而有尊严的死亡。

IF 9 2区医学

Trends in Cardiovascular Medicine Pub Date : 2025-09-30 DOI: 10.1016/j.tcm.2025.09.009

Richard Z Lin, Shaun Evans, Dennis H Lau

引用次数: 0

Dilated cardiomyopathy in primary aldosteronism: A state-of-the-art of mechanistic insights, therapeutic strategies, and future perspectives. 原发性醛固酮增多症的扩张性心肌病：最新的机制见解、治疗策略和未来展望。

IF 9 2区医学

Trends in Cardiovascular Medicine Pub Date : 2025-09-27 DOI: 10.1016/j.tcm.2025.09.008

Luigi Marzano, Francesca Zoccatelli, Simonetta Friso

{"title":"Dilated cardiomyopathy in primary aldosteronism: A state-of-the-art of mechanistic insights, therapeutic strategies, and future perspectives.","authors":"Luigi Marzano, Francesca Zoccatelli, Simonetta Friso","doi":"10.1016/j.tcm.2025.09.008","DOIUrl":"10.1016/j.tcm.2025.09.008","url":null,"abstract":"Dilated cardiomyopathy (DCM) is an underrecognized yet potentially reversible cardiac complication of primary aldosteronism (PA), the most prevalent cause of secondary hypertension. Beyond its well-established hypertensive and profibrotic effects, chronic aldosterone excess exerts direct myocardial toxicity, driving progressive left ventricular remodeling. This remodeling follows a characteristic trajectory, evolving from concentric remodeling to eccentric hypertrophy with diastolic dysfunction, and ultimately culminating in overt systolic impairment. Importantly, these pathological changes result from mechanisms extending beyond mere pressure overload, including mineralocorticoid receptor overactivation, inflammation, oxidative stress, and myocardial fibrosis. This state-of-the-art review integrates current epidemiological data, mechanistic insights, and therapeutic outcomes from both clinical and experimental studies on PA-related DCM. We critically assess the pathophysiological cascade linking aldosterone excess to adverse cardiac remodeling and evaluate the comparative impact of adrenalectomy and mineralocorticoid receptor antagonists on myocardial recovery. Special emphasis is placed on diagnostic challenges, clinical implications, and the importance of early recognition. By consolidating available evidence and highlighting key knowledge gaps, this review aims to inform clinical decision-making and stimulate future research in the emerging field of endocrine cardiomyopathy.","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":" ","pages":""},"PeriodicalIF":9.0,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plaque erosion: Defining the biology and future of therapy. 斑块侵蚀：定义生物学和治疗的未来。

IF 9 2区医学

Trends in Cardiovascular Medicine Pub Date : 2025-09-19 DOI: 10.1016/j.tcm.2025.09.007

Tomoyo Hamana, Alyssa Grogan, Atsushi Sakamoto, Aloke V Finn

引用次数: 0

Current insights and challenges in the management of left ventricular thrombus. 当前左室血栓治疗的见解和挑战。

IF 9 2区医学

Trends in Cardiovascular Medicine Pub Date : 2025-09-15 DOI: 10.1016/j.tcm.2025.09.006

Christos S Katsouras, Xenofon M Sakellariou, Aris Bechlioulis, Lampros Lakkas, Panagiotis Korantzopoulos, Qin-Fen Chen, Xiao-Dong Zhou

