Journal of Cognitive Neuroscience最新文献_第2页

Long-term Memory Contributions to Working Memory: A Contralateral Delay Activity Study. 长期记忆对工作记忆的贡献：一个对侧延迟活动的研究。

IF 3 3区医学

Journal of Cognitive Neuroscience Pub Date : 2026-09-15 DOI: 10.1162/JOCN.a.2719

Ana Rodriguez, Peter Shepherdson, Lea M Bartsch

{"title":"Long-term Memory Contributions to Working Memory: A Contralateral Delay Activity Study.","authors":"Ana Rodriguez, Peter Shepherdson, Lea M Bartsch","doi":"10.1162/JOCN.a.2719","DOIUrl":"https://doi.org/10.1162/JOCN.a.2719","url":null,"abstract":"How does long-term memory (LTM) support working memory (WM) performance? Proposed mechanisms include \"boosting,\" where LTM enhances WM representations through additional activation but does not reduce WM load; \"chunking,\" where WM holds references to LTM, reducing WM load; and \"offloading,\" where LTM substitutes active maintenance in WM. To distinguish between these mechanisms, we measured the contralateral delay activity (CDA) and behavioral performance during a three-alternative forced-choice WM task, in which some trials (varying in memory array set size) included a prelearned color-object binding. The CDA is a well-established neural correlate that indexes the amount of information actively stored in WM, allowing us to distinguish between the three accounts by examining whether including prelearned bindings in a memory set of a given size reduced its amplitude compared with maintaining entirely new bindings. Overall, our findings supported the boosting account. Prelearned bindings improved performance for matching items in WM, but the benefit did not extend to newly encoded items, indicating no reduction in WM load. CDA amplitude increased with set size irrespective of whether the items were prelearned or new, reflecting active maintenance of all the to-be-remembered items. Overall, these results show that prelearned associations in LTM can boost WM performance without substituting for WM storage, providing evidence against offloading or chunking accounts in the context of our paradigm.","PeriodicalId":51081,"journal":{"name":"Journal of Cognitive Neuroscience","volume":" ","pages":"1-14"},"PeriodicalIF":3.0,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148984210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abstract Property-selective Clusters Link Continuous Property Representations to Discrete Category-selective Regions in Human Higher Visual Cortex. 属性选择聚类将连续属性表示与人类高级视觉皮层的离散类别选择区域联系起来。

IF 3 3区医学

Journal of Cognitive Neuroscience Pub Date : 2026-09-15 DOI: 10.1162/JOCN.a.2720

Qiande Zhao, Junhai Xu, Deying Li, Xia Wu, Kang Zhang, Congying Chu, Lingzhong Fan

{"title":"Abstract Property-selective Clusters Link Continuous Property Representations to Discrete Category-selective Regions in Human Higher Visual Cortex.","authors":"Qiande Zhao, Junhai Xu, Deying Li, Xia Wu, Kang Zhang, Congying Chu, Lingzhong Fan","doi":"10.1162/JOCN.a.2720","DOIUrl":"https://doi.org/10.1162/JOCN.a.2720","url":null,"abstract":"Object representations in the human higher visual cortex (HVC) support complex recognition behaviors early in development, yet the principles linking continuous dimensional representations and discrete category-selective areas in the HVC remain incompletely understood. Here, we propose a \"property-cluster-category\" organization that bridges object conceptual dimensions and discrete category areas in the HVC. Using a large-scale naturalistic stimulus data set and voxel-wise encoding methods, we analyzed the encoding patterns of a low-dimensional abstract property space and identified distinct brain clusters with shared cortical property profiles. These clusters broadly aligned with category-selective areas, suggesting that category regions can be understood as local peaks within a continuous property topology. We further tested whether this visual organization could emerge in a visual-only Topographic Deep Artificial Neural Network trained without semantic supervision. The model recapitulated property tuning for physical and biological dimensions but showed weaker affective tuning, suggesting that affective dimensions may require embodied or nonvisual experience. Finally, model-based lesion and stimulation analyses showed that Topographic Deep Artificial Neural Network units aligned with brain clusters contributed selectively to object classification. Together, these results provide a framework for understanding how the continuous property topology and discrete category selectivity are jointly organized in the human HVC, and suggest that abstract visual properties-which shape this topological organization-can be learned in part from statistical regularities in visual input.","PeriodicalId":51081,"journal":{"name":"Journal of Cognitive Neuroscience","volume":" ","pages":"1-18"},"PeriodicalIF":3.0,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148984245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neural Reinstatement of Features in Audiovisual Working Memory Indicates Object-based Retrieval. 视听工作记忆特征的神经恢复表明基于对象的检索。

