DNA Research最新文献_第4页

The genome of a globally invasive passerine, the common myna, Acridotheres tristis. 具有全球入侵性的雀形目鸟类--普通贻贝（Acridotheres tristis）的基因组。

IF 3.9 2区生物学

DNA Research Pub Date : 2024-01-01 DOI: 10.1093/dnares/dsae005

Katarina C Stuart, Rebecca N Johnson, Richard E Major, Kamolphat Atsawawaranunt, Kyle M Ewart, Lee A Rollins, Anna W Santure, Annabel Whibley

{"title":"The genome of a globally invasive passerine, the common myna, Acridotheres tristis.","authors":"Katarina C Stuart, Rebecca N Johnson, Richard E Major, Kamolphat Atsawawaranunt, Kyle M Ewart, Lee A Rollins, Anna W Santure, Annabel Whibley","doi":"10.1093/dnares/dsae005","DOIUrl":"10.1093/dnares/dsae005","url":null,"abstract":"In an era of global climate change, biodiversity conservation is receiving increased attention. Conservation efforts are greatly aided by genetic tools and approaches, which seek to understand patterns of genetic diversity and how they impact species health and their ability to persist under future climate regimes. Invasive species offer vital model systems in which to investigate questions regarding adaptive potential, with a particular focus on how changes in genetic diversity and effective population size interact with novel selection regimes. The common myna (Acridotheres tristis) is a globally invasive passerine and is an excellent model species for research both into the persistence of low-diversity populations and the mechanisms of biological invasion. To underpin research on the invasion genetics of this species, we present the genome assembly of the common myna. We describe the genomic landscape of this species, including genome wide allelic diversity, methylation, repeats, and recombination rate, as well as an examination of gene family evolution. Finally, we use demographic analysis to identify that some native regions underwent a dramatic population increase between the two most recent periods of glaciation, and reveal artefactual impacts of genetic bottlenecks on demographic analysis.","PeriodicalId":51014,"journal":{"name":"DNA Research","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10917472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139747746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genome features of a novel hydrocarbonoclastic Chryseobacterium oranimense strain and its comparison to bacterial oil-degraders and to other C. oranimense strains. 一株新的烃破溶性黄杆菌的基因组特征及其与其它油降解菌的比较。

IF 4.1 2区生物学

DNA Research Pub Date : 2023-12-01 DOI: 10.1093/dnares/dsad025

Amanda Christine Ramdass, Sephra Nalini Rampersad

{"title":"Genome features of a novel hydrocarbonoclastic Chryseobacterium oranimense strain and its comparison to bacterial oil-degraders and to other C. oranimense strains.","authors":"Amanda Christine Ramdass, Sephra Nalini Rampersad","doi":"10.1093/dnares/dsad025","DOIUrl":"10.1093/dnares/dsad025","url":null,"abstract":"For the first time, we report the whole genome sequence of a hydrocarbonoclastic Chryseobacterium oranimense strain isolated from Trinidad and Tobago (COTT) and its genes involved in the biotransformation of hydrocarbons and xenobiotics through functional annotation. The assembly consisted of 11 contigs with 2,794 predicted protein-coding genes which included a diverse group of gene families involved in aliphatic and polycyclic hydrocarbon degradation. Comparative genomic analyses with 18 crude-oil degrading bacteria in addition to two C. oranimense strains not associated with oil were carried out. The data revealed important differences in terms of annotated genes involved in the hydrocarbon degradation process that may explain the molecular mechanisms of hydrocarbon and xenobiotic biotransformation. Notably, many gene families were expanded to explain COTT's competitive ability to manage habitat-specific stressors. Gene-based evidence of the metabolic potential of COTT supports the application of indigenous microbes for the remediation of polluted terrestrial environments and provides a genomic resource for improving our understanding of how to optimize these characteristics for more effective bioremediation.","PeriodicalId":51014,"journal":{"name":"DNA Research","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10710014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89720459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evolution of the viral genomes of SARS-CoV-2 in association with the changes in local condition: a genomic epidemiological study of a suburban city of Japan. 严重急性呼吸系统综合征冠状病毒2型病毒基因组的进化与当地条件的变化：日本郊区城市的基因组流行病学研究。

