Toxics Pub Date : 2024-04-17 DOI: 10.3390/toxics12040298

Tao Xu, Yang Liu, Tie-Qing You, J. Bao

{"title":"Innovation of BiOBr/BiOI@Bi5O7I Ternary Heterojunction for Catalytic Degradation of Sodium P-Perfluorous Nonenoxybenzenesulfonate.","authors":"Tao Xu, Yang Liu, Tie-Qing You, J. Bao","doi":"10.3390/toxics12040298","DOIUrl":"https://doi.org/10.3390/toxics12040298","url":null,"abstract":"As an alternative for perfluorooctane sulfonic acid (PFOS), sodium p-perfluorononyloxybenzene sulfonate (OBS) has been widely used in petroleum, fire-fighting materials, and other industries. In order to efficiently and economically remove OBS contaminations from water bodies, in this study, a ternary heterojunction was constructed by coupling BiOBr and BiOI@Bi5O7I for improving the redox capacity and carrier separation ability of the material and investigating the effect of the doping ratios of BiOBr and BiOI@ Bi5O7I on the performance of the catalysts. Furthermore, the effects on the degradation of OBS were also explored by adjusting different catalyst doping ratios, OBS concentrations, catalyst amounts, and pH values. It was observed that when the concentration of OBS was 50 mg/L, the amount of catalyst used was 0.5 g/L, and the pH was not changed. The application of BiOBr/BiOI@ Bi5O7I consisting of 25% BiOBr and 75% BiOI@ Bi5O7I showed excellent stability and adsorption degradation performance for OBS, and almost all of the OBS in the aqueous solution could be removed. The removal rate of OBS by BiOBr/BiOI@ Bi5O7I was more than 20% higher than that of OBS by BiOI@Bi5O7I and BiOBr when the OBS concentration was 100 mg/L. In addition, the reaction rate constants of BiOBr/BiOI@ Bi5O7I were 2.4 and 10.8 times higher than those of BiOI@ Bi5O7I and BiOBr, respectively. Therefore, the BiOBr/BiOI@ Bi5O7I ternary heterojunction can be a novel type of heterojunction for the efficient degradation of OBS in water bodies.","PeriodicalId":508978,"journal":{"name":"Toxics","volume":" 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140692400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decreased Ubiquitination and Acetylation of Histones 3 and 4 Are Associated with Obesity-Induced Disorders of Spermatogenesis in Mice. 组蛋白 3 和 4 的泛素化和乙酰化减少与肥胖诱导的小鼠精子发生障碍有关。

