Clinical nephrology. Case studies最新文献_第2页

Horns, nails, and leaky kidneys: A rare case of congenital nephrotic syndrome. 角、指甲和漏肾：罕见的先天性肾病综合征病例。

Clinical nephrology. Case studies Pub Date : 2026-02-22 eCollection Date: 2026-01-01 DOI: 10.5414/CNCS111949

Dwarak Sampath Kumar, Mythri Shankar, C G Sreedhara

引用次数: 0

Idiopathic erythrocytosis as a potential early manifestation with IgA nephropathy: A case report and systematic review. 特发性红细胞增多症作为IgA肾病的潜在早期表现：一个病例报告和系统回顾。

Clinical nephrology. Case studies Pub Date : 2026-02-05 eCollection Date: 2026-01-01 DOI: 10.5414/CNCS111797

Yagmur Ersoy, Seyda Gul Ozcan, Mevlut Tamer Dincer, Ayse Salihoglu, Nurhan Seyahi, Sinan Trabulus

{"title":"Idiopathic erythrocytosis as a potential early manifestation with IgA nephropathy: A case report and systematic review.","authors":"Yagmur Ersoy, Seyda Gul Ozcan, Mevlut Tamer Dincer, Ayse Salihoglu, Nurhan Seyahi, Sinan Trabulus","doi":"10.5414/CNCS111797","DOIUrl":"10.5414/CNCS111797","url":null,"abstract":"IgA nephropathy (IgAN) is the most common primary glomerulonephritis, characterized by mesangial IgA immune complex deposition, potentially leading to chronic kidney disease. Idiopathic erythrocytosis, an unexplained elevation of red blood cell mass, has rarely been reported in association with IgAN. We present a systematic literature review and a new case highlighting the temporal relationship between IgAN and idiopathic erythrocytosis. A PubMed search identified four relevant studies detailing IgAN accompanied by unexplained erythrocytosis. The literature suggests an association predominantly observed in male patients, typically concurrent with or subsequent to an IgAN diagnosis. In our case, however, idiopathic erythrocytosis was detected 2 years prior to the onset of clinical signs of IgAN. The patient, initially treated with phlebotomy, presented 2 years later with significant proteinuria, leading to a renal biopsy confirming IgAN. This temporal progression raises the hypothesis that polymeric IgA1 immune complexes may influence erythropoiesis prior to evident renal involvement. Clinicians should consider underlying glomerular disease in patients with unexplained erythrocytosis, even in the absence of overt renal symptoms.","PeriodicalId":510898,"journal":{"name":"Clinical nephrology. Case studies","volume":"14 ","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12887845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146168915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Membranous nephropathy in Kimura disease: A case report and literature review on renal biopsy findings. 木村病的膜性肾病：1例报告及肾活检结果的文献复习。

Clinical nephrology. Case studies Pub Date : 2025-12-19 eCollection Date: 2025-01-01 DOI: 10.5414/CNCS111774

Motoki Murata, Kenichi Koga, Satoshi Yamaoka, Masako Hasebe, Chiho Fukushima, Chiaki Omiya, Kensei Yahata

{"title":"Membranous nephropathy in Kimura disease: A case report and literature review on renal biopsy findings.","authors":"Motoki Murata, Kenichi Koga, Satoshi Yamaoka, Masako Hasebe, Chiho Fukushima, Chiaki Omiya, Kensei Yahata","doi":"10.5414/CNCS111774","DOIUrl":"10.5414/CNCS111774","url":null,"abstract":"Kimura disease (KD) is a chronic benign granulomatous disease. Approximately 20% of patients with KD have renal disease. Membranous nephropathy (MN) is one of the main renal pathologies in KD; however, the underlying mechanism remains unknown. We herein present a 28-year-old male diagnosed with KD after biopsy of a left lower eyelid mass 11 years earlier. He visited our hospital with edema in the lower legs and scrotum. A blood test showed a serum creatinine level of 0.95 mg/dL and serum albumin level of 0.9 g/dL. Urinalysis revealed heavy proteinuria with mild hematuria. Renal biopsy showed spike formation by PAM staining and granular deposits of IgG and C3 in the glomerular basement membrane by direct immunofluorescence microscopy (IF). Electron microscopy revealed subepithelial electron-dense deposits (EDD). IF staining for the phospholipase A2 receptor (PLA2R) was positive in the glomerular basement membrane, leading to a diagnosis of PLA2R-associated MN. Our literature review on MN in KD included 14 cases, all of which exhibited subepithelial EDD, while subendothelial EDD was absent in 10. PLA2R staining was positive in 2 of the 3 cases examined. The results of this case and the literature review suggest the involvement of autoantibodies against podocyte antigens in the pathogenesis of MN in KD. Further studies are needed on these antigens.","PeriodicalId":510898,"journal":{"name":"Clinical nephrology. Case studies","volume":"13 ","pages":"96-102"},"PeriodicalIF":0.0,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12723602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145829506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute renal cortical necrosis following postpartum hemorrhage - successful discontinuation of peritoneal dialysis: A case report. 产后出血后急性肾皮质坏死-成功停止腹膜透析1例报告。

