Advances in Anatomy Embryology and Cell Biology最新文献_第7页

Development of Pre-implantation Mammalian Blastocyst. 哺乳动物胚胎着床前囊胚的发育。

4区生物学

Advances in Anatomy Embryology and Cell Biology Pub Date : 2021-01-01 DOI: 10.1007/978-3-030-77360-1_3

Bhanu P Telugu, Laramie Pence

{"title":"Development of Pre-implantation Mammalian Blastocyst.","authors":"Bhanu P Telugu, Laramie Pence","doi":"10.1007/978-3-030-77360-1_3","DOIUrl":"https://doi.org/10.1007/978-3-030-77360-1_3","url":null,"abstract":"The preimplantation mammalian embryo is a simplistic, self-contained, and a superior model for investigating the inherent complexities of cell fate decision mechanisms. All mammals begin their humble journey from a single-cell fertilized zygote contained within a proteinaceous coat called the zona pellucida. The zygote embarks on a series of well-orchestrated events, beginning with the activation of embryonic genome, transition from meiotic to mitotic divisions, spatial organization of the cells, timely differentiation into committed trophectoderm (TE) and primitive endoderm (PrE), and ultimately escape from zona pellucida for implantation into the uterus. The entire development of preimplantation embryo can be studied in vitro using a minimalistic and defined culture system. The ease of culture along with the ability to manipulate gene expression and image the embryos makes them an ideal model system for investigation into the first two of several cell fate decisions made by the embryo that result in a pluripotent epiblast (EPI) and differentiated TE and PrE lineages. This chapter reviews our latest knowledge of preimplantation embryo development, setting the stage for understanding placental development in subsequent chapters in this Book.","PeriodicalId":50879,"journal":{"name":"Advances in Anatomy Embryology and Cell Biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39557918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Implantation and Placentation in Ruminants. 反刍动物的着床和胎盘。

4区生物学

Advances in Anatomy Embryology and Cell Biology Pub Date : 2021-01-01 DOI: 10.1007/978-3-030-77360-1_7

Jonathan A Green, Rodney D Geisert, Greg A Johnson, Thomas E Spencer

{"title":"Implantation and Placentation in Ruminants.","authors":"Jonathan A Green, Rodney D Geisert, Greg A Johnson, Thomas E Spencer","doi":"10.1007/978-3-030-77360-1_7","DOIUrl":"https://doi.org/10.1007/978-3-030-77360-1_7","url":null,"abstract":"In comparison to many other mammalian species, ruminant ungulates have a unique form of placentation. Ruminants initially display an epitheliochorial type of placentation; however, during the period of placental attachment, trophoblast giant binucleate cells (BNC) develop within the chorion to migrate and fuse with the uterine surface epithelium to form syncytial plaques. Binucleate cell migration and fusion continues throughout pregnancy but never appears to breach the basal lamina, beneath the uterine surface or luminal epithelium. Therefore, the semi-invasive type of placentation in ruminants is classified as synepitheliochorial. The endometrium of ruminant species also contains unique specialized aglandular structures termed \"caruncles\" in which the chorioallantois (cotyledons) interdigitates and forms highly vascularized fetal-maternal \"placentomes.\" This chapter will discuss the current knowledge of early conceptus development during the peri-attachment period, establishment of pregnancy, conceptus attachment, and placentation in ruminant ungulates. The features of placentomes, BNCs, fetomaternal hybrid cells, and multinucleated syncytial plaques of the cotyledonary placenta of ruminant species will be reviewed to highlight the unique form of placentation compared to the placentae of other artiodactyls.","PeriodicalId":50879,"journal":{"name":"Advances in Anatomy Embryology and Cell Biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39557922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Development of the Mouse Placenta. 小鼠胎盘的发育。

4区生物学

Advances in Anatomy Embryology and Cell Biology Pub Date : 2021-01-01 DOI: 10.1007/978-3-030-77360-1_10

