Advances in Immunology最新文献_第6页

The development and physiological and pathophysiological functions of resident macrophages and glial cells. 巨噬细胞和胶质细胞的发育和生理病理生理功能。

3区医学

Advances in Immunology Pub Date : 2021-01-01 Epub Date: 2021-10-04 DOI: 10.1016/bs.ai.2021.08.001

Nelli Blank, Marina Mayer, Elvira Mass

引用次数: 2

Panorama of stepwise involvement of the IgH 3' regulatory region in murine B cells. 小鼠B细胞中ig3调控区逐步参与的全景图。

3区医学

Advances in Immunology Pub Date : 2021-01-01 Epub Date: 2021-04-27 DOI: 10.1016/bs.ai.2021.03.004

Charlotte Bruzeau, Jeanne Moreau, Sandrine Le Noir, Eric Pinaud

{"title":"Panorama of stepwise involvement of the IgH 3' regulatory region in murine B cells.","authors":"Charlotte Bruzeau, Jeanne Moreau, Sandrine Le Noir, Eric Pinaud","doi":"10.1016/bs.ai.2021.03.004","DOIUrl":"https://doi.org/10.1016/bs.ai.2021.03.004","url":null,"abstract":"Among the multiple events leading to immunoglobulin (Ig) expression in B cells, stepwise activation of the Ig heavy chain locus (IgH) is of critical importance. Transcription regulation of the complex IgH locus has always been an interesting viewpoint to unravel the multiple and complex events required for IgH expression. First, regulatory germline transcripts (GLT) assist DNA remodeling events such as VDJ recombination, class switch recombination (CSR) and somatic hypermutation (SHM). Second, productive spliced transcripts restrict heavy chain protein expression associated either with the surface receptor of developing B cells or secreted in large amounts in plasma cells. One main transcriptional regulator for IgH lies at its 3' extremity and includes both a set of enhancers grouped in a large 3' regulatory region (3'RR) and a cluster of 3'CTCF-binding elements (3'CBEs). In this focused review, we will preferentially refer to evidence reported for the murine endogenous IgH locus, whether it is wt or carries deletions or insertions within the IgH 3' boundary and associated regulatory region.","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":"149 ","pages":"95-114"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.ai.2021.03.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38986922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

The multi-faceted roles of TGF-β in regulation of immunity to infection. TGF-β在感染免疫调节中的多重作用

3区医学

Advances in Immunology Pub Date : 2021-01-01 DOI: 10.1016/bs.ai.2021.05.001

Rick M Maizels

引用次数: 6

Immunology of SARS-CoV-2 infections and vaccines. SARS-CoV-2感染的免疫学和疫苗。

3区医学

Advances in Immunology Pub Date : 2021-01-01 Epub Date: 2021-09-10 DOI: 10.1016/bs.ai.2021.08.002

Dominik Schenten, Deepta Bhattacharya

引用次数: 9

Modeling a complex disease: Multiple sclerosis-Update 2020. 建模一个复杂的疾病:多发性硬化症-更新2020。

3区医学

Advances in Immunology Pub Date : 2021-01-01 Epub Date: 2021-03-29 DOI: 10.1016/bs.ai.2021.03.002

Tommy Regen, Ari Waisman

{"title":"Modeling a complex disease: Multiple sclerosis-Update 2020.","authors":"Tommy Regen, Ari Waisman","doi":"10.1016/bs.ai.2021.03.002","DOIUrl":"https://doi.org/10.1016/bs.ai.2021.03.002","url":null,"abstract":"Multiple sclerosis (MS) is a complex inflammatory disease of the central nervous system (CNS) with an unknown etiology. Thereby, MS is not a uniform disease but rather represents a spectrum of disorders, where each aspect needs to be modeled with specific requirements-for a systematic overview see our previous issue of this review (Kurschus, Wortge, & Waisman, 2011). However, there is broad consensus about the critical involvement of the immune system in the disease pathogenesis. To better understand how the immune system contributes to CNS autoimmunity, the model of experimental autoimmune encephalomyelitis (EAE) was developed. EAE can be induced in susceptible animals in many different ways, with the most popular protocol involving the activation of self-reactive T cells by a peptide based on the myelin oligodendrocyte glycoprotein sequence. In the last 10 years this model has led to major advances in our understanding of the immune system, especially the nature of IL-17-producing T cells (Th17 cells), host-microbiome interactions, the gut-brain axis and how the immune system can cause damage in different regions of the brain and the spinal cord. This update summarizes some of the main achievements in the field in the last 10 years.","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":"149 ","pages":"25-34"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.ai.2021.03.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38998006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuropsychiatric disorders: An immunological perspective. 神经精神疾病:免疫学视角。

