{"title":"Editorial commentary: Highlighting important (selected) issues in hypertension therapeutics","authors":"","doi":"10.1016/j.tcm.2023.12.001","DOIUrl":"10.1016/j.tcm.2023.12.001","url":null,"abstract":"","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":"34 6","pages":"Pages 421-422"},"PeriodicalIF":7.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138575923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gender and race-related disparities in the management of ventricular arrhythmias","authors":"","doi":"10.1016/j.tcm.2023.10.001","DOIUrl":"10.1016/j.tcm.2023.10.001","url":null,"abstract":"<div><p>Modern studies have revealed gender and race-related disparities in the management and outcomes of cardiac arrhythmias<span><span><span>, but few studies have focused on outcomes for ventricular arrhythmias (VAs) such as </span>ventricular tachycardia<span><span> (VT) or ventricular fibrillation<span> (VF). The aim of this article is to review relevant studies and identify outcome differences in the management of VA among Black and female patients. We found that female patients typically present younger for VA, are more likely to have recurrent VA after catheter ablation, are less likely to be prescribed </span></span>antiarrhythmic medication, and are less likely to receive primary prevention </span></span>ICD<span> placement as compared to male patients. Additionally, female patients appear to derive similar overall mortality benefit from primary prevention ICD placement as compared to male patients, but they may have an increased risk of acute post-procedural complications. We also found that Black patients presenting with VA are less likely to undergo catheter ablation, receive appropriate primary prevention ICD placement, and have significantly higher risk-adjusted 1-year mortality rates after hospital discharge as compared to White patients. Black female patients appear to have the worst outcomes out of any demographic subgroup.</span></span></p></div>","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":"34 6","pages":"Pages 381-386"},"PeriodicalIF":7.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41219631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Editorial commentary: Revisiting time-restricted-eating interventions for cardiometabolic risk reduction: Do they have a clinically relevant role?","authors":"","doi":"10.1016/j.tcm.2023.12.004","DOIUrl":"10.1016/j.tcm.2023.12.004","url":null,"abstract":"","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":"34 6","pages":"Pages 402-403"},"PeriodicalIF":7.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138824827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Percutaneous suture-based patent foramen ovale closure: A state-of-the-art review","authors":"","doi":"10.1016/j.tcm.2023.10.004","DOIUrl":"10.1016/j.tcm.2023.10.004","url":null,"abstract":"<div><p><span>Percutaneous closure of a patent foramen ovale (PFO), a common variation of </span>interatrial septum<span><span> anatomy, is a commonly performed procedure in the </span>catheterization laboratory to reduce the risk of recurrent stroke in selected patients and to treat other PFO-related syndromes. In the last twenty years, disc-based devices have represented the armamentarium of the interventional cardiologist; recently, suture-based devices have become an attractive alternative, despite limited data regarding their long-term performance. The present review gives an overview of the current evidence regarding suture-based PFO closure, the device's characteristics, the echocardiographic evaluation of the PFO anatomy, and recommendations for patient selection. A detailed procedural guide is then provided, and potential complications and future developments in the field are discussed.</span></p></div>","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":"34 6","pages":"Pages 404-413"},"PeriodicalIF":7.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71488654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Editorial commentary: Screening for aortic stenosis in at risk older patients – A new paradigm in valvular heart disease care?","authors":"Onyedika J. Ilonze","doi":"10.1016/j.tcm.2023.04.005","DOIUrl":"10.1016/j.tcm.2023.04.005","url":null,"abstract":"","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":"34 5","pages":"Pages 302-303"},"PeriodicalIF":7.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9468895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jimmy JH. Kang , Nicholas M. Fialka , Ryaan EL-Andari , Abeline Watkins , Yongzhe Hong , Anoop Mathew , Sabin J. Bozso , Jeevan Nagendran
