Best Practice & Research in Clinical Rheumatology最新文献_第8页

Pipeline treatments on psoriatic disease 银屑病的管道治疗。

IF 4.8 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2025-12-01 Epub Date: 2025-09-22 DOI: 10.1016/j.berh.2025.102090

André L. Ribeiro , Leandro L. Leite , Raphael Micheroli , Daniela B. Tovar-Batisdas , Maria-Angeliki Gkini , Fabian Proft

{"title":"Pipeline treatments on psoriatic disease","authors":"André L. Ribeiro , Leandro L. Leite , Raphael Micheroli , Daniela B. Tovar-Batisdas , Maria-Angeliki Gkini , Fabian Proft","doi":"10.1016/j.berh.2025.102090","DOIUrl":"10.1016/j.berh.2025.102090","url":null,"abstract":"<div><div>Psoriatic disease is a heterogeneous and multifaceted disease affecting musculoskeletal, dermatologic, and systemic domains, with low sustained remission rates despite advances in therapy. Current treatments, primarily targeting TNF, IL-17, IL-23, PDE4 inhibitors and JAK-STAT pathways, remain insufficient for many patients, highlighting the need for novel therapeutic approaches. This review explores pipeline treatments in psoriatic disease, including new JAK-STAT inhibitors (TYK2, JAK1), next-generation IL-17 inhibitors, IL-23-targeted therapies, and novel immune-modulating agents. The emerging role of combination therapy is also discussed, with dual biologic and small-molecule approaches showing potential in refractory disease. Additionally, microbiome-targeted therapies and metabolic interventions, including probiotics and GLP-1 receptor agonists, are being investigated as adjunctive strategies to improve disease control. While these innovations offer exciting opportunities for personalized medicine, challenges remain regarding long-term safety, optimal treatment sequencing, and combination strategies. Further randomized controlled trials and real-world data are necessary to define the most effective and sustainable treatment approaches for psoriatic disease.</div></div>","PeriodicalId":50983,"journal":{"name":"Best Practice & Research in Clinical Rheumatology","volume":"39 4","pages":"Article 102090"},"PeriodicalIF":4.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel therapies in SSc SSc的新疗法。

IF 4.8 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2025-12-01 Epub Date: 2025-09-30 DOI: 10.1016/j.berh.2025.102104

Janet Pope

引用次数: 0

Novel therapies in Sjögren’s disease: A systematic review of the literature Sjögren病的新疗法：文献系统综述

IF 4.8 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2025-12-01 Epub Date: 2025-07-07 DOI: 10.1016/j.berh.2025.102084

Cristina Pelkas , Kyle B. Franke , Fabien B. Vincent , Maureen Rischmueller

{"title":"Novel therapies in Sjögren’s disease: A systematic review of the literature","authors":"Cristina Pelkas , Kyle B. Franke , Fabien B. Vincent , Maureen Rischmueller","doi":"10.1016/j.berh.2025.102084","DOIUrl":"10.1016/j.berh.2025.102084","url":null,"abstract":"<div><div>Sjögren's disease (SjD) is a chronic systemic autoimmune disorder that primarily involves lymphocytic infiltration of exocrine glands, with frequent extra-glandular manifestations. Historically, treatment options for SjD have been limited to alleviating symptoms, rather than treating the underlying cause or preventing disease progression. Furthermore, past clinical trials of therapies such as rituximab failed to demonstrate improvement in symptoms or disease activity. Recently, novel therapeutic strategies targeting underlying disease pathogenesis – including transcription factors, circulating RNA, and B and T cell activity – herald a paradigm shift. Given the complexities of diagnosis, clinical assessment and treatment in SjD, improved clinical trial design with enhanced patient stratification, greater inclusivity and better outcome measures are paramount in evaluating new therapeutics. This systematic review aims to provide a comprehensive overview of recent SjD therapeutic advances, assess trial inclusivity with respect to sex/gender and ethnicity, critically examine negative pivotal trials and highlight promising directions for future research.</div></div>","PeriodicalId":50983,"journal":{"name":"Best Practice & Research in Clinical Rheumatology","volume":"39 4","pages":"Article 102084"},"PeriodicalIF":4.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Imaging rheumatology: Emerging tools and expanding applications 风湿病影像学：新兴工具和扩展应用。

IF 4.8 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2025-09-01 Epub Date: 2025-08-07 DOI: 10.1016/j.berh.2025.102088

Pamela Diaz P.D., MD, MSc , Gurjit S. Kaeley G.S.K., MBBS, MRCP, RhMSUS

引用次数: 0

Imaging in sarcoid disease 结节病的影像学。

IF 4.8 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2025-09-01 Epub Date: 2025-03-14 DOI: 10.1016/j.berh.2025.102054

Sherief Ghozy , Jonathan W. Revels , Aakanksha Sriwastwa , Lily L. Wang , Jennifer S. Weaver , Sherry S. Wang

{"title":"Imaging in sarcoid disease","authors":"Sherief Ghozy , Jonathan W. Revels , Aakanksha Sriwastwa , Lily L. Wang , Jennifer S. Weaver , Sherry S. Wang","doi":"10.1016/j.berh.2025.102054","DOIUrl":"10.1016/j.berh.2025.102054","url":null,"abstract":"<div><div>Sarcoidosis is a complex multisystem inflammatory disease characterized by noncaseating granulomas and variable clinical manifestations, most commonly affecting the lungs, skin, heart, and nervous system. Imaging is central in its diagnosis, staging, and management, providing essential insights into organ involvement and disease activity. Pulmonary manifestations remain the hallmark, with modalities such as high-resolution chest computed tomography (CT) and chest radiography offering critical diagnostic clues. Imaging techniques, including Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) and cardiac magnetic resonance imaging, are invaluable for identifying cardiac and systemic involvement, including cutaneous and musculoskeletal, while abdominal MRI and ultrasound help delineate hepatic and splenic manifestations. Neurosarcoidosis requires MRI for precise evaluation, supplemented by FDG-PET to guide biopsy and monitor treatment response. This chapter synthesizes the imaging features of sarcoidosis across organ systems, emphasizing practical approaches to diagnosis and management while identifying key areas for future research.</div></div>","PeriodicalId":50983,"journal":{"name":"Best Practice & Research in Clinical Rheumatology","volume":"39 3","pages":"Article 102054"},"PeriodicalIF":4.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Imaging of crystal-induced arthropathies in 2025 2025年晶体诱发关节病的影像学研究。

