发布求助
文献互助 智能选刊 最新文献

Advances in Anatomy Embryology and Cell Biology最新文献

筛选
英文 中文
The Centrosome and its Functions and Dysfunctions 中心体及其功能和功能障碍
4区 生物学
Advances in Anatomy Embryology and Cell Biology Pub Date : 2022-01-01 DOI: 10.1007/978-3-031-20848-5
H. Schatten
{"title":"The Centrosome and its Functions and Dysfunctions","authors":"H. Schatten","doi":"10.1007/978-3-031-20848-5","DOIUrl":"https://doi.org/10.1007/978-3-031-20848-5","url":null,"abstract":"","PeriodicalId":50879,"journal":{"name":"Advances in Anatomy Embryology and Cell Biology","volume":"56 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50987247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Centrosome Cycle within the Cell Cycle. 细胞周期中的中心体周期。
4区 生物学
Advances in Anatomy Embryology and Cell Biology Pub Date : 2022-01-01 DOI: 10.1007/978-3-031-20848-5_2
Heide Schatten
{"title":"The Centrosome Cycle within the Cell Cycle.","authors":"Heide Schatten","doi":"10.1007/978-3-031-20848-5_2","DOIUrl":"https://doi.org/10.1007/978-3-031-20848-5_2","url":null,"abstract":"<p><p>The synchronized distribution of centrosomal and genetic materials to the dividing daughter cells is critically important and depends on precisely orchestrated processes on structural and molecular levels. Structural and functional relationships between the nucleus and centrosomes facilitate cellular communication and coordination of cell cycle control and progression which becomes especially important during the transition from interphase to mitosis when synchrony between centrosomes and nuclear events is critical.</p>","PeriodicalId":50879,"journal":{"name":"Advances in Anatomy Embryology and Cell Biology","volume":"235 ","pages":"17-35"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10445420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Centrosomes in Reproduction. 生殖中的中心体。
4区 生物学
Advances in Anatomy Embryology and Cell Biology Pub Date : 2022-01-01 DOI: 10.1007/978-3-031-20848-5_6
Heide Schatten
{"title":"Centrosomes in Reproduction.","authors":"Heide Schatten","doi":"10.1007/978-3-031-20848-5_6","DOIUrl":"https://doi.org/10.1007/978-3-031-20848-5_6","url":null,"abstract":"<p><p>Centrosome functions are vitally important for all aspects of reproduction with essential functions during meiosis, fertilization, cell division, centrosome remodeling during cellular polarization for tissue formation, and all stages of subsequent embryo development. Any defects in centrosome organization and dynamics can result in meiotic spindle formation errors, meiotic division errors, infertility, subfertility, arrested or failed development, and predisposition to various diseases including cancer. These aspects of reproduction will be addressed in more detail in the following sections.</p>","PeriodicalId":50879,"journal":{"name":"Advances in Anatomy Embryology and Cell Biology","volume":"235 ","pages":"55-73"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10445422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Centrosome Dysfunctions in Cancer. 癌症中的中心体功能障碍。
4区 生物学
Advances in Anatomy Embryology and Cell Biology Pub Date : 2022-01-01 DOI: 10.1007/978-3-031-20848-5_4
Heide Schatten
{"title":"Centrosome Dysfunctions in Cancer.","authors":"Heide Schatten","doi":"10.1007/978-3-031-20848-5_4","DOIUrl":"https://doi.org/10.1007/978-3-031-20848-5_4","url":null,"abstract":"<p><p>As major accomplishments and breakthroughs in centrosome research had been achieved by Theodor Boveri in reproductive cells with the invertebrate sea urchin being an ideal model system for such studies on fertilization, cell division, and embryo development, these studies also gave rise to Boveri's brilliant concept regarding cancer cells. He discovered that eggs fertilized with two sperm resulted in tripolar mitosis and abnormal cell division, similar to cells observed in cancer tissue.</p>","PeriodicalId":50879,"journal":{"name":"Advances in Anatomy Embryology and Cell Biology","volume":"235 ","pages":"43-50"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10445419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transitions from Centrosomal to Non-centrosomal Microtubule Organization During Cellular Polarization. 细胞极化过程中中心体向非中心体微管组织的转变。
