Annals of Agricultural and Environmental Medicine最新文献

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Prospective assessment of functional and clinical results of surgical patellar stabilization in rural and urban populations. Equal chance to success? 对城乡居民髌骨稳定手术的功能和临床效果进行前瞻性评估。成功机会均等?
IF 1.7 4区 医学
Annals of Agricultural and Environmental Medicine Pub Date : 2024-03-25 Epub Date: 2024-01-29 DOI: 10.26444/aaem/178137
Jacek Walawski, Oliwer Sygacz, Martyna Jarocka, Tomasz Sacewicz
{"title":"Prospective assessment of functional and clinical results of surgical patellar stabilization in rural and urban populations. Equal chance to success?","authors":"Jacek Walawski, Oliwer Sygacz, Martyna Jarocka, Tomasz Sacewicz","doi":"10.26444/aaem/178137","DOIUrl":"10.26444/aaem/178137","url":null,"abstract":"<p><strong>Introduction and objective: </strong>Patella dislocation represents 3.3% of all knee injuries often leading to persistent instability. Medial patello-femoral ligament(MPFL) reconstruction is the standard method of treatment in the patellar instability. Rehabilitation after MPFL-R is a long and demanding procedure. The hypothesis presented reflects the idea that despite relatively good access to hospital care and surgical options, the post-operative rehabilitation care system is still inferior in rural areas versus the one offered in major cities and towns.</p><p><strong>Material and methods: </strong>Between January 2015 - January 2018, 47 patients met the study inclusion criteria, diagnosed and operated on due to patellar instability. 8 patients were lost for full follow-up. Finally, 39 patients were included, divided into two groups - group A (19 from cities), group B (20 from rural area). Prospective KOOS and Kujala scales assessments were conducted: preoperative, 6 and 12 months after surgery. Knee isokinetic muscle strength was measured at 3 stages; prior to surgery, 6 and 12 months after reconstruction.</p><p><strong>Results: </strong>All patients showed significant improvement measured in the KOOS and Kujala scales after the procedure, compared to the pre-operational results. Despite equal clinical improvement, patients from Group A(city) achieved better functional outcomes as presented in the results of knee extensor functional tests using a Biodex dynamometer.</p><p><strong>Conclusions: </strong>Rehabilitation after MPFL reconstruction improves muscle strength and clinical outcome. Patients from rural areas had inferior functional results in comparison to the patients from major cities, even 12 months after surgical patella stabilization. Despite the development of roads and transport according to the EU cohesion policy, there are still differences in rehabilitation results between rural and city areas.</p>","PeriodicalId":50970,"journal":{"name":"Annals of Agricultural and Environmental Medicine","volume":"31 1","pages":"131-137"},"PeriodicalIF":1.7,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140319790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Registered incidence of acute upper respiratory tract infections diagnosed by primary care physicians in Poland - 5-year retrospective analysis of the national health insurance database. 波兰初级保健医生诊断的急性上呼吸道感染登记发病率--对国家医疗保险数据库的五年回顾性分析。
IF 1.7 4区 医学
Annals of Agricultural and Environmental Medicine Pub Date : 2024-03-25 Epub Date: 2024-03-04 DOI: 10.26444/aaem/183993
Iwona Paciepnik, Agata Bąk, Katarzyna Leoszkiewicz, Adam Windak, Tomasz Madej, Oleszczyk Marek, Krzysztof Studziński, Tomasz Tomasik
{"title":"Registered incidence of acute upper respiratory tract infections diagnosed by primary care physicians in Poland - 5-year retrospective analysis of the national health insurance database.","authors":"Iwona Paciepnik, Agata Bąk, Katarzyna Leoszkiewicz, Adam Windak, Tomasz Madej, Oleszczyk Marek, Krzysztof Studziński, Tomasz Tomasik","doi":"10.26444/aaem/183993","DOIUrl":"10.26444/aaem/183993","url":null,"abstract":"<p><strong>Introduction and objective: </strong>Upper respiratory tract infection (URTIs), caused by a variety of viruses and sometimes by bacteria, represents the most common acute illness in primary health care. The aim of the study was to explore the registered incidence of URTIs in Poland in the period between 2015-2019, and its burden on the health care system.