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Nanoparticles for mRNA-based cancer immunotherapy. 纳米颗粒用于基于mrna的癌症免疫治疗。
3区 医学
Advances in Immunology Pub Date : 2025-01-01 Epub Date: 2025-02-04 DOI: 10.1016/bs.ai.2024.10.012
Rakesh Pahwa, Gulshan Sharma, Rohil Panwar, Neeraj Mishra
{"title":"Nanoparticles for mRNA-based cancer immunotherapy.","authors":"Rakesh Pahwa, Gulshan Sharma, Rohil Panwar, Neeraj Mishra","doi":"10.1016/bs.ai.2024.10.012","DOIUrl":"https://doi.org/10.1016/bs.ai.2024.10.012","url":null,"abstract":"<p><p>The emergence of mRNA-based cancer immunotherapy has transformed the avenue of cancer treatment, offering an innovative strategy that leverages the body's immune system to identify and eradicate tumor cells selectively. Effective delivery of mRNA to specific organs and cells is limited by its instability, low cellular uptake efficiency, and degradation during extracellular transport and endosomal escape. Significant advancements in nanoparticle design have driven the rapid progress of mRNA-based immunotherapies. Nanocarriers have emerged as vital delivery systems, providing enhanced stability, resistance to enzymatic degradation, and efficient mRNA delivery to target cells. This chapter investigates the design, synthesis, and functionalization of different types of nanoparticles, including lipid-based, polymeric, and hybrid nanoparticles and also highlights their unique characteristics and mechanisms for mRNA delivery in cancer immunotherapy. This chapter explores cellular uptake mechanisms, strategies for endosomal escape, and the subsequent translation of mRNA into therapeutic proteins that elicit a vigorous anti-tumor immune response. Recent advances in nanoparticle-based mRNA vaccines are also explored, with an emphasis on research findings and clinical trials that reveal both their potential and challenges. The chapter aims to provide a thorough overview of nanoparticle integration in mRNA-based cancer immunotherapy and also offer insights into future developments and emerging trends in the field.</p>","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":"166 ","pages":"77-101"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent progress, challenges (stability and in vivo distribution), and opportunities of DNA & mRNA vaccine in cancer immunotherapy. DNA和mRNA疫苗在癌症免疫治疗中的最新进展、挑战（稳定性和体内分布）和机遇。
3区 医学
Advances in Immunology Pub Date : 2025-01-01 Epub Date: 2024-10-30 DOI: 10.1016/bs.ai.2024.10.008
Monika Kaushik, Prathap Madeswaraguptha, Murugesan Vanangamudi, Vijayaraj Surendran, Sumel Ashique, Anas Islam, Naheed Mojgani, Afzal Hussain
{"title":"Recent progress, challenges (stability and in vivo distribution), and opportunities of DNA & mRNA vaccine in cancer immunotherapy.","authors":"Monika Kaushik, Prathap Madeswaraguptha, Murugesan Vanangamudi, Vijayaraj Surendran, Sumel Ashique, Anas Islam, Naheed Mojgani, Afzal Hussain","doi":"10.1016/bs.ai.2024.10.008","DOIUrl":"https://doi.org/10.1016/bs.ai.2024.10.008","url":null,"abstract":"<p><p>Cancer immunotherapy recently has emerged as a revolutionary method in oncology. It takes the help of the body's immune system in fighting against tumor cells. Amongst the various approaches, DNA and mRNA vaccines are novel modalities with the potential to revolutionize cancer treatment. They represent one such approach that can result in potent immune responses against tumor-specific antigens. The few but serious translation bottlenecks at the clinical level have been related to stability, in vivo distribution, and efficient delivery systems for DNA and mRNA vaccines. It is against this salient background that this chapter takes readers through recent success stories of DNA and mRNA vaccines, right from the formulation of the vaccine to delivery mechanisms, stability, and bioavailability in cancer immunotherapy. The further challenges that are discussed in this chapter are those of effect in vivo distribution and how such challenges impact therapeutic efficacy. In addition, the new emerging technologies for in vivo distribution and opportunities for optimization of emerging vaccines to clinical use are approached, with the main focus placed on new delivery platforms. The aim of this chapter is to help understand the current landscape and future directions toward DNA and mRNA vaccines in designing more effective and personalized cancer therapies.</p>","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":"166 ","pages":"211-258"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advances in antifungal immunity. 抗真菌免疫的最新进展。
3区 医学
Advances in Immunology Pub Date : 2025-01-01 Epub Date: 2025-06-24 DOI: 10.1016/bs.ai.2025.04.003