3区医学

Advances in Immunology Pub Date : 2021-01-01 Epub Date: 2021-11-18 DOI: 10.1016/bs.ai.2021.09.002

Ernest Aw, Yingying Zhang, Esra Yalcin, Uli S Herrmann, Michael C Carroll

{"title":"Neuropsychiatric disorders: An immunological perspective.","authors":"Ernest Aw, Yingying Zhang, Esra Yalcin, Uli S Herrmann, Michael C Carroll","doi":"10.1016/bs.ai.2021.09.002","DOIUrl":"https://doi.org/10.1016/bs.ai.2021.09.002","url":null,"abstract":"Neuropsychiatric diseases have traditionally been studied from brain, and mind-centric perspectives. However, mounting epidemiological and clinical evidence shows a strong correlation of neuropsychiatric manifestations with immune system activation, suggesting a likely mechanistic interaction between the immune and nervous systems in mediating neuropsychiatric disease. Indeed, immune mediators such as cytokines, antibodies, and complement proteins have been shown to affect various cellular members of the central nervous system in multitudinous ways, such as by modulating neuronal firing rates, inducing cellular apoptosis, or triggering synaptic pruning. These observations have in turn led to the exciting development of clinical therapies aiming to harness this neuro-immune interaction for the treatment of neuropsychiatric disease and symptoms. Besides the clinic, important theoretical fundamentals can be drawn from the immune system and applied to our understanding of the brain and neuropsychiatric disease. These new frameworks could lead to novel insights in the field and further potentiate the development of future therapies to treat neuropsychiatric disease.","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":"152 ","pages":"83-155"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39944449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Interleukin-9. Interleukin-9。

3区医学

Advances in Immunology Pub Date : 2020-02-07 DOI: 10.32388/ls6fci

J. Renauld, F. Houssiau, J. Louahed, A. Vink, J. Van Snick, C. Uyttenhove

引用次数: 53

Deciphering the pathways to antiviral innate immunity and inflammation. 破解抗病毒先天免疫和炎症的途径。

3区医学

Advances in Immunology Pub Date : 2020-01-01 Epub Date: 2019-12-03 DOI: 10.1016/bs.ai.2019.11.001

Qing Yang, Hong-Bing Shu

{"title":"Deciphering the pathways to antiviral innate immunity and inflammation.","authors":"Qing Yang, Hong-Bing Shu","doi":"10.1016/bs.ai.2019.11.001","DOIUrl":"https://doi.org/10.1016/bs.ai.2019.11.001","url":null,"abstract":"The antiviral innate immune and inflammatory responses are critical for host defense against viral infection. How these antiviral responses are initiated and regulated has been intensively investigated. Viral nucleic acids are sensed by pattern-recognition receptors (PRRs), which trigger various signaling pathways by utilizing distinct adaptor proteins, kinases and regulatory proteins. These pathways lead to activation of the transcriptional factors NF-κB and IRF3 and ultimate induction of antiviral effector proteins including type I interferons (IFNs), TNF and IL-1β, which are critical mediators of antiviral innate immune and inflammatory responses. For the past 20 years, our groups at Peking University and Wuhan University have made restless efforts in deciphering the molecular mechanisms of antiviral innate immune and inflammatory responses. Here, we summarize the major discoveries from our groups, including the identifications of the critical adaptors VISA/MAVS and MITA/STING, regulatory mechanisms of these adapter-mediated signaling, and regulation of TNF- and IL1β-triggered inflammatory responses.","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":"145 ","pages":"1-36"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.ai.2019.11.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37661836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 32

Tissue-resident NK cells and other innate lymphoid cells. 组织常驻NK细胞和其他先天淋巴样细胞。

3区医学

Advances in Immunology Pub Date : 2020-01-01 Epub Date: 2019-12-09 DOI: 10.1016/bs.ai.2019.11.002

Jing Zhou, Zhigang Tian, Hui Peng

引用次数: 18

Metabolic regulation of innate immunity. 先天免疫的代谢调节。

3区医学

Advances in Immunology Pub Date : 2020-01-01 Epub Date: 2019-12-05 DOI: 10.1016/bs.ai.2019.11.005

Shaonan Liang, Liangliang Ji, Lan Kang, Xiaoyu Hu

引用次数: 5