Trends in Cardiovascular Medicine最新文献

{"title":"Coronary artery calcification: Contemporary diagnosis from invasive imaging to percutaneous treatment.","authors":"Kevin Mohee, Eirinaios Tsiartas, Jason Sangha, Michael Roberts, Martin Bennett","doi":"10.1016/j.tcm.2026.08.010","DOIUrl":"10.1016/j.tcm.2026.08.010","url":null,"abstract":"<p><p>Coronary artery calcification (CAC) represents a significant challenge in contemporary interventional cardiology, substantially affecting percutaneous coronary intervention (PCI) outcomes. Understanding the distinct morphological patterns of calcium deposition, from microcalcification to macrocalcific nodules, including eruptive and non-eruptive lesions, is crucial for optimizing procedural planning and improving clinical outcomes. Recent advances in artificial intelligence-assisted imaging interpretation and novel calcium modification techniques have expanded our therapeutic armamentarium. This review examines the pathophysiological mechanisms underlying CAC, epidemiological patterns, contemporary diagnostic approaches with emphasis on invasive imaging modalities, and current percutaneous treatment strategies. We provide an evidence-based framework for managing calcified coronary lesions in modern interventional practice.</p>","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":" ","pages":""},"PeriodicalIF":8.6,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial commentary: Artificial intelligence in cardiovascular imaging: will we still need the human touch?","authors":"Gabriele Fragasso","doi":"10.1016/j.tcm.2026.08.009","DOIUrl":"10.1016/j.tcm.2026.08.009","url":null,"abstract":"","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":" ","pages":""},"PeriodicalIF":8.6,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond technical success: confronting persistent racial and ethnic disparities in percutaneous coronary intervention care.","authors":"Revathy Sampath-Kumar, Ehtisham Mahmud","doi":"10.1016/j.tcm.2026.08.008","DOIUrl":"10.1016/j.tcm.2026.08.008","url":null,"abstract":"","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":" ","pages":""},"PeriodicalIF":8.6,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wearable detection of atrial fibrillation: Absence of evidence or evidence for adoption?","authors":"Timothy Nathan Kwan, Saurabh Kumar","doi":"10.1016/j.tcm.2026.08.007","DOIUrl":"10.1016/j.tcm.2026.08.007","url":null,"abstract":"","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":" ","pages":""},"PeriodicalIF":8.6,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stereotactic body radiotherapy for cardiac arrhythmias: Current evidence and clinical boundaries.","authors":"Hansheng Li, Hao Ju, Manqi Yang, Shuijing He, Saeed Kashkooli, Gang Wu","doi":"10.1016/j.tcm.2026.08.006","DOIUrl":"10.1016/j.tcm.2026.08.006","url":null,"abstract":"<p><p>Stereotactic arrhythmia radioablation (STAR), also known as cardiac stereotactic body radiotherapy, is an emerging noninvasive strategy for arrhythmia substrate modification. It translates electrophysiological and anatomic information into a radiotherapy target, but it should not be treated as catheter ablation delivered from outside the body. Its biology remains unsettled: early electrical reprogramming may precede delayed fibrosis, dose-response relationships are poorly defined, and atrial and ventricular substrates may not respond in the same way. The most developed clinical experience is in refractory ventricular tachycardia (VT), where prospective studies and pooled analyses show large reductions in VT burden and implantable cardioverter-defibrillator therapies, although recurrence, competing mortality, and delayed toxicity keep VT-STAR in a salvage role. Atrial fibrillation (AF) remains experimental. Preclinical studies support radiation-induced atrial lesion formation, and small human series demonstrate that AF-STAR can be technically delivered in selected elderly patients with paroxysmal AF; however, these findings do not establish durable rhythm control or clinical suitability. In particular, the current 25-Gy regimen cannot be assumed safe for the thin left atrial posterior wall or other large atrial targets, whereas substantially lower doses may not achieve durable electrical isolation, leaving no validated therapeutic window. AF-STAR therefore still lacks acute verification of isolation, reproducible target standards, disease-specific dosing, and mature esophageal and coronary safety data. This review follows STAR from mechanistic uncertainty through the VT evidence to the experimental AF field, emphasizing disease-specific target design, motion-aware planning, and long-term safety surveillance.