Toxics Pub Date : 2024-04-17 DOI: 10.3390/toxics12040296

Mahamadou Fofana, Zhenyang Li, Han Li, Wenqi Li, Lu Wu, Lu Lu, Qizhan Liu

{"title":"Decreased Ubiquitination and Acetylation of Histones 3 and 4 Are Associated with Obesity-Induced Disorders of Spermatogenesis in Mice.","authors":"Mahamadou Fofana, Zhenyang Li, Han Li, Wenqi Li, Lu Wu, Lu Lu, Qizhan Liu","doi":"10.3390/toxics12040296","DOIUrl":"https://doi.org/10.3390/toxics12040296","url":null,"abstract":"BACKGROUND\u0000Obesity, a chronic metabolic disorder, is related to cardiovascular diseases, diabetes, cancer, and reproductive disorders. The relationship between obesity and male infertility is now well recognized, but the mechanisms involved are unclear. We aimed to observe the effect of obesity on spermatogenesis and to investigate the role of histone ubiquitination and acetylation modifications in obesity-induced spermatogenesis disorders.\u0000\u0000\u0000METHODS\u0000Thirty male C57BL/6J mice were randomly divided into two groups. The control group was fed with a general maintenance diet (12% fat), while a high-fat diet (HFD) group was fed with 40% fat for 10 weeks; then, they were mated with normal females. The fertility of male mice was calculated, testicular and sperm morphology were observed, and the expression levels of key genes and the levels of histone acetylation and ubiquitination modification during spermatogenesis were detected.\u0000\u0000\u0000RESULTS\u0000The number of sperm was decreased, as well as the sperm motility, while the number of sperm with malformations was increased. In the testes, the mRNA and protein expression levels of gonadotropin-regulated testicular RNA helicase (GRTH/DDX25), chromosome region maintenance-1 protein (CRM1), high-mobility group B2 (HMGB2), phosphoglycerate kinase 2 (PGK2), and testicular angiotensin-converting enzyme (tACE) were decreased. Furthermore, obesity led to a decrease in ubiquitinated H2A (ubH2A) and reduced levels of histone H3 acetylation K18 (H3AcK18) and histone H4 acetylation K5, K8, K12, and K16 (H4tetraAck), which disrupted protamine 1 (Prm1) deposition in testis tissue.\u0000\u0000\u0000CONCLUSION\u0000These results suggest that low levels of histone ubiquitination and acetylation are linked with obesity-induced disorders during spermatogenesis, contributing to a better understanding of obesity-induced damage to male reproduction.","PeriodicalId":508978,"journal":{"name":"Toxics","volume":" 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140692284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bisphenol A Exposure Interferes with Reproductive Hormones and Decreases Sperm Counts: A Systematic Review and Meta-Analysis of Epidemiological Studies. 暴露于双酚 A 会干扰生殖激素并降低精子数量：流行病学研究的系统回顾和元分析》。

Toxics Pub Date : 2024-04-17 DOI: 10.3390/toxics12040294

Lei Lü, Yuan Liu, Yuhong Yang, Jinxing He, Lulu Luo, Shanbin Chen, Hanzhu Xing

{"title":"Bisphenol A Exposure Interferes with Reproductive Hormones and Decreases Sperm Counts: A Systematic Review and Meta-Analysis of Epidemiological Studies.","authors":"Lei Lü, Yuan Liu, Yuhong Yang, Jinxing He, Lulu Luo, Shanbin Chen, Hanzhu Xing","doi":"10.3390/toxics12040294","DOIUrl":"https://doi.org/10.3390/toxics12040294","url":null,"abstract":"Bisphenol A (BPA), an acknowledged endocrine disrupter, is easily exposed to humans via food packaging and container. However, a consensus has not been reached on the extent to which BPA exposure affects the reproductive system. We therefore conducted this systematic review and meta-analysis to elucidate the relationship between BPA exposure and male reproduction-related indicators. Up to October 2023, a comprehensive search was carried out in the PubMed, Embase, Cochrane and Web of Science, and 18 studies were ultimately included. β coefficients from multivariate linear regression analyses were pooled using a random effects model. The results showed that the urinary BPA concentration was negatively correlated with the sperm concentration (β coefficient = -0.03; 95% CI: -0.06 to -0.01; I2 = 0.0%, p = 0.003) and total sperm count (β coefficient = -0.05; 95% CI: -0.08 to -0.02; I2 = 0.0%, p < 0.001). In addition, BPA concentrations were associated with increased sex hormone-binding globulin (SHBG) levels, increased estradiol (E2) levels, and reduced biologically active androgen levels. However, the relationship between an increased risk of below-reference sperm quality and BPA exposure was not robust. This systematic review revealed that BPA exposure disrupts reproductive hormones, reduces sperm counts and may ultimately adversely affect male reproduction.","PeriodicalId":508978,"journal":{"name":"Toxics","volume":"120 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140693455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PM2.5 Extracts Induce INFγ-Independent Activation of CIITA, MHCII, and Increases Inflammation in Human Bronchial Epithelium. PM2.5 提取物可诱导 INFγ 独立激活 CIITA、MHCII 并增加人类支气管上皮细胞的炎症反应。