Clinical nephrology. Case studies Pub Date : 2025-12-19 eCollection Date: 2025-01-01 DOI: 10.5414/CNCS111741

Chiho Fukushima, Kenichi Koga, Masako Hasebe, Chiaki Omiya, Keisuke Nishioka, Kensei Yahata

{"title":"Acute renal cortical necrosis following postpartum hemorrhage - successful discontinuation of peritoneal dialysis: A case report.","authors":"Chiho Fukushima, Kenichi Koga, Masako Hasebe, Chiaki Omiya, Keisuke Nishioka, Kensei Yahata","doi":"10.5414/CNCS111741","DOIUrl":"10.5414/CNCS111741","url":null,"abstract":"Renal cortical necrosis (RCN) is a rare but severe cause of acute kidney injury primarily observed in obstetric complications. We herein present a case of RCN in a 32-year-old Mongolian primigravida transferred to our hospital with uncontrolled massive postpartum hemorrhage. Contrast-enhanced computed tomography revealed ongoing uterine hemorrhage, prompting endovascular intervention for control. It also showed the loss of cortical perfusion in the kidneys, while preserving medullary blood flow, which is consistent with RCN. The patient remained anuric from transfer and required continuous hemodiafiltration followed by intermittent hemodialysis. Renal biopsy on day 23 revealed coagulative necrosis in glomeruli and tubules in the outer cortex, consistent with RCN, while glomeruli in the deeper cortex were spared. Glomeruli in the outer cortex displayed glomerular paralysis. The patient transitioned to peritoneal dialysis (PD) to facilitate infant care at home. Over 6 months, renal function improved, allowing dialysis discontinuation. Four years post-discharge, she remains free of renal replacement therapy, with serum creatinine of 2.67 mg/dL. The present case highlights the potential for gradual renal function improvement in RCN through the recovery of residual nephrons. PD may be a promising modality for patients with RCN.","PeriodicalId":510898,"journal":{"name":"Clinical nephrology. Case studies","volume":"13 ","pages":"89-95"},"PeriodicalIF":0.0,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12723601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145829486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute renal failure as the initial presentation of T-lymphoblastic lymphoma: A case report. 急性肾衰作为t淋巴母细胞淋巴瘤的初始表现：1例报告。

Clinical nephrology. Case studies Pub Date : 2025-12-19 eCollection Date: 2025-01-01 DOI: 10.5414/CNCS111766