IF 4.1 2区生物学

DNA Research Pub Date : 2023-10-01 DOI: 10.1093/dnares/dsad020

Yukie Kashima, Taketoshi Mizutani, Yuki Okimoto, Minami Maeda, Kaoru Musashino, Ryo-Ichi Nishide, Akira Matsukura, Jison Nagase, Yutaka Suzuki

{"title":"Evolution of the viral genomes of SARS-CoV-2 in association with the changes in local condition: a genomic epidemiological study of a suburban city of Japan.","authors":"Yukie Kashima, Taketoshi Mizutani, Yuki Okimoto, Minami Maeda, Kaoru Musashino, Ryo-Ichi Nishide, Akira Matsukura, Jison Nagase, Yutaka Suzuki","doi":"10.1093/dnares/dsad020","DOIUrl":"10.1093/dnares/dsad020","url":null,"abstract":"Understanding the factors driving the spread and evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at the local, regional, national, and international levels is important in protecting against future pandemics. By exploring their viral genomes, we attempted to analyse the spread of SARS-CoV-2 and its evolutionary convergence in Kashiwa City, as an example of a representative commuter town in Japan. From September 2020 to January 2023, a total of 47,134 nasopharyngeal swab and saliva specimens were collected from patients in 47 local clinics and hospitals, covering the vast majority of healthcare facilities. All SARS-CoV-2-positive samples were subjected to whole genome sequencing. Based on the analysis of 5,536 identified genomes, all major strains were represented. Unique regional mutations were occasionally identified in each strain. Inspection of these mutations revealed that the overall base substitution rate increased with progressive waves of the pandemic, at an overall rate of 2.56 bases/year. Interestingly, the spread and evolutionary patterns appeared to be distinct between regions and between individual clinics. Further analysis of the synonymous base substitution rate showed that the speed of viral evolution accelerated coincident with the beginning of public vaccination. Comprehensive genomic epidemiological studies, as presented here, should be useful in precisely understanding the pandemic and preparing for possible future pandemics.","PeriodicalId":51014,"journal":{"name":"DNA Research","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8b/70/dsad020.PMC10562954.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10592178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Telomere-to-telomere genome assembly of an allotetraploid pernicious weed, Echinochloa phyllopogon. 一种异源四倍体恶性杂草叶棘鱼的端粒到端粒基因组组装。

IF 4.1 2区生物学

DNA Research Pub Date : 2023-10-01 DOI: 10.1093/dnares/dsad023

Mitsuhiko P Sato, Satoshi Iwakami, Kanade Fukunishi, Kai Sugiura, Kentaro Yasuda, Sachiko Isobe, Kenta Shirasawa

{"title":"Telomere-to-telomere genome assembly of an allotetraploid pernicious weed, Echinochloa phyllopogon.","authors":"Mitsuhiko P Sato, Satoshi Iwakami, Kanade Fukunishi, Kai Sugiura, Kentaro Yasuda, Sachiko Isobe, Kenta Shirasawa","doi":"10.1093/dnares/dsad023","DOIUrl":"10.1093/dnares/dsad023","url":null,"abstract":"Echinochloa phyllopogon is an allotetraploid pernicious weed species found in rice fields worldwide that often exhibit resistance to multiple herbicides. An accurate genome sequence is essential to comprehensively understand the genetic basis underlying the traits of this species. Here, the telomere-to-telomere genome sequence of E. phyllopogon was presented. Eighteen chromosome sequences spanning 1.0 Gb were constructed using the PacBio highly fidelity long technology. Of the 18 chromosomes, 12 sequences were entirely assembled into telomere-to-telomere and gap-free contigs, whereas the remaining six sequences were constructed at the chromosomal level with only eight gaps. The sequences were assigned to the A and B genome with total lengths of 453 and 520 Mb, respectively. Repetitive sequences occupied 42.93% of the A genome and 48.47% of the B genome, although 32,337, and 30,889 high-confidence genes were predicted in the A and B genomes, respectively. This suggested that genome extensions and gene disruptions caused by repeated sequence accumulation often occur in the B genome before polyploidization to establish a tetraploid genome. The highly accurate and comprehensive genome sequence could be a milestone in understanding the molecular mechanisms of the pernicious traits and in developing effective weed control strategies to avoid yield loss in rice production.","PeriodicalId":51014,"journal":{"name":"DNA Research","volume":"30 5","pages":""},"PeriodicalIF":4.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71523329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic basis of lineage-specific evolution of fruit traits in hexaploid persimmon. 六倍体柿子果实性状谱系特异性进化的遗传基础。

