Trends in Cardiovascular Medicine最新文献_第9页

Editorial commentary: The mundane and the profound of QT prolongation in the opioid abuse crisis 社论评论：阿片类药物滥用危机中QT延长的平凡与深刻

IF 7.3 2区医学

Trends in Cardiovascular Medicine Pub Date : 2024-07-01 DOI: 10.1016/j.tcm.2023.06.001

J. Kevin Donahue

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Regression and stabilization of atherogenic plaques 致动脉粥样硬化斑块的消退和稳定

IF 7.3 2区医学

Trends in Cardiovascular Medicine Pub Date : 2024-07-01 DOI: 10.1016/j.tcm.2023.07.002

Jairo Aldana-Bitar , Deepak L. Bhatt , Matthew J. Budoff

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Editorial commentary: Transcatheter aortic valve implantation in bicuspid aortic valve stenosis 编辑评论：双尖瓣主动脉瓣狭窄的经导管主动脉瓣植入术

IF 7.3 2区医学

Trends in Cardiovascular Medicine Pub Date : 2024-07-01 DOI: 10.1016/j.tcm.2023.05.001

Michel Pompeu Sá , Xander Jacquemyn , Ibrahim Sultan

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Editorial commentary: Rhythm control in atrial fibrillation: How the early bird may get the worm 编辑评论：心房颤动的节律控制：早起的鸟儿有虫吃

IF 7.3 2区医学

Trends in Cardiovascular Medicine Pub Date : 2024-07-01 DOI: 10.1016/j.tcm.2023.04.002

Alexander Turin , Eugene H Chung

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Editorial commentary: Understanding the pathology of plaque progression and regression 了解斑块进展和消退的病理学。

IF 7.3 2区医学

Trends in Cardiovascular Medicine Pub Date : 2024-07-01 DOI: 10.1016/j.tcm.2023.09.004

Arielle Bellissard , Aloke V. Finn , Renu Virmani

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A call to consider an aortic stenosis screening program 呼吁考虑主动脉瓣狭窄筛查计划

IF 7.3 2区医学

Trends in Cardiovascular Medicine Pub Date : 2024-07-01 DOI: 10.1016/j.tcm.2023.04.003

Ju Young Bae , Arzhang Fallahi , Wayne Miller , Martin B. Leon , Theodore P. Abraham , Sripal Bangalore , David H. Hsi

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Editorial commentary: Clinical translation of vagus nerve stimulation in cardiovascular diseases: How bright is the light at the end of the tunnel? 编辑评论：迷走神经刺激在心血管疾病中的临床应用：隧道尽头的曙光有多亮？

IF 7.3 2区医学

Trends in Cardiovascular Medicine Pub Date : 2024-07-01 DOI: 10.1016/j.tcm.2023.07.006

Richard L. Verrier

引用次数: 0

Vagus nerve stimulation for cardiovascular diseases: Is there light at the end of the tunnel? 迷走神经刺激治疗心血管疾病：隧道尽头是否有曙光？

IF 7.3 2区医学

Trends in Cardiovascular Medicine Pub Date : 2024-07-01 DOI: 10.1016/j.tcm.2023.07.003

Stefanos Zafeiropoulos , Umair Ahmed , Alexia Bikou , Ibrahim T. Mughrabi , Stavros Stavrakis , Stavros Zanos

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Opioids-induced inhibition of HERG ion channels and sudden cardiac death, a systematic review of current literature 阿片类药物诱导的 HERG 离子通道抑制与心脏性猝死，当前文献的系统回顾

IF 7.3 2区医学

Trends in Cardiovascular Medicine Pub Date : 2024-07-01 DOI: 10.1016/j.tcm.2023.03.006

Adham El Sherbini , Kiera Liblik , Junsu Lee , Adrian Baranchuk , Shetuan Zhang , Mohammad El-Diasty

