Ania Lipat, Jessica Peterson, Larissa Strath, Roger B Fillingim, Kyle D Allen, Yenisel Cruz-Almeida
{"title":"The Mediating Role of Physical Function on the Self-Reported Pain and Cognitive Function Association.","authors":"Ania Lipat, Jessica Peterson, Larissa Strath, Roger B Fillingim, Kyle D Allen, Yenisel Cruz-Almeida","doi":"10.1123/japa.2024-0084","DOIUrl":"https://doi.org/10.1123/japa.2024-0084","url":null,"abstract":"<p><strong>Background/objectives: </strong>Studies that have investigated the relationship between pain intensity and interference and cognitive function have failed to fully consider the role physical function may play in this relationship. Therefore, the purpose of this study was to examine the mediating role of physical function in the relationship between self-reported pain intensity and interference and cognitive function in middle-to-older aged adults with knee pain.</p><p><strong>Methods: </strong>Middle-to-older aged participants with knee pain (n = 202) completed the Graded Chronic Pain Scale to assess pain intensity and interference, the Short Performance Physical Battery to assess lower-extremity physical function, and the Montreal Cognitive Assessment to assess global cognitive function. Linear regression-based mediation analyses were used to assess associations between pain intensity and interference and cognitive function, with lower-extremity physical function as the mediator.</p><p><strong>Results: </strong>The direct relationship between pain intensity and cognitive function was significant (β = -0.269, p < .001) and remained significant when physical function was included as a mediator (c'=-0.0854, p = .003). The direct relationship between pain interference and cognitive function was also significant (β = -0.149, p = .023) but was attenuated when physical function was included as a mediator (c'=-0.0100, p = .09).</p><p><strong>Conclusion: </strong>Physical function partially mediated the relationship between pain intensity and cognitive function and fully mediated the relationship between pain interference and cognitive function. Significance/Implications: Higher levels of pain intensity and interference may lead to worse cognitive function when physical function is also impaired. Improving physical function may improve cognitive function in those with pain.</p>","PeriodicalId":51073,"journal":{"name":"Journal of Aging and Physical Activity","volume":" ","pages":"1-7"},"PeriodicalIF":1.4,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gökçe Yağmur Güneş Gencer, Neriman Temel Aksu, Yeliz Teke, Hanife Hale Hekim, Ali Akdağ
{"title":"Relationship Between Community Integration, Physical Activity, Pain Quality, and Quality of Life in Older Adults With Knee Osteoarthritis.","authors":"Gökçe Yağmur Güneş Gencer, Neriman Temel Aksu, Yeliz Teke, Hanife Hale Hekim, Ali Akdağ","doi":"10.1123/japa.2023-0452","DOIUrl":"https://doi.org/10.1123/japa.2023-0452","url":null,"abstract":"<p><strong>Objectives: </strong>This cross-sectional study investigated the relationship between community integration, physical activity, pain quality, and quality of life in older adults with knee osteoarthritis.</p><p><strong>Methods: </strong>It included 92 older adults aged 60 and over diagnosed with osteoarthritis of Stage 2 and above, according to the Kellgren-Lawrence classification. Participants were evaluated using the Community Integration Questionnaire, Western Ontario and McMaster Universities Osteoarthritis Index, International Physical Activity Questionnaire, Pain Quality Assessment Scale, and World Health Organization Quality of Life-old module Scales.</p><p><strong>Results: </strong>The mean age of 92 older adults included in the study was 67.5 ± 7.6 years. Specifically, for every 0.599 unit decrease in the Western Ontario and McMaster Universities Osteoarthritis Index physical function score (indicating an improvement in physical function), the community integration level increased by 0.196 units. Additionally, for every 0.380 unit increase in total physical activity level (measured in metabolic equivalent of task), the community integration level increased by 0.001 units. Also, community integration was negatively associated with pain intensity and positively associated with quality of life (p < .05).