Xander Jacquemyn , Jef Van den Eynde , Quinten Iwens , Janne Billiau , Habib Jabagi , Derek Serna-Gallegos , Danny Chu , Ibrahim Sultan , Michel Pompeu Sá
{"title":"Transcatheter aortic valve implantation versus surgical aortic valve replacement in chronic kidney disease: Meta-analysis of reconstructed time-to-event data","authors":"Xander Jacquemyn , Jef Van den Eynde , Quinten Iwens , Janne Billiau , Habib Jabagi , Derek Serna-Gallegos , Danny Chu , Ibrahim Sultan , Michel Pompeu Sá","doi":"10.1016/j.tcm.2023.04.006","DOIUrl":"10.1016/j.tcm.2023.04.006","url":null,"abstract":"<div><h3>Background</h3><p><span>Patients with advanced chronic kidney disease (CKD) are a challenging and understudied population. Specifically, the late outcomes following surgical </span>aortic valve replacement<span> (SAVR) or transcatheter aortic valve implantation<span> (TAVI) in patients with CKD remains uncertain.</span></span></p></div><div><h3>Objectives</h3><p>To compare overall mortality risk in patients with moderate-to-severe CKD following TAVI versus SAVR.</p></div><div><h3>Methods</h3><p>Study-level meta-analysis of reconstructed time-to-event data from Kaplan-Meier curves of studies published by August 2022.</p></div><div><h3>Results</h3><p>Nine studies met our inclusion criteria. Patients who underwent TAVI had a higher 5-year mortality compared with patients undergoing SAVR in the overall population (HR 1.56, 95% CI 1.44–1.69, <em>P</em> < 0.001) and in populations with similar risk scores (HR 1.15, 95% CI 1.01–1.31, <em>P</em> = 0.035). The landmark analysis revealed a lower risk of 30-day mortality with TAVI (HR 0.62, 95% CI 0.41–0.94, <em>P</em> = 0.023), followed by similar risk until 7.5 months (HR 1, 95% CI 0.78–1.27, <em>P</em> = 0.978). In contrast, the landmark analysis beyond 7.5 months yielded a reversal of the HR in favor of SAVR (TAVI with HR 1.27, 95% CI 1.08–1.49 <em>P</em> = 0.003).</p></div><div><h3>Conclusions</h3><p>In patients with CKD, TAVI provides an initial survival benefit over SAVR. However, in the long run, a significant survival benefit of SAVR over TAVI was observed. Our findings highlight the need for randomized controlled trials to investigate outcomes in this special population.</p></div>","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":"34 5","pages":"Pages 317-324"},"PeriodicalIF":7.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9577567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Editorial commentary: The mundane and the profound of QT prolongation in the opioid abuse crisis","authors":"J. Kevin Donahue","doi":"10.1016/j.tcm.2023.06.001","DOIUrl":"10.1016/j.tcm.2023.06.001","url":null,"abstract":"","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":"34 5","pages":"Pages 286-287"},"PeriodicalIF":7.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9941334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jairo Aldana-Bitar , Deepak L. Bhatt , Matthew J. Budoff
{"title":"Regression and stabilization of atherogenic plaques","authors":"Jairo Aldana-Bitar , Deepak L. Bhatt , Matthew J. Budoff","doi":"10.1016/j.tcm.2023.07.002","DOIUrl":"10.1016/j.tcm.2023.07.002","url":null,"abstract":"<div><p>Atherosclerotic plaque assessment has become a crucial element in the examination of cardiovascular diseases. Plaque may exhibit progression and could become unstable if not treated, making plaque regression and stabilization among the most important goals of any cardiovascular intervention in cardiovascular medicine. In this review, we explore the current understanding of plaque regression and stabilization, discuss imaging and measurement techniques, and examine the evidence for pharmacological interventions and other interventions aimed at addressing this condition.</p></div>","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":"34 5","pages":"Pages 340-346"},"PeriodicalIF":7.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10301298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Editorial commentary: Rhythm control in atrial fibrillation: How the early bird may get the worm","authors":"Alexander Turin , Eugene H Chung","doi":"10.1016/j.tcm.2023.04.002","DOIUrl":"10.1016/j.tcm.2023.04.002","url":null,"abstract":"","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":"34 5","pages":"Pages 295-296"},"PeriodicalIF":7.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9441536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Editorial commentary: Understanding the pathology of plaque progression and regression","authors":"Arielle Bellissard , Aloke V. Finn , Renu Virmani","doi":"10.1016/j.tcm.2023.09.004","DOIUrl":"10.1016/j.tcm.2023.09.004","url":null,"abstract":"","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":"34 5","pages":"Pages 347-349"},"PeriodicalIF":7.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41171830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ju Young Bae , Arzhang Fallahi , Wayne Miller , Martin B. Leon , Theodore P. Abraham , Sripal Bangalore , David H. Hsi
{"title":"A call to consider an aortic stenosis screening program","authors":"Ju Young Bae , Arzhang Fallahi , Wayne Miller , Martin B. Leon , Theodore P. Abraham , Sripal Bangalore , David H. Hsi","doi":"10.1016/j.tcm.2023.04.003","DOIUrl":"10.1016/j.tcm.2023.04.003","url":null,"abstract":"<div><p>Aortic stenosis<span><span><span> (AS) is the most common age-related valvular condition with a prevalence of 13.1% in patients older than 75 years of age. Based on the severity of AS and </span>symptoms, current guidelines recommend interval monitoring with transthoracic </span>echocardiogram<span><span> (TTE). However, no guidelines exist regarding screening asymptomatic persons for AS. Prevalence of AS is comparable to conditions such as colorectal cancer, lung cancer, breast cancer, and abdominal aortic aneurysm where dedicated screening programs are offered resulting in reduction of overall morbidity and mortality. We review recent advancements in </span>treatment options, and we propose an AS screening program for high-risk individuals without known history of AS including all persons over age 75 and persons aged 70 years and older with dialysis dependent end-stage renal disease (ESRD).</span></span></p></div>","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":"34 5","pages":"Pages 297-301"},"PeriodicalIF":7.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9361811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Editorial commentary: Clinical translation of vagus nerve stimulation in cardiovascular diseases: How bright is the light at the end of the tunnel?","authors":"Richard L. Verrier","doi":"10.1016/j.tcm.2023.07.006","DOIUrl":"10.1016/j.tcm.2023.07.006","url":null,"abstract":"","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":"34 5","pages":"Pages 338-339"},"PeriodicalIF":7.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10021360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}