4区 生物学
Advances in Anatomy Embryology and Cell Biology Pub Date : 2022-01-01 DOI: 10.1007/978-3-031-20848-5_7
Heide Schatten
{"title":"Transitions from Centrosomal to Non-centrosomal Microtubule Organization During Cellular Polarization.","authors":"Heide Schatten","doi":"10.1007/978-3-031-20848-5_7","DOIUrl":"https://doi.org/10.1007/978-3-031-20848-5_7","url":null,"abstract":"<p><p>Cellular polarization involves significant remodeling and decentralization of the nucleus-associated centrosome to focal points at the apical and basolateral surfaces which is associated with major remodeling of the microtubule system in which individual microtubules become nucleated and organized from the polarizing cell surfaces, as studied in polarizing epithelial cells (reviewed in Müsch 2004; Muroyama and Lechler 2017). These changes are associated with cellular asymmetry in preparation for cellular differentiation of previously non-committed cells. During this process, the previously nucleus-associated centrosome becomes deconstructed into specific centrosomal components which are now referred to as \"non-centrosomal.\" At the present time we still only have limited information about this process and to understanding the mechanisms underlying the centrosome decentralization process. Gaining detailed insights is further complicated by the fact that there is considerable diversity in the molecular mechanisms of centrosome and microtubule reorganization.</p>","PeriodicalId":50879,"journal":{"name":"Advances in Anatomy Embryology and Cell Biology","volume":"235 ","pages":"75-79"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10734190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Centrosome as Center for Proteolytic Activity and Dysfunctions Associated with Pathogenesis of Human Disease. 中心体作为与人类疾病发病机制相关的蛋白水解活性和功能障碍的中心。
4区 生物学
Advances in Anatomy Embryology and Cell Biology Pub Date : 2022-01-01 DOI: 10.1007/978-3-031-20848-5_3
Heide Schatten
{"title":"Centrosome as Center for Proteolytic Activity and Dysfunctions Associated with Pathogenesis of Human Disease.","authors":"Heide Schatten","doi":"10.1007/978-3-031-20848-5_3","DOIUrl":"https://doi.org/10.1007/978-3-031-20848-5_3","url":null,"abstract":"<p><p>Among the multiple and intriguing roles of centrosomes in cellular functions is the ubiquitin-proteasome-mediated protein degradation. It has been shown that proteasomes are concentrated at the mammalian centrosome which led to further studies to view the centrosome as a proteolytic center (Wojcik et al. 1996; Wigley et al. 1999; reviewed in Badano et al. 2005). Proteasomal components that are concentrated around the centrosome include ubiquitin, the 20S and 19S subunits of the proteasome, as well as the E3 enzyme parkin. These proteasomal components colocalize with the centrosomal marker γ-tubulin and co-purify with γ-tubulin in the centrosomal fractions after sucrose-gradient ultracentrifugation (Wigley et al. 1999). The localization, accumulation, and concentration of proteasomal components around centrosomes appear to be microtubule independent which has been shown experimentally by inhibiting microtubule functions. When intracellular levels of misfolded proteins were experimentally increased by either proteasome inhibition with drugs such as lactacystin, or by overexpression of misfolded mutant proteins, the centrosome-associated proteasome network became expanded and proteolytic components were recruited from the cytosol without involvement of microtubules. These studies revealed a critical role of centrosomes in the organization and subcellular localization of proteasomes (Wigley et al. 1999; Fabunmi et al. 2000).</p>","PeriodicalId":50879,"journal":{"name":"Advances in Anatomy Embryology and Cell Biology","volume":"235 ","pages":"37-42"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10445421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-centrosomal Microtubule Organization in Plant Cells. 植物细胞中的非中心体微管组织。
4区 生物学
Advances in Anatomy Embryology and Cell Biology Pub Date : 2022-01-01 DOI: 10.1007/978-3-031-20848-5_10
Heide Schatten