Toxics Pub Date : 2024-04-16 DOI: 10.3390/toxics12040292

Héctor Jirau-Colón, B. Jiménez-Vélez

{"title":"PM2.5 Extracts Induce INFγ-Independent Activation of CIITA, MHCII, and Increases Inflammation in Human Bronchial Epithelium.","authors":"Héctor Jirau-Colón, B. Jiménez-Vélez","doi":"10.3390/toxics12040292","DOIUrl":"https://doi.org/10.3390/toxics12040292","url":null,"abstract":"The capacity of particulate matter (PM) to enhance and stimulate the expression of pro-inflammatory mediators has been previously demonstrated in non-antigen-presenting cells (human bronchial epithelia). Nonetheless, many proposed mechanisms for this are extrapolated from known canonical molecular pathways. This work evaluates a possible mechanism for inflammatory exacerbation after exposure to PM2.5 (from Puerto Rico) and CuSO4, using human bronchial epithelial cells (BEAS-2B) as a model. The induction of CIITA, MHCII genes, and various pro-inflammatory mediators was investigated. Among these, the phosphorylation of STAT1 Y701 was significantly induced after 4 h of PM2.5 exposure, concurrent with a slight increase in CIITA and HLA-DRα mRNA levels. INFγ mRNA levels remained low amidst exposure time, while IL-6 levels significantly increased at earlier times. IL-8 remained low, as expected from attenuation by IL-6 in the known INFγ-independent inflammation pathway. The effects of CuSO4 showed an increase in HLA-DRα expression after 8 h, an increase in STAT1 at 1 h, and RF1 at 8 h We hypothesize and show evidence that an inflammatory response due to PM2.5 extract exposure in human bronchial epithelia can be induced early via an alternate non-canonical pathway in the absence of INFγ.","PeriodicalId":508978,"journal":{"name":"Toxics","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140698628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urinary Volatile Organic Compound Metabolites Are Associated with Reduced Lung Function in U.S. Children and Adolescents. 尿液中挥发性有机化合物代谢物与美国儿童和青少年肺功能降低有关。

Toxics Pub Date : 2024-04-16 DOI: 10.3390/toxics12040289

A. Mendy, Sara Burcham, A. Merianos, T. Mersha, K. Yolton, Aimin Chen, E. M. Mahabee-gittens

{"title":"Urinary Volatile Organic Compound Metabolites Are Associated with Reduced Lung Function in U.S. Children and Adolescents.","authors":"A. Mendy, Sara Burcham, A. Merianos, T. Mersha, K. Yolton, Aimin Chen, E. M. Mahabee-gittens","doi":"10.3390/toxics12040289","DOIUrl":"https://doi.org/10.3390/toxics12040289","url":null,"abstract":"(1) Background: Volatile organic compounds (VOCs) are indoor pollutants absorbed by inhalation. The association of several VOCs with lung function in children and adolescents is unknown. (2) Methods: We analyzed 505 participants, 6-17-year-olds from the 2011-2012 National Health and Nutrition Examination Survey. Multiple linear regression models were fitted to estimate the associations of VOC metabolites with spirometry outcomes adjusting for covariates. (3) Results: Urinary metabolites of xylene, acrylamide, acrolein, 1,3-butadiene, cyanide, toluene, 1-bromopropane, acrylonitrile, propylene oxide, styrene, ethylbenzene, and crotonaldehyde were all detected in ≥64.5% of participants. Forced expiratory volume in 1 s (FEV1) % predicted was lower in participants with higher levels of metabolites of acrylamide (β: -7.95, 95% CI: -13.69, -2.21) and styrene (β: -6.33, 95% CI: -11.60, -1.07), whereas the FEV1 to forced vital capacity (FVC) ratio % was lower in children with higher propylene oxide metabolite levels (β: -2.05, 95% CI: -3.49, -0.61). FEV1 % predicted was lower with higher crotonaldehyde metabolite levels only in overweight/obese participants (β: -15.42, 95% CI: -26.76, -4.08) (Pinteraction < 0.001) and with higher 1-bromopropane metabolite levels only in those with serum cotinine > 1 ng/mL (β: -6.26, 95% CI: -9.69, -2.82) (Pinteraction < 0.001). (4) Conclusions: We found novel associations of metabolites for acrylamide, propylene oxide, styrene, 1-bromopropane and crotonaldehyde with lower lung function in children and adolescents.","PeriodicalId":508978,"journal":{"name":"Toxics","volume":"8 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140695966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Concordance between In Vitro and In Vivo Relative Toxic Potencies of Diesel Exhaust Particles from Different Biodiesel Blends. 不同生物柴油混合物产生的柴油废气颗粒的体外和体内相对毒力之间的一致性