</p><p><strong>Conclusion: </strong>In the treatment of knee osteoarthritis, it is essential to provide intervention support to combat the symptoms of the disease, increase physical activity, and maintain community integration.</p><p><strong>Implications: </strong>In older adults diagnosed with knee osteoarthritis, community integration decreases as the severity of osteoarthritis increases with age. For older adults with knee osteoarthritis to have a better quality of life and active aging, it would be appropriate to add interventions to maintain and increase community integration in osteoarthritis treatment programs.</p>","PeriodicalId":51073,"journal":{"name":"Journal of Aging and Physical Activity","volume":" ","pages":"1-7"},"PeriodicalIF":1.4,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Helena Bilsborough, Amy Davies, Chris Todd, Afroditi Stathi, Helen Hawley-Hague
{"title":"Motives of Peer Volunteers Aged Over 50 in Physical Activity Programs: A Scoping Review.","authors":"Helena Bilsborough, Amy Davies, Chris Todd, Afroditi Stathi, Helen Hawley-Hague","doi":"10.1123/japa.2023-0229","DOIUrl":"https://doi.org/10.1123/japa.2023-0229","url":null,"abstract":"<p><p>Peer-volunteering schemes can facilitate health improvement via increasing physical activity levels. Understanding what motivates peer volunteers is valuable for the feasibility of volunteering schemes. This scoping review aims to explore the motivations of peer volunteers aged over 50 who participate in programs that promote physical activity. Four databases were searched in March 2023 with no date restrictions. The inclusion criteria were adults over 50 years of age, experience in physical activity peer-volunteering schemes, assessed volunteer motivation, and uses English language. Nine studies were included (252 participants, aged 54-85) Peer-volunteer and volunteering characteristics were extracted from the papers. An inductive thematic analysis approach was taken to analyze the motivation data. The themes were then mapped onto theoretical constructs of motivation. Three themes of motivation emerged that could enable us to better design peer-volunteer recruitment strategies: altruistic (giving back), personal improvement (meeting goals), and past experience (helping others overcome experienced barriers). The review suggested that peer-volunteer motivations fall in line with the mechanisms of motivation suggested by psychological theories such as social cognitive and self-determination theories. To improve peer-volunteer uptake and retention, appropriate theoretical frameworks should be employed to inform the content of future interventions to ensure that volunteers will have their motivations met.</p>","PeriodicalId":51073,"journal":{"name":"Journal of Aging and Physical Activity","volume":" ","pages":"1-11"},"PeriodicalIF":1.4,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elisa F Ogawa, Rebekah Harris, Jennifer Moye, Jonathan F Bean, Bo Kim
{"title":"Veterans' Motivation, Preference, and Feedback After Completing a Novel Physical Therapy Treatment.","authors":"Elisa F Ogawa, Rebekah Harris, Jennifer Moye, Jonathan F Bean, Bo Kim","doi":"10.1123/japa.2023-0446","DOIUrl":"https://doi.org/10.1123/japa.2023-0446","url":null,"abstract":"<p><strong>Objectives: </strong>This study evaluated Veterans' motivation and perception of different components of a novel physical therapy (PT) treatment aimed at increasing mobility, motivation, and exercise adoption.</p><p><strong>Methods: </strong>Patient-satisfaction surveys were administered to middle-aged to older Veterans (≥50 years old) with slow walking speed who completed the 8-week PT treatment. Mixed methods were employed to assess rating-based responses and examine themes derived from open-ended responses.</p><p><strong>Results: </strong>Twenty-three participants completed the surveys (mean age: 73 years, Short Physical Performance Battery: 8.5, 96% male). Overall, participants were satisfied with the PT treatment (80%), and over 85% responded that the PT treatment met its objectives by improving their mobility. Veterans rated functional power training as challenging and the most valuable component of Live Long Walk Strong mobility training. Factors that influenced Veterans' motivations for meeting their exercise goals, were having a personal goal, a motivated physical therapist, and scheduled appointments. Participants rated aspects of behavioral coaching to be \"somewhat useful\" or \"very useful.