Sourav Panja, Bibhash C Paria

{"title":"Development of the Mouse Placenta.","authors":"Sourav Panja, Bibhash C Paria","doi":"10.1007/978-3-030-77360-1_10","DOIUrl":"https://doi.org/10.1007/978-3-030-77360-1_10","url":null,"abstract":"Placenta forms as a momentary organ inside the uterus with a slew of activities only when the woman is pregnant. It is a discoid-shaped hybrid structure consisting of maternal and embryonic components. It develops in the mesometrial side of the uterus following blastocyst implantation to keep the two genetically different entities, the mother and embryo, separated but connected. The beginning and progression of placental formation and development following blastocyst implantation coincides with the chronological developmental stages of the embryo. It gradually acquires the ability to perform the vascular, respiratory, hepatic, renal, endocrine, gastrointestinal, immune, and physical barrier functions synchronously that are vital for fetal development, growth, and safety inside the maternal environment. The uterus ejects the placenta when its embryonic growth and survival supportive roles are finished; that is usually the birth of the baby. Despite its irreplaceable role in fetal development and survival over the post-implantation progression of pregnancy, it still remains unclear how it forms, matures, performs all of its activities, and starts to fail functioning. Thus, a detailed understanding about normal developmental, structural, and functional aspects of the placenta may lead to avoid pregnancy problems that arise with the placenta.","PeriodicalId":50879,"journal":{"name":"Advances in Anatomy Embryology and Cell Biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9109784/pdf/nihms-1805559.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39557925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Introduction to Preclinical Evidence from Animal Models of Endometriosis. 子宫内膜异位症动物模型的临床前证据介绍。

4区生物学

Advances in Anatomy Embryology and Cell Biology Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-51856-1_1

Kathy L Sharpe-Timms, Julie A W Stilley

引用次数: 1

Endometriosis-Associated Pain - Do Preclinical Rodent Models Provide a Good Platform for Translation? 子宫内膜异位症相关的疼痛-临床前啮齿动物模型提供了一个很好的翻译平台吗?

4区生物学

Advances in Anatomy Embryology and Cell Biology Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-51856-1_3

Erin Greaves, Matthew Rosser, Philippa T K Saunders

{"title":"Endometriosis-Associated Pain - Do Preclinical Rodent Models Provide a Good Platform for Translation?","authors":"Erin Greaves, Matthew Rosser, Philippa T K Saunders","doi":"10.1007/978-3-030-51856-1_3","DOIUrl":"10.1007/978-3-030-51856-1_3","url":null,"abstract":"Pelvic pain is a common symptom of endometriosis. Our understanding of its etiology remains incomplete and medical management is limited by poor translation from preclinical models to clinical trials. In this review, we briefly consider the evidence, or lack thereof, that different subtypes of lesion, extra-uterine bleeding, and neuropathic pathways add to the complex and heterogeneous pain experience of women with the condition. We summarize the studies in rodent models of endometriosis that have used behavioral endpoints (evoked and non-evoked) to explore mechanisms of endometriosis-associated pain. Lesion innervation, activation of nerves by pronociceptive molecules released by immune cells, and a role for estrogen in modulating hyperalgesia are key endometriosis-associated pain mechanisms replicated in preclinical rodent models. The presence of ectopic (full thickness uterus or endometrial) tissue may be associated with changes in the spinal cord and brain, which appear to model changes reported in patients. While preclinical models using rats and mice have yielded insights that appear relevant to mechanisms responsible for the development of endometriosis-associated pain, they are limited in scope. Specifically, most studies are based on models that only resulted in the formation of superficial lesions and use induced (evoked) behavioral 'pain' tests. We suggest that translation for patient benefit will be improved by new approaches including models of ovarian and deep infiltrating disease and measurement of spontaneous pain behaviors. Future studies must also capitalize on new advances in the wider field of pain medicine to identify more effective treatments for endometriosis-associated pain.","PeriodicalId":50879,"journal":{"name":"Advances in Anatomy Embryology and Cell Biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38676805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

What Have We Learned from Animal Models of Endometriosis and How Can We Use the Knowledge Gained to Improve Treatment of Patients? 我们从子宫内膜异位症的动物模型中学到了什么?我们如何利用所获得的知识来改善患者的治疗?

