Advances in Immunology最新文献_第3页

System-level integrative omics analysis to identify the virus-host immunometabolic footprint during infection. 通过系统级综合全局分析确定病毒感染期间病毒-宿主免疫代谢足迹。

3区医学

Advances in Immunology Pub Date : 2024-01-01 Epub Date: 2024-09-13 DOI: 10.1016/bs.ai.2024.08.002

Anoop Ambikan, Sara Svensson Akusjärvi, Maike Sperk, Ujjwal Neogi

{"title":"System-level integrative omics analysis to identify the virus-host immunometabolic footprint during infection.","authors":"Anoop Ambikan, Sara Svensson Akusjärvi, Maike Sperk, Ujjwal Neogi","doi":"10.1016/bs.ai.2024.08.002","DOIUrl":"https://doi.org/10.1016/bs.ai.2024.08.002","url":null,"abstract":"The emergence and re-emergence of infectious diseases present significant global health threats. Understanding their pathogenesis is crucial for developing diagnostics, therapeutics, and preventive strategies. System-level integrative omics analysis offers a comprehensive approach to deciphering virus-host immunometabolic interactions during infections. Multi-omics approaches, integrating genomics, transcriptomics, proteomics, and metabolomics, provide holistic insights into disease mechanisms, host-pathogen interactions, and immune responses. The interplay between the immune system and metabolic processes, termed immunometabolism, has gained attention, particularly in infectious diseases. Immunometabolic studies reveal how metabolic processes regulate immune cell function, shaping immune responses and influencing infection outcomes. Metabolic reprogramming is crucial for immune cell activation, differentiation, and function. Using systems biological algorithms to understand the immunometabolic alterations can provide a holistic view of immune and metabolic pathway interactions, identifying regulatory nodes and predicting responses to perturbations. Understanding these pathways enhances the knowledge of immune regulation and offers avenues for therapeutic interventions. This review highlights the contributions of multi-omics systems biology studies in understanding infectious disease pathogenesis, focusing on RNA viruses. The integrative approach enables personalized medicine strategies, considering individual metabolic and immune variations. Leveraging these interdisciplinary approaches promises advancements in combating RNA virus infections and improving health outcomes, highlighting the transformative impact of multi-omics technologies in infectious disease research.","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":"164 ","pages":"73-100"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AID in non-Hodgkin B-cell lymphomas: The consequences of on- and off-target activity. 非霍奇金 B 细胞淋巴瘤中的 AID：靶上和靶下活性的后果

3区医学

Advances in Immunology Pub Date : 2024-01-01 Epub Date: 2024-03-31 DOI: 10.1016/bs.ai.2024.03.005

Rebecca J Leeman-Neill, Govind Bhagat, Uttiya Basu

引用次数: 0

Recent advances in immunopeptidomic-based tumor neoantigen discovery. 基于免疫肽的肿瘤新抗原发现的最新进展。

3区医学

Advances in Immunology Pub Date : 2023-01-01 Epub Date: 2023-11-03 DOI: 10.1016/bs.ai.2023.10.001