Noureldien Darwish, Andrea Lightle

{"title":"Acute renal failure as the initial presentation of T-lymphoblastic lymphoma: A case report.","authors":"Noureldien Darwish, Andrea Lightle","doi":"10.5414/CNCS111766","DOIUrl":"10.5414/CNCS111766","url":null,"abstract":"T-lymphoblastic lymphoma/leukemia (T-LBL) is a rare and aggressive hematologic malignancy characterized by a neoplastic proliferation of immature T lymphocytes that is restricted to nodal/extra-nodal sites with minimal involvement of bone marrow. While T-LBL is the second most frequent subtype of pediatric non-Hodgkin lymphoma, primary renal involvement in T-LBL is exceedingly rare and can pose a significant diagnostic challenge. We present the case of an 11-year-old male who initially presented with new-onset seizure, hypertensive crisis, and acute renal failure. Renal ultrasounds demonstrated enlarged kidneys with loss of corticomedullary differentiation suggestive of medical renal disease. A kidney biopsy was performed, revealing an atypical interstitial T-cell infiltrate with diffuse expression of CD4, CD8, and TdT, raising concern for T-cell acute lymphoblastic lymphoma (instead of leukemia) (T-ALL/LBL). A subsequent bone marrow biopsy was negative, and no other sites of involvement were identified on PET/CT, so chemotherapy was deferred until the diagnosis could be confirmed. The patient re-presented 2 months later with visual changes and diffuse leptomeningeal enhancement on MRI. Repeat kidney biopsy with flow cytometry demonstrated a population of aberrant T cells with CD4/CD8 co-expression. A repeat bone marrow biopsy contained < 1% blasts, and no aberrant lymphocytes were detected in peripheral blood. CT scan revealed new retroperitoneal adenopathy with infiltrative disease involving kidneys, pancreas, adrenal glands, and liver, consistent with stage IV T-LBL.Kidney involvement in acute LBL is uncommon, and renal failure due to leukemic infiltration is rarely reported. This case underscores the importance of performing kidney biopsies in cases of unexplained acute renal failure and considering lymphoma in the differential for interstitial nephritis, even in the absence of abnormal hematological findings.","PeriodicalId":510898,"journal":{"name":"Clinical nephrology. Case studies","volume":"13 ","pages":"103-108"},"PeriodicalIF":0.0,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12723600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145829541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunotactoid glomerulopathy in rheumatoid arthritis. 类风湿关节炎中的免疫因子样肾小球病变。

Clinical nephrology. Case studies Pub Date : 2025-12-11 eCollection Date: 2025-01-01 DOI: 10.5414/CNCS111805

Adriana Dejman, Jaylou M Velez Torres, Youley Tjendra, Juan C Duque, Yiqin Zuo

引用次数: 0

Acute kidney injury after treatment with arsenic trioxide. 三氧化二砷治疗后急性肾损伤。

Clinical nephrology. Case studies Pub Date : 2025-12-11 eCollection Date: 2025-01-01 DOI: 10.5414/CNCS111813

Hatem Najar, Julia Evans, Sai Vedula, Gina Keiffer, Jingjing Zhang

引用次数: 0

Successful kidney transplantation in a patient with late-onset type II Bartter syndrome: A rare case report. 迟发性II型Bartter综合征患者肾移植成功一例报道。

Clinical nephrology. Case studies Pub Date : 2025-11-20 eCollection Date: 2025-01-01 DOI: 10.5414/CNCS111808

Kallappa Baligeri, Mythri Shankar, Dwarak Sampath Kumar, Sreedhara C Gurusiddiah

{"title":"Successful kidney transplantation in a patient with late-onset type II Bartter syndrome: A rare case report.","authors":"Kallappa Baligeri, Mythri Shankar, Dwarak Sampath Kumar, Sreedhara C Gurusiddiah","doi":"10.5414/CNCS111808","DOIUrl":"10.5414/CNCS111808","url":null,"abstract":"Bartter syndrome (BS) is a rare autosomal recessive disorder characterized by inherited salt-losing tubulopathies. Distinguished into six types, each associated with specific genetic mutations, type II is particularly rare in adults and typically presents early. This report documents a rare case of an adult diagnosed with type II Bartter syndrome that progressed to end-stage kidney disease (ESKD) and underwent successful kidney transplantation, marking it a first of its kind in India and only the second globally. The patient, diagnosed in adulthood, experienced a delayed onset of symptoms, including uremia, hypocalcemia, and medullary nephrocalcinosis, which progressed to ESKD. Genetic testing confirmed a homozygous missense mutation in the KCNJ1 gene. After prolonged hemodialysis, a kidney transplant from a deceased donor resulted in successful graft function and symptom resolution. This case underlines the phenotypic variability of Bartter syndrome and provides critical insights into managing severe, late-onset cases through transplantation.","PeriodicalId":510898,"journal":{"name":"Clinical nephrology. Case studies","volume":"13 ","pages":"73-76"},"PeriodicalIF":0.0,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12687742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145727917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxalate nephropathy precipitated by linaclotide in a high-risk patient. 利那洛肽诱发草酸肾病1例。

Clinical nephrology. Case studies Pub Date : 2025-11-05 eCollection Date: 2025-01-01 DOI: 10.5414/CNCS111722

