Advances in Immunology最新文献_第6页

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Advances in Immunology Pub Date : 2021-01-01 DOI: 10.1016/s0065-2776(21)00010-9

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Advances in Immunology Pub Date : 2021-01-01 DOI: 10.1016/s0065-2776(21)00046-8

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Advances in Immunology Pub Date : 2021-01-01 DOI: 10.1016/s0065-2776(21)00020-1

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Advances in Immunology Pub Date : 2021-01-01 DOI: 10.1016/s0065-2776(21)00048-1

引用次数: 0

Renal diseases and the role of complement: Linking complement to immune effector pathways and therapeutics. 肾脏疾病与补体的作用：将补体与免疫效应途径和疗法联系起来。

3区医学

Advances in Immunology Pub Date : 2021-01-01 Epub Date: 2021-11-19 DOI: 10.1016/bs.ai.2021.09.001

Tilo Freiwald, Behdad Afzali

{"title":"Renal diseases and the role of complement: Linking complement to immune effector pathways and therapeutics.","authors":"Tilo Freiwald, Behdad Afzali","doi":"10.1016/bs.ai.2021.09.001","DOIUrl":"10.1016/bs.ai.2021.09.001","url":null,"abstract":"The complement system is an ancient and phylogenetically conserved key danger sensing system that is critical for host defense against pathogens. Activation of the complement system is a vital component of innate immunity required for the detection and removal of pathogens. It is also a central orchestrator of adaptive immune responses and a constituent of normal tissue homeostasis. Once complement activation occurs, this system deposits indiscriminately on any cell surface in the vicinity and has the potential to cause unwanted and excessive tissue injury. Deposition of complement components is recognized as a hallmark of a variety of kidney diseases, where it is indeed associated with damage to the self. The provenance and the pathophysiological role(s) played by complement in each kidney disease is not fully understood. However, in recent years there has been a renaissance in the study of complement, with greater appreciation of its intracellular roles as a cell-intrinsic system and its interplay with immune effector pathways. This has been paired with a profusion of novel therapeutic agents antagonizing complement components, including approved inhibitors against complement components (C)1, C3, C5 and C5aR1. A number of clinical trials have investigated the use of these more targeted approaches for the management of kidney diseases. In this review we present and summarize the evidence for the roles of complement in kidney diseases and discuss the available clinical evidence for complement inhibition.","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":"152 ","pages":"1-81"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8905641/pdf/nihms-1785441.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39789672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complement as a powerful "influencer" in the brain during development, adulthood and neurological disorders. 在大脑发育、成年和神经紊乱期间，补体是一个强大的“影响者”。

3区医学

Advances in Immunology Pub Date : 2021-01-01 Epub Date: 2021-11-18 DOI: 10.1016/bs.ai.2021.09.003

Tiffany J Petrisko, Angela Gomez-Arboledas, Andrea J Tenner

{"title":"Complement as a powerful \"influencer\" in the brain during development, adulthood and neurological disorders.","authors":"Tiffany J Petrisko, Angela Gomez-Arboledas, Andrea J Tenner","doi":"10.1016/bs.ai.2021.09.003","DOIUrl":"https://doi.org/10.1016/bs.ai.2021.09.003","url":null,"abstract":"The complement system was long considered as only a powerful effector arm of the immune system that, while critically protective, could lead to inflammation and cell death if overactivated, even in the central nervous system (CNS). However, in the past decade it has been recognized as playing critical roles in key physiological processes in the CNS, including neurogenesis and synaptic remodeling in the developing and adult brain. Inherent in these processes are the interactions with cells in the brain, and the cascade of interactions and functional consequences that ensue. As a result, investigations of therapeutic approaches for both suppressing excessive complement driven neurotoxicity and aberrant sculpting of neuronal circuits, require broad (and deep) knowledge of the functional activities of multiple components of this highly evolved and regulated system to avoid unintended negative consequences in the clinic. Advances in basic science are beginning to provide a roadmap for translation to therapeutics, with both small molecule and biologics. Here, we present examples of the critical roles of proper complement function in the development and sculpting of the nervous system, and in enabling rapid protection from infection and clearance of dying cells. Microglia are highlighted as important command centers that integrate signals from the complement system and other innate sensors that are programed to provide support and protection, but that direct detrimental responses to aberrant activation and/or regulation of the system. Finally, we present promising research areas that may lead to effective and precision strategies for complement targeted interventions to promote neurological health.","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":"152 ","pages":"157-222"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39944448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

The development and physiological and pathophysiological functions of resident macrophages and glial cells. 巨噬细胞和胶质细胞的发育和生理病理生理功能。

3区医学

Advances in Immunology Pub Date : 2021-01-01 Epub Date: 2021-10-04 DOI: 10.1016/bs.ai.2021.08.001

Nelli Blank, Marina Mayer, Elvira Mass

引用次数: 2

Panorama of stepwise involvement of the IgH 3' regulatory region in murine B cells. 小鼠B细胞中ig3调控区逐步参与的全景图。

3区医学

Advances in Immunology Pub Date : 2021-01-01 Epub Date: 2021-04-27 DOI: 10.1016/bs.ai.2021.03.004

Charlotte Bruzeau, Jeanne Moreau, Sandrine Le Noir, Eric Pinaud

{"title":"Panorama of stepwise involvement of the IgH 3' regulatory region in murine B cells.","authors":"Charlotte Bruzeau, Jeanne Moreau, Sandrine Le Noir, Eric Pinaud","doi":"10.1016/bs.ai.2021.03.004","DOIUrl":"https://doi.org/10.1016/bs.ai.2021.03.004","url":null,"abstract":"Among the multiple events leading to immunoglobulin (Ig) expression in B cells, stepwise activation of the Ig heavy chain locus (IgH) is of critical importance. Transcription regulation of the complex IgH locus has always been an interesting viewpoint to unravel the multiple and complex events required for IgH expression. First, regulatory germline transcripts (GLT) assist DNA remodeling events such as VDJ recombination, class switch recombination (CSR) and somatic hypermutation (SHM). Second, productive spliced transcripts restrict heavy chain protein expression associated either with the surface receptor of developing B cells or secreted in large amounts in plasma cells. One main transcriptional regulator for IgH lies at its 3' extremity and includes both a set of enhancers grouped in a large 3' regulatory region (3'RR) and a cluster of 3'CTCF-binding elements (3'CBEs). In this focused review, we will preferentially refer to evidence reported for the murine endogenous IgH locus, whether it is wt or carries deletions or insertions within the IgH 3' boundary and associated regulatory region.","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":"149 ","pages":"95-114"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.ai.2021.03.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38986922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

The multi-faceted roles of TGF-β in regulation of immunity to infection. TGF-β在感染免疫调节中的多重作用

3区医学

Advances in Immunology Pub Date : 2021-01-01 DOI: 10.1016/bs.ai.2021.05.001

Rick M Maizels

引用次数: 6

Immunology of SARS-CoV-2 infections and vaccines. SARS-CoV-2感染的免疫学和疫苗。

3区医学

Advances in Immunology Pub Date : 2021-01-01 Epub Date: 2021-09-10 DOI: 10.1016/bs.ai.2021.08.002

Dominik Schenten, Deepta Bhattacharya

引用次数: 9