Wei Meng, Robert D Schreiber, Cheryl F Lichti

{"title":"Recent advances in immunopeptidomic-based tumor neoantigen discovery.","authors":"Wei Meng, Robert D Schreiber, Cheryl F Lichti","doi":"10.1016/bs.ai.2023.10.001","DOIUrl":"10.1016/bs.ai.2023.10.001","url":null,"abstract":"The role of aberrantly expressed proteins in tumors in driving immune-mediated control of cancer has been well documented for more than five decades. Today, we know that both aberrantly expressed normal proteins as well as mutant proteins (neoantigens) can function as tumor antigens in both humans and mice. Next-generation sequencing (NGS) and high-resolution mass spectrometry (MS) technologies have made significant advances since the early 2010s, enabling detection of rare but clinically relevant neoantigens recognized by T cells. MS profiling of tumor-specific immunopeptidomes remains the most direct method to identify mutant peptides bound to cellular MHC. However, the need for use of large numbers of cells or significant amounts of tumor tissue to achieve neoantigen detection has historically limited the application of MS. Newer, more sensitive MS technologies have recently demonstrated the capacities to detect neoantigens from fewer cells. Here, we highlight recent advancements in immunopeptidomics-based characterization of tumor-specific neoantigens. Various tumor antigen categories and neoantigen identification approaches are also discussed. Furthermore, we summarize recent reports that achieved successful tumor neoantigen detection by MS using a variety of starting materials, MS acquisition modes, and novel ion mobility devices.","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":"160 ","pages":"1-36"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138479151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How B cells drive T-cell responses: A key role for cross-presentation of antibody-targeted antigens. B细胞如何驱动t细胞反应:抗体靶向抗原交叉呈递的关键作用。

3区医学

Advances in Immunology Pub Date : 2023-01-01 Epub Date: 2023-11-18 DOI: 10.1016/bs.ai.2023.09.002

Ferry Ossendorp, Nataschja I Ho, Nadine Van Montfoort

{"title":"How B cells drive T-cell responses: A key role for cross-presentation of antibody-targeted antigens.","authors":"Ferry Ossendorp, Nataschja I Ho, Nadine Van Montfoort","doi":"10.1016/bs.ai.2023.09.002","DOIUrl":"10.1016/bs.ai.2023.09.002","url":null,"abstract":"In this review we discuss an underexposed mechanism in the adaptive immune system where B cell and T cell immunity collaborate. The main function of B cell immunity is the generation of antibodies which are well known for their high affinity and antigen-specificity. Antibodies can bind antigens in soluble form making so-called immune complexes (ICs) or can opsonize antigen-exposing cells or particles for degradation. This leads to well-known effector mechanisms complement activation, antibody-dependent cytotoxicity and phagocytosis. What is less realized is that antibodies can play an important role in the targeting of antigen to dendritic cells (DCs) and thereby can drive T cell immunity. Here we summarize the studies that described this highly efficient process of antibody-mediated antigen uptake in DCs in vitro and in vivo. Only very low doses of antigen can be captured by circulating antibodies and subsequently trapped by DCs in vivo. We studied the handling of these ICs by DCs in subcellular detail. Upon immune complex engulfment DCs can sustain MHC class I and II antigen presentation for many days. Cell biological analysis showed that this function is causally related to intracellular antigen-storage compartments which are functional endolysosomal organelles present in DCs. We speculate that this function is immunologically very important as DCs require time to migrate from the site of infection to the draining lymph nodes to activate T cells. The implications of these findings and the consequences for the immune system, immunotherapy with tumor-specific antibodies and novel vaccination strategies are discussed.","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":"160 ","pages":"37-57"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138479148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