Omar Ali, Mauricio Monrroy, Andrea Lightle, Giovanni Faddoul

{"title":"Oxalate nephropathy precipitated by linaclotide in a high-risk patient.","authors":"Omar Ali, Mauricio Monrroy, Andrea Lightle, Giovanni Faddoul","doi":"10.5414/CNCS111722","DOIUrl":"10.5414/CNCS111722","url":null,"abstract":"Introduction: Oxalate nephropathy (ON) is a rare condition caused by calcium oxalate crystal deposition in renal tubules, leading to acute kidney injury (AKI), chronic kidney disease (CKD), or both. The etiologies of ON are divided into two main categories: primary and secondary. Linaclotide is used for the constipation subtype of irritable bowel syndrome (IBS-C), which is not reported to precipitate ON.Case presentation: We report a unique case of linaclotide-precipitated ON in a 50-year-old female with predisposing comorbidities. The patient developed severe AKI (creatinine 8.37 mg/dL) 3 months after starting linaclotide for IBS-C. Symptoms included fatigue, flank pain, and pale stools. Kidney biopsy confirmed ON. Linaclotide was discontinued, and supportive treatment led to significant renal recovery, with creatinine returning to baseline (0.92 mg/dL) within 2 months.Discussion: This case highlights linaclotide's potential to precipitate ON in patients with risk factors such as malabsorption and dehydration. Secretory diarrhea caused by linaclotide may increase intestinal oxalate absorption, triggering hyperoxaluria. While not inherently nephrotoxic, linaclotide may exacerbate existing susceptibilities.Conclusion: Linaclotide can contribute to ON in predisposed patients. Clinicians should consider medication history and risk factors in unexplained AKI and pursuing kidney biopsy for diagnosis.","PeriodicalId":510898,"journal":{"name":"Clinical nephrology. Case studies","volume":"13 ","pages":"66-72"},"PeriodicalIF":0.0,"publicationDate":"2025-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12612843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145544715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute kidney injury and nephrotic syndrome caused by a "magic pill". 引起急性肾损伤和肾病综合征的“神奇药丸”。

Clinical nephrology. Case studies Pub Date : 2025-09-04 eCollection Date: 2025-01-01 DOI: 10.5414/CNCS111804

Yangming Cao, Thao Phan, Patil Armenian, Jonathan E Zuckerman

{"title":"Acute kidney injury and nephrotic syndrome caused by a \"magic pill\".","authors":"Yangming Cao, Thao Phan, Patil Armenian, Jonathan E Zuckerman","doi":"10.5414/CNCS111804","DOIUrl":"10.5414/CNCS111804","url":null,"abstract":"Introduction: The sudden onset of nephrotic syndrome (NS) and acute interstitial nephritis (AIN) seems to be an uncommon but distinct nonsteroidal anti-inflammatory drug (NSAID)-related renal syndrome.Case presentation: We present such a case in a patient who took a \"magic pill\" for gout. Renal biopsy revealed minimal change disease (MCD), acute interstitial nephritis (AIN), severe acute tubular injury (ATI), and IgA nephropathy (IgAN). He was treated with an aborted course of high-dose prednisone, with complete resolution of his renal diseases. The pathologic finding of the combination of MCD and AIN raised the possibility of a drug effect. One of the pills was analyzed and found to be primarily composed of diclofenac. Initially, we considered IgAN a bystander, considering primary IgAN is the most common glomerulonephritis worldwide, especially in Asians and Hispanics. However, the complete resolution of urinary findings after discontinuation of the pill followed by a few days' treatment with prednisone, together with no recurrence of the kidney disease over 6 years, made us speculate that IgAN may have also been triggered by diclofenac.Conclusion: We presented a case of AIN, MCD, and IgAN associated with diclofenac masquerading as a \"herbal\" medicine. The cause was suggested by pathology and confirmed with high-resolution liquid chromatography mass spectrometry testing of the pills. A history of NSAID use should be diligently sought in any patient who presents with NS and AIN. In addition, this is the first report of IgAN possibly induced by NSAID without recurrence after 6 years' follow-up.","PeriodicalId":510898,"journal":{"name":"Clinical nephrology. Case studies","volume":"13 ","pages":"59-65"},"PeriodicalIF":0.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145115933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0