IF 4.1 2区生物学

DNA Research Pub Date : 2023-10-01 DOI: 10.1093/dnares/dsad015

Ayano Horiuchi, Kanae Masuda, Kenta Shirasawa, Noriyuki Onoue, Ryusuke Matsuzaki, Ryutaro Tao, Yasutaka Kubo, Koichiro Ushijima, Takashi Akagi

{"title":"Genetic basis of lineage-specific evolution of fruit traits in hexaploid persimmon.","authors":"Ayano Horiuchi, Kanae Masuda, Kenta Shirasawa, Noriyuki Onoue, Ryusuke Matsuzaki, Ryutaro Tao, Yasutaka Kubo, Koichiro Ushijima, Takashi Akagi","doi":"10.1093/dnares/dsad015","DOIUrl":"10.1093/dnares/dsad015","url":null,"abstract":"Frequent polyploidization events in plants have led to the establishment of many lineage-specific traits representing each species. Little is known about the genetic bases for these specific traits in polyploids, presumably due to plant genomic complexity and their difficulties in applying genetic approaches. Hexaploid Oriental persimmon (Diospyros kaki) has evolved specific fruit characteristics, including wide variations in fruit shapes and astringency. In this study, using whole-genome diploidized/quantitative genotypes from ddRAD-Seq data of 173 persimmon cultivars, we examined their population structures and potential correlations between their structural transitions and variations in nine fruit traits. The population structures of persimmon cultivars were highly randomized and not substantially correlated with the representative fruit traits focused on in this study, except for fruit astringency. With genome-wide association analytic tools considering polyploid alleles, we identified the loci associated with the nine fruit traits; we mainly focused on fruit-shape variations, which have been numerically characterized by principal component analysis of elliptic Fourier descriptors. The genomic regions that putatively underwent selective sweep exhibited no overlap with the loci associated with these persimmon-specific fruit traits. These insights will contribute to understanding the genetic mechanisms by which fruit traits are independently established, possibly due to polyploidization events.","PeriodicalId":51014,"journal":{"name":"DNA Research","volume":"30 5","pages":""},"PeriodicalIF":4.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5c/6e/dsad015.PMC10468310.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10489365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chromosome-level assembly and annotation of the Xyrichtys novacula (Linnaeus, 1758) genome. Xyrichtys novacula（林奈，1758）基因组的染色体水平组装和注释。

IF 3.9 2区生物学

DNA Research Pub Date : 2023-10-01 DOI: 10.1093/dnares/dsad021

Fernando Cruz, Jèssica Gómez-Garrido, Marta Gut, Tyler S Alioto, Joan Pons, Josep Alós, Margarida Barcelo-Serra