{"title":"Non-centrosomal Microtubule Organization in Plant Cells.","authors":"Heide Schatten","doi":"10.1007/978-3-031-20848-5_10","DOIUrl":"https://doi.org/10.1007/978-3-031-20848-5_10","url":null,"abstract":"<p><p>It is well known that plant cells do not contain typical centrosomes and the question has been asked how plant cells undergo mitosis and cell division in the absence of mechanisms that are well known for eukaryotic animal cells. Several papers are now available to address this question.</p>","PeriodicalId":50879,"journal":{"name":"Advances in Anatomy Embryology and Cell Biology","volume":"235 ","pages":"105-111"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10734192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cell and Molecular Biology of Centrosome Structure and Function. 中心体结构与功能的细胞与分子生物学。
4区 生物学
Advances in Anatomy Embryology and Cell Biology Pub Date : 2022-01-01 DOI: 10.1007/978-3-031-20848-5_1
Heide Schatten
{"title":"Cell and Molecular Biology of Centrosome Structure and Function.","authors":"Heide Schatten","doi":"10.1007/978-3-031-20848-5_1","DOIUrl":"https://doi.org/10.1007/978-3-031-20848-5_1","url":null,"abstract":"<p><p>The centrosome field has seen enormous progress during the past few decades which spans the large areas of cell biology with new information on cell cycle controls and cellular health; immunology with centrosomes being essential for the formation of the immunological synapse; neurobiology with new insights into centrosome dysfunctions leading to disorders and disease; stem cell biology with fate-determining distribution of centrosomal material during asymmetric cell division; cancer biology with huge insights into the role of centrosomes in disease initiation, progression, and manifestation; reproductive biology with essential centrosome functions in oocytes, during fertilization and embryo development in which centrosome dysfunctions can be related back to abnormal centrosomal material in the meiotic spindle of oocytes; and several others that will be highlighted in the specific chapters of this book.</p>","PeriodicalId":50879,"journal":{"name":"Advances in Anatomy Embryology and Cell Biology","volume":"235 ","pages":"1-16"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10445417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Virus Exploitation (Hijacking) of Centrosomes. 中心体的病毒利用(劫持)。
4区 生物学
Advances in Anatomy Embryology and Cell Biology Pub Date : 2022-01-01 DOI: 10.1007/978-3-031-20848-5_5
Heide Schatten
{"title":"Virus Exploitation (Hijacking) of Centrosomes.","authors":"Heide Schatten","doi":"10.1007/978-3-031-20848-5_5","DOIUrl":"https://doi.org/10.1007/978-3-031-20848-5_5","url":null,"abstract":"<p><p>One of the most interesting aspects of host cell-viral interactions is how the pathogen exploits the host cell cytoskeleton and centrosomes for survival in the host cell.</p>","PeriodicalId":50879,"journal":{"name":"Advances in Anatomy Embryology and Cell Biology","volume":"235 ","pages":"51-54"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10445423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Centrosomes and Centrosome Equivalents in Other Systems. 其他系统中的中心体和中心体等同物。
4区 生物学
Advances in Anatomy Embryology and Cell Biology Pub Date : 2022-01-01 DOI: 10.1007/978-3-031-20848-5_9
Heide Schatten
{"title":"Centrosomes and Centrosome Equivalents in Other Systems.","authors":"Heide Schatten","doi":"10.1007/978-3-031-20848-5_9","DOIUrl":"https://doi.org/10.1007/978-3-031-20848-5_9","url":null,"abstract":"<p><p>Stem cells are important to sustain tissue growth during development, to repair damaged tissue after injury, and to maintain homeostasis during adulthood. Precisely programmed stem cell renewal and differentiation is critical, as failure in balance can lead to tumorigenesis as a result of over-proliferation or to degeneration as a result of decline in stem cell functions (reviewed in Roth et al (2012); Chen et al (2021).</p>","PeriodicalId":50879,"journal":{"name":"Advances in Anatomy Embryology and Cell Biology","volume":"235 ","pages":"85-104"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10445424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信
小红书