</p><p><strong>Material and methods: </strong>A retrospective analysis was carried out of all medical encounters in Poland registered within the national billing database of public healthcare services. Medical services provided due to acute URTIs were classified according to the ICD-10 codes. Registered Incidence Rate (RIR) was calculated yearly, in a 100,000 population. A generalised additive model was used to calculate the Incidence Rate Ratio (IRR).</p><p><strong>Results: </strong>In the analysed 5-year period, acute URTI was diagnosed in 24.3 million patients (61.7% of the whole population registered in PHC). The RIR of all acute URTIs in PHC was 50,762/100,000/year. Nearly 99% of consultations in this group of patients were provided by PHC physicians. Only 0.8% were referred to an OSC consultation and 0.4% were hospitalised. In PHC, indeterminate URTIs were most frequently diagnosed. The estimated IRR for children aged 1-4 years was 1.65 (95% CI: 1.64; 1.66, p<0.01) and for men 0.79 (95% CI: 0.79; 0.79; p<0.01). In the studied period, the number of patients consulted for acute URTI decreased slightly in PHC, but significantly in specialist services.</p><p><strong>Conclusions: </strong>The registered incidence of URTIs in Poland burdens mainly PHC physicians. Women and children aged 1-4 years are more frequent users of medical services related to URTIs. It appears that strategies for increasing patient empowerment to provide efficient self-care reducing the utilisation of PHC services are needed.</p>","PeriodicalId":50970,"journal":{"name":"Annals of Agricultural and Environmental Medicine","volume":"31 1","pages":"100-113"},"PeriodicalIF":1.7,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140319808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of functional efficiency and risk of falls in patients with different types of dementia - preliminary observations. 不同类型痴呆症患者的功能效率和跌倒风险分析--初步观察。
IF 1.7 4区 医学
Annals of Agricultural and Environmental Medicine Pub Date : 2024-03-25 Epub Date: 2023-07-18 DOI: 10.26444/aaem/168787
Magdalena Zawadzka, Joanna Kozłowska, Ewelina Ejchman-Pac, Gabriela Henrykowska, Małgorzata Lewicka
{"title":"Analysis of functional efficiency and risk of falls in patients with different types of dementia - preliminary observations.","authors":"Magdalena Zawadzka, Joanna Kozłowska, Ewelina Ejchman-Pac, Gabriela Henrykowska, Małgorzata Lewicka","doi":"10.26444/aaem/168787","DOIUrl":"10.26444/aaem/168787","url":null,"abstract":"<p><strong>Introduction and objective: </strong>Dementia is a multifactorial neurological disease that affects 50 million people worldwide. It is a disorder that impairs cognitive functions, functional efficiency, balance and gait. It contributes to an increased risk of falls, reduces independence in everyday activities and deepens disability. The aim of the study was to investigate the correlation between dementia and independence related to functional efficiency and risk of falls in the elderly.</p><p><strong>Material and methods: </strong>The eligibility criterion for participation in the study was age over 60, the presence of cognitive disorders, including dementia, and the ability to move with the use of orthopaedic equipment or independently. A total of 51 people participated in the study, including 13 people who underwent rehabilitation procedures. Each subject was evaluated once for cognitive abilities using two types of tests: the ADL scale, MMSE (Mini-Mental state Examination) and three physical fitness tests: SPPB (Short Physical Performance Battery), TUG (Timed Up & Go) and FRT (Functional Reach Test).</p><p><strong>Results: </strong>The average score of the MMSE test was 13.29±6.23 points, the average of the ADL scale was 4.20±1.23 points. A positive correlation was found between the level of dementia and the independence of the examined person, as well as a positive relationship between the MMSE test and the result of the Functional Reach Test, and the relationship between the ADL scale and the SPPB and 'Get-Up and Go' tests.</p><p><strong>Conclusions: </strong>It has been demonstrated <i>inter alia</i> that static balance and functional efficiency depends on the patient's independence in everyday activities, and the level of dementia may suggest the patient's dynamic balance. In addition, the need for a broader analysis of targeted studies was recognized to confirm the conclusions obtained.</p>","PeriodicalId":50970,"journal":{"name":"Annals of Agricultural and Environmental Medicine","volume":"1 1","pages":"114-118"},"PeriodicalIF":1.7,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69325684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Red LED light therapy for telogen effluvium in the course of long COVID in patients with and without androgenetic alopecia 红光 LED 光疗法治疗雄激素性脱发和非雄激素性脱发患者长 COVID 过程中的毛囊性脱发
