Advances in Immunology最新文献_第9页

Mechanism and regulation of class switch recombination by IgH transcriptional control elements. IgH转录控制元件对类开关重组的调控机制。

3区医学

Advances in Immunology Pub Date : 2020-01-01 Epub Date: 2020-07-25 DOI: 10.1016/bs.ai.2020.06.003

Chloé Oudinet, Fatima-Zohra Braikia, Audrey Dauba, Ahmed Amine Khamlichi

{"title":"Mechanism and regulation of class switch recombination by IgH transcriptional control elements.","authors":"Chloé Oudinet, Fatima-Zohra Braikia, Audrey Dauba, Ahmed Amine Khamlichi","doi":"10.1016/bs.ai.2020.06.003","DOIUrl":"https://doi.org/10.1016/bs.ai.2020.06.003","url":null,"abstract":"Class switch recombination (CSR) plays an important role in humoral immunity by generating antibodies with different effector functions. CSR to a particular antibody isotype is induced by external stimuli, and occurs between highly repetitive switch (S) sequences. CSR requires transcription across S regions, which generates long non-coding RNAs and secondary structures that promote accessibility of S sequences to activation-induced cytidine deaminase (AID). AID initiates DNA double-strand breaks (DSBs) intermediates that are repaired by general DNA repair pathways. Switch transcription is controlled by various regulatory elements, including enhancers and insulators. The current paradigm posits that transcriptional control of CSR involves long-range chromatin interactions between regulatory elements and chromatin loops-stabilizing factors, which promote alignment of partner S regions in a CSR centre (CSRC) and initiation of CSR. In this review, we focus on the role of IgH transcriptional control elements in CSR and the chromatin-based mechanisms underlying this control.","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":" ","pages":"89-137"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.ai.2020.06.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38426856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Advances in Immunology in China - Part B 免疫学在中国的进展- B部分

3区医学

Advances in Immunology Pub Date : 2020-01-01 DOI: 10.1016/s0065-2776(20)x0002-2

引用次数: 0

Friend or foe? Lactobacillus in the context of autoimmune disease. 是敌是友?乳酸菌在自身免疫性疾病中的作用。

3区医学

Advances in Immunology Pub Date : 2020-01-01 Epub Date: 2020-03-19 DOI: 10.1016/bs.ai.2020.02.002

Rebecca L Fine, Derek L Mubiru, Martin A Kriegel

{"title":"Friend or foe? Lactobacillus in the context of autoimmune disease.","authors":"Rebecca L Fine, Derek L Mubiru, Martin A Kriegel","doi":"10.1016/bs.ai.2020.02.002","DOIUrl":"https://doi.org/10.1016/bs.ai.2020.02.002","url":null,"abstract":"Over the last decade, the interplay between the gut microbiota, the consortium of intestinal microbes that colonizes intestinal mucosal barriers, and its host immune system has been increasingly better understood. Disruption of the delicate balance between beneficial and pathogenic commensals, known as dysbiosis, contributes to a variety of chronic immunologic and metabolic diseases. Complicating this paradigm are bacterial strains that can operate paradoxically both as instigators and attenuators of inflammatory responses, depending on host background. Here, we review the role of several strains in the genus Lactobacillus within the context of autoimmune and other chronic disorders with a predominant focus on L. reuteri. While strains within this species have been shown to provide immune health benefits, they have also been demonstrated to act as a pathobiont in autoimmune-prone hosts. Beneficial functions in healthy hosts include competing with pathogenic microbes, promoting regulatory T cell development, and protecting the integrity of the gut barrier. On the other hand, certain strains can also break through a dysfunctional gut barrier, colonize internal tissues such as the spleen or liver and promote inflammatory responses in host tissues that lead to autoimmune disease. This review summarizes the manifold roles that these commensals play in the context of health and disease.","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":"146 ","pages":"29-56"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.ai.2020.02.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37866016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Multilayer regulation of CD4 T cell subset differentiation in the era of single cell genomics. 单细胞基因组学时代CD4 T细胞亚群分化的多层调控

3区医学

Advances in Immunology Pub Date : 2019-01-01 Epub Date: 2019-01-03 DOI: 10.1016/bs.ai.2018.12.001

Waradon Sungnak, Chao Wang, Vijay K Kuchroo

引用次数: 11

Signaling control of antibody isotype switching. 抗体同型转换的信号控制。

3区医学

Advances in Immunology Pub Date : 2019-01-01 Epub Date: 2019-02-11 DOI: 10.1016/bs.ai.2019.01.001

Zhangguo Chen, Jing H Wang

引用次数: 15

Series Page 系列页面

3区医学

Advances in Immunology Pub Date : 2019-01-01 DOI: 10.1016/s0065-2776(19)30020-3

引用次数: 0

Series Page 系列页面

3区医学

Advances in Immunology Pub Date : 2019-01-01 DOI: 10.1016/s0065-2776(19)30060-4

引用次数: 0

Copyright 版权

3区医学

Advances in Immunology Pub Date : 2019-01-01 DOI: 10.1016/s0065-2776(19)30008-2

引用次数: 0

Thymocyte selection: From signaling to epigenetic regulation. 胸腺细胞选择:从信号传导到表观遗传调控。

3区医学

Advances in Immunology Pub Date : 2019-01-01 DOI: 10.1016/bs.ai.2019.08.005

Jun Lyu, Lie Wang, Linrong Lu

引用次数: 5

Transcription factories in Igκ allelic choice and diversity. Igκ等位基因选择和多样性的转录工厂。

3区医学

Advances in Immunology Pub Date : 2019-01-01 Epub Date: 2018-12-19 DOI: 10.1016/bs.ai.2018.11.001

Sophiya Karki, Shiladitya Banerjee, Kaitlin Mclean, Aaron Dinner, Marcus R Clark

{"title":"Transcription factories in Igκ allelic choice and diversity.","authors":"Sophiya Karki, Shiladitya Banerjee, Kaitlin Mclean, Aaron Dinner, Marcus R Clark","doi":"10.1016/bs.ai.2018.11.001","DOIUrl":"https://doi.org/10.1016/bs.ai.2018.11.001","url":null,"abstract":"The vertebrate immune system is tasked with the challenge of responding to any pathogen the organism might encounter, and retaining memory of that pathogen in case of future infection. Recognition and memory of pathogens are encoded within the adaptive immune system and production of T and B lymphocytes with diverse antigen receptor repertoires. In B lymphocytes, diversity is generated by sequential recombination between Variable (V), Diversity (D) and Joining (J) gene segments in the immunoglobulin heavy chain gene (Igh) and subsequent V-J recombination in immunoglobulin light chain genes (Igκ followed by Igλ). However, the process by which particular V, D and J segments are selected during recombination, and stochasticity is maintained to ensure antibody repertoire diversity, is still unclear. In this review, we focus on Igκ and recent findings regarding the relationships between gene structure, the generation of diversity and allelic choice. Surprisingly, the nuclear environment in which each Igκ allele resides, including transcription factories assembled on the nuclear matrix, plays critical roles in both gene regulation and in shaping the diversity of Vκ genes accessible to recombination. These findings provide a new paradigm for understanding Igκ recombination and Vκ diversity in the context of B lymphopoiesis.","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":"141 ","pages":"33-49"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.ai.2018.11.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37085111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3