Advances in ImmunologyPub Date : 2021-01-01Epub Date: 2021-03-29DOI: 10.1016/bs.ai.2021.03.002
Tommy Regen, Ari Waisman
{"title":"Modeling a complex disease: Multiple sclerosis-Update 2020.","authors":"Tommy Regen, Ari Waisman","doi":"10.1016/bs.ai.2021.03.002","DOIUrl":"https://doi.org/10.1016/bs.ai.2021.03.002","url":null,"abstract":"<p><p>Multiple sclerosis (MS) is a complex inflammatory disease of the central nervous system (CNS) with an unknown etiology. Thereby, MS is not a uniform disease but rather represents a spectrum of disorders, where each aspect needs to be modeled with specific requirements-for a systematic overview see our previous issue of this review (Kurschus, Wortge, & Waisman, 2011). However, there is broad consensus about the critical involvement of the immune system in the disease pathogenesis. To better understand how the immune system contributes to CNS autoimmunity, the model of experimental autoimmune encephalomyelitis (EAE) was developed. EAE can be induced in susceptible animals in many different ways, with the most popular protocol involving the activation of self-reactive T cells by a peptide based on the myelin oligodendrocyte glycoprotein sequence. In the last 10 years this model has led to major advances in our understanding of the immune system, especially the nature of IL-17-producing T cells (Th17 cells), host-microbiome interactions, the gut-brain axis and how the immune system can cause damage in different regions of the brain and the spinal cord. This update summarizes some of the main achievements in the field in the last 10 years.</p>","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":"149 ","pages":"25-34"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.ai.2021.03.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38998006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Advances in ImmunologyPub Date : 2021-01-01Epub Date: 2021-11-18DOI: 10.1016/bs.ai.2021.09.002
Ernest Aw, Yingying Zhang, Esra Yalcin, Uli S Herrmann, Michael C Carroll
{"title":"Neuropsychiatric disorders: An immunological perspective.","authors":"Ernest Aw, Yingying Zhang, Esra Yalcin, Uli S Herrmann, Michael C Carroll","doi":"10.1016/bs.ai.2021.09.002","DOIUrl":"https://doi.org/10.1016/bs.ai.2021.09.002","url":null,"abstract":"<p><p>Neuropsychiatric diseases have traditionally been studied from brain, and mind-centric perspectives. However, mounting epidemiological and clinical evidence shows a strong correlation of neuropsychiatric manifestations with immune system activation, suggesting a likely mechanistic interaction between the immune and nervous systems in mediating neuropsychiatric disease. Indeed, immune mediators such as cytokines, antibodies, and complement proteins have been shown to affect various cellular members of the central nervous system in multitudinous ways, such as by modulating neuronal firing rates, inducing cellular apoptosis, or triggering synaptic pruning. These observations have in turn led to the exciting development of clinical therapies aiming to harness this neuro-immune interaction for the treatment of neuropsychiatric disease and symptoms. Besides the clinic, important theoretical fundamentals can be drawn from the immune system and applied to our understanding of the brain and neuropsychiatric disease. These new frameworks could lead to novel insights in the field and further potentiate the development of future therapies to treat neuropsychiatric disease.</p>","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":"152 ","pages":"83-155"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39944449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Renauld, F. Houssiau, J. Louahed, A. Vink, J. Van Snick, C. Uyttenhove
{"title":"Interleukin-9.","authors":"J. Renauld, F. Houssiau, J. Louahed, A. Vink, J. Van Snick, C. Uyttenhove","doi":"10.32388/ls6fci","DOIUrl":"https://doi.org/10.32388/ls6fci","url":null,"abstract":"kDa) is encoded by the human IL9 gene. This a role in the T-cells.","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":"54 1","pages":"79-97"},"PeriodicalIF":0.0,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45700685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Advances in ImmunologyPub Date : 2020-01-01Epub Date: 2019-12-03DOI: 10.1016/bs.ai.2019.11.001
Qing Yang, Hong-Bing Shu
