Best Practice & Research in Clinical Rheumatology最新文献_第9页

Pain in osteoarthritis from a symptom to a disease 骨关节炎的疼痛从症状到疾病。

IF 5.2 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2023-06-01 DOI: 10.1016/j.berh.2023.101825

Serge Perrot , Trouvin Anne-Priscille

{"title":"Pain in osteoarthritis from a symptom to a disease","authors":"Serge Perrot , Trouvin Anne-Priscille","doi":"10.1016/j.berh.2023.101825","DOIUrl":"10.1016/j.berh.2023.101825","url":null,"abstract":"<div>Pain is the most frequent symptom of osteoarthritis (OA), occurring much more commonly than stiffness or disability. Classically, OA-related pain has been considered to be a nociceptive pain condition and an alarm signal correlated to the intensity of joint degradation.However, OA-related pain is a specific disease, with a complex pathophysiology, including neuropathic peripheral and central abnormalities, together with local inflammation involving all joint structures. Clinical findings emphasize that it is not a stable and linear condition, that pain experience is poorly correlated to structural modifications, and that the quality of pain in OA is important to consider, aside from its intensity. OA-related pain is modulated by many factors, including the individual patient's psychological and genetic factors, as well as the theoretical role of meteorological influences. Recent findings have improved our knowledge about the central mechanisms of OA pain, especially in persistent cases. A specific questionnaire on OA pain is currently being developed to assess more precisely the patient's experience and target specific pain mechanisms. In conclusion, OA-related pain should be analyzed specifically aside from OA, taking into account the complexity of OA pain as a disease, distinguishing different OA pain phenotypes, to guide more precisely analgesic treatment and OA global management.</div>","PeriodicalId":50983,"journal":{"name":"Best Practice & Research in Clinical Rheumatology","volume":"37 2","pages":"Article 101825"},"PeriodicalIF":5.2,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9879417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The role of imaging in osteoarthritis 成像在骨关节炎中的作用。

IF 5.2 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2023-06-01 DOI: 10.1016/j.berh.2023.101866

Eun Hae Park , Jan Fritz

{"title":"The role of imaging in osteoarthritis","authors":"Eun Hae Park , Jan Fritz","doi":"10.1016/j.berh.2023.101866","DOIUrl":"10.1016/j.berh.2023.101866","url":null,"abstract":"<div>Osteoarthritis is a complex whole-organ disorder that involves molecular, anatomic, and physiologic derangement. Advances in imaging techniques have expanded the role of imaging in evaluating osteoarthritis and functional changes. Radiography, magnetic resonance imaging, computed tomography (CT), and ultrasonography are commonly used imaging modalities, each with advantages and limitations in evaluating osteoarthritis. Radiography comprehensively analyses alignment and osseous features, while MRI provides detailed information about cartilage damage, bone marrow edema, synovitis, and soft tissue abnormalities. Compositional imaging derives quantitative data for detecting cartilage and tendon degeneration before structural damage occurs. Ultrasonography permits real-time scanning and dynamic joint evaluation, whereas CT is useful for assessing final osseous detail. Imaging plays an essential role in the diagnosis, management, and research of osteoarthritis. The use of imaging can help differentiate osteoarthritis from other diseases with similar symptoms, and recent advances in deep learning have made the acquisition, management, and interpretation of imaging data more efficient and accurate. Imaging is useful in monitoring and predicting the prognosis of osteoarthritis, expanding our understanding of its pathophysiology. Ultimately, this enables early detection and personalized medicine for patients with osteoarthritis. This article reviews the current state of imaging in osteoarthritis, focusing on the strengths and limitations of various imaging modalities, and introduces advanced techniques, including deep learning, applied in clinical practice.</div>","PeriodicalId":50983,"journal":{"name":"Best Practice & Research in Clinical Rheumatology","volume":"37 2","pages":"Article 101866"},"PeriodicalIF":5.2,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10494578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What is new in pharmacological treatment for osteoarthritis? 骨关节炎的药物治疗有何新进展？

IF 5.2 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2023-06-01 DOI: 10.1016/j.berh.2023.101841

Halise Hande Gezer , Andrew Ostor

引用次数: 0

Biomarkers for osteoarthritis: Current status and future prospects 骨关节炎的生物标志物：现状与前景。

IF 5.2 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2023-06-01 DOI: 10.1016/j.berh.2023.101852

Ali Mobasheri , Christian S. Thudium , Anne-Christine Bay-Jensen , Tazio Maleitzke , Sven Geissler , Georg N. Duda , Tobias Winkler