Toxics Pub Date : 2024-04-16 DOI: 10.3390/toxics12040290

Subramanian Karthikeyan, D. Breznan, Errol M. Thomson, E. Blais, Renaud Vincent, P. Kumarathasan

{"title":"Concordance between In Vitro and In Vivo Relative Toxic Potencies of Diesel Exhaust Particles from Different Biodiesel Blends.","authors":"Subramanian Karthikeyan, D. Breznan, Errol M. Thomson, E. Blais, Renaud Vincent, P. Kumarathasan","doi":"10.3390/toxics12040290","DOIUrl":"https://doi.org/10.3390/toxics12040290","url":null,"abstract":"Diesel exhaust particles (DEPs) contribute to air pollution exposure-related adverse health impacts. Here, we examined in vitro, and in vivo toxicities of DEPs from a Caterpillar C11 heavy-duty diesel engine emissions using ultra-low-sulfur diesel (ULSD) and biodiesel blends (20% v/v) of canola (B20C), soy (B20S), or tallow-waste fry oil (B20T) in ULSD. The in vitro effects of DEPs (DEPULSD, DEPB20C, DEPB20S, and DEPB20T) in exposed mouse monocyte/macrophage cells (J774A.1) were examined by analyzing the cellular cytotoxicity endpoints (CTB, LDH, and ATP) and secreted proteins. The in vivo effects were assessed in BALB/c mice (n = 6/group) exposed to DEPs (250 µg), carbon black (CB), or saline via intratracheal instillation 24 h post-exposure. Bronchoalveolar lavage fluid (BALF) cell counts, cytokines, lung/heart mRNA, and plasma markers were examined. In vitro cytotoxic potencies (e.g., ATP) and secreted TNF-α were positively correlated (p < 0.05) with in vivo inflammatory potency (BALF cytokines, lung/heart mRNA, and plasma markers). Overall, DEPULSD and DEPB20C appeared to be more potent compared to DEPB20S and DEPB20T. These findings suggested that biodiesel blend-derived DEP potencies can be influenced by biodiesel sources, and inflammatory process- was one of the potential underlying toxicity mechanisms. These observations were consistent across in vitro and in vivo exposures, and this work adds value to the health risk analysis of cleaner fuel alternatives.","PeriodicalId":508978,"journal":{"name":"Toxics","volume":"358 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140698153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatiotemporal Gradients of PAH Concentrations in Greek Cities and Associated Exposure Impacts. 希腊城市多环芳烃浓度的时空梯度及相关暴露影响。

Toxics Pub Date : 2024-04-16 DOI: 10.3390/toxics12040293

Irini Tsiodra, K. Tavernaraki, G. Grivas, C. Parinos, K. Papoutsidaki, D. Paraskevopoulou, E. Liakakou, A. Gogou, A. Bougiatioti, E. Gerasopoulos, M. Kanakidou, N. Mihalopoulos

