Advances in Immunology最新文献_第5页

Harnessing the immune system: Insights into cancer vaccines. 利用免疫系统：对癌症疫苗的洞察。

3区医学

Advances in Immunology Pub Date : 2025-01-01 Epub Date: 2025-03-24 DOI: 10.1016/bs.ai.2024.10.006

Sushree Subhadra Acharya, Subhasmita Bhal, Biswajit Das, Chanakya Nath Kundu

{"title":"Harnessing the immune system: Insights into cancer vaccines.","authors":"Sushree Subhadra Acharya, Subhasmita Bhal, Biswajit Das, Chanakya Nath Kundu","doi":"10.1016/bs.ai.2024.10.006","DOIUrl":"10.1016/bs.ai.2024.10.006","url":null,"abstract":"Cancer vaccines have become a promising approach in the fight against cancer, harnessing the remarkable capability of the human immune system to recognize and eliminate cancer cells. These vaccines are specifically engineered to activate the immune response against malignant cells, marking a significant advancement in contemporary research. By capitalizing on the unique ability of the immune system to detect and eliminate cancer cells, these vaccines present promising prospects for both prevention and therapeutic intervention. Recent advancements have provided profound insights into how these vaccines can be tailored to target specific cancer types, enhancing their efficacy and minimizing side effects. This innovative strategy holds the potential to transform cancer care, offering new avenues for durable and effective treatments. This chapter delves into the historical context of cancer vaccine research, discussing various types of cancer vaccines, their mechanisms of action, and the role of adjuvants and delivery systems in enhancing vaccine efficacy. It also covers tumor immunogenicity, how tumor cells evade the immune system, and the combined use of cancer vaccines with other treatment approaches. The chapter aims to elucidate the potential of cancer vaccines to revolutionize cancer treatment and improve patient outcomes.","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":"166 ","pages":"1-35"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

B-cell editing: An emerging alternative of precision oncotherapy. b细胞编辑：一种新兴的精确肿瘤治疗方法。

3区医学

Advances in Immunology Pub Date : 2025-01-01 Epub Date: 2024-10-30 DOI: 10.1016/bs.ai.2024.10.002

Pritha Roy Choudhury, Mohona Chakravarti, Saptak Banerjee, Rathindranath Baral, Anamika Bose

{"title":"B-cell editing: An emerging alternative of precision oncotherapy.","authors":"Pritha Roy Choudhury, Mohona Chakravarti, Saptak Banerjee, Rathindranath Baral, Anamika Bose","doi":"10.1016/bs.ai.2024.10.002","DOIUrl":"10.1016/bs.ai.2024.10.002","url":null,"abstract":"Lately, the urgency of precision medicine in cancer care through immunotherapy has reformed the arena of oncology. Although immunomodulatory therapeutics in cancer have been preliminarily concentrated on T-cells, emerging evidences have suggested that intra-tumoral B-cells and plasma cells have significant contributions in cancer prognosis primarily through the production of antibodies. B-cell oriented cancer vaccines have been used in early clinical trials of breast and other cancers after multiple preclinical studies. Passive immunotherapy via administration of monoclonal antibodies (mAbs) and emergence of anti-idiotypic antibodies have led to considerable advancement in oncotherapy. Endogenous production of mAbs would be of significant benefit in recurrent or residual malignancies and permanent infusion would help in the overcoming of issues related to pharmacodynamic variations observed in case of intravenous inoculations of bi or tri specific mAbs. This has directed towards the development of genome reprogrammed B-cells with the capability of yielding therapeutic mAbs independently. Genetic alteration through clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) nucleases have enabled the introduction of transgenes into B-cell genome thereby stimulating the plasma cells to produce exogenous remedial antibodies. It also facilitates ex vivo B-cell editing to elevate specificities of antigen receptors and generate target specific antibody responses which cannot normally be evoked in patient's immune system. Hence, genome-altered B-cells possess the potential of engineered therapeutics against certain malignancies. Co-operation of B-cells in T-cell based vaccines are ultimate need for vaccine success. In this chapter, the mechanisms, challenges and potential advantages of B-cell editing in cancer immune therapy shall be explored. The prospects of B-cell editing in onco-therapy will be clearly elucidated with all its strength and weaknesses.","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":"166 ","pages":"103-135"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulation of humoral immunity by γδ T cells: A potential adjuvant strategy for vaccination. γδ T细胞调节体液免疫：一种潜在的疫苗佐剂策略。