{"title":"Deciphering the pathways to antiviral innate immunity and inflammation.","authors":"Qing Yang, Hong-Bing Shu","doi":"10.1016/bs.ai.2019.11.001","DOIUrl":"https://doi.org/10.1016/bs.ai.2019.11.001","url":null,"abstract":"<p><p>The antiviral innate immune and inflammatory responses are critical for host defense against viral infection. How these antiviral responses are initiated and regulated has been intensively investigated. Viral nucleic acids are sensed by pattern-recognition receptors (PRRs), which trigger various signaling pathways by utilizing distinct adaptor proteins, kinases and regulatory proteins. These pathways lead to activation of the transcriptional factors NF-κB and IRF3 and ultimate induction of antiviral effector proteins including type I interferons (IFNs), TNF and IL-1β, which are critical mediators of antiviral innate immune and inflammatory responses. For the past 20 years, our groups at Peking University and Wuhan University have made restless efforts in deciphering the molecular mechanisms of antiviral innate immune and inflammatory responses. Here, we summarize the major discoveries from our groups, including the identifications of the critical adaptors VISA/MAVS and MITA/STING, regulatory mechanisms of these adapter-mediated signaling, and regulation of TNF- and IL1β-triggered inflammatory responses.</p>","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":"145 ","pages":"1-36"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.ai.2019.11.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37661836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Advances in ImmunologyPub Date : 2020-01-01Epub Date: 2019-12-09DOI: 10.1016/bs.ai.2019.11.002
Jing Zhou, Zhigang Tian, Hui Peng
{"title":"Tissue-resident NK cells and other innate lymphoid cells.","authors":"Jing Zhou, Zhigang Tian, Hui Peng","doi":"10.1016/bs.ai.2019.11.002","DOIUrl":"https://doi.org/10.1016/bs.ai.2019.11.002","url":null,"abstract":"<p><p>Natural killer (NK) cells are important innate effectors for their defense against pathogens and tumors without the need of prior sensitization. Along with the growing understanding of basic NK cell biology, it has been widely accepted that NK cells are a heterogeneous population of innate lymphoid cell (ILC) family. Apart from the conventional NK cell (cNK) subset that circulates throughout the body, some non-lymphoid tissues contain tissue-resident NK (trNK) cell subsets, and the composition of NK cell subsets varies greatly with different locations. Except for cNK cells, other ILCs are known as tissue-resident cells. In this review, we summarize the unique properties of trNK cells, discuss their lineage relationship with other ILCs, and highlight recent advances in our understanding of the functions of trNK cells and other ILCs.</p>","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":"145 ","pages":"37-53"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.ai.2019.11.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37661839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Advances in ImmunologyPub Date : 2020-01-01Epub Date: 2019-12-05DOI: 10.1016/bs.ai.2019.11.005
Shaonan Liang, Liangliang Ji, Lan Kang, Xiaoyu Hu
{"title":"Metabolic regulation of innate immunity.","authors":"Shaonan Liang, Liangliang Ji, Lan Kang, Xiaoyu Hu","doi":"10.1016/bs.ai.2019.11.005","DOIUrl":"https://doi.org/10.1016/bs.ai.2019.11.005","url":null,"abstract":"<p><p>Immune responses are often accompanied by radical changes of cellular metabolism of immune cells. On the other hand, an ever increasing number of metabolic pathways and products have been found to possess immune regulatory functions. The field of immunometabolism that investigates the interplay between metabolism and immunity has developed rapidly during the past decade. In this chapter, we attempt to summarize the recent progresses by scientists in China on metabolic regulation of innate immunity from the following three perspectives: metabolic regulation of myeloid cell functions, metabolic adaptations of tissue resident myeloid cells, and metabolism and immunity at the mucosal surfaces.</p>","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":"145 ","pages":"129-157"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.ai.2019.11.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37661837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Advances in ImmunologyPub Date : 2020-01-01Epub Date: 2020-10-27DOI: 10.1016/bs.ai.2020.10.001
Bahram Razani, Barbara A Malynn, Averil Ma