{"title":"Spatiotemporal Gradients of PAH Concentrations in Greek Cities and Associated Exposure Impacts.","authors":"Irini Tsiodra, K. Tavernaraki, G. Grivas, C. Parinos, K. Papoutsidaki, D. Paraskevopoulou, E. Liakakou, A. Gogou, A. Bougiatioti, E. Gerasopoulos, M. Kanakidou, N. Mihalopoulos","doi":"10.3390/toxics12040293","DOIUrl":"https://doi.org/10.3390/toxics12040293","url":null,"abstract":"To study the spatiotemporal variability of particle-bound polycyclic aromatic hydrocarbons (PAHs) and assess their carcinogenic potential in six contrasting urban environments in Greece, a total of 305 filter samples were collected and analyzed. Sampling sites included a variety of urban background, traffic (Athens, Ioannina and Heraklion), rural (Xanthi) and near-port locations (Piraeus and Volos). When considering the sum of 16 U.S. EPA priority PAHs, as well as that of the six EU-proposed members, average concentrations observed across locations during summer varied moderately (0.4-2.2 ng m-3) and independently of the population of each site, with the highest values observed in the areas of Piraeus and Volos that are affected by port and industrial activities. Winter levels were significantly higher and more spatially variable compared to summer, with the seasonal enhancement ranging from 7 times in Piraeus to 98 times in Ioannina, indicating the large impact of PAH emissions from residential wood burning. Regarding benzo(a)pyrene (BaP), an IARC Group 1 carcinogen and the only EU-regulated PAH, the winter/summer ratios were 24-33 in Athens, Volos, Heraklion and Xanthi; 60 in Piraeus; and 480 in Ioannina, which is afflicted by severe wood-burning pollution events. An excellent correlation was observed between organic carbon (OC) and benzo(a)pyrene (BaP) during the cold period at all urban sites (r2 > 0.8) with stable BaP/OC slopes (0.09-0.14 × 10-3), highlighting the potential use of OC as a proxy for the estimation of BaP in winter conditions. The identified spatiotemporal contrasts, which were explored for the first time for PAHs at such a scale in the Eastern Mediterranean, provide important insights into sources and controlling atmospheric conditions and reveal large deviations in exposure risks among cities that raise the issue of environmental injustice on a national level.","PeriodicalId":508978,"journal":{"name":"Toxics","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140695504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improving Lead Phytoremediation Using Endophytic Bacteria Isolated from the Pioneer Plant Ageratina adenophora (Spreng.) from a Mining Area. 利用从矿区先锋植物 Ageratina adenophora（Spreng.）

Toxics Pub Date : 2024-04-16 DOI: 10.3390/toxics12040291

Qiqian Li, Siyu Yao, Hua Wen, Wenqi Li, Ling Jin, Xiuxiang Huang

{"title":"Improving Lead Phytoremediation Using Endophytic Bacteria Isolated from the Pioneer Plant Ageratina adenophora (Spreng.) from a Mining Area.","authors":"Qiqian Li, Siyu Yao, Hua Wen, Wenqi Li, Ling Jin, Xiuxiang Huang","doi":"10.3390/toxics12040291","DOIUrl":"https://doi.org/10.3390/toxics12040291","url":null,"abstract":"This study aimed to isolate and characterise endophytic bacteria from the pioneer plant Ageratina adenophora in a mining area. Seven strains of metal-resistant endophytic bacteria that belong to five genera were isolated from the roots of A. adenophora. These strains exhibited various plant growth-promoting (PGP) capabilities. Sphingomonas sp. ZYG-4, which exhibited the ability to secrete indoleacetic acid (IAA; 53.2 ± 8.3 mg·L-1), solubilize insoluble inorganic phosphates (Phosphate solubilization; 11.2 ± 2.9 mg·L-1), and regulate root ethylene levels (1-aminocyclopropane-1-carboxylic acid deaminase activity; 2.87 ± 0.19 µM α-KB·mg-1·h-1), had the highest PGP potential. Therefore, Sphingomonas sp. ZYG-4 was used in a pot experiment to study its effect on the biomass and Pb uptake of both host (Ageratina adenophora) and non-host (Dysphania ambrosioides) plants. Compared to the uninoculated control, Sphingomonas sp. ZYG-4 inoculation increased the biomass of shoots and roots by 59.4% and 144.4% for A. adenophora and by 56.2% and 57.1% for D. ambrosioides, respectively. In addition, Sphingomonas sp. ZYG-4 inoculation enhanced Pb accumulation in the shoot and root by 268.9% and 1187.3% for A. adenophora, and by 163.1% and 343.8% for D. ambrosioides, respectively, compared to plants without bacterial inoculation. Our research indicates that endophytic bacteria are promising candidates for enhancing plant growth and facilitating microbe-assisted phytoremediation in heavy metal-contaminated soil.","PeriodicalId":508978,"journal":{"name":"Toxics","volume":"31 47","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140696870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exposure to Molybdate Results in Metabolic Disorder: An Integrated Study of the Urine Elementome and Serum Metabolome in Mice. 暴露于钼酸盐会导致代谢紊乱：小鼠尿液元素组和血清代谢组的综合研究。

