Best Practice & Research in Clinical Rheumatology最新文献_第9页

Biomarkers for osteoarthritis: Current status and future prospects 骨关节炎的生物标志物：现状与前景。

IF 5.2 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2023-06-01 DOI: 10.1016/j.berh.2023.101852

Ali Mobasheri , Christian S. Thudium , Anne-Christine Bay-Jensen , Tazio Maleitzke , Sven Geissler , Georg N. Duda , Tobias Winkler

{"title":"Biomarkers for osteoarthritis: Current status and future prospects","authors":"Ali Mobasheri , Christian S. Thudium , Anne-Christine Bay-Jensen , Tazio Maleitzke , Sven Geissler , Georg N. Duda , Tobias Winkler","doi":"10.1016/j.berh.2023.101852","DOIUrl":"10.1016/j.berh.2023.101852","url":null,"abstract":"<div><p>Osteoarthritis (OA) is the most common form of arthritis globally and a major cause of pain, physical disability, and loss of economic productivity, with currently no causal treatment available. This review article focuses on current research on OA biomarkers and the potential for using biomarkers in future clinical practice and clinical trials of investigational drugs. We discuss how biomarkers, specifically soluble ones, have a long path to go before reaching clinical standards of care. We also discuss how biomarkers can help in phenotyping and subtyping to achieve enhanced stratification and move toward better-designed clinical trials. We also describe how biomarkers can be used for molecular endotyping and for determining the clinical outcomes of investigational cell-based therapies. Biomarkers have the potential to be developed as surrogate end points in clinical trials and help private-public consortia and the biotechnology and pharmaceutical industries develop more effective and targeted personalized treatments and enhance clinical care for patients with OA.</p></div>","PeriodicalId":50983,"journal":{"name":"Best Practice & Research in Clinical Rheumatology","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1521694223000384/pdfft?md5=1b5ed7f5b7c4f44b66381d1ba9c0667f&pid=1-s2.0-S1521694223000384-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10071278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regenerative methods in osteoarthritis 骨关节炎的再生方法。

IF 5.2 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2023-06-01 DOI: 10.1016/j.berh.2023.101824

Nilay Sahin , Hilal Yesil

引用次数: 0

Index 索引

IF 5.2 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2023-06-01 DOI: 10.1016/S1521-6942(23)00104-3

引用次数: 0

Recent targets of osteoarthritis research 骨关节炎研究的最新目标。

IF 5.2 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2023-06-01 DOI: 10.1016/j.berh.2023.101851

Po-Cheng Shih , Yung-Heng Lee , Hsi-Kai Tsou , James Cheng-Chung Wei

引用次数: 0

The burden of osteoarthritis: Is it a rising problem? 骨关节炎的负担：骨关节炎是一个日益严重的问题吗？

IF 5.2 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2023-06-01 DOI: 10.1016/j.berh.2023.101836

William J. Scheuing , Anthony M. Reginato , Mery Deeb , Sevtap Acer Kasman

{"title":"The burden of osteoarthritis: Is it a rising problem?","authors":"William J. Scheuing , Anthony M. Reginato , Mery Deeb , Sevtap Acer Kasman","doi":"10.1016/j.berh.2023.101836","DOIUrl":"10.1016/j.berh.2023.101836","url":null,"abstract":"<div><p><span>The objective of this review is to provide an overview of the current status of osteoarthritis (OA) as one of the most common </span>joint disorders<span><span> worldwide. Despite being the 11th cause of disability globally, there has been an increase in the prevalence, annual incidence, and years lived with disability of OA, particularly in developed and developing countries. Erosive hand OA, which affects approximately 10% of the general population, has been associated with a higher clinical burden compared to non-erosive hand OA. Patients with knee and hip OA, but not hand OA, are also at an increased risk of cardiovascular disease and all-cause mortality. Furthermore, OA has a significant contribution to healthcare costs in most countries. The recent COVID-19 pandemic has further exacerbated the </span>disease burden of OA patients due to limited access to medical and surgical treatment. With increasing life expectancy and the aging of the global population, the burden of OA is expected to worsen. Therefore, this review highlights the importance of improving population and policymaker awareness of risk factors, such as obesity and injury, as well as early intervention and management of OA to control the future burden of the disease.</span></p></div>","PeriodicalId":50983,"journal":{"name":"Best Practice & Research in Clinical Rheumatology","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10131616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring osteoarthritis: Unraveling challenges, innovations, and hope for a better future 探索骨关节炎:揭开挑战、创新和对更美好未来的希望。

IF 5.2 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2023-06-01 DOI: 10.1016/j.berh.2023.101872

Mehmet Tuncay Duruöz

引用次数: 0

When are patients with osteoarthritis referred for surgery? 骨关节炎患者何时转诊接受手术治疗？

IF 5.2 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2023-06-01 DOI: 10.1016/j.berh.2023.101835

A.E. Postler , C. Lützner , J. Goronzy , T. Lange , S. Deckert , K.P. Günther , J. Lützner

{"title":"When are patients with osteoarthritis referred for surgery?","authors":"A.E. Postler , C. Lützner , J. Goronzy , T. Lange , S. Deckert , K.P. Günther , J. Lützner","doi":"10.1016/j.berh.2023.101835","DOIUrl":"10.1016/j.berh.2023.101835","url":null,"abstract":"<div><p><span><span>Current treatment strategies in hip and </span>knee osteoarthritis<span><span> (OA) involve a combined approach that includes not only modification of risk factors and conservative treatment but also joint-preserving surgical therapy in the early stages, or joint replacement in late OA. With the recent development of new etiological concepts (i.e. </span>hip dysplasia<span> and femoroacetabular impingement<span> as major risk factors for hip OA), treatment alternatives for joint preservation could be extended significantly. Satisfactory results of osteotomies and other reconstructive procedures around hip and knee joints can only be expected in early OA (Kellgren/Lawrence grade 0-II). If patients with advanced radiographic OA grades III-IV do not respond to conservative treatment over at least 3 months and express a relevant burden of </span></span></span></span>disease, joint replacement might be considered. Prior to surgery, potential contraindications must be excluded, patient expectations need to be discussed, and modifiable risk factors, which may negatively influence the outcome, should be optimized.</p></div>","PeriodicalId":50983,"journal":{"name":"Best Practice & Research in Clinical Rheumatology","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9561700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rehabilitation interventions in osteoarthritis 骨关节炎的康复干预。

IF 5.2 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2023-06-01 DOI: 10.1016/j.berh.2023.101846

Ayşe A. Küçükdeveci

引用次数: 0

Clinical aspects and outcomes in osteoarthritis 骨关节炎的临床表现和疗效。

IF 5.2 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2023-06-01 DOI: 10.1016/j.berh.2023.101855

Mehmet Tuncay Duruöz , Nuran Öz , Didem Erdem Gürsoy , Halise Hande Gezer

引用次数: 0

Patient-reported outcomes in vasculitis 脉管炎的患者报告结果

IF 5.2 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2023-03-01 DOI: 10.1016/j.berh.2023.101829

Helena Crawshaw , Shalini Janagan , Keziah Austin , Charlotte Baker , Julia Day , Joanna C. Robson

引用次数: 0