IF 3 3区医学

Journal of Cognitive Neuroscience Pub Date : 2026-09-15 DOI: 10.1162/JOCN.a.2722

Ceren Arslan, Daniel Schneider, Stephan Getzmann, Edmund Wascher, Laura-Isabelle Klatt

{"title":"Neural Reinstatement of Features in Audiovisual Working Memory Indicates Object-based Retrieval.","authors":"Ceren Arslan, Daniel Schneider, Stephan Getzmann, Edmund Wascher, Laura-Isabelle Klatt","doi":"10.1162/JOCN.a.2722","DOIUrl":"https://doi.org/10.1162/JOCN.a.2722","url":null,"abstract":"Selective attention allows us to prioritize or retrieve task-relevant features and items from working memory. However, previous work has largely relied on unisensory paradigms, leaving open the question of how attentional mechanisms act on audiovisual working memory representations. Here, using an EEG-based audiovisual delayed-match-to-sample task, we investigate whether attention to audiovisual working memory contents operates on the level of individual unisensory features or bound cross-modal objects. On each trial, participants memorized an audiovisual item. At test, they were randomly presented with either an auditory, visual, or audiovisual probe stimulus and indicated whether the latter matched their working memory content. Compared with recalling the entire audiovisual object, recall of unisensory visual or auditory features resulted in poorer behavioral performance and elevated midfrontal theta power. Multivariate pattern analyses (MVPAs) showed that task-irrelevant feature representations were retrieved in both auditory and visual probe trials, consistent with object-based retrieval. Moreover, these results shed light on the representational structure underlying cross-modal feature storage in working memory, suggesting that audiovisual features are stored as bound objects and that attentional selection of individual object features in one modality spreads to cross-modal object features in another modality. In task conditions where such incidental recall of task-irrelevant features is detrimental to task performance, this places greater demands on cognitive control mechanisms.","PeriodicalId":51081,"journal":{"name":"Journal of Cognitive Neuroscience","volume":" ","pages":"1-16"},"PeriodicalIF":3.0,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148984226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

N1 Suppression to Audiovisual Self-generated Sensory Events. 视听自生感觉事件的抑制。

IF 3 3区医学

Journal of Cognitive Neuroscience Pub Date : 2026-09-15 DOI: 10.1162/JOCN.a.2717

Shabnamalsadat Ayatollahi, Christina Bermeitinger, Tim Wittenberg, Pamela Baess

{"title":"N1 Suppression to Audiovisual Self-generated Sensory Events.","authors":"Shabnamalsadat Ayatollahi, Christina Bermeitinger, Tim Wittenberg, Pamela Baess","doi":"10.1162/JOCN.a.2717","DOIUrl":"https://doi.org/10.1162/JOCN.a.2717","url":null,"abstract":"The ability to discriminate between self-generated and externally generated events is crucial for adaptive behavior. Attenuated N1 responses to self-initiated sensory events indicate a successful discrimination process based on internal prediction models. The sensory attenuation in the N1 (and P2) component has been shown across different sensory modalities (audition, vision, touch), emphasizing the modality independence of the underlying mechanism. However, N1 sensory attenuation was only studied in isolation across different sensory modalities, although self-generated actions in everyday life typically produce multisensory consequences. Moreover, internal prediction models propose modality-specific predictions, making it particularly interesting to examine sensory attenuation when multiple sensory consequences occur simultaneously. Therefore, the current study investigated the N1 (and P2) sensory attenuation using self-initiated audiovisual stimuli known to be the most frequent combination of sensory events in our environment. Two EEG studies were conducted using different visual stimuli (i.e., Gabor patches vs. checkerboard reversals), each combined with tones. Each study compares the N1 sensory attenuation for unisensory stimulus presentation (only visual stimuli or auditory tones) with the multisensory presentation of audiovisual sensory events. Multisensory audiovisual stimuli elicited N1 attenuation comparable with the attenuation observed for unisensory auditory stimuli. In contrast, no N1 attenuation was observed for unisensory visual stimuli. These findings may be consistent with the presence of parallel, action-dependent mechanisms operating across modalities in the present paradigm. However, they do not permit a clear distinction between existing theoretical accounts on sensory attenuation.","PeriodicalId":51081,"journal":{"name":"Journal of Cognitive Neuroscience","volume":" ","pages":"1-17"},"PeriodicalIF":3.0,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148984255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Animate-Inanimate Object Categorization from Minimal Visual Information in the Human Brain, Human Behavior, and Deep Neural Networks. 从人类大脑、人类行为和深度神经网络的最小视觉信息中进行有生命和无生命的物体分类。