Toxics Pub Date : 2024-04-14 DOI: 10.3390/toxics12040288

Kun Zhou, Miaomiao Tang, Wei Zhang, Yanling Chen, Yusheng Guan, Rui Huang, Jiawei Duan, Zibo Liu, Xiaoming Ji, Yingtong Jiang, Yanhui Hu, Xiaoling Zhang, Jingjing Zhou, Minjian Chen

{"title":"Exposure to Molybdate Results in Metabolic Disorder: An Integrated Study of the Urine Elementome and Serum Metabolome in Mice.","authors":"Kun Zhou, Miaomiao Tang, Wei Zhang, Yanling Chen, Yusheng Guan, Rui Huang, Jiawei Duan, Zibo Liu, Xiaoming Ji, Yingtong Jiang, Yanhui Hu, Xiaoling Zhang, Jingjing Zhou, Minjian Chen","doi":"10.3390/toxics12040288","DOIUrl":"https://doi.org/10.3390/toxics12040288","url":null,"abstract":"The increasing use of molybdate has raised concerns about its potential toxicity in humans. However, the potential toxicity of molybdate under the current level of human exposure remains largely unknown. Endogenous metabolic alterations that are caused in humans by environmental exposure to pollutants are associated with the occurrence and progression of many diseases. This study exposed eight-week-old male C57 mice to sodium molybdate at doses relevant to humans (0.01 and 1 mg/kg/day) for eight weeks. Inductively coupled plasma mass spectrometry (ICP-MS) and ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS) were utilized to assess changes in urine element levels and serum metabolites in mice, respectively. A total of 838 subjects from the NHANES 2017-2018 population database were also included in our study to verify the associations between molybdenum and cadmium found in mice. Analysis of the metabolome in mice revealed that four metabolites in blood serum exhibited significant changes, including 5-aminolevulinic acid, glycolic acid, l-acetylcarnitine, and 2,3-dihydroxypropyl octanoate. Analysis of the elementome revealed a significant increase in urine levels of cadmium after molybdate exposure in mice. Notably, molybdenum also showed a positive correlation with cadmium in humans from the NHANES database. Further analysis identified a positive correlation between cadmium and 2,3-dihydroxypropyl octanoate in mice. In conclusion, these findings suggest that molybdate exposure disrupted amino acid and lipid metabolism, which may be partially mediated by molybdate-altered cadmium levels. The integration of elementome and metabolome data provides sensitive information on molybdate-induced metabolic disorders and associated toxicities at levels relevant to human exposure.","PeriodicalId":508978,"journal":{"name":"Toxics","volume":"146 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140706798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dimethylcyclosiloxanes in Mobile Smart Terminal Devices: Concentrations, Distributions, Profiles, and Environmental Emissions. 移动智能终端设备中的二甲基环硅氧烷：移动智能终端设备中的二甲基环硅氧烷：浓度、分布、轮廓和环境排放。

Toxics Pub Date : 2024-04-13 DOI: 10.3390/toxics12040287

Yuanna Xing, Yiming Ge, Shaoyou Lu, Tao Yang, Xianzhi Peng

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