IF 4.8 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2025-09-01 Epub Date: 2025-04-08 DOI: 10.1016/j.berh.2025.102063

Silvia Sirotti , Tristan Pascart , Ralf Thiele , Georgios Filippou

{"title":"Imaging of crystal-induced arthropathies in 2025","authors":"Silvia Sirotti , Tristan Pascart , Ralf Thiele , Georgios Filippou","doi":"10.1016/j.berh.2025.102063","DOIUrl":"10.1016/j.berh.2025.102063","url":null,"abstract":"<div><div>In recent years, imaging has become an essential tool in the assessment of crystal-induced arthropathies (CIAs), including gout, calcium pyrophosphate deposition disease, and basic calcium phosphate crystal deposition. Advances in imaging have improved diagnosis and disease monitoring, leading to its integration into classification criteria and clinical guidelines.</div><div>Ultrasound (US), conventional radiography (CR), and dual-energy computed tomography (DECT) each offer unique advantages. US is a widely accessible, cost-effective, and dynamic tool, while DECT provides crystal-specific images, aiding particularly in gout diagnosis. CR, though less sensitive to early crystal deposition, remains valuable for evaluating structural damage and chronic changes.</div><div>Despite these advances, challenges remain. The specificity and sensitivity of imaging findings need further validation, and the clinical relevance of certain imaging features is debated. This review summarizes recent developments, highlights key strengths, and discusses unresolved issues, emphasizing areas where future research is needed to optimize imaging use in CIAs.</div></div>","PeriodicalId":50983,"journal":{"name":"Best Practice & Research in Clinical Rheumatology","volume":"39 3","pages":"Article 102063"},"PeriodicalIF":4.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New developments in ultrasound and MRI imaging of pediatric rheumatic diseases 风湿病的最佳实践：儿童风湿病超声和MRI成像的新发展。

IF 4.8 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2025-09-01 Epub Date: 2025-05-07 DOI: 10.1016/j.berh.2025.102069

Johannes Roth , Clara Malattia

引用次数: 0

Advances in imaging techniques for Sjogren's disease 干燥病的影像技术进展。

IF 4.8 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2025-09-01 Epub Date: 2025-08-20 DOI: 10.1016/j.berh.2025.102087

Baptiste Quéré , Sandrine Jousse-Joulin

{"title":"Advances in imaging techniques for Sjogren's disease","authors":"Baptiste Quéré , Sandrine Jousse-Joulin","doi":"10.1016/j.berh.2025.102087","DOIUrl":"10.1016/j.berh.2025.102087","url":null,"abstract":"<div><div>Imaging of salivary glands (SG), particularly Salivary Glands Ultrasonography (SGUS) is increasingly used in patients with suspected Sjogren's disease (SD). SGUS is the first-line imaging modality. Numerous studies have highlighted this non-invasive, non-irradiating, and low-cost imaging modality. The OMERACT group has established a classification of SG structural damage based on B-mode findings, ranging from grade 0 (normal) to 3 (severe structural damage). SGUS abnormalities (≥ grade 2) have been reported in approximately 63 % of patients with SD. More recently, Hocevar et al. described a Doppler-based classification assessing SG parenchymal vascularization, graded from 0 (normal) to 3 (Doppler signals occupying the entire glandular surface) and could be used as a marker of disease activity and as a biomarker of response to therapy. Moreover, SGUS can be useful for looking for complications such as lymphoma. New ultrasound techniques are currently being developed, including elastography for assessing tissue stiffness, analysis of microvascularization using contrast-enhanced ultrasound with microbubbles, and analysis of minor salivary glands using the ultra-high frequency probe. The combination of several US modalities enhances both sensitivity and specificity of the technique, allowing for the development of a comprehensive multimodal imaging approach. Other imaging techniques can be performed for SD, such as MRI of the parotid glands, allowing analysis of the glandular parenchyma (“salt and pepper” appearance), and certain sequences (DWI-MR) should be performed when lymphoma or other tumors are suspected. 18-FDG PET-CT may be useful to detect systemic manifestations or complications in SD and new PET tracers are currently being developed.</div></div>","PeriodicalId":50983,"journal":{"name":"Best Practice & Research in Clinical Rheumatology","volume":"39 3","pages":"Article 102087"},"PeriodicalIF":4.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Update of imaging in the assessment of axial spondyloarthritis 轴型脊柱性关节炎影像学评估的最新进展。

IF 4.8 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2025-09-01 Epub Date: 2025-04-13 DOI: 10.1016/j.berh.2025.102064

Natalya Horbal , Krystel Aouad , Xenofon Baraliakos , Nelly Ziade , Walter P. Maksymowych

引用次数: 0

Interstitial lung disease imaging for autoimmune diseases 自身免疫性疾病的间质性肺疾病影像学研究

IF 4.8 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2025-09-01 Epub Date: 2025-04-25 DOI: 10.1016/j.berh.2025.102065

John P. Lichtenberger , Sean Hagaman , Wesley Jong , Sydney Yee , Darwish Alabyad , Nadeem Kandalaft

引用次数: 0