3区医学

Advances in Immunology Pub Date : 2025-01-01 Epub Date: 2025-05-23 DOI: 10.1016/bs.ai.2025.05.001

Kirsty Emery, Matthias Eberl

引用次数: 0

Progress in modifying and delivering mRNA therapies for cancer immunotherapy. 修饰和递送mRNA疗法用于癌症免疫治疗的进展。

3区医学

Advances in Immunology Pub Date : 2025-01-01 Epub Date: 2024-12-02 DOI: 10.1016/bs.ai.2024.10.004

Karan Goel, Isha Chawla, Garima, Meenakshi Dhanawat, Pramila Chaubey

{"title":"Progress in modifying and delivering mRNA therapies for cancer immunotherapy.","authors":"Karan Goel, Isha Chawla, Garima, Meenakshi Dhanawat, Pramila Chaubey","doi":"10.1016/bs.ai.2024.10.004","DOIUrl":"10.1016/bs.ai.2024.10.004","url":null,"abstract":"Advancements in mRNA-based therapeutics have greatly enhanced cancer immunotherapy by using the immune system to specifically target and eradicate cancer cells. There has been notable advancement in tailoring and administering mRNA to treat cancer. Codon optimization, chemical alterations, and sequence manipulation are complex design methodologies employed in the production of mRNA vaccines and treatments. The goal is to improve the ability of the chemicals to stimulate an immune response, increase their ability to be translated into practical applications, and boost their stability. Lipid nanoparticles (LNPs) are currently the most efficient means of delivering mRNA because they can withstand degradation, enhance cellular uptake, and facilitate endosomal escape. Scientists are currently investigating the possibility of using alternate methods of delivering substances, including as exosomes, lipoplexes, and polymeric nanoparticles, to enhance the ability to target specific tissues and minimize unwanted negative consequences. In addition, recent clinical trials and preclinical investigations have demonstrated encouraging findings in terms of the advancement of strong anti-tumor immune responses, long-lasting tumor shrinkage, and enhanced patient outcomes. The remaining challenges involve optimizing the equilibrium between tolerance and immunological activation, addressing systemic toxicity, and expanding manufacturing techniques. The upcoming study seeks to improve the design and dissemination of mRNA, include it in combination drugs, and investigate its therapeutic uses outside cancer. The advancement in cancer treatment represents a change in the current approach, highlighting the significant impact of mRNA technology in revolutionizing immunotherapy and enabling tailored cancer treatments.","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":"165 ","pages":"89-115"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoparticles for mRNA-based cancer immunotherapy. 纳米颗粒用于基于mrna的癌症免疫治疗。

3区医学

Advances in Immunology Pub Date : 2025-01-01 Epub Date: 2025-02-04 DOI: 10.1016/bs.ai.2024.10.012