IF 3 3区医学

Journal of Cognitive Neuroscience Pub Date : 2026-09-15 DOI: 10.1162/JOCN.a.2721

Céline Spriet, Farzad Rostami, Jean-Rémy Hochmann, Liuba Papeo

{"title":"Animate-Inanimate Object Categorization from Minimal Visual Information in the Human Brain, Human Behavior, and Deep Neural Networks.","authors":"Céline Spriet, Farzad Rostami, Jean-Rémy Hochmann, Liuba Papeo","doi":"10.1162/JOCN.a.2721","DOIUrl":"https://doi.org/10.1162/JOCN.a.2721","url":null,"abstract":"The distinction between animate and inanimate things is a main organizing principle of information in perception and cognition. Yet, animacy, as a visual property, has so far eluded operationalization. Which visual features are necessary and sufficient to discriminate between animate and inanimate objects? At which level of the visual hierarchy does the animate-inanimate distinction emerge? Here, we show that the categorical boundary between animate and inanimate objects is preserved even among images of objects that are made unrecognizable and only retain the low- and mid-level visual features of their natural version. In three experiments, healthy human adults viewed rapid sequences of images (6 Hz), in which an exemplar from another category (e.g., animate) was presented after every five exemplars from a given category (i.e., inanimate), at a rate of 1.2 Hz. Using frequency-tagging electroencephalography, we found significant neural responses at 1.2 Hz, indicating rapid and automatic detection of the periodic categorical change. Moreover, such effect was found-although increasingly weaker-for \"impoverished\" stimulus sets that retained only certain (high-, mid-, or low-level) features of the original colorful images (i.e., grayscale, texform, and phase-scramble images), and even if the images were unrecognizable, as tested with an object recognition task. Similar effects were found with deep neural networks presented with the same stimulus sets. Reliable categorization effects for dramatically impoverished and unrecognizable images, in humans' EEG and deep neural network data, demonstrate that the animate-inanimate distinction emerges early in the visual hierarchy and is remarkably resilient to the loss of visual information.","PeriodicalId":51081,"journal":{"name":"Journal of Cognitive Neuroscience","volume":" ","pages":"1-17"},"PeriodicalIF":3.0,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148984197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How the Percept of Face Familiarity Unfolds Over Time. 对面孔熟悉度的感知如何随着时间的推移而展开。

IF 3 3区医学

Journal of Cognitive Neuroscience Pub Date : 2026-08-27 DOI: 10.1162/JOCN.a.2690

Mengdan Sun, Menglei Yao, Xiaoqing Gao

{"title":"How the Percept of Face Familiarity Unfolds Over Time.","authors":"Mengdan Sun, Menglei Yao, Xiaoqing Gao","doi":"10.1162/JOCN.a.2690","DOIUrl":"https://doi.org/10.1162/JOCN.a.2690","url":null,"abstract":"A single glance at a face can evoke a sense of familiarity, yet how this percept unfolds over time remains unclear. We adopted a frequency-tagging EEG paradigm to investigate neural responses to face familiarity across different SOAs. Streams of unfamiliar faces were presented at base frequencies of 8, 12, 16, and 20 Hz (SOAs: 125, 83, 62.5, and 50 msec), with personally familiar faces inserted periodically at 2 Hz. Significant oddball responses were observed at all four SOAs over occipito-temporal regions, indicating reliable discrimination between familiar and unfamiliar faces even at the shortest SOA of 50 msec. Time domain analysis revealed a significant N170 component in all four conditions, with amplitudes increasing progressively as SOA lengthened. In contrast, a reliable P300 component emerged only at SOAs of 83 msec and longer. These findings suggest two temporally distinct stages of familiar face processing: an early stage indexed by the N170 that scales with available processing time and likely reflects familiarity-sensitive perceptual processing and a later stage indexed by P300 that requires a longer processing window and likely reflects higher-order evaluative processing.","PeriodicalId":51081,"journal":{"name":"Journal of Cognitive Neuroscience","volume":" ","pages":"1-14"},"PeriodicalIF":3.0,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148867791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subjective Visibility Enhances Early Posterior EEG Decoding of Stimulus Location across Report and No-report Tasks. 主观可视性增强报告和非报告任务刺激位置的早期后验脑电解码。