{"title":"Preserving immune homeostasis with A20.","authors":"Bahram Razani, Barbara A Malynn, Averil Ma","doi":"10.1016/bs.ai.2020.10.001","DOIUrl":"https://doi.org/10.1016/bs.ai.2020.10.001","url":null,"abstract":"<p><p>A20/TNFAIP3 is a TNF induced gene that plays a profound role in preserving cellular and organismal homeostasis (Lee, et al., 2000; Opipari etal., 1990). This protein has been linked to multiple human diseases via genetic, epigenetic, and an emerging series of patients with mono-allelic coding mutations. Diverse cellular functions of this pleiotropically expressed protein include immune-suppressive, anti-inflammatory, and cell protective functions. The A20 protein regulates ubiquitin dependent cell signals; however, the biochemical mechanisms by which it performs these functions is surprisingly complex. Deciphering these cellular and biochemical facets of A20 dependent biology should greatly improve our understanding of murine and human disease pathophysiology as well as unveil new mechanisms of cell and tissue biology.</p>","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":" ","pages":"1-48"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.ai.2020.10.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38689930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unexplored horizons of cDC1 in immunity and tolerance.","authors":"Sreekumar Balan, Kristen J Radford, Nina Bhardwaj","doi":"10.1016/bs.ai.2020.10.002","DOIUrl":"https://doi.org/10.1016/bs.ai.2020.10.002","url":null,"abstract":"<p><p>Dendritic cells are a specialized subset of hematopoietic cells essential for mounting immunity against tumors and infectious disease as well as inducing tolerance for maintenance of homeostasis. DCs are equipped with number of immunoregulatory or stimulatory molecules that interact with other leukocytes to modulate their functions. Recent advances in DC biology identified a specific role for the conventional dendritic cell type 1 (cDC1) in eliciting cytotoxic CD8+ T cells essential for clearance of tumors and infected cells. The critical role of this subset in eliciting immune responses or inducing tolerance has largely been defined in mice whereas the biology of human cDC1 is poorly characterized owing to their extremely low frequency in tissues. A detailed characterization of the functions of many immunoregulatory and stimulatory molecules expressed by human cDC1 is critical for understanding their biology to exploit this subset for designing novel therapeutic modalities against cancer, infectious disease and autoimmune disorders.</p>","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":"148 ","pages":"49-91"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.ai.2020.10.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9838524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Copyright","authors":"","doi":"10.1016/s0065-2776(20)30010-9","DOIUrl":"https://doi.org/10.1016/s0065-2776(20)30010-9","url":null,"abstract":"","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/s0065-2776(20)30010-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55885651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Advances in ImmunologyPub Date : 2020-01-01Epub Date: 2019-12-09DOI: 10.1016/bs.ai.2019.11.003
Hua Jiang, Tao Gong, Rongbin Zhou
{"title":"The strategies of targeting the NLRP3 inflammasome to treat inflammatory diseases.","authors":"Hua Jiang, Tao Gong, Rongbin Zhou","doi":"10.1016/bs.ai.2019.11.003","DOIUrl":"https://doi.org/10.1016/bs.ai.2019.11.003","url":null,"abstract":"<p><p>The NLRP3 inflammasome is a cytoplasmic multiprotein complex, the assembly of which can be initiated in response to various exogenous or endogenous danger signals. Excessive activation of the NLRP3 inflammasome has been implicated in the pathogenesis of a wide variety of human inflammatory diseases, suggesting that the NLRP3 inflammasome is a potential target for the treatment of these diseases. However, clinical drugs targeting the NLRP3 inflammasome are still not available. Recent data have elucidated the different signaling pathways or events that can control NLRP3 inflammasome activation and have provided some potential compounds with anti-NLRP3 inflammasome activity. Here, we summarize the molecular mechanisms and diseases involved in NLRP3 inflammasome activation and discuss the potential strategies targeting different aspects of the NLRP3 inflammasome and its implications for the treatment of inflammatory diseases.</p>","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":"145 ","pages":"55-93"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.ai.2019.11.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37661841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
