Bisphenol A Exposure Interferes with Reproductive Hormones and Decreases Sperm Counts: A Systematic Review and Meta-Analysis of Epidemiological Studies.

Toxics Pub Date : 2024-04-17 DOI:10.3390/toxics12040294

Lei Lü, Yuan Liu, Yuhong Yang, Jinxing He, Lulu Luo, Shanbin Chen, Hanzhu Xing

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Abstract

Bisphenol A (BPA), an acknowledged endocrine disrupter, is easily exposed to humans via food packaging and container. However, a consensus has not been reached on the extent to which BPA exposure affects the reproductive system. We therefore conducted this systematic review and meta-analysis to elucidate the relationship between BPA exposure and male reproduction-related indicators. Up to October 2023, a comprehensive search was carried out in the PubMed, Embase, Cochrane and Web of Science, and 18 studies were ultimately included. β coefficients from multivariate linear regression analyses were pooled using a random effects model. The results showed that the urinary BPA concentration was negatively correlated with the sperm concentration (β coefficient = -0.03; 95% CI: -0.06 to -0.01; I2 = 0.0%, p = 0.003) and total sperm count (β coefficient = -0.05; 95% CI: -0.08 to -0.02; I2 = 0.0%, p < 0.001). In addition, BPA concentrations were associated with increased sex hormone-binding globulin (SHBG) levels, increased estradiol (E2) levels, and reduced biologically active androgen levels. However, the relationship between an increased risk of below-reference sperm quality and BPA exposure was not robust. This systematic review revealed that BPA exposure disrupts reproductive hormones, reduces sperm counts and may ultimately adversely affect male reproduction.

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暴露于双酚 A 会干扰生殖激素并降低精子数量：流行病学研究的系统回顾和元分析》。

双酚 A（BPA）是一种公认的内分泌干扰物，人类很容易通过食品包装和容器接触到它。然而，人们尚未就双酚 A 暴露对生殖系统的影响程度达成共识。因此，我们进行了这项系统回顾和荟萃分析，以阐明双酚 A 暴露与男性生殖相关指标之间的关系。截至 2023 年 10 月，我们在 PubMed、Embase、Cochrane 和 Web of Science 中进行了全面检索，最终纳入了 18 项研究。采用随机效应模型对多元线性回归分析的β系数进行了汇总。结果显示，尿液中双酚 A 浓度与精子浓度（β 系数 = -0.03；95% CI：-0.06 至 -0.01；I2 = 0.0%，p = 0.003）和精子总数（β 系数 = -0.05；95% CI：-0.08 至 -0.02；I2 = 0.0%，p < 0.001）呈负相关。此外，双酚 A 浓度与性激素结合球蛋白 (SHBG) 水平升高、雌二醇 (E2) 水平升高和生物活性雄激素水平降低有关。然而，精子质量低于参考值的风险增加与双酚 A 暴露之间的关系并不紧密。本系统综述显示，暴露于双酚 A 会扰乱生殖激素，降低精子数量，最终可能对男性生殖产生不利影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Toxics

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