</p>","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":" ","pages":""},"PeriodicalIF":8.6,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148726183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence in cardiovascular imaging and risk stratification: From algorithmic discovery to meaningful clinical implication.","authors":"Xu Xia, Wasim Ullah Khan, Qaisar Khan, Chen Zhong, Muhammad Shehzad Khan","doi":"10.1016/j.tcm.2026.08.005","DOIUrl":"10.1016/j.tcm.2026.08.005","url":null,"abstract":"<p><p>Cardiovascular disease (CVD) remains the leading global cause of mortality, with timely diagnosis and precise risk stratification serving as cornerstones of effective management. Traditional cardiovascular imaging and risk assessment have long been constrained by operator-dependent interpretation, time-intensive manual quantification, and a reliance on static, population-derived diagnostic thresholds. The rapid maturation of artificial intelligence (AI), particularly deep learning (DL), foundation models (FMs), and multimodal integration (MI), has catalyzed a paradigm shift toward automated, quantitative, and patient-specific cardiovascular evaluation. Between 2023 and 2026, AI-driven tools have progressed from retrospective proof-of-concept studies to early prospective clinical validations across echocardiography (EchoCG), cardiac magnetic resonance (CMR), coronary computed tomography angiography (CCTA), and nuclear imaging. Concurrently, AI-enhanced electrocardiography (ECG) and polygenic risk integration have enabled dynamic, longitudinal risk prediction models that outperform conventional scores. Despite these advances, clinical adoption faces substantial hurdles including algorithmic bias, limited generalizability across diverse populations, regulatory fragmentation, workflow integration challenges, and unresolved questions regarding clinical utility and cost-effectiveness. This review critically examines the technological evolution of AI in cardiovascular imaging, evaluates modality-specific applications and emerging digital biomarkers, appraises regulatory and implementation landscapes, and outlines priority research directions. We emphasize that successful integration of AI into cardiovascular care requires rigorous prospective validation, transparent algorithmic governance, equitable data representation, and human-AI collaborative frameworks. As cardiovascular medicine enters the era of precision diagnostics, AI will increasingly serve as a powerful augmentative partner in imaging interpretation, risk stratification, and therapeutic decision-making, provided its meaningful clinical implication is demonstrated through improved patient outcomes.</p>","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":" ","pages":""},"PeriodicalIF":8.6,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148714479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From risk prediction to risk-guided prevention: Why CIED infection prevention is needed.","authors":"Benito Jonas Baldauf","doi":"10.1016/j.tcm.2026.08.004","DOIUrl":"10.1016/j.tcm.2026.08.004","url":null,"abstract":"","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":" ","pages":""},"PeriodicalIF":8.6,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148708486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac implantable electronic device infections: Emerging paradigms in precision prevention and personalized management.","authors":"Antoine Da Costa, Pierre Groussin, Alberto Barengo, Cedric Yvorel, Rayan Mohammed, Cécile Romeyer, Marouane Boukhris, Karim Benali","doi":"10.1016/j.tcm.2026.08.002","DOIUrl":"https://doi.org/10.1016/j.tcm.2026.08.002","url":null,"abstract":"<p><p>Cardiac implantable electronic device (CIED) infections remain a major source of morbidity, mortality, and healthcare expenditure despite continuing advances in device technology. Increasing procedural complexity, repeat interventions, and an aging population with multiple comorbidities have shifted the focus from treatment alone toward comprehensive infection prevention. Biofilm formation is now recognized as the central pathogenic mechanism underlying CIED infection, explaining both the limited efficacy of antimicrobial therapy in the presence of retained hardware and the need for complete system extraction in established infection. This narrative review summarizes contemporary evidence supporting a multimodal approach to CIED infection prevention and personalized management. Prevention extends beyond perioperative antibiotic prophylaxis and skin antisepsis to encompass structured patient optimization, procedural contamination control, hematoma prevention, targeted Staphylococcus aureus decolonization, antibacterial envelopes, taurolidine-based pocket antisepsis, emerging antibiofilm technologies, and novel device platforms such as leadless pacemakers and extravascular implantable cardioverter-defibrillators. Risk stratification using PADIT, BLISTER, and complementary prediction models enables individualized allocation of preventive interventions according to estimated infection risk rather than uniform prophylaxis. Advances in diagnosis now combine multimodality imaging with biofilm-oriented microbiology, including device sonication, molecular diagnostics, and metagenomic sequencing, supporting pathogen-directed antimicrobial therapy and individualized clinical decision-making. Contemporary management likewise requires multidisciplinary expertise integrating extraction-risk assessment, complete hardware removal when indicated, optimized antimicrobial stewardship, and carefully planned reimplantation strategies. Rather than using the term precision medicine in its traditional genomic sense, this review emphasizes precision prevention and personalized management, whereby preventive and therapeutic interventions are tailored to each patient's quantified infection risk by integrating procedural, microbiological, host-related, and biofilm-associated determinants. Future improvements in clinical outcomes will depend on implementing integrated, risk-guided prevention strategies supported by multidisciplinary expert teams and emerging diagnostic and preventive technologies.