Best Practice & Research in Clinical Rheumatology最新文献_第7页

Classification of systemic lupus erythematosus: From the development of classification criteria to a new taxonomy? 系统性红斑狼疮的分类：从制定分类标准到新的分类法？

IF 4.5 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2023-12-01 Epub Date: 2024-05-10 DOI: 10.1016/j.berh.2024.101949

Martin Aringer, Daniel Toro-Domínguez, Marta E Alarcón-Riquelme

{"title":"Classification of systemic lupus erythematosus: From the development of classification criteria to a new taxonomy?","authors":"Martin Aringer, Daniel Toro-Domínguez, Marta E Alarcón-Riquelme","doi":"10.1016/j.berh.2024.101949","DOIUrl":"10.1016/j.berh.2024.101949","url":null,"abstract":"SLE is a highly variable systemic autoimmune disease. Its immunopathological effector phase is partly understood. However, the background of its variability is not. SLE classification criteria have been relying on the clinical manifestations and standard autoimmune serology. This still holds true for the 2019 EULAR/ACR classification criteria. On one hand, this has led to significant precision in defining patients with SLE. On the other hand, the information in the criteria neither helps understanding the individual patient's pathophysiology, nor does it predict the efficacy of the available immunomodulatory therapies. Chances of further improvement of clinical criteria are most likely limited. This is where new multi-omic approaches have started to make an impact. While not yet able to differentiate diseases with the same precision as the classification criteria, the results of these studies go far beyond the scope of the criteria with regard to immune dysregulation. Looking at both sides in detail, we here try to synthesize the available data, aiming at a better understanding of SLE and its immune pathophysiology.","PeriodicalId":50983,"journal":{"name":"Best Practice & Research in Clinical Rheumatology","volume":" ","pages":"101949"},"PeriodicalIF":4.5,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140904974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kidney involvement in systemic lupus erythematosus: From the patient assessment to a tailored treatment. 系统性红斑狼疮的肾脏受累：从患者评估到针对性治疗。

IF 4.5 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2023-12-01 Epub Date: 2023-12-26 DOI: 10.1016/j.berh.2023.101925

Juan M Mejia-Vilet, Tabitha Turner-Stokes, Frederic Houssiau, Brad H Rovin

引用次数: 0

Translational implications of newly characterized pathogenic pathways in systemic lupus erythematosus. 系统性红斑狼疮新特征致病途径的转化意义。

IF 4.5 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2023-12-01 Epub Date: 2023-08-23 DOI: 10.1016/j.berh.2023.101864

Mariele Gatto, Roberto Depascale, Ana Luisa Stefanski, Eva Schrezenmeier, Thomas Dörner

{"title":"Translational implications of newly characterized pathogenic pathways in systemic lupus erythematosus.","authors":"Mariele Gatto, Roberto Depascale, Ana Luisa Stefanski, Eva Schrezenmeier, Thomas Dörner","doi":"10.1016/j.berh.2023.101864","DOIUrl":"10.1016/j.berh.2023.101864","url":null,"abstract":"Improved characterization of relevant pathogenic pathways in systemic lupus erythematosus (SLE) has been further delineated over the last decades. This led to the development of targeted treatments including belimumab and anifrolumab, which recently became available in clinics. Therapeutic targets in SLE encompass interferon (IFN) signaling, B-T costimulation including immune checkpoints, and increasing modalities of B lineage targeting, such as chimeric antigen receptor (CAR) T cells directed against CD19 or sequential anti-B cell targeting. Patient profiling based on characterization of underlying molecular abnormalities, often performed through comprehensive omics analyses, has recently been shown to better predict patients' treatment responses and also holds promise to unravel key molecular mechanisms driving SLE. SLE carries two key signatures, namely the IFN and B lineage/plasma cell signatures. Recent advances in SLE treatments clearly indicate that targeting innate and adaptive immunity is successful in such a complex autoimmune disease. Although those signatures may interact at the molecular level and provide the basis for the first selective treatments in SLE, it remains to be clarified whether these distinct treatments show different treatment responses among certain patient subsets. In fact, notwithstanding the remarkable amount of novel clues for innovative SLE treatment, harmonization of big data within tailored treatment strategies will be instrumental to better understand and treat this challenging autoimmune disorder. This review will provide an overview of recent improvements in SLE pathogenesis, related insights by analyses of big data and machine learning as well as technical improvements in conducting clinical trials with the ultimate goal that translational research results in improved patient outcomes.","PeriodicalId":50983,"journal":{"name":"Best Practice & Research in Clinical Rheumatology","volume":" ","pages":"101864"},"PeriodicalIF":4.5,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10448758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The communication GAP between patients and clinicians and the importance of patient reported outcomes in Systemic Lupus Erythematosus. 系统性红斑狼疮患者与临床医生之间的沟通差距以及患者报告结果的重要性。

IF 4.5 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2023-12-01 Epub Date: 2024-03-14 DOI: 10.1016/j.berh.2024.101939

Elena Elefante, Alain Cornet, Jeanette Andersen, Amy Somers, Marta Mosca

引用次数: 0

Pregnancy in systemic lupus erythematosus. 系统性红斑狼疮患者的妊娠。

IF 4.5 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2023-12-01 Epub Date: 2023-08-16 DOI: 10.1016/j.berh.2023.101860

Dina Zucchi, Rebecca Fischer-Betz, Chiara Tani

引用次数: 0

Systemic lupus erythematosus and glucocorticoids: A never-ending story? 系统性红斑狼疮和糖皮质激素:一个永无止境的故事?

