Advances in Immunology最新文献_第10页

The airway epithelium in asthma. 哮喘患者的气道上皮。

3区医学

Advances in Immunology Pub Date : 2019-01-01 Epub Date: 2019-07-01 DOI: 10.1016/bs.ai.2019.05.001

Luke R Bonser, David J Erle

引用次数: 168

Roles of cysteinyl leukotrienes and their receptors in immune cell-related functions. 半胱氨酸白三烯及其受体在免疫细胞相关功能中的作用。

3区医学

Advances in Immunology Pub Date : 2019-01-01 Epub Date: 2019-05-14 DOI: 10.1016/bs.ai.2019.04.002

Yoshihide Kanaoka, K Frank Austen

{"title":"Roles of cysteinyl leukotrienes and their receptors in immune cell-related functions.","authors":"Yoshihide Kanaoka, K Frank Austen","doi":"10.1016/bs.ai.2019.04.002","DOIUrl":"https://doi.org/10.1016/bs.ai.2019.04.002","url":null,"abstract":"The cysteinyl leukotrienes (cys-LTs), leukotriene C4, (LTC4), LTD4, and LTE4, are lipid mediators of inflammation. LTC4 is the only intracellularly synthesized cys-LT through the 5-lipoxygenase and LTC4 synthase pathway and after transport is metabolized to LTD4 and LTE4 by specific extracellular peptidases. Each cys-LT has a preferred functional receptor in vivo; LTD4 to the type 1 cys-LT receptor (CysLT1R), LTC4 to CysLT2R, and LTE4 to CysLT3R (OXGR1 or GPR99). Recent studies in mouse models revealed that there are multiple regulatory mechanisms for these receptor functions and each receptor plays a distinct role as observed in different mouse models of inflammation and immune responses. This review focuses on the integrated host responses to the cys-LT/CysLTR pathway composed of sequential ligands with preferred receptors as seen from mouse models. It also discusses potential therapeutic targets for LTC4 synthase, CysLT2R, and CysLT3R.","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":"142 ","pages":"65-84"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.ai.2019.04.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37415295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28

Antibody responses to the HIV-1 envelope high mannose patch. 抗体对HIV-1包膜高甘露糖贴片的应答。

3区医学

Advances in Immunology Pub Date : 2019-01-01 DOI: 10.1016/BS.AI.2019.08.002

C. N. Daniels, K. Saunders

引用次数: 17

B cell mechanosensing: A mechanistic overview. B细胞机械传感:机械原理概述。

3区医学

Advances in Immunology Pub Date : 2019-01-01 DOI: 10.1016/bs.ai.2019.08.003

Samina Shaheen, Zhengpeng Wan, K. Haneef, Yingyue Zeng, Wang Jing, Wanli Liu

引用次数: 9

T cell immune response within B-cell follicles. b细胞滤泡内的T细胞免疫反应。

3区医学

Advances in Immunology Pub Date : 2019-01-01 DOI: 10.1016/BS.AI.2019.08.008

Qizhao Huang, Lifan Xu, L. Ye

引用次数: 13

Neuronal regulation of group 2 innate lymphoid cells and type 2 inflammation. 2组先天淋巴样细胞与2型炎症的神经元调控。

3区医学

Advances in Immunology Pub Date : 2019-01-01 DOI: 10.1016/BS.AI.2019.08.001

Saya Moriyama, D. Artis

引用次数: 10

Models of dendritic cell development correlate ontogeny with function. 树突状细胞发育模型将本体发育与功能联系起来。

3区医学

Advances in Immunology Pub Date : 2019-01-01 Epub Date: 2019-09-16 DOI: 10.1016/bs.ai.2019.09.001

David A Anderson, Kenneth M Murphy

{"title":"Models of dendritic cell development correlate ontogeny with function.","authors":"David A Anderson, Kenneth M Murphy","doi":"10.1016/bs.ai.2019.09.001","DOIUrl":"10.1016/bs.ai.2019.09.001","url":null,"abstract":"Rapid advances have been made to uncover the mechanisms that regulate dendritic cell (DC) development, and in turn, how models of development can be employed to define dendritic cell function. Models of DC development have been used to define the unique functions of DC subsets during immune responses to distinct pathogens. More recently, models of DC function have expanded to include their homeostatic and inflammatory physiology, modes of communication with various innate and adaptive immune lineages, and specialized functions across different lymphoid organs. New models of DC development call for revisions of previously accepted paradigms with respect to the ontogeny of plasmacytoid DC (pDC) and classical DC (cDC) subsets. By far, development of the cDC1 subset is best understood, and models have now been developed that can separate deficiencies in development from deficiencies in function. Such models are lacking for pDCs and cDC2s, limiting the depth of our understanding of their unique and essential roles during immune responses. If novel immunotherapies aim to harness the functions of human DCs, understanding of DC development will be essential to develop models DC function. Here we review emerging models of DC development and function.","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":"143 1","pages":"99-119"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10931540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54025795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contributors 贡献者

3区医学

Advances in Immunology Pub Date : 2019-01-01 DOI: 10.1016/s0065-2776(19)30010-0

引用次数: 0

Copyright 版权

3区医学

Advances in Immunology Pub Date : 2019-01-01 DOI: 10.1016/s0065-2776(19)30052-5

引用次数: 0

Series Page 系列页面

3区医学

Advances in Immunology Pub Date : 2019-01-01 DOI: 10.1016/s0065-2776(19)30006-9

引用次数: 0