TCF1 在先天性和适应性淋巴细胞中的多重作用。

3区医学 Q2 Medicine

Advances in Immunology Pub Date : 2024-01-01 Epub Date: 2024-10-22 DOI:10.1016/bs.ai.2024.10.001

Matthew McCullen, Eugene Oltz

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引用次数: 0

摘要

免疫系统需要一个由特化细胞类型组成的复杂网络来抵御一系列威胁。这些细胞类型的特定作用和命运是由一系列基因调控程序控制的，而这些程序又是通过特定品系的转录因子来协调的。T细胞因子1（TCF1）是其中许多程序的核心转录因子，指导着适应性和先天性淋巴细胞的发育和功能。这篇综述重点介绍了最近对TCF1在各种淋巴细胞亚群中的功能及其在免疫疾病和癌症转化应用中的潜力的深入研究。

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The multifaceted roles of TCF1 in innate and adaptive lymphocytes.

The immune system