Rebecca A Drummond
{"title":"Recent advances in antifungal immunity.","authors":"Rebecca A Drummond","doi":"10.1016/bs.ai.2025.04.003","DOIUrl":"https://doi.org/10.1016/bs.ai.2025.04.003","url":null,"abstract":"<p><p>Fungal infections are increasingly recognised as a major threat to global human health, with several million preventable deaths each year now attributable to fungal diseases. Climate change, global pandemics and increased use of antibiotics and immune-suppressing drugs in modern medicine have all contributed towards recent rises in the number of cases of life-threatening fungal infections. To circumvent these trends, it is imperative that we develop a deeper understanding of the immune responses that operate to protect against fungal invasion if we are to develop adjunctive immune-based therapies for these infections. Recent work has already demonstrated how mechanistic insights into antifungal immune responses can yield therapeutic benefits. This chapter covers the major processes, cells and receptors that are required for successful antifungal immune responses, focusing on recent developments that have driven significant new step-changes in our understanding of how these pathogens are detected and removed from the body.</p>","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":"167 ","pages":"1-41"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DNA and mRNA vaccines: Significant therapeutic approach against cancer management. DNA和mRNA疫苗：对癌症管理的重要治疗方法
3区 医学
Advances in Immunology Pub Date : 2025-01-01 Epub Date: 2024-12-10 DOI: 10.1016/bs.ai.2024.10.007
Aniruddha Sen, Vijay Singh, Sumel Ashique, Jagriti, Sombuddha Biswas, Anas Islam, Iman Ehsan, Naheed Mojgani
{"title":"DNA and mRNA vaccines: Significant therapeutic approach against cancer management.","authors":"Aniruddha Sen, Vijay Singh, Sumel Ashique, Jagriti, Sombuddha Biswas, Anas Islam, Iman Ehsan, Naheed Mojgani","doi":"10.1016/bs.ai.2024.10.007","DOIUrl":"10.1016/bs.ai.2024.10.007","url":null,"abstract":"<p><p>Cancer's complex nature and personal variety make it among the toughest cancers to conquer. Innovative treatment strategies can be achieved through new biotechnology developments. DNA and mRNA vaccinations deliver an opportunity to take a new path for cancer. The ways in which DNA and mRNA vaccinations generate immune reactions that specifically focus on cancer cells are discussed in this section. This chapter focuses on the development and creation of these vaccines. We will focus on the latest research that proves the effectiveness of these vaccines and their safety over different types of cancer. Also, we discuss the technological and biological barriers in the process of vaccine development that hinder the development of these vaccines, such as the stability of delivery methods and a patient-specific design for vaccines. DNA and mRNA vaccinations are an important therapeutic approach against cancer with genetic information. They offer an opportunity for the future to develop tailored as well as more efficient treatment options.</p>","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":"165 ","pages":"1-36"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
mRNA-based cancer vaccines: A novel approach to melanoma treatment. 基于mrna的癌症疫苗：黑色素瘤治疗的新方法
3区 医学
Advances in Immunology Pub Date : 2025-01-01 Epub Date: 2024-12-03 DOI: 10.1016/bs.ai.2024.10.010
Pranav Kumar Prabhakar, Tarun Kumar Upadhyay, Sanjeev Kumar Sahu
{"title":"mRNA-based cancer vaccines: A novel approach to melanoma treatment.","authors":"Pranav Kumar Prabhakar, Tarun Kumar Upadhyay, Sanjeev Kumar Sahu","doi":"10.1016/bs.ai.2024.10.010","DOIUrl":"10.1016/bs.ai.2024.10.010","url":null,"abstract":"<p><p>Malignant melanoma is one of the most aggressive forms of cancer and a leading cause of death from skin tumors. With the rising incidence of melanoma diagnoses, there is an urgent need to develop effective treatments. Among the most modern approaches are cancer vaccines, which aim to enhance cell-mediated immunity. Recently, mRNA-based cancer vaccines have gained significant attention due to their rapid production, low manufacturing costs, and ability to induce both humoral and cellular immune responses. These vaccines hold great potential in melanoma treatment, yet their application faces several challenges, including mRNA stabilization, delivery methods, and tumor heterogeneity. The recent success of mRNA vaccines in combating COVID-19 has renewed interest in their potential for cancer immunotherapy. In particular, mRNA cancer vaccines offer high specificity and better efficacy compared to traditional treatments. They can target tumor-specific