IF 1.7 4区 医学
Annals of Agricultural and Environmental Medicine Pub Date : 2024-01-08 DOI: 10.26444/aaem/177238
A. Gerkowicz, J. Bartosińska, P. Krakowski, R. Karpiński, D. Krasowska, Dorota Raczkiewicz, Mirosław Kwaśny, Dorota Krasowska
{"title":"Red LED light therapy for telogen effluvium in the course of long COVID in patients with and without androgenetic alopecia","authors":"A. Gerkowicz, J. Bartosińska, P. Krakowski, R. Karpiński, D. Krasowska, Dorota Raczkiewicz, Mirosław Kwaśny, Dorota Krasowska","doi":"10.26444/aaem/177238","DOIUrl":"https://doi.org/10.26444/aaem/177238","url":null,"abstract":"Introduction and Objective . Photobiomodulation with the use of light-emitting diodes (LEDs) seems to be a promising option for long COVID. This retrospective study evaluates the efficiency of LED irradiation in the treatment of TE in the course of long COVID in patients with and without androgenetic alopecia. Materials and methods. A retrospective single-centre chart review of patients with post-COVID hair loss was performed. 140 patients enrolled to the study were divided into four groups depending on the type of alopecia and treatment: 1) telogen effluvium with LED therapy (TE LED+), 2) telogen effluvium without LED therapy (TE LED-), 3) telogen effluvium and androgenetic alopecia with LED therapy (TE+AGA LED+), and 4) telogen effluvium and androgenetic alopecia without LED therapy (TE+AGA LED-). Clinical and trichoscopic parameters were compared. Results . After 12 weeks, cessation of hair loss and a negative hair pull test were more common in TE LED+ and TE+AGA LED+ in comparison to the patients without LED therapy (p<0.001, p=0.035, respectively). An increased number of thick hairs and an increased number of hairs within follicular units were more common in patients treated with LED irradiation, regardless of the type of alopecia, compared to the patients without LED therapy. Conclusions . The study revealed that LED therapy is safe, well tolerated and seems to be a promising therapeutic option for TE in patients with long COVID. It can be used as adjuvant therapy leading to faster reduction of hair loss, enhancing hair regrowth as well as hair shaft thickness and density.","PeriodicalId":50970,"journal":{"name":"Annals of Agricultural and Environmental Medicine","volume":"56 8","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139447877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Knowledge, attitudes, and practices towards COVID-19 and COVID-19 vaccines among Obstetrician-Gynaecologists. 妇产科医生对 COVID-19 和 COVID-19 疫苗的认识、态度和做法。
IF 1.7 4区 医学
Annals of Agricultural and Environmental Medicine Pub Date : 2023-12-22 Epub Date: 2023-12-21 DOI: 10.26444/aaem/176959
Nicola Luigi Bragazzi, Michele Buchinger, Lukasz Szarpak, Jaroslaw Chmielewski, Małgorzata Goździewska, Joanna Gotlib, Rola Elias Farah
{"title":"Knowledge, attitudes, and practices towards COVID-19 and COVID-19 vaccines among Obstetrician-Gynaecologists.","authors":"Nicola Luigi Bragazzi, Michele Buchinger, Lukasz Szarpak, Jaroslaw Chmielewski, Małgorzata Goździewska, Joanna Gotlib, Rola Elias Farah","doi":"10.26444/aaem/176959","DOIUrl":"10.26444/aaem/176959","url":null,"abstract":"<p><strong>Introduction and objective: </strong>The article assesses the knowledge, attitudes, and practices of Obstetrician-Gynaecologists (OB/GYNs) in Israel regarding COVID-19, its impact on fertility, pregnancy and childbirth, and their positions on COVID-19 vaccines.</p><p><strong>Material and methods: </strong>A cross-sectional anonymous survey was employed, and the data analyzed using logistic regression models.