{"title":"Chromosome-level assembly and annotation of the Xyrichtys novacula (Linnaeus, 1758) genome.","authors":"Fernando Cruz, Jèssica Gómez-Garrido, Marta Gut, Tyler S Alioto, Joan Pons, Josep Alós, Margarida Barcelo-Serra","doi":"10.1093/dnares/dsad021","DOIUrl":"10.1093/dnares/dsad021","url":null,"abstract":"The pearly razorfish (Xyrichtys novacula), commonly known as raor in the Balearic Islands, is a wrasse within the family Labridae. This fish species has particular biological and socio-cultural characteristics making it an ideal model organism in the fields of behavioural ecology, molecular ecology and conservation biology. In this study, we present the first annotated chromosome-level assembly for this species. Sequencing involved a combination of long reads with Oxford Nanopore Technologies, Illumina paired-end short reads (2 × 151 bp), Hi-C and RNA-seq from different tissues. The nuclear genome assembly has a scaffold N50 of 34.33 Mb, a total assembly span of 775.53 Mb and 99.63% of the sequence assembled into 24 superscaffolds, consistent with its known karyotype. Quality metrics revealed a consensus accuracy (QV) of 42.92 and gene completeness > 98%. The genome annotation resulted in 26,690 protein-coding genes and 12,737 non-coding transcripts. The coding regions encoded 39,613 unique protein products, 93% of them with assigned function. Overall, the publication of the X. novacula's reference genome will broaden the scope and impact of genomic research conducted on this iconic and colourful species.","PeriodicalId":51014,"journal":{"name":"DNA Research","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41150703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unravelling the genomic features, phylogeny and genetic basis of tooth ontogenesis in Characiformes through analysis of four genomes. 通过对四个基因组的分析，揭示炭形目牙齿个体发生的基因组特征、系统发育和遗传基础。

IF 3.9 2区生物学

DNA Research Pub Date : 2023-10-01 DOI: 10.1093/dnares/dsad022

Xianwei Yang, Yue Song, Rui Zhang, Mengjun Yu, Xinyu Guo, Haobing Guo, Xiao Du, Shuai Sun, Chunhua Li, Xuebin Mao, Guangyi Fan, Xin Liu

{"title":"Unravelling the genomic features, phylogeny and genetic basis of tooth ontogenesis in Characiformes through analysis of four genomes.","authors":"Xianwei Yang, Yue Song, Rui Zhang, Mengjun Yu, Xinyu Guo, Haobing Guo, Xiao Du, Shuai Sun, Chunhua Li, Xuebin Mao, Guangyi Fan, Xin Liu","doi":"10.1093/dnares/dsad022","DOIUrl":"10.1093/dnares/dsad022","url":null,"abstract":"Characiformes is a diverse and evolutionarily significant order of freshwater fish encompassing over 2,300 species. Despite its diversity, our understanding of Characiformes' evolutionary relationships and adaptive mechanisms is limited due to insufficient genome sequences. In this study, we sequenced and assembled the genomes of four Characiformes species, three of which were chromosome-level assemblies. Our analyses revealed dynamic changes in gene family evolution, repeat sequences and variations in chromosomal collinearity within these genomes. With the assembled genomes, we were not only able to elucidate the evolutionary relationship of the four main orders in Otophysi but also indicated Characiformes as the paraphyletic group. Comparative genomic analysis with other available fish genomes shed light on the evolution of genes related to tooth development in Characiformes. Notably, variations in the copy number of secretory calcium-binding phosphoproteins (SCPP) genes were observed among different orders of Otophysi, indicating their potential contribution to the diversity of tooth types. Our study offers invaluable genome sequences and novel insights into Characiformes' evolution, paving the way for further genomic and evolutionary research in fish.","PeriodicalId":51014,"journal":{"name":"DNA Research","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41162960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genome and transcriptome analyses reveal genes involved in the formation of fine ridges on petal epidermal cells in Hibiscus trionum. 基因组和转录组分析揭示了参与木槿花瓣表皮细胞细脊形成的基因。

IF 4.1 2区生物学

DNA Research Pub Date : 2023-10-01 DOI: 10.1093/dnares/dsad019

Shizuka Koshimizu, Sachiko Masuda, Arisa Shibata, Takayoshi Ishii, Ken Shirasu, Atsushi Hoshino, Masanori Arita

引用次数: 0

Genome assembly of the pioneer species Plantago major L. (Plantaginaceae) provides insight into its global distribution and adaptation to metal-contaminated soil. 车前草(Plantago major L.，车前草科)的基因组组装有助于了解其全球分布及其对金属污染土壤的适应。