neoantigens, prompting a robust immune response. This chapter reviews the mechanism of action of mRNA vaccines, advancements in adjuvant identification, and innovations in delivery systems such as lipid nanoparticles. It also discusses ongoing clinical trials evaluating the efficacy of mRNA-based vaccines in melanoma, highlighting promising early-phase results. Despite their potential, the development of mRNA cancer vaccines faces significant obstacles. Tumor heterogeneity, immunosuppressive tumor microenvironments, and practical issues like vaccine administration and clinical evaluation methods are major barriers to success. By addressing these challenges and advancing innovations, mRNA cancer vaccines hold promise for transforming melanoma treatment. A careful balance between the opportunities and challenges will be key to unlocking the full potential of mRNA vaccines in cancer immunotherapy.</p>","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":"165 ","pages":"117-162"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroimmunology beyond the CNS: Nerve-macrophage interactions in peripheral tissues. 中枢神经系统以外的神经免疫学：外周组织中神经-巨噬细胞的相互作用。
3区 医学
Advances in Immunology Pub Date : 2025-01-01 Epub Date: 2025-06-23 DOI: 10.1016/bs.ai.2025.04.001
Erin Watson, Elaine Emmerson
{"title":"Neuroimmunology beyond the CNS: Nerve-macrophage interactions in peripheral tissues.","authors":"Erin Watson, Elaine Emmerson","doi":"10.1016/bs.ai.2025.04.001","DOIUrl":"https://doi.org/10.1016/bs.ai.2025.04.001","url":null,"abstract":"<p><p>Macrophages are now recognised to be highly heterogeneous, with diverse ontogenies, anatomical locations and characteristics, all of which inform their function. Nerve-associated macrophage subpopulations have been found to exist across tissues, and whilst they appear to have roles in neuronal maintenance and repair, their function is still being elucidated. Although nerve-associated macrophage functions in the Central Nervous System have taken centre-stage, nerve-associated macrophages also interact with peripheral nerves and this field remains relatively understudied. This review discusses recent studies into nerve-associated macrophages across peripheral tissues. These studies identify populations of nerve-associated macrophages in many peripheral tissues, and reveal elegant neuroimmune communication pathways which coordinate functions from infection defence and anti-inflammatory actions to neuronal maintenance for homeostatic tissue function and nerve repair. We highlight nerve-associated macrophage interactions with nerves in peripheral tissues as a rapidly evolving field which could revolutionise our understanding of macrophage function in both homeostasis and disease.</p>","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":"167 ","pages":"43-89"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Revolutionizing cancer treatment: Exploring novel immunotherapeutics, checkpoints, bispecifics, and vaccines in development. 革新癌症治疗：探索新的免疫疗法、检查点、双特异性和正在开发的疫苗。
3区 医学
Advances in Immunology Pub Date : 2025-01-01 Epub Date: 2024-12-02 DOI: 10.1016/bs.ai.2024.10.005
Anas Islam, Vijay Singh, Pooja S Murkute, Sumel Ashique, Shriyansh Srivastava, Mohammad Yousuf Ansari, Sabina Yasmin
{"title":"Revolutionizing cancer treatment: Exploring novel immunotherapeutics, checkpoints, bispecifics, and vaccines in development.","authors":"Anas Islam, Vijay Singh, Pooja S Murkute, Sumel Ashique, Shriyansh Srivastava, Mohammad Yousuf Ansari, Sabina Yasmin","doi":"10.1016/bs.ai.2024.10.005","DOIUrl":"https://doi.org/10.1016/bs.ai.2024.10.005","url":null,"abstract":"<p><p>This chapter focuses on the groundbreaking advances in the treatment of cancer via the development of innovative immunotherapies, which include immune checkpoint inhibitors, bispecific antibodies, and cancer vaccines. The chapter begins with an overview of current cancer treatment paradigms and the pressing need for innovative therapeutic strategies. It then explores the principles and latest trends in immunotherapy, highlighting the mechanisms of action and key players in checkpoint blockade therapy. The discussion extends to bispecific antibodies, focusing on their unique mechanisms, developmental challenges, and current clinical applications. The chapter also explores the frontier of cancer vaccines, distinguishing between preventive and therapeutic approaches, and examining the development of personalized vaccines. Finally, the chapter provides insights into future directions in cancer treatment, offering a comprehensive perspective on the evolving landscape of immunotherapy and its potential to transform patient outcomes.</p>","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":"166 ","pages":"169-210"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unravelling the contribution of lymph node fibroblasts to vaccine responses. 揭示淋巴结成纤维细胞对疫苗反应的贡献。