</p><p><strong>Results: </strong>A total of 172 OB/GYN participants aged 44.9 years, primarily female (59.7%), mostly attending physicians (60.4%), had a mean knowledge score of 75.62%, with 81.1% having sufficient knowledge about general COVID-19 information, 11.9% having specific knowledge about pregnancy, birth, and breastfeeding, and 40.3% having knowledge about COVID-19 vaccination. Notably, only 27% of participants correctly identified the increased risk of preeclampsia in pregnant women with COVID-19. Nevertheless, all OB/GYN participants recommended the COVID-19 vaccination during pregnancy. The majority (65.1%) recommended vaccination across all trimesters, while a smaller percentage recommended it only in the second (25%) or third (6%) trimesters, and very few in the first trimester (4%). The study found that attitudes towards vaccination were influenced by workplace, role, religion, religious observance, and marital status.</p><p><strong>Conclusions: </strong>The study showed a good level of knowledge regarding COVID-19 vaccines which contributed to OB/GYNs' recommendations to their patients. These findings can be valuable for designing future COVID-19 vaccination campaigns.</p>","PeriodicalId":50970,"journal":{"name":"Annals of Agricultural and Environmental Medicine","volume":"30 4","pages":"669-676"},"PeriodicalIF":1.7,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139049731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship between the components of disability definition and the effectiveness of rehabilitation measures as a process. 残疾定义的组成部分与康复措施作为一个过程的有效性之间的关系。
IF 1.7 4区 医学
Annals of Agricultural and Environmental Medicine Pub Date : 2023-12-22 Epub Date: 2023-12-20 DOI: 10.26444/aaem/177341
Witold Piotr Kołłątaj, Barbara Kołłątaj, Elżbieta Cipora, Katarzyna Sygit, Irena Dorota Karwat
{"title":"Relationship between the components of disability definition and the effectiveness of rehabilitation measures as a process.","authors":"Witold Piotr Kołłątaj, Barbara Kołłątaj, Elżbieta Cipora, Katarzyna Sygit, Irena Dorota Karwat","doi":"10.26444/aaem/177341","DOIUrl":"10.26444/aaem/177341","url":null,"abstract":"<p><strong>Introduction and objective: </strong>The number of disabled persons is most often only estimated. The disabled require multidirectional, effective support in almost every field of functioning. There is no arbitrarily accepted definition of disability, and those currently available outline the ranges of support for which rehabilitation measures are necessary.</p><p><strong>Objective: </strong>The aim of the review is to present the problem areas that contribute to the definition of disability and their interdependence and effectiveness in relation to rehabilitation interventions, as well as identification of the most frequent medical and social problems interdependent on the quality and feasibility of rehabilitation interventions.</p><p><strong>Review methods: </strong>Scientific literature in Polish and English for 1993-2023 and legal acts concerning the definition of disability, definition of rehabilitation and the problem of employment were reviewed. The following key words were used to search the NIZP-PZH, MZ, JAHEE and ISAP databases: disabled persons, definitions of disability, rehabilitation as a process, synchronization of thematic groups of disability definitions with the rehabilitation process.</p><p><strong>Brief description of the state of knowledge: </strong>Disability is a public health problem. The actual determination of the extent, medical and social needs of people with disabilities involves methods and measures for classifying people as disabled. The effects of treatment and rehabilitation are assessed by the level of functioning of the disabled in society.</p><p><strong>Summary: </strong>The multiplicity of characteristics included in the definitions of disability account for all problems in health and social terms. In view of the social, environmental and cultural changes, the scope of needs of people with disabilities is also changing, which can be seen in newly-developed definitions, including rehabilitation.</p>","PeriodicalId":50970,"journal":{"name":"Annals of Agricultural and Environmental Medicine","volume":"30 4","pages":"595-601"},"PeriodicalIF":1.7,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139049733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Parasitological contamination of arable soil in selected regions of Poland - preliminary study. 波兰部分地区耕地土壤的寄生虫污染--初步研究。