{"title":"Opioids-induced inhibition of HERG ion channels and sudden cardiac death, a systematic review of current literature","authors":"Adham El Sherbini , Kiera Liblik , Junsu Lee , Adrian Baranchuk , Shetuan Zhang , Mohammad El-Diasty","doi":"10.1016/j.tcm.2023.03.006","DOIUrl":"10.1016/j.tcm.2023.03.006","url":null,"abstract":"<div><h3>Background</h3><p>It is estimated that over 60 million individuals regularly use opioids globally, with opioid use disorder increasing substantially in the past decade. Several reports have linked sudden cardiac death, QTc prolongation, and other adverse cardiovascular outcomes with opioid use through their inhibitory effect on the human ether-a-go-go-related gene (HERG) ion channel. Therefore, understanding this underlying mechanism may be critical for risk prevention and management in prescribing opioids and treating patients with opioid dependency.</p></div><div><h3>Aim</h3><p>The present systematic review summarizes the current literature on the impact of opioids-induced inhibition of HERG channel function and its relationship with sudden cardiac death, QTc prolongation, and other cardiovascular adverse effects.</p></div><div><h3>Methods</h3><p>A systematic review was conducted of the databases PubMed, EMBASE, Cochrane, and ClinicalTrials.gov of primary studies that reported the effects of opioids on HERG channel function and associated cardiovascular outcomes.</p></div><div><h3>Results</h3><p>The search identified 1,546 studies, of which 12 were finally included for data extraction. Based on the current literature, methadone, oliceridine, l-α-acetylmethadol (LAAM), and fentanyl were found to inhibit the HERG channel function and were associated with QTc prolongation. However, other opioids such as morphine, codeine, tramadol, and buprenorphine were not associated with inhibition of HERG channels or QTc prolongation. Additional cardiac outcomes associated with opioid related HERG channels dysfunction included sudden cardiac death and Torsade de Pointes.</p></div><div><h3>Conclusion</h3><p>Our findings suggest that certain opioid consumption may result in the inhibition of HERG channels, subsequently prolonging the QTc interval and increasing patient susceptibility to sudden cardiac death.</p></div>","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":"34 5","pages":"Pages 279-285"},"PeriodicalIF":7.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9264857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Benefits of early rhythm control of atrial fibrillation 早期控制心房颤动节律的益处

IF 7.3 2区医学

Trends in Cardiovascular Medicine Pub Date : 2024-07-01 DOI: 10.1016/j.tcm.2023.04.001

L. Eckardt , J. Wolfes , G. Frommeyer

{"title":"Benefits of early rhythm control of atrial fibrillation","authors":"L. Eckardt , J. Wolfes , G. Frommeyer","doi":"10.1016/j.tcm.2023.04.001","DOIUrl":"10.1016/j.tcm.2023.04.001","url":null,"abstract":"<div><p><span><span>In contrast to current guidelines and earlier trials, recent studies demonstrated superiority of rhythm- over rate-control and challenged the strategy of \"rate versus rhythm\" therapy </span>in patients with atrial fibrillation. These newer studies have started to shift the use of rhythm-control therapy from the symptom-driven therapy of current guidelines to a risk-reducing strategy aimed at restoring and maintaining </span>sinus rhythm<span>. This review discusses recent data and presents an overview on the current discourse: The concept of early rhythm control seems attractive. Patients with rhythm control may undergo less atrial remodeling<span><span> compared to those with rate control. In addition, in EAST-AFNET 4 an outcome-reducing effect of rhythm control was achieved by delivering therapy with relatively few complications early after the initial AF diagnosis. Successful rhythm control therapy and most likely reduced AF burden, estimated by the presence of sinus rhythm at 12 months after randomization, explained most of the reduction in cardiovascular outcomes achieved by rhythm control. However, it is too early to call for early rhythm control for all AF patients. Rhythm control may raise concerns regarding the generalizability of trial results in routine practice involving important questions on the definition of \"early\" and \"successful\", and the relevant issue of antiarrhythmic drugs versus </span>catheter ablation. Further information is required to select patients who will benefit from an early ablative or non-ablative rhythm management.</span></span></p></div>","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":"34 5","pages":"Pages 288-294"},"PeriodicalIF":7.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9338007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0