IF 4.5 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2023-12-01 Epub Date: 2023-11-11 DOI: 10.1016/j.berh.2023.101873

Diana Paredes-Ruiz, Guillermo Ruiz-Irastorza, Zahir Amoura

{"title":"Systemic lupus erythematosus and glucocorticoids: A never-ending story?","authors":"Diana Paredes-Ruiz, Guillermo Ruiz-Irastorza, Zahir Amoura","doi":"10.1016/j.berh.2023.101873","DOIUrl":"10.1016/j.berh.2023.101873","url":null,"abstract":"Glucocorticoids (GCs) continue to be essential agents for the management of systemic lupus erythematosus, since there are no other drugs able to active remission of active disease so rapidly. However, their potential for causing irreversible damage greatly limit their use. Fortunately, some strategies may help take advantage of their huge anti-inflammatory power while limiting GC-induced side effects. This article reviews the pharmacological basis of GC action and their translation into the clinical ground. We also offer the practical approach for the use of GC in induction and maintenance therapy as well as the strategies for GC withdrawal of the respective practice of the authors. The three main basic principles are a) using methyl-prednisolone pulses to induce remission not only in severe disease; b) limiting initial doses of prednisone to ≤30 mg/d, with rapid tapering to ≤5 mg/d, which should be the dose for maintenance therapy; and c) individualizing the decision and the strategy to withdraw GCs. Long-term therapy with HCQ and the early introduction of immunosuppressive treatment would help achieve these objectives.","PeriodicalId":50983,"journal":{"name":"Best Practice & Research in Clinical Rheumatology","volume":" ","pages":"101873"},"PeriodicalIF":4.5,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92157242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clash of the titans: Current CT and CT-like imaging modalities in sacroiliitis in spondyloarthritis 泰坦之战:脊柱炎伴骶髂炎的CT及CT样成像方式。

IF 5.2 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2023-09-01 DOI: 10.1016/j.berh.2023.101876

Kelly Di Dier , Dominik Deppe , Torsten Diekhoff , Nele Herregods , Lennart Jans

{"title":"Clash of the titans: Current CT and CT-like imaging modalities in sacroiliitis in spondyloarthritis","authors":"Kelly Di Dier , Dominik Deppe , Torsten Diekhoff , Nele Herregods , Lennart Jans","doi":"10.1016/j.berh.2023.101876","DOIUrl":"10.1016/j.berh.2023.101876","url":null,"abstract":"<div>Sacroiliitis is characterised by active and structural changes of the joint. While the Assessment of Spondyloarthritis international Society (ASAS) classification criteria stress the importance of bone marrow inflammation, recent reports suggest that osteitis can occur in various diseases, mechanical conditions and healthy individuals. Thus, structural lesions such as joint surface erosion and ankylosis are important factors for differential diagnosis. Various imaging modalities are available to examine these changes. However, computed tomography (CT) is generally considered the reference standard. Nonetheless, recent advances in magnetic resonance imaging (MRI) allow for direct bone imaging and the reconstruction of CT-like images that can provide similar information. This way, the ability of MRI to detect and measure structural lesions is strengthened. The aim of this review is to provide an overview of the pros and cons of CT and CT-like imaging modalities in sacroiliitis.</div>","PeriodicalId":50983,"journal":{"name":"Best Practice & Research in Clinical Rheumatology","volume":"37 3","pages":"Article 101876"},"PeriodicalIF":5.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89720450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peripheral spondyloarthritis: What have we learned? 外周脊柱关节炎：我们学到了什么？

IF 5.2 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2023-09-01 DOI: 10.1016/j.berh.2023.101862

María Ángeles Puche-Larrubia , Clementina López-Medina , Nelly Ziadé

引用次数: 0

Impact of sex and gender on axSpA diagnosis and outcomes 性别和性别对axSpA诊断和结局的影响。

IF 5.2 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2023-09-01 DOI: 10.1016/j.berh.2023.101875

Samantha O. Kohn , Abeera Azam , Lauren E. Hamilton , Stephanie R. Harrison , Elizabeth R. Graef , Kristen J. Young , Helena Marzo-Ortega , Jean W. Liew

{"title":"Impact of sex and gender on axSpA diagnosis and outcomes","authors":"Samantha O. Kohn , Abeera Azam , Lauren E. Hamilton , Stephanie R. Harrison , Elizabeth R. Graef , Kristen J. Young , Helena Marzo-Ortega , Jean W. Liew","doi":"10.1016/j.berh.2023.101875","DOIUrl":"10.1016/j.berh.2023.101875","url":null,"abstract":"<div>Axial spondyloarthritis (axSpA) was historically considered a disease of men, largely due to the recognition of a more severe, progressive phenotype, ankylosing spondylitis (AS; or radiographic axSpA, r-axSpA) aiding the clinical diagnosis [[1], [2]]. Data demonstrating the near equal prevalence of axSpA in women only started to emerge in the last decades, highlighting intrinsic differences in disease phenotype, and clinical and imaging characteristics between sexes, which partly explain the issue of underdiagnosis in women. Similar to the evolving understanding of spondyloarthritis and the diseases that term describes, the concepts of gender and sex also warrant further clarification to accurately assess their potential role in disease pathophysiology and phenotypic expression. This narrative review delves into the most recent evidence from the literature on the true prevalence of sex differences in axSpA, and the impact of sex and gender on diagnosis, disease characteristics and treatment response in this, still underserved, chronic disease.</div>","PeriodicalId":50983,"journal":{"name":"Best Practice & Research in Clinical Rheumatology","volume":"37 3","pages":"Article 101875"},"PeriodicalIF":5.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138441657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathophysiology and immunolgical basis of axial spondyloarthritis 轴性脊柱炎的病理生理学和免疫学基础。

IF 5.2 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2023-09-01 DOI: 10.1016/j.berh.2023.101897

Marleen G.H. van de Sande , Dirk Elewaut

引用次数: 0