4区生物学

Advances in Anatomy Embryology and Cell Biology Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-51856-1_6

Philippa T K Saunders

引用次数: 2

Identifying Mechanisms of Endometriosis-Associated Reduced Fecundity in a Rat Model: Novel Insights toward Understanding Human Infertility. 在大鼠模型中识别子宫内膜异位症相关的生育能力降低的机制:对理解人类不孕症的新见解。

4区生物学

Advances in Anatomy Embryology and Cell Biology Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-51856-1_2

Kathy L Sharpe-Timms, Henda Nabli, Julie A W Stilley

{"title":"Identifying Mechanisms of Endometriosis-Associated Reduced Fecundity in a Rat Model: Novel Insights toward Understanding Human Infertility.","authors":"Kathy L Sharpe-Timms, Henda Nabli, Julie A W Stilley","doi":"10.1007/978-3-030-51856-1_2","DOIUrl":"https://doi.org/10.1007/978-3-030-51856-1_2","url":null,"abstract":"The existence of endometriosis has been known since at least the nineteenth century, yet the lack of understanding of causes of infertility and therefore inadequate treatment approaches in endometriosis creates a significant challenge in reproductive medicine. Women worldwide suffer not only pain and infertility but also economical, societal, and physiological burdens. Studies of reproductive events in women are difficult to conduct due to a host of confounding personal and environmental factors and ethically limited due to the very nature of working with reproductive tissues and cells, especially embryos. Animal models are a viable adjunct to study mechanisms causing human reproductive anomalies and infertility in endometriosis. This chapter discusses reproductive anomalies causing infertility in endometriosis and well-established animal models which help decipher the problems and lead to heretofore unknown nonsurgical, nonhormonal methods to manage endometriosis in women. In addition, studies of effects of developmental exposure to endometriosis are revealing for the first time, in both female and male offspring, transgenerational subfertility in a rat model providing insights into the familial nature of endometriosis and possible epigenetic involvement.","PeriodicalId":50879,"journal":{"name":"Advances in Anatomy Embryology and Cell Biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38676804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Environmental Endocrine Disruptors and Endometriosis. 环境内分泌干扰物与子宫内膜异位症。

4区生物学

Advances in Anatomy Embryology and Cell Biology Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-51856-1_4

Jelonia T Rumph, Victoria R Stephens, Anthony E Archibong, Kevin G Osteen, Kaylon L Bruner-Tran

{"title":"Environmental Endocrine Disruptors and Endometriosis.","authors":"Jelonia T Rumph, Victoria R Stephens, Anthony E Archibong, Kevin G Osteen, Kaylon L Bruner-Tran","doi":"10.1007/978-3-030-51856-1_4","DOIUrl":"https://doi.org/10.1007/978-3-030-51856-1_4","url":null,"abstract":"As a consequence of industrialization, thousands of man-made chemicals have been developed with few undergoing rigorous safety assessment prior to commercial use. Ubiquitous exposure to these compounds, many of which act as endocrine-disrupting chemicals (EDCs), has been suggested to be one factor in the increasing incidence of numerous diseases, including endometriosis. Endometriosis, the presence of endometrial glands and stroma outside the uterus, is a common disorder of reproductive-age women. Although a number of population-based studies have suggested that exposure to environmental EDCs may affect a woman's risk of developing this disease, results of epidemiology assessments are often equivocal. The development of endometriosis is, however, a process occurring over time; thus, a single assessment of toxicant body burden cannot definitively be linked to causation of disease. For this reason, numerous investigators have utilized a variety of rodent models to examine the impact of specific EDCs on the development of experimental endometriosis. These studies identified multiple chemicals capable of influencing physiologic processes necessary for the establishment and/or survival of ectopic tissues in rodents, suggesting that these compounds may also be of concern for women. Importantly, these models serve as useful tools to explore strategies that may prevent adverse outcomes following EDC exposure.","PeriodicalId":50879,"journal":{"name":"Advances in Anatomy Embryology and Cell Biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7978485/pdf/nihms-1679893.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38677246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Deciphering the Role of miRNAs in Endometriosis Pathophysiology Using Experimental Endometriosis Mouse Models. 利用实验性子宫内膜异位症小鼠模型解读mirna在子宫内膜异位症病理生理中的作用。

4区生物学

Advances in Anatomy Embryology and Cell Biology Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-51856-1_5

Ayushi Vashisht, Zahraa Alali, Warren B Nothnick

引用次数: 1

The Origin of a New Progenitor Stem Cell Group in Human Development. 一个新的祖干细胞群在人类发育中的起源。

4区生物学

Advances in Anatomy Embryology and Cell Biology Pub Date : 2019-01-01 DOI: 10.1007/978-3-030-02050-7_1

Hubert Wartenberg, Andreas Miething, Kjeld Møllgård

引用次数: 0