IF 1.7 4区 医学
Annals of Agricultural and Environmental Medicine Pub Date : 2023-12-22 Epub Date: 2023-12-21 DOI: 10.26444/aaem/176816
Jolanta Małgorzata Zdybel, Jacek Karamon, Jacek Sroka, Angelina Wójcik-Fatla, Piotr Skowron, Katarzyna Kowalczyk, Jan Jadczyszyn, Tomasz Cencek
{"title":"Parasitological contamination of arable soil in selected regions of Poland - preliminary study.","authors":"Jolanta Małgorzata Zdybel, Jacek Karamon, Jacek Sroka, Angelina Wójcik-Fatla, Piotr Skowron, Katarzyna Kowalczyk, Jan Jadczyszyn, Tomasz Cencek","doi":"10.26444/aaem/176816","DOIUrl":"10.26444/aaem/176816","url":null,"abstract":"<p><strong>Introduction and objective: </strong>The hygienic status of arable soils in most developed countries has been unknown. In the presented study, a preliminary investigation was undertaken to determine the contamination with eggs of parasitic nematodes in the soil of arable fields in Poland. The aim of the study was to determine whether such contamination is common enough to constitute a significant problem and what factors may influence it.</p><p><strong>Material and methods: </strong>The study was conducted in 5 Polish provinces from autumn 2021 to spring 2022. The provinces differed significantly in terms of the area of agricultural land, agricultural suitability, type of soil, scale of cattle and pig breeding, production of manure and slurry, and the use of manures and organic fertilizers for fertilization. A total of 133 soil samples were collected. Parasitological examination of soil samples was carried out using the PN-Z-19006 method [1], with confirmed high sensitivity.</p><p><strong>Results: </strong>Parasite eggs were found in a total of 67 samples, of which 56 samples contained eggs of roundworms of the genus <i>Ascaris</i> (an average of 3.29 eggs/100 g of soil), 23 contained eggs of whipworms (an average of 1.22 eggs/100 g), and 3 contained eggs of Toxocara (1 egg/100 g).</p><p><strong>Conclusions: </strong>Differences in the percentage of positive samples were found depending on the period in which the samples were taken. The percentage of positive samples collected in autumn (53.57%) was higher than the percentage of positive samples collected in spring (48.05%). Similarly, the average number of eggs of in positive samples collected in autumn (3.43 eggs/100 g) was higher than the average number of eggs in samples collected in spring (2.90 eggs/100 g). Differences in the percentage of positive samples were also found depending on the region of origin of the samples.</p>","PeriodicalId":50970,"journal":{"name":"Annals of Agricultural and Environmental Medicine","volume":"30 4","pages":"661-668"},"PeriodicalIF":1.7,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139049732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of 2.4 GHz radiofrequency electromagnetic field (RF-EMF) on glioblastoma cells (U -118 MG) 2.4 GHz 射频电磁场(RF-EMF)对胶质母细胞瘤细胞(U -118 MG)的影响
IF 1.7 4区 医学
Annals of Agricultural and Environmental Medicine Pub Date : 2023-12-21 DOI: 10.26444/aaem/176405
A. Nowak-Terpiłowska, Romuald Górski, Małgorzata Marszałek, S. Wosiński, R. Przesmycki, M. Bugaj, L. Nowosielski, Mikołaj Baranowski, Joanna Zeyland
{"title":"Effects of 2.4 GHz radiofrequency electromagnetic field (RF-EMF) on glioblastoma cells (U -118 MG)","authors":"A. Nowak-Terpiłowska, Romuald Górski, Małgorzata Marszałek, S. Wosiński, R. Przesmycki, M. Bugaj, L. Nowosielski, Mikołaj Baranowski, Joanna Zeyland","doi":"10.26444/aaem/176405","DOIUrl":"https://doi.org/10.26444/aaem/176405","url":null,"abstract":"","PeriodicalId":50970,"journal":{"name":"Annals of Agricultural and Environmental Medicine","volume":"91 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138951395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgical resection of lung cancer inhibits mRNA expression of GOT2 gene encoding kynurenine aminotransferase in leukocytes 肺癌手术切除可抑制白细胞中编码犬尿氨酸氨基转移酶的 GOT2 基因的 mRNA 表达
IF 1.7 4区 医学
Annals of Agricultural and Environmental Medicine Pub Date : 2023-12-21 DOI: 10.26444/aaem/176813
Tomasz Prystupa, Dariusz Sagan, J. Kocki, Tomasz Kocki, Rafał Szymanowski, Jacek Bogucki