</p>","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":" ","pages":""},"PeriodicalIF":8.6,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148698398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smartwatch and wearable detection of atrial fibrillation: Current evidence and clinical implications.","authors":"Mark Davies, Heerajnarain Bulluck, Muzahir H Tayebjee","doi":"10.1016/j.tcm.2026.08.003","DOIUrl":"10.1016/j.tcm.2026.08.003","url":null,"abstract":"<p><p>Consumer wearables have made atrial fibrillation (AF) detectable at population scale. Since 2019, smartwatch and smartphone studies enrolling thousands of participants have shown that photoplethysmography-based algorithms reliably generate AF notifications in real-world use, and that such a notification carries a high positive predictive value when benchmarked against a gold-standard electrocardiogram patch. This review follows the evidence along the clinical chain, from detection through notification and confirmation of diagnosis to treatment and outcome, and the strength of that evidence diminishes at each link. Population-scale studies established feasibility but did not measure sensitivity. Diagnostic accuracy is heterogeneous and conditional: it depends on the reference standard, the degree of supervision, the population studied, and the handling of inconclusive recordings. Randomised trials show that wearable-enabled pathways can accelerate diagnosis, a process outcome; yet none has shown that wearable-detected AF screening reduces stroke, systemic embolism or death. The treatment evidence that would justify acting on a detected arrhythmia comes from implanted-device populations, not consumer-wearable cohorts, and shows that anticoagulating device-detected AF trades a reduction in ischaemic stroke against an increase in major bleeding. Implementation raises further unresolved problems: confirmation-pathway heterogeneity, workflow burden, adherence, equity and overdiagnosis. Consumer wearables can detect AF at population scale, yet whether this improves hard clinical outcomes remains unresolved. Ongoing randomised trials must answer this critical question.</p>","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":" ","pages":""},"PeriodicalIF":8.6,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148702609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrocardiographic abnormalities secondary to acute central nervous system injury.","authors":"Nicolas Johner, Ravi Vazirani, Carla Amarante-Cuadrado, Marc Arcens, Mehdi Namdar, Dipen C Shah","doi":"10.1016/j.tcm.2026.08.001","DOIUrl":"10.1016/j.tcm.2026.08.001","url":null,"abstract":"<p><p>Most patients with acute central nervous system (CNS) lesions, including acute ischemic stroke, intracranial bleeding, traumatic brain or spinal cord injury, exhibit electrocardiographic (ECG) abnormalities. These are generally transient and considered secondary to the neurological condition. The most common neurogenic ECG alterations include ST-segment elevation or depression, T wave inversion, prominent U wave, prolonged QTc interval, sinus bradycardia and atrioventricular block. The primary mechanism involves autonomic nervous system alterations due to damage to the central autonomic network, causing regional changes in myocardial action potential duration, altered ventricular repolarization gradients, altered automaticity, or altered atrioventricular node conduction. These may promote arrhythmias including atrial fibrillation and ventricular arrhythmias. Sympathetic hyperactivation may additionally induce non-ischemic acute myocardial injury characterized by contraction band necrosis. The functional neuroanatomy of the central autonomic network determines the diverse cardiac manifestations observed with distinct CNS injuries. Insular cortex lesions typically result in sympathetic hyperactivation, whereas brain stem or spinal cord lesions above T6 can cause autonomic failure with reduced sympathetic tone and altered autonomic reflexes. While most patients exhibit asymptomatic ECG abnormalities, initial clinical evaluation should identify underlying cardiac conditions such as Takotsubo cardiomyopathy, myocardial infarction, or pre-existing chronic coronary syndromes. Serial ECG, cardiac biomarkers and echocardiography are key. Additional targeted work-up may be useful in selected patients. The implications of distinct ECG findings for neurological and cardiovascular prognosis should also be considered.</p>","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":" ","pages":""},"PeriodicalIF":8.6,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148702578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}