{"title":"Current insights and challenges in the management of left ventricular thrombus.","authors":"Christos S Katsouras, Xenofon M Sakellariou, Aris Bechlioulis, Lampros Lakkas, Panagiotis Korantzopoulos, Qin-Fen Chen, Xiao-Dong Zhou","doi":"10.1016/j.tcm.2025.09.006","DOIUrl":"10.1016/j.tcm.2025.09.006","url":null,"abstract":"Left ventricular thrombus is a relatively common and serious complication in patients with left ventricular systolic dysfunction, resulting in an increased risk of embolic events such as ischemic stroke and contributing to higher mortality rates. Current clinical guidelines recommend anticoagulation therapy for 3 to 6 months in patients with left ventricular thrombus; however, the evidence supporting this approach primarily derives from small-scale randomized trials or retrospective observation studies, which limit the generalizability of findings across diverse patient populations. Several critical aspects of left ventricular thrombus identification and management remain inadequately studied, and these areas include optimal time and detection imaging methods, anticoagulation strategies (treatment of choice and optimal duration), and the need for periodic re-evaluation. This review consolidates the current evidence, identifies gaps in left ventricular thrombus management, and proposes individualized strategies that consider factors like left ventricular function and bleeding risks.","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":" ","pages":""},"PeriodicalIF":9.0,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The implantable cardioverter-defibrillators at the end of life: a double-edged sword of a life-saving technology. 生命末期植入式心律转复除颤器：一种救命技术的双刃剑。

IF 9 2区医学

Trends in Cardiovascular Medicine Pub Date : 2025-09-12 DOI: 10.1016/j.tcm.2025.09.005

Giacomo Mugnai, Davide Genovese, Luca Tomasi, Alessia Gambaro, Flavio Ribichini

引用次数: 0

Pathogenesis of plaque erosion. 斑块侵蚀的发病机制。

IF 9 2区医学

Trends in Cardiovascular Medicine Pub Date : 2025-09-09 DOI: 10.1016/j.tcm.2025.09.004

Dario F Riascos-Bernal, Gabriel Quinones, Shadi A Abdelaal, Mark A Menegus, Nicholas E S Sibinga

{"title":"Pathogenesis of plaque erosion.","authors":"Dario F Riascos-Bernal, Gabriel Quinones, Shadi A Abdelaal, Mark A Menegus, Nicholas E S Sibinga","doi":"10.1016/j.tcm.2025.09.004","DOIUrl":"10.1016/j.tcm.2025.09.004","url":null,"abstract":"Plaque erosion is the second most common cause of acute coronary syndromes. It occurs in the absence of fibrous cap rupture, and typically shows luminal thrombi in direct contact with an intimal surface that lacks endothelial cells (ECs) but is enriched in smooth muscle cells and proteoglycan matrix. First described almost thirty years ago, plaque erosion accounts for an increasing fraction of acute coronary syndromes, but its frequency decreases with age in both men and women. Although a higher prevalence of erosion in women was suggested based on early observations, this has not been clearly borne out in more recent studies. The pathogenesis of plaque erosion is largely unknown; nevertheless, potential etiologic factors include disturbed flow and altered endothelial shear stress, elements of the innate and adaptive immune systems, hyaluronan and Toll-like receptor 2 signaling, activation of the NRF2 transcription factor, matrix metallopeptidase-mediated disruption of EC-extracellular matrix interactions, and distinct thrombotic mechanisms. While several of these factors are also linked to plaque rupture, existing evidence suggests that the biology of plaque erosion is substantially different from that of rupture; therefore, a deeper understanding of the molecular basis of coronary thrombosis associated with plaque erosion may guide the development of biomarkers and specific preventive or therapeutic strategies for acute coronary syndromes with intact fibrous cap. Such progress would pave the way for personalized care of these patients.","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":" ","pages":""},"PeriodicalIF":9.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial: Artificial intelligence in cardio-obstetrics - A technological leap toward safer pregnancies. 社论：心脏产科的人工智能——迈向更安全怀孕的技术飞跃。

IF 9 2区医学

Trends in Cardiovascular Medicine Pub Date : 2025-09-07 DOI: 10.1016/j.tcm.2025.09.003

Melissa Spiel

引用次数: 0

The role of artificial intelligence in cardio-obstetrics - current applications and future directions. 人工智能在心脏产科中的作用-当前应用和未来方向。

IF 9 2区医学

Trends in Cardiovascular Medicine Pub Date : 2025-09-06 DOI: 10.1016/j.tcm.2025.09.002

Gurleen Wander, Thomas M Hopkins, Andrew Scatola, Guthrie Ruby, Mark R Johnson, Shilpi Mehta-Lee, Benjamin S Glicksberg, Chayakrit Krittanawong

引用次数: 0