\" Approximately half of the Veterans did not use the exercise journal to keep track of their home exercises. Reasons for not using the exercise journal were feeling busy or already having an exercise routine.</p><p><strong>Conclusion: </strong>Our results highlight the importance of prescribing challenging and meaningful PT treatment even among mobility-limited Veterans. Veterans may achieve their exercise goals by being instructed by a motivated physical therapist, having personal goals, and scheduling future appointments. There may be individual variability among those who may benefit from aspects of behavioral coaching and may need to be adjusted based on Veteran's needs.</p>","PeriodicalId":51073,"journal":{"name":"Journal of Aging and Physical Activity","volume":" ","pages":"1-8"},"PeriodicalIF":1.4,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Erratum. A 3-Month Dual-Task Exercise Randomized Pilot Trial Improves Dynamic Stability and Coordination in Community-Dwelling Older Adults.","authors":"","doi":"10.1123/japa.2025-0006","DOIUrl":"https://doi.org/10.1123/japa.2025-0006","url":null,"abstract":"","PeriodicalId":51073,"journal":{"name":"Journal of Aging and Physical Activity","volume":" ","pages":"1"},"PeriodicalIF":1.4,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wen Qi, David Alarcón, María José Arenilla, Hongli Yu, José Carlos Jaenes, Manuel Trujillo, Dominika Wilczyńska
{"title":"A Systematic Review and Meta-Analysis of Asian Exercise Techniques and Various Physical Activity Interventions in Middle and Late Adulthood Patients With Knee Osteoarthritis.","authors":"Wen Qi, David Alarcón, María José Arenilla, Hongli Yu, José Carlos Jaenes, Manuel Trujillo, Dominika Wilczyńska","doi":"10.1123/japa.2024-0077","DOIUrl":"https://doi.org/10.1123/japa.2024-0077","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this review and meta-analysis is to compare different low-intensity forms of physical activity (PA; Baduanjin, Tai Chi, walking, and general PA) as treatments for knee osteoarthritis.</p><p><strong>Methods: </strong>Between 2003 and 2023, pertinent articles published in scientific electronic databases (PubMed, Web of Science, EBSCOhost, and Google Scholar) were searched in preparation for a systematic review and meta-analysis. Twenty-four studies that satisfied the requirements were selected, with a total sample size of 1,972 participants, of which 71.46% were female. Preferred Reporting Items for Systematic Reviews and Meta-Analyses criteria were followed in the study selection process, and the Cochrane Collaboration's risk of bias tool was used to evaluate the quality of the included studies.</p><p><strong>Results: </strong>The systematic review and meta-analysis indicated that various low-intensity PAs, particularly Asian exercise techniques such as Baduanjin, Tai Chi, and walking, significantly alleviated symptoms of knee osteoarthritis in middle and late adulthood. Pain reduction showed a moderately significant effect size (d = -0.65, SE = 0.14, p < .001), with all interventions, including Baduanjin, general PA, Tai Chi, and walking, significantly decreasing pain levels. Stiffness also improved, with a moderate effect size (d = -0.71, SE = 0.17, p < .001), and physical function significantly improved (d = -0.58, SE = 0.15, p < .001).</p><p><strong>Conclusion: </strong>The results suggest that walking and Baduanjin exercises can be effectively integrated into community-based programs for middle-aged and older adults to manage knee osteoarthritis symptoms, offering a cost-effective nonpharmacological intervention.</p>","PeriodicalId":51073,"journal":{"name":"Journal of Aging and Physical Activity","volume":" ","pages":"1-12"},"PeriodicalIF":1.4,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pedro Henrique Martins Monteiro, Paola Janeiro Valenciano, Pedro Henrique Silva Mendes, Luis Augusto Teixeira