3区 医学
Advances in Immunology Pub Date : 2024-01-01 Epub Date: 2024-08-12 DOI: 10.1016/bs.ai.2024.07.001
Isabella Cinti, Kassandra Vezyrgianni, Alice E Denton
{"title":"Unravelling the contribution of lymph node fibroblasts to vaccine responses.","authors":"Isabella Cinti, Kassandra Vezyrgianni, Alice E Denton","doi":"10.1016/bs.ai.2024.07.001","DOIUrl":"https://doi.org/10.1016/bs.ai.2024.07.001","url":null,"abstract":"<p><p>Vaccination is one of the most effective medical interventions, saving millions of lives and reducing the morbidity of infections across the lifespan, from infancy to older age. The generation of plasma cells and memory B cells that produce high affinity class switched antibodies is central to this protection, and these cells are the ultimate output of the germinal centre response. Optimal germinal centre responses require different immune cells to interact with one another in the right place and at the right time and this delicate cellular ballet is coordinated by a network of interconnected stromal cells. In this review we will discuss the various types of lymphoid stromal cells and how they coordinate immune cell homeostasis, the induction and maintenance of the germinal centre response, and how this is disorganised in older bodies.</p>","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":"164 ","pages":"1-37"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanisms and functions of lncRNAs linked to autoimmune disease risk alleles. 与自身免疫性疾病风险等位基因相关的 lncRNA 的机制和功能。
3区 医学
Advances in Immunology Pub Date : 2024-01-01 Epub Date: 2024-03-29 DOI: 10.1016/bs.ai.2024.03.006
Ruxiao Tian, Sankar Ghosh
{"title":"Mechanisms and functions of lncRNAs linked to autoimmune disease risk alleles.","authors":"Ruxiao Tian, Sankar Ghosh","doi":"10.1016/bs.ai.2024.03.006","DOIUrl":"10.1016/bs.ai.2024.03.006","url":null,"abstract":"<p><p>Recent advances in human genomics technologies have helped uncover genetic risk alleles for many complex autoimmune diseases. Intriguingly, over 90% of genome-wide association study (GWAS) risk alleles reside within the non-coding regions of the genome. An emerging new frontier of functional and mechanistic studies have shed light on the functional relevance of risk alleles that lie within long noncoding RNAs (lncRNAs). Here, we review the mechanisms and functional implications of five evolutionarily conserved lncRNAs that display risk allele association with highly prevalent autoimmune diseases.</p>","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":"161 ","pages":"1-15"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141066356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Innate immune sensing of macromolecule homeostasis. 先天免疫对大分子平衡的感知
3区 医学
Advances in Immunology Pub Date : 2024-01-01 Epub Date: 2024-03-30 DOI: 10.1016/bs.ai.2024.03.004
Kun Yang, Devon Jeltema, Nan Yan
{"title":"Innate immune sensing of macromolecule homeostasis.","authors":"Kun Yang, Devon Jeltema, Nan Yan","doi":"10.1016/bs.ai.2024.03.004","DOIUrl":"10.1016/bs.ai.2024.03.004","url":null,"abstract":"<p><p>The innate immune system uses a distinct set of germline-encoded pattern recognition receptors to recognize molecular patterns initially thought to be unique to microbial invaders, named pathogen-associated molecular patterns. The concept was later further developed to include similar molecular patterns originating from host cells during tissue damage, known as damage-associated molecular patterns. However, recent advances in the mechanism of monogenic inflammatory diseases have highlighted a much more expansive repertoire of cellular functions that are monitored by innate immunity. Here, we summarize several examples in which an innate immune response is triggered when homeostasis of macromolecule in the cell is disrupted in non-infectious or sterile settings. These ever-growing sensing mechanisms expand the repertoire of innate immune recognition, positioning it not only as a key player in host defense but also as a gatekeeper of cellular homeostasis. Therapeutics inspired by these advances to restore cellular homeostasis and correct the immune system could have far-reaching implications.</p>","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":"161 ","pages":"17-51"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141066387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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