{"title":"Biomarkers for osteoarthritis: Current status and future prospects","authors":"Ali Mobasheri , Christian S. Thudium , Anne-Christine Bay-Jensen , Tazio Maleitzke , Sven Geissler , Georg N. Duda , Tobias Winkler","doi":"10.1016/j.berh.2023.101852","DOIUrl":"10.1016/j.berh.2023.101852","url":null,"abstract":"<div>Osteoarthritis (OA) is the most common form of arthritis globally and a major cause of pain, physical disability, and loss of economic productivity, with currently no causal treatment available. This review article focuses on current research on OA biomarkers and the potential for using biomarkers in future clinical practice and clinical trials of investigational drugs. We discuss how biomarkers, specifically soluble ones, have a long path to go before reaching clinical standards of care. We also discuss how biomarkers can help in phenotyping and subtyping to achieve enhanced stratification and move toward better-designed clinical trials. We also describe how biomarkers can be used for molecular endotyping and for determining the clinical outcomes of investigational cell-based therapies. Biomarkers have the potential to be developed as surrogate end points in clinical trials and help private-public consortia and the biotechnology and pharmaceutical industries develop more effective and targeted personalized treatments and enhance clinical care for patients with OA.</div>","PeriodicalId":50983,"journal":{"name":"Best Practice & Research in Clinical Rheumatology","volume":"37 2","pages":"Article 101852"},"PeriodicalIF":5.2,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1521694223000384/pdfft?md5=1b5ed7f5b7c4f44b66381d1ba9c0667f&pid=1-s2.0-S1521694223000384-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10071278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regenerative methods in osteoarthritis 骨关节炎的再生方法。

IF 5.2 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2023-06-01 DOI: 10.1016/j.berh.2023.101824

Nilay Sahin , Hilal Yesil

引用次数: 0

Index 索引

IF 5.2 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2023-06-01 DOI: 10.1016/S1521-6942(23)00104-3

引用次数: 0

Recent targets of osteoarthritis research 骨关节炎研究的最新目标。

IF 5.2 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2023-06-01 DOI: 10.1016/j.berh.2023.101851

Po-Cheng Shih , Yung-Heng Lee , Hsi-Kai Tsou , James Cheng-Chung Wei

引用次数: 0

The burden of osteoarthritis: Is it a rising problem? 骨关节炎的负担：骨关节炎是一个日益严重的问题吗？

IF 5.2 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2023-06-01 DOI: 10.1016/j.berh.2023.101836

William J. Scheuing , Anthony M. Reginato , Mery Deeb , Sevtap Acer Kasman

{"title":"The burden of osteoarthritis: Is it a rising problem?","authors":"William J. Scheuing , Anthony M. Reginato , Mery Deeb , Sevtap Acer Kasman","doi":"10.1016/j.berh.2023.101836","DOIUrl":"10.1016/j.berh.2023.101836","url":null,"abstract":"<div>The objective of this review is to provide an overview of the current status of osteoarthritis (OA) as one of the most common joint disorders worldwide. Despite being the 11th cause of disability globally, there has been an increase in the prevalence, annual incidence, and years lived with disability of OA, particularly in developed and developing countries. Erosive hand OA, which affects approximately 10% of the general population, has been associated with a higher clinical burden compared to non-erosive hand OA. Patients with knee and hip OA, but not hand OA, are also at an increased risk of cardiovascular disease and all-cause mortality. Furthermore, OA has a significant contribution to healthcare costs in most countries. The recent COVID-19 pandemic has further exacerbated the disease burden of OA patients due to limited access to medical and surgical treatment. With increasing life expectancy and the aging of the global population, the burden of OA is expected to worsen. Therefore, this review highlights the importance of improving population and policymaker awareness of risk factors, such as obesity and injury, as well as early intervention and management of OA to control the future burden of the disease.</div>","PeriodicalId":50983,"journal":{"name":"Best Practice & Research in Clinical Rheumatology","volume":"37 2","pages":"Article 101836"},"PeriodicalIF":5.2,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10131616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring osteoarthritis: Unraveling challenges, innovations, and hope for a better future 探索骨关节炎:揭开挑战、创新和对更美好未来的希望。

IF 5.2 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2023-06-01 DOI: 10.1016/j.berh.2023.101872

Mehmet Tuncay Duruöz

引用次数: 0

When are patients with osteoarthritis referred for surgery? 骨关节炎患者何时转诊接受手术治疗？

IF 5.2 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2023-06-01 DOI: 10.1016/j.berh.2023.101835

A.E. Postler , C. Lützner , J. Goronzy , T. Lange , S. Deckert , K.P. Günther , J. Lützner

{"title":"When are patients with osteoarthritis referred for surgery?","authors":"A.E. Postler , C. Lützner , J. Goronzy , T. Lange , S. Deckert , K.P. Günther , J. Lützner","doi":"10.1016/j.berh.2023.101835","DOIUrl":"10.1016/j.berh.2023.101835","url":null,"abstract":"<div>Current treatment strategies in hip and knee osteoarthritis (OA) involve a combined approach that includes not only modification of risk factors and conservative treatment but also joint-preserving surgical therapy in the early stages, or joint replacement in late OA. With the recent development of new etiological concepts (i.e. hip dysplasia and femoroacetabular impingement as major risk factors for hip OA), treatment alternatives for joint preservation could be extended significantly. Satisfactory results of osteotomies and other reconstructive procedures around hip and knee joints can only be expected in early OA (Kellgren/Lawrence grade 0-II). If patients with advanced radiographic OA grades III-IV do not respond to conservative treatment over at least 3 months and express a relevant burden of disease, joint replacement might be considered. Prior to surgery, potential contraindications must be excluded, patient expectations need to be discussed, and modifiable risk factors, which may negatively influence the outcome, should be optimized.</div>","PeriodicalId":50983,"journal":{"name":"Best Practice & Research in Clinical Rheumatology","volume":"37 2","pages":"Article 101835"},"PeriodicalIF":5.2,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9561700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0