{"title":"Association of 30-s Sit-to-Stand Power Test Outcome With Body Balance in Physically Active Older Adults.","authors":"Pedro Henrique Martins Monteiro, Paola Janeiro Valenciano, Pedro Henrique Silva Mendes, Luis Augusto Teixeira","doi":"10.1123/japa.2023-0373","DOIUrl":"https://doi.org/10.1123/japa.2023-0373","url":null,"abstract":"<p><p>Amount of serial sitting and standing movements has been employed in clinical and research settings to assess legs' muscular strength. In this cross-sectional study, we aimed to test the correlation between the 30-s sit-to-stand power test (30STSp) outcome and body balance in older adults. We evaluated physically active male and female (n = 51) individuals with an age range of 60-80 years (M = 69.29). Participants were assessed on the maximum number of repetitions for 30STSp and on the performance of balance tasks, as follows: quiet standing in unipedal support, unipedal support while alternately touching two targets on the ground with the toe of the nonsupporting foot in either the anteroposterior (AP) or mediolateral (ML) direction, and paced sit-to-stand supported on a narrow bipedal support base. Performance on the balance tasks was measured through smartphone-based triaxial trunk accelerometry (meters per second squared), with analysis made through root mean square for the AP and ML axes. Analysis indicated significant negative correlation coefficients of 30STSp outcome with trunk acceleration on unipedal quiet stance tasks both in the ML (rs = -.46) and AP (rs = -.40) directions and with the AP alternate target touching task for ML trunk acceleration (rs = -.34) and the ML alternate target touching task for AP trunk acceleration (rs = -.31). These results suggest that in active older adults, the 30STSp outcome is associated with balance in unipedal quiet standing and dynamic tasks. Our findings indicate the contribution of balance control in the performance of 30STSp.</p>","PeriodicalId":51073,"journal":{"name":"Journal of Aging and Physical Activity","volume":" ","pages":"1-9"},"PeriodicalIF":1.4,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Helaine M Alessio, Nancy Malay, Annemarie Jones, Lindsay Stein, Taylor Thornburg, Michael O'Connell, Dean L Smith
{"title":"A 3-Month Dual-Task Exercise Randomized Pilot Trial Improves Dynamic Stability and Coordination in Community-Dwelling Older Adults.","authors":"Helaine M Alessio, Nancy Malay, Annemarie Jones, Lindsay Stein, Taylor Thornburg, Michael O'Connell, Dean L Smith","doi":"10.1123/japa.2023-0270","DOIUrl":"10.1123/japa.2023-0270","url":null,"abstract":"<p><strong>Introduction: </strong>Dual-task (DT) exercises combine both physical and cognitive activities and have the potential to efficiently enhance both physical and cognitive function.</p><p><strong>Background/objectives: </strong>This study aimed to determine if, compared with exercise-only (EO) and control (C) groups, adults in a DT training program improved measures of cognitive and/or physical functioning.</p><p><strong>Methods: </strong>Thirty-five participants (Mage = 65.7 ± 8.5 years; 74.3% female, 25.7% male) were randomly sorted into EO (n = 15), DT (n = 10), and C (n = 10). EO and DT participated in 3 months of twice weekly, 50-min exercise. DT played cognitive games on a SMARTfit Cognitive-Motor Exercise System during exercise sessions. C did not participate in any supervised sessions. Cognition was assessed with a Cognivue Thrive program. Dynamic stability, coordination, and lower body strength were assessed. Linear mixed-effects models investigated effects for different groups. For outcomes showing significant (p < .05) differences, pairwise t tests were conducted between all treatment and time comparisons.</p><p><strong>Results: </strong>Dynamic stability and coordination improved in DT and EO (p = .002 and .04, respectively), but not in C in the first 6 weeks (p = .58). Cognition and memory did not change over time among the three groups.</p><p><strong>Conclusion: </strong>Healthy, independent-living older adults in either DT or EO improved dynamic stability and coordination over time and DT improved balance and functional mobility more than either EO or C. No improvements in several standard cognition or memory measurements were observed. Significance/Implications: A DT exercise program improved balance and coordination, but not cognition or memory, in healthy, independent-living older adults.