IF 4.1 2区生物学

DNA Research Pub Date : 2023-08-01 DOI: 10.1093/dnares/dsad013

Shanwu Lyu, Qiming Mei, Hui Liu, Baosheng Wang, Jun Wang, Hans Lambers, Zhengfeng Wang, Bin Dong, Zhanfeng Liu, Shulin Deng

{"title":"Genome assembly of the pioneer species Plantago major L. (Plantaginaceae) provides insight into its global distribution and adaptation to metal-contaminated soil.","authors":"Shanwu Lyu, Qiming Mei, Hui Liu, Baosheng Wang, Jun Wang, Hans Lambers, Zhengfeng Wang, Bin Dong, Zhanfeng Liu, Shulin Deng","doi":"10.1093/dnares/dsad013","DOIUrl":"https://doi.org/10.1093/dnares/dsad013","url":null,"abstract":"Plantago is a major genus belonging to the Plantaginaceae family and is used in herbal medicine, functional food, and pastures. Several Plantago species are also characterized by their global distribution, but the mechanism underpinning this is not known. Here, we present a high-quality, chromosome-level genome assembly of Plantago major L., a species of Plantago, by incorporating Oxford Nanopore sequencing and Hi-C technologies. The genome assembly size was approximately 671.27 Mb with a contig N50 length of 31.30 Mb. 31,654 protein-coding genes were identified from the genome. Evolutionary analysis showed that P. major diverged from other Lamiales species at ~62.18 Mya and experienced two rounds of WGD events. Notably, many gene families related to plant acclimation and adaptation expanded. We also found that many polyphenol biosynthesis genes showed high expression patterns in roots. Some amino acid biosynthesis genes, such as those involved in histidine synthesis, were highly induced under metal (Ni) stress that led to the accumulation of corresponding metabolites. These results suggest persuasive arguments for the global distribution of P. major through multiscale analysis. Decoding the P. major genome provides a valuable genomic resource for research on dissecting biological function, molecular evolution, taxonomy, and breeding.","PeriodicalId":51014,"journal":{"name":"DNA Research","volume":"30 4","pages":""},"PeriodicalIF":4.1,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9651551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Base-excision restriction enzymes: expanding the world of epigenetic immune systems. 碱基切除限制性内切酶:扩展表观遗传免疫系统的世界。

IF 4.1 2区生物学

DNA Research Pub Date : 2023-08-01 DOI: 10.1093/dnares/dsad009

Kenji K Kojima, Ichizo Kobayashi

{"title":"Base-excision restriction enzymes: expanding the world of epigenetic immune systems.","authors":"Kenji K Kojima, Ichizo Kobayashi","doi":"10.1093/dnares/dsad009","DOIUrl":"https://doi.org/10.1093/dnares/dsad009","url":null,"abstract":"The restriction enzymes examined so far are phosphodiesterases, which cleave DNA strands by hydrolysing phosphodiester bonds. Based on the mobility of restriction-modification systems, recent studies have identified a family of restriction enzymes that excise a base in their recognition sequence to generate an abasic (AP) site unless the base is properly methylated. These restriction glycosylases also show intrinsic but uncoupled AP lyase activity at the AP site, generating an atypical strand break. Action of an AP endonuclease at the AP site may generate another atypical break, rejoining/repairing of which is difficult. This PabI family of restriction enzymes contain a novel fold (HALFPIPE) and show unusual properties, such as non-requirement of divalent cations for cleavage. These enzymes are present in Helicobacteraceae/Campylobacteraceae and in few hyperthermophilic archaeal species. In Helicobacter genomes, their recognition sites are strongly avoided, and the encoding genes are often inactivated by mutations or replacement, indicating that their expression is toxic for the cells. The discovery of restriction glycosylases generalizes the concept of restriction-modification systems to epigenetic immune systems, which may use any mode of damage to DNA that are considered 'non-self' based on epigenetic modifications. This concept will add to our understanding of immunity and epigenetics.","PeriodicalId":51014,"journal":{"name":"DNA Research","volume":"30 4","pages":""},"PeriodicalIF":4.1,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10273834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9654022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0