{"title":"Surgical resection of lung cancer inhibits mRNA expression of GOT2 gene encoding kynurenine aminotransferase in leukocytes","authors":"Tomasz Prystupa, Dariusz Sagan, J. Kocki, Tomasz Kocki, Rafał Szymanowski, Jacek Bogucki","doi":"10.26444/aaem/176813","DOIUrl":"https://doi.org/10.26444/aaem/176813","url":null,"abstract":"Introduction and Objective. Lung cancer is the most common malignant tumour. More than 80% of all diagnosed cases are non-small cell carcinoma which can be effectively treated by radical resection. Despite significant progress in the field of diagnostic and therapeutic methods, the results of lung cancer treatment are still unsatisfactory. Lung cancer is detected relatively late, which leads to an unfavourable prognosis. Kynurenine aminotransferases are an important element of the kynurenine pathway of tryptophan metabolism, which has recently aroused great interest from the aspect of possible use as a target point of personalized therapies in malignant tumours.The aim of the study was to analyze the expression of the selected gene of kynurenine aminotransferases GOT 2 at the mRNA level in peripheral blood leukocytes of patients with lung cancer. Materials and method. The mRNA expression of the GOT 2 gene was tested on blood samples from 50 patients treated surgically for non-small cell lung cancer.The control group consisted of 15 healthy individuals.The determination of mRNA expression of the GOT 2 gene was performed using the real-time PCR method.The GAPDH gene was used as the endogenous reference level. Results. The mRNA expression of the GOT2 gene on the 6th day after surgery was statistically significantly lower than before surgery (p = 0,05). In the study group, the average LogRQ mRNA expression of the GOT2 gene before the procedure was 0.192082±0.292174 in woman. This was statistically significantly higher than in men whose average LogRQ mRNA expression of the GOT2 gene before the procedure was 0.004210±0.235065 (p=0.0183). Conclusions. Surgical resection of lung cancer results in inhibition of GOT2 mRNA expression in leukocytes. Further studies are expected to show whether it may be used as a target point for personalized therapies in lung cancer.","PeriodicalId":50970,"journal":{"name":"Annals of Agricultural and Environmental Medicine","volume":"17 10","pages":""},"PeriodicalIF":1.7,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138948371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbial community, pathogenic bacteria and high-risk anti-biotic resistance genes at two tropical coastal beaches adjacent to villages in Hainan, China 中国海南毗邻村庄的两个热带沿海海滩的微生物群落、致病菌和高风险抗生素耐药基因
IF 1.7 4区 医学
Annals of Agricultural and Environmental Medicine Pub Date : 2023-12-21 DOI: 10.26444/aaem/176090
Wenfang Long, mingxue Li, Yi Gao, Yu Zhang, xinyu Yuan, Haimei Ye, Hairong Huang, wenjuan Liang, rongguang Zhang, Guankui Du
{"title":"Microbial community, pathogenic bacteria and high-risk anti-biotic resistance genes at two tropical coastal beaches adjacent to villages in Hainan, China","authors":"Wenfang Long, mingxue Li, Yi Gao, Yu Zhang, xinyu Yuan, Haimei Ye, Hairong Huang, wenjuan Liang, rongguang Zhang, Guankui Du","doi":"10.26444/aaem/176090","DOIUrl":"https://doi.org/10.26444/aaem/176090","url":null,"abstract":"Objective. The aim of the study was to explore the correlation between characteristics of microbial community, pathogenic bacteria and high-risk antibiotic-resistant genes, between coastal beaches and a multi-warm-blooded host, as well as to determine potential species biomarkers for faecal source contamination on tropical coastal beaches in China. Methods. The ‘One-Health’ approach was used in a microbiological study of beaches and warm-blooded hosts. The microbial.community was analyzed using 16S rRNA gene amplicons and shotgun metagenomics on Illumina NovaSeq. Results. The Chao, Simpson, Shannon, and ACE indices of non-salt beach were greater than those of salt beaches at the genus and OTU levels ( P < 0.001). Bacteroidota, Halanaerobiaeota, Cyanobacteria","PeriodicalId":50970,"journal":{"name":"Annals of Agricultural and Environmental Medicine","volume":"30 10","pages":""},"PeriodicalIF":1.7,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138949702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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