IF 3 3区医学

Journal of Cognitive Neuroscience Pub Date : 2026-08-27 DOI: 10.1162/JOCN.a.2691

Sabine Gnodde, Vlada Aslanov, Abigail Hogan, Jolien C Francken, Umberto Olcese, Timo Stein

{"title":"Subjective Visibility Enhances Early Posterior EEG Decoding of Stimulus Location across Report and No-report Tasks.","authors":"Sabine Gnodde, Vlada Aslanov, Abigail Hogan, Jolien C Francken, Umberto Olcese, Timo Stein","doi":"10.1162/JOCN.a.2691","DOIUrl":"https://doi.org/10.1162/JOCN.a.2691","url":null,"abstract":"A central question in consciousness research is whether perceptual awareness is primarily reflected in early posterior sensory activity or in later frontal processes associated with access and report. Empirical tests of these alternatives are challenging because most paradigms rely on explicit perceptual reports, introducing motor and decisional confounds. Here, we used an electroencephalography design combining two independent tasks to decode stimulus location across report and no-report conditions and to examine how these task-general stimulus-location signals vary with subjective visibility. Participants viewed lateralized gratings in a backward-masking task and rated their subjective visibility, whereas in a separate no-report task, they viewed unmasked gratings without reporting. Classifiers were trained on stimulus location in the no-report task and tested on masked trials sorted by subjective visibility in the masking task. This cross-decoding approach identifies stimulus-location signals that generalize across tasks and vary with subjective visibility, making them less likely to reflect reporting or decision-related processes. Decoding revealed stronger stimulus-location signals for subjectively visible than invisible stimuli in an early time window from 130 to 170 msec, most prominently over posterior occipital, temporal, and parietal electrode groups. These results indicate that subjective visibility enhances early posterior EEG decoding of stimulus location across report contexts.","PeriodicalId":51081,"journal":{"name":"Journal of Cognitive Neuroscience","volume":" ","pages":"1-15"},"PeriodicalIF":3.0,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148867766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Task Relevance Modulates Early Threat and Prediction Signals in Face Processing: An Event-Related Potential Study. 任务关联调节面部加工中的早期威胁和预测信号：一项事件相关电位研究。

IF 3 3区医学

Journal of Cognitive Neuroscience Pub Date : 2026-08-27 DOI: 10.1162/JOCN.a.2692

Philip T Chalk, Derek H Arnold, Alan J Pegna

{"title":"Task Relevance Modulates Early Threat and Prediction Signals in Face Processing: An Event-Related Potential Study.","authors":"Philip T Chalk, Derek H Arnold, Alan J Pegna","doi":"10.1162/JOCN.a.2692","DOIUrl":"https://doi.org/10.1162/JOCN.a.2692","url":null,"abstract":"Threat and prediction signals are proposed to influence perceptual processing automatically. Here, we examine how the pre-allocation of spatial attention and the task relevance of the stimulus modulate early neural responses to likely and unlikely facial expressions. Thirty participants viewed pairs of bilaterally presented stimuli consisting of either faces (one emotional, one neutral) or Gabor patches (one tilted, one vertical). Electroencephalography was recorded, and early ERPs associated with visual processing (P1 and N170) were analyzed. Participants were explicitly informed of the probabilities with which each facial expression would appear, and then engaged in one of three tasks: judging the emotion of facial expressions, the orientation of Gabor patches, or the location of missing pixels at a central fixation cross. We observed that event probabilities modulated P1 amplitudes and that facial threat modulated N170 amplitudes. Critically, these modulations were reliable only when facial expressions were task relevant. They were absent when faces were task irrelevant, including when spatial attention remained pre-allocated to the face locations. Together, these findings suggest that early neural responses to threat and prediction signals depend on task-relevant engagement with the stimulus rather than on the pre-allocation of spatial attention alone, constraining accounts that characterize these effects as automatic.","PeriodicalId":51081,"journal":{"name":"Journal of Cognitive Neuroscience","volume":" ","pages":"1-13"},"PeriodicalIF":3.0,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148867821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Attention and Explicit Knowledge Drive Predictive Sharpening in Early Visual Cortex. 注意和外显知识驱动早期视觉皮层的预测锐化。

IF 3 3区医学

Journal of Cognitive Neuroscience Pub Date : 2026-08-17 DOI: 10.1162/JOCN.a.2689

Marc Sabio-Albert, David Richter, Lluis Fuentemilla Garriga, Alexis Pérez-Bellido