Rakesh Pahwa, Gulshan Sharma, Rohil Panwar, Neeraj Mishra

{"title":"Nanoparticles for mRNA-based cancer immunotherapy.","authors":"Rakesh Pahwa, Gulshan Sharma, Rohil Panwar, Neeraj Mishra","doi":"10.1016/bs.ai.2024.10.012","DOIUrl":"10.1016/bs.ai.2024.10.012","url":null,"abstract":"The emergence of mRNA-based cancer immunotherapy has transformed the avenue of cancer treatment, offering an innovative strategy that leverages the body's immune system to identify and eradicate tumor cells selectively. Effective delivery of mRNA to specific organs and cells is limited by its instability, low cellular uptake efficiency, and degradation during extracellular transport and endosomal escape. Significant advancements in nanoparticle design have driven the rapid progress of mRNA-based immunotherapies. Nanocarriers have emerged as vital delivery systems, providing enhanced stability, resistance to enzymatic degradation, and efficient mRNA delivery to target cells. This chapter investigates the design, synthesis, and functionalization of different types of nanoparticles, including lipid-based, polymeric, and hybrid nanoparticles and also highlights their unique characteristics and mechanisms for mRNA delivery in cancer immunotherapy. This chapter explores cellular uptake mechanisms, strategies for endosomal escape, and the subsequent translation of mRNA into therapeutic proteins that elicit a vigorous anti-tumor immune response. Recent advances in nanoparticle-based mRNA vaccines are also explored, with an emphasis on research findings and clinical trials that reveal both their potential and challenges. The chapter aims to provide a thorough overview of nanoparticle integration in mRNA-based cancer immunotherapy and also offer insights into future developments and emerging trends in the field.","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":"166 ","pages":"77-101"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent progress, challenges (stability and in vivo distribution), and opportunities of DNA & mRNA vaccine in cancer immunotherapy. DNA和mRNA疫苗在癌症免疫治疗中的最新进展、挑战（稳定性和体内分布）和机遇。

3区医学

Advances in Immunology Pub Date : 2025-01-01 Epub Date: 2024-10-30 DOI: 10.1016/bs.ai.2024.10.008

Monika Kaushik, Prathap Madeswaraguptha, Murugesan Vanangamudi, Vijayaraj Surendran, Sumel Ashique, Anas Islam, Naheed Mojgani, Afzal Hussain

{"title":"Recent progress, challenges (stability and in vivo distribution), and opportunities of DNA & mRNA vaccine in cancer immunotherapy.","authors":"Monika Kaushik, Prathap Madeswaraguptha, Murugesan Vanangamudi, Vijayaraj Surendran, Sumel Ashique, Anas Islam, Naheed Mojgani, Afzal Hussain","doi":"10.1016/bs.ai.2024.10.008","DOIUrl":"10.1016/bs.ai.2024.10.008","url":null,"abstract":"Cancer immunotherapy recently has emerged as a revolutionary method in oncology. It takes the help of the body's immune system in fighting against tumor cells. Amongst the various approaches, DNA and mRNA vaccines are novel modalities with the potential to revolutionize cancer treatment. They represent one such approach that can result in potent immune responses against tumor-specific antigens. The few but serious translation bottlenecks at the clinical level have been related to stability, in vivo distribution, and efficient delivery systems for DNA and mRNA vaccines. It is against this salient background that this chapter takes readers through recent success stories of DNA and mRNA vaccines, right from the formulation of the vaccine to delivery mechanisms, stability, and bioavailability in cancer immunotherapy. The further challenges that are discussed in this chapter are those of effect in vivo distribution and how such challenges impact therapeutic efficacy. In addition, the new emerging technologies for in vivo distribution and opportunities for optimization of emerging vaccines to clinical use are approached, with the main focus placed on new delivery platforms. The aim of this chapter is to help understand the current landscape and future directions toward DNA and mRNA vaccines in designing more effective and personalized cancer therapies.","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":"166 ","pages":"211-258"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in antifungal immunity. 抗真菌免疫的最新进展。

3区医学

Advances in Immunology Pub Date : 2025-01-01 Epub Date: 2025-06-24 DOI: 10.1016/bs.ai.2025.04.003

Rebecca A Drummond

引用次数: 0

DNA and mRNA vaccines: Significant therapeutic approach against cancer management. DNA和mRNA疫苗：对癌症管理的重要治疗方法

3区医学

Advances in Immunology Pub Date : 2025-01-01 Epub Date: 2024-12-10 DOI: 10.1016/bs.ai.2024.10.007

Aniruddha Sen, Vijay Singh, Sumel Ashique, Jagriti, Sombuddha Biswas, Anas Islam, Iman Ehsan, Naheed Mojgani