{"title":"Surgical vs transcatheter aortic valve replacement in bicuspid aortic valve stenosis: A systematic review and meta-analysis","authors":"Jimmy JH. Kang , Nicholas M. Fialka , Ryaan EL-Andari , Abeline Watkins , Yongzhe Hong , Anoop Mathew , Sabin J. Bozso , Jeevan Nagendran","doi":"10.1016/j.tcm.2023.04.004","DOIUrl":"10.1016/j.tcm.2023.04.004","url":null,"abstract":"<div><p><span>This systematic review<span><span> and meta-analysis aim to provide a comprehensive analysis of the literature directly comparing the outcomes of surgical aortic valve replacement<span> (SAVR) and TAVR </span></span>in patients<span> with BAV stenosis. Medline, PubMed, and Scopus were systematically searched for articles published between 2000 and 2023, 1862 studies were screened, and 6 retrospective studies met the inclusion criteria. We included 6550 patients in the final analyses: 3,292 and 3,258 in the SAVR and TAVR groups, respectively. Both groups have similar rates of in-hospital mortality (odds ratio (OR) 1.11; 95% CI 0.59–2.10; </span></span></span><em>p</em> = 0.75) and stroke (OR 1.25; 95% CI 0.85–1.86; <em>p</em><span> = 0.26. Patients who underwent SAVR experienced lower rates of permanent pacemaker implantation (OR 0.54; 95% CI 0.35–0.83; </span><em>p</em><span> = 0.005) and paravalvular leak (OR 0.47; 95% CI 0.26–0.86; </span><em>p</em><span> = 0.02). On the other hand, patients who underwent TAVR displayed lower rates of acute kidney injury (OR 1.81; 95% CI 1.15–2.84; </span><em>p</em> = 0.010), major bleeding (OR 3.76; 95% CI 2.18–6.49; <em>p</em> < 0.00001), and pulmonary complications (OR 7.68; 95% CI 1.21–48.84; <em>p</em><span> = 0.03). Despite the early mortality data suggesting that TAVR may be a reasonable strategy for patients with bicuspid AS with low to intermediate surgical risk, the increased risk of PPI and PVL is concerning. A prospective, randomized, controlled trial reporting long-term outcomes with pre-defined subgroup analyses based on BAV morphology is paramount. In the interim, caution should be exercised in the widespread adoption of TAVR in lower surgical-risk patients.</span></p></div>","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":"34 5","pages":"Pages 304-313"},"PeriodicalIF":7.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9896410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xander Jacquemyn , Jef Van den Eynde , Quinten Iwens , Janne Billiau , Habib Jabagi , Derek Serna-Gallegos , Danny Chu , Ibrahim Sultan , Michel Pompeu Sá
{"title":"Transcatheter aortic valve implantation versus surgical aortic valve replacement in chronic kidney disease: Meta-analysis of reconstructed time-to-event data","authors":"Xander Jacquemyn , Jef Van den Eynde , Quinten Iwens , Janne Billiau , Habib Jabagi , Derek Serna-Gallegos , Danny Chu , Ibrahim Sultan , Michel Pompeu Sá","doi":"10.1016/j.tcm.2023.04.006","DOIUrl":"10.1016/j.tcm.2023.04.006","url":null,"abstract":"<div><h3>Background</h3><p><span>Patients with advanced chronic kidney disease (CKD) are a challenging and understudied population. Specifically, the late outcomes following surgical </span>aortic valve replacement<span> (SAVR) or transcatheter aortic valve implantation<span> (TAVI) in patients with CKD remains uncertain.</span></span></p></div><div><h3>Objectives</h3><p>To compare overall mortality risk in patients with moderate-to-severe CKD following TAVI versus SAVR.</p></div><div><h3>Methods</h3><p>Study-level meta-analysis of reconstructed time-to-event data from Kaplan-Meier curves of studies published by August 2022.</p></div><div><h3>Results</h3><p>Nine studies met our inclusion criteria. Patients who underwent TAVI had a higher 5-year mortality compared with patients undergoing SAVR in the overall population (HR 1.56, 95% CI 1.44–1.69, <em>P</em> < 0.001) and in populations with similar risk scores (HR 1.15, 95% CI 1.01–1.31, <em>P</em> = 0.035). The landmark analysis revealed a lower risk of 30-day mortality with TAVI (HR 0.62, 95% CI 0.41–0.94, <em>P</em> = 0.023), followed by similar risk until 7.5 months (HR 1, 95% CI 0.78–1.27, <em>P</em> = 0.978). In contrast, the landmark analysis beyond 7.5 months yielded a reversal of the HR in favor of SAVR (TAVI with HR 1.27, 95% CI 1.08–1.49 <em>P</em> = 0.003).</p></div><div><h3>Conclusions</h3><p>In patients with CKD, TAVI provides an initial survival benefit over SAVR. However, in the long run, a significant survival benefit of SAVR over TAVI was observed. Our findings highlight the need for randomized controlled trials to investigate outcomes in this special population.</p></div>","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":"34 5","pages":"Pages 317-324"},"PeriodicalIF":7.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9577567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}