{"title":"Attention and Explicit Knowledge Drive Predictive Sharpening in Early Visual Cortex.","authors":"Marc Sabio-Albert, David Richter, Lluis Fuentemilla Garriga, Alexis Pérez-Bellido","doi":"10.1162/JOCN.a.2689","DOIUrl":"https://doi.org/10.1162/JOCN.a.2689","url":null,"abstract":"Perception is increasingly understood as an inferential process in which sensory input is interpreted in light of prior knowledge. Although predictive effects are widely documented in sensory cortices and interact with higher cognitive functions such as attention, predictive processes are generally assumed to unfold implicitly. Consequently, research often overlooks the possibility that participants may possess explicit knowledge of task structures, which they might use to guide their predictive processing. In this study, we investigated how the attentional relevance of predicted stimuli and explicit knowledge of predictive associations interact to shape the sensory encoding of visual stimuli. Using a multisensory fMRI paradigm with concurrent but independent visual and auditory probabilistic associations (75% validity), we manipulated endogenous attention across sensory modalities. Consistent with prior work, expected, relative to unexpected, visual stimuli elicited an overall reduction in BOLD activity. Critically, however, representational sharpening-an enhanced encoding fidelity of neural representations for expected inputs-occurred exclusively when visual inputs were attended and concurrently presented auditory inputs were expected. Furthermore, the magnitude of this visual representational sharpening correlated positively with participants' retained explicit knowledge of the predictive associations. These findings highlight the key roles of attention and explicit knowledge in promoting predictive sharpening and underscore the need to study predictive processing in multisensory contexts.","PeriodicalId":51081,"journal":{"name":"Journal of Cognitive Neuroscience","volume":" ","pages":"1-15"},"PeriodicalIF":3.0,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148814765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced Episodic Memory Encoding Following Modulation of the Amygdala via Transcranial Low-intensity Focused Ultrasound. 经颅低强度聚焦超声对杏仁核调制后情景记忆编码的增强。

IF 3 3区医学

Journal of Cognitive Neuroscience Pub Date : 2026-08-04 DOI: 10.1162/JOCN.a.2687

Manoj K Doss, Sydney R Lambert, Jason Samaha, Sai Prashanth Raja Sundaram, Charles B Nemeroff, Gregory A Fonzo, Joseph E Dunsmoor

{"title":"Enhanced Episodic Memory Encoding Following Modulation of the Amygdala via Transcranial Low-intensity Focused Ultrasound.","authors":"Manoj K Doss, Sydney R Lambert, Jason Samaha, Sai Prashanth Raja Sundaram, Charles B Nemeroff, Gregory A Fonzo, Joseph E Dunsmoor","doi":"10.1162/JOCN.a.2687","DOIUrl":"https://doi.org/10.1162/JOCN.a.2687","url":null,"abstract":"The amygdala is considered crucial to the formation of emotional episodic memories, yet causal evidence in humans is limited due to challenges in noninvasive neuromodulation of deep brain structures. In a double-blind, sham-controlled, repeated-measures study, we tested whether transcranial low-intensity focused ultrasound (tFUS) targeting the left amygdala before encoding emotional and neutral pictures impacted memory for these pictures 24 hr later (n = 23). Using a putative inhibitory tFUS protocol previously shown to attenuate amygdala BOLD-dependent signal, we hypothesized that preencoding amygdala inhibition would impair emotional memory. Contrary to this hypothesis, active (vs. sham) sonication enhanced-or tended to enhance-memory for both neutral and emotional memory across two memory tests. As a secondary measure of amygdala modulation, participants completed a dynamic emotional facial recognition task (n = 20). Active tFUS selectively enhanced recognition of subtle fearful expressions. Computational modeling further supported tFUS-mediated memory and emotion recognition enhancements. Assuming that this tFUS protocol did indeed inhibit amygdala function, these findings suggest that rather than solely amplifying emotional salience, the amygdala may act as a filter that suppresses weaker, ambiguous signals. Inhibiting the amygdala may thus attenuate this gating function, thereby unmasking subtle affective cues and enhancing their processing into memory. Nevertheless, the purported inhibitory nature of this tFUS protocol requires further investigation. Should these findings replicate, they highlight the potential for tFUS as a translational tool to modulate affective processes for disorders such as depression and posttraumatic disorder characterized by impairments in emotional processing and memory.","PeriodicalId":51081,"journal":{"name":"Journal of Cognitive Neuroscience","volume":" ","pages":"1-14"},"PeriodicalIF":3.0,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0