</p>","PeriodicalId":51073,"journal":{"name":"Journal of Aging and Physical Activity","volume":" ","pages":"1-11"},"PeriodicalIF":1.4,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Effect of Adherence to a Tai Chi Intervention on Quality of Life of Older People Living With Dementia.","authors":"Iram Bibi, Remco Polman, Samuel R Nyman","doi":"10.1123/japa.2024-0017","DOIUrl":"https://doi.org/10.1123/japa.2024-0017","url":null,"abstract":"<p><strong>Background/objectives: </strong>Adherence to exercise programs is required to reap their established benefits and to sustain Quality of Life (QoL). This study explored People Living with Dementia's (PLWD) adherence to a Tai Chi exercise program and its effects on their QoL. The study included assessment of factors affecting adherence to a Tai Chi exercise intervention, causes of nonadherence, and effect of adherence on PLWD's QoL.</p><p><strong>Methods: </strong>This study was part of a randomized controlled trial where 41 community-dwelling PLWD received a Tai Chi exercise intervention in addition to usual care for 20 weeks. The measures used in this study included PLWD's QoL, global cognitive function, moderate physical activity, intention and confidence to attend classes, record of PLWD's and their carers' health conditions, and percentages of PLWD's Tai Chi class attendance and home practice during the intervention phase. Multiple linear regression, bivariate correlation, and independent sample t-test analyses were conducted to evaluate associations between these variables.</p><p><strong>Results: </strong>PLWD's overall percentage of class attendance, M (SD) = 69.19 (29.95), demonstrated high adherence. Moreover, QoL of highly adherent PLWD was significantly higher than low adherents. Among all variables, PLWD's and carers' health conditions (β = -0.64; p < .001, β = -0.38; p < .001, respectively) were the dominating factors that reduced PLWD's Tai Chi adherence, while PLWD's moderate physical activity at baseline (β = 0.27; p = .02) was significant positive predictor. Significance/Implications: PLWD's and their carers' health issues must be addressed to enhance PLWD's exercise adherence and sustain good QoL.</p>","PeriodicalId":51073,"journal":{"name":"Journal of Aging and Physical Activity","volume":" ","pages":"1-11"},"PeriodicalIF":1.4,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Júlio Benvenutti Bueno de Camargo, Felipe Alves Brigatto
{"title":"Beta-Alanine for Improving Exercise Capacity, Muscle Strength, and Functional Performance of Older Adults: A Systematic Review.","authors":"Júlio Benvenutti Bueno de Camargo, Felipe Alves Brigatto","doi":"10.1123/japa.2024-0118","DOIUrl":"https://doi.org/10.1123/japa.2024-0118","url":null,"abstract":"<p><strong>Background/objective: </strong> Beta-alanine supplementation increases muscle carnosine content and also improves exercise capacity and performance in young adults, with mixed findings emerging from the few studies investigating its effects on older participants. Therefore, this study aimed to systematically review the evidence regarding the effects of beta-alanine on exercise capacity, muscle strength, and functional performance of older adults.</p><p><strong>Methods: </strong> This systematic review was conducted following the specific methodological guidelines of the Preferred Report Items for Systematic Reviews and Meta-Analyses and the Physiotherapy Evidence Database scale. Furthermore, the Cochrane risk-of-bias assessment tool was used. The search was carried out in five relevant databases (MEDLINE, Embase, Web of Science, Scopus, and Cochrane Library) from inception up to March 2024.</p><p><strong>Results: </strong> Of the 1,749 registers identified, only five met the established criteria and were included in this systematic review. A total of 163 older adults (mean age ± SD: 69.1 ± 2.8 years; range: 66.2-72.7 years) were included across all five studies. The majority of studies included participants from both genders. The mean intervention duration ± SD was 11.7 ± 1.0 weeks. The mean daily dosage was 2.7 ± 0.4 g/day (range: 2.4-3.2 g/day).</p><p><strong>Conclusion: </strong> Overall, exercise capacity may be improved following supplementation protocols with dosages ranging from 2.4 to 3.2 g/day. Muscle strength and functional performance do not seem to be improved by beta-alanine since these tasks are not significantly impacted by acidosis buildup.</p>","PeriodicalId":51073,"journal":{"name":"Journal of Aging and Physical Activity","volume":" ","pages":"1-9"},"PeriodicalIF":1.4,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}