T cells in the brain inflammation. 大脑中的T细胞发炎。

3区医学

Advances in Immunology Pub Date : 2023-01-01 DOI: 10.1016/bs.ai.2022.10.001

Akihiko Yoshimura, Masaki Ohyagi, Minako Ito

引用次数: 2

The CARD8 inflammasome in HIV infection. HIV感染中的CARD8炎性体。

3区医学

Advances in Immunology Pub Date : 2023-01-01 DOI: 10.1016/bs.ai.2022.11.001

Kolin M Clark, Priya Pal, Josh G Kim, Qiankun Wang, Liang Shan

{"title":"The CARD8 inflammasome in HIV infection.","authors":"Kolin M Clark, Priya Pal, Josh G Kim, Qiankun Wang, Liang Shan","doi":"10.1016/bs.ai.2022.11.001","DOIUrl":"https://doi.org/10.1016/bs.ai.2022.11.001","url":null,"abstract":"The biggest challenge to immune control of HIV infection is the rapid within-host viral evolution, which allows selection of viral variants that escape from T cell and antibody recognition. Thus, it is impossible to clear HIV infection without targeting \"immutable\" components of the virus. Unlike the adaptive immune system that recognizes cognate epitopes, the CARD8 inflammasome senses the essential enzymatic activity of the HIV-1 protease, which is immutable for the virus. Hence, all subtypes of HIV clinical isolates can be recognized by CARD8. In HIV-infected cells, the viral protease is expressed as a subunit of the viral Gag-Pol polyprotein and remains functionally inactive prior to viral budding. A class of anti-HIV drugs, the non-nucleoside reverse transcriptase inhibitors (NNRTIs), can promote Gag-pol dimerization and subsequent premature intracellular activation of the viral protease. NNRTI treatment triggers CARD8 inflammasome activation, which leads to pyroptosis of HIV-infected CD4+ T cells and macrophages. Targeting the CARD8 inflammasome can be a potent and broadly effective strategy for HIV eradication.","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":"157 ","pages":"59-100"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9349417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antigen receptor structure and signaling. 抗原受体结构和信号传导。

3区医学

Advances in Immunology Pub Date : 2023-01-01 DOI: 10.1016/bs.ai.2023.01.001

Fang Han, Yan Chen, Yuwei Zhu, Zhiwei Huang

引用次数: 0

RIG-I-like receptors: Molecular mechanism of activation and signaling. RIG-I 样受体：激活和信号传导的分子机制。

3区医学

Advances in Immunology Pub Date : 2023-01-01 Epub Date: 2023-05-09 DOI: 10.1016/bs.ai.2023.03.001

Jie Zheng, Wenjia Shi, Ziqun Yang, Jin Chen, Ao Qi, Yulin Yang, Ying Deng, Dongyuan Yang, Ning Song, Bin Song, Dahai Luo

引用次数: 0

Advances in structure-guided mechanisms impacting on the cGAS-STING innate immune pathway. 影响cGAS-STING先天免疫通路的结构导向机制研究进展。

3区医学

Advances in Immunology Pub Date : 2023-01-01 Epub Date: 2023-09-12 DOI: 10.1016/bs.ai.2023.08.001

Kexin Chen, Jialing Liao, Dinshaw J Patel, Wei Xie

引用次数: 0

Immunometabolism of dendritic cells in health and disease. 树突状细胞在健康和疾病中的免疫代谢。

3区医学

Advances in Immunology Pub Date : 2023-01-01 Epub Date: 2023-10-25 DOI: 10.1016/bs.ai.2023.10.002

Chuansheng Guo, Hongbo Chi

{"title":"Immunometabolism of dendritic cells in health and disease.","authors":"Chuansheng Guo, Hongbo Chi","doi":"10.1016/bs.ai.2023.10.002","DOIUrl":"10.1016/bs.ai.2023.10.002","url":null,"abstract":"Dendritic cells (DCs) are crucial mediators that bridge the innate and adaptive immune responses. Cellular rewiring of metabolism is an emerging regulator of the activation, migration, and functional specialization of DC subsets in specific microenvironments and immunological conditions. DCs undergo metabolic adaptation to exert immunogenic or tolerogenic effects in different contexts. Also, beyond their intracellular metabolic and signaling roles, metabolites and nutrients mediate the intercellular crosstalk between DCs and other cell types, and such crosstalk orchestrates DC function and immune responses. Here, we provide a comprehensive review of the metabolic regulation of DC biology in various contexts and summarize the current understanding of such regulation in directing immune homeostasis and inflammation, specifically with respect to infections, autoimmunity, tolerance, cancer, metabolic diseases, and crosstalk with gut microbes. Understanding context-specific metabolic alterations in DCs may identify mechanisms for physiological and pathological functions of DCs and yield potential opportunities for therapeutic targeting of DC metabolism in many diseases.","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":"160 ","pages":"83-116"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11086980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138479149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0