引用次数: 0

mRNA-based cancer vaccines: A novel approach to melanoma treatment. 基于mrna的癌症疫苗：黑色素瘤治疗的新方法

3区医学

Advances in Immunology Pub Date : 2025-01-01 Epub Date: 2024-12-03 DOI: 10.1016/bs.ai.2024.10.010

Pranav Kumar Prabhakar, Tarun Kumar Upadhyay, Sanjeev Kumar Sahu

{"title":"mRNA-based cancer vaccines: A novel approach to melanoma treatment.","authors":"Pranav Kumar Prabhakar, Tarun Kumar Upadhyay, Sanjeev Kumar Sahu","doi":"10.1016/bs.ai.2024.10.010","DOIUrl":"10.1016/bs.ai.2024.10.010","url":null,"abstract":"Malignant melanoma is one of the most aggressive forms of cancer and a leading cause of death from skin tumors. With the rising incidence of melanoma diagnoses, there is an urgent need to develop effective treatments. Among the most modern approaches are cancer vaccines, which aim to enhance cell-mediated immunity. Recently, mRNA-based cancer vaccines have gained significant attention due to their rapid production, low manufacturing costs, and ability to induce both humoral and cellular immune responses. These vaccines hold great potential in melanoma treatment, yet their application faces several challenges, including mRNA stabilization, delivery methods, and tumor heterogeneity. The recent success of mRNA vaccines in combating COVID-19 has renewed interest in their potential for cancer immunotherapy. In particular, mRNA cancer vaccines offer high specificity and better efficacy compared to traditional treatments. They can target tumor-specific neoantigens, prompting a robust immune response. This chapter reviews the mechanism of action of mRNA vaccines, advancements in adjuvant identification, and innovations in delivery systems such as lipid nanoparticles. It also discusses ongoing clinical trials evaluating the efficacy of mRNA-based vaccines in melanoma, highlighting promising early-phase results. Despite their potential, the development of mRNA cancer vaccines faces significant obstacles. Tumor heterogeneity, immunosuppressive tumor microenvironments, and practical issues like vaccine administration and clinical evaluation methods are major barriers to success. By addressing these challenges and advancing innovations, mRNA cancer vaccines hold promise for transforming melanoma treatment. A careful balance between the opportunities and challenges will be key to unlocking the full potential of mRNA vaccines in cancer immunotherapy.","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":"165 ","pages":"117-162"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroimmunology beyond the CNS: Nerve-macrophage interactions in peripheral tissues. 中枢神经系统以外的神经免疫学：外周组织中神经-巨噬细胞的相互作用。

3区医学

Advances in Immunology Pub Date : 2025-01-01 Epub Date: 2025-06-23 DOI: 10.1016/bs.ai.2025.04.001

Erin Watson, Elaine Emmerson

{"title":"Neuroimmunology beyond the CNS: Nerve-macrophage interactions in peripheral tissues.","authors":"Erin Watson, Elaine Emmerson","doi":"10.1016/bs.ai.2025.04.001","DOIUrl":"10.1016/bs.ai.2025.04.001","url":null,"abstract":"Macrophages are now recognised to be highly heterogeneous, with diverse ontogenies, anatomical locations and characteristics, all of which inform their function. Nerve-associated macrophage subpopulations have been found to exist across tissues, and whilst they appear to have roles in neuronal maintenance and repair, their function is still being elucidated. Although nerve-associated macrophage functions in the Central Nervous System have taken centre-stage, nerve-associated macrophages also interact with peripheral nerves and this field remains relatively understudied. This review discusses recent studies into nerve-associated macrophages across peripheral tissues. These studies identify populations of nerve-associated macrophages in many peripheral tissues, and reveal elegant neuroimmune communication pathways which coordinate functions from infection defence and anti-inflammatory actions to neuronal maintenance for homeostatic tissue function and nerve repair. We highlight nerve-associated macrophage interactions with nerves in peripheral tissues as a rapidly evolving field which could revolutionise our understanding of macrophage function in both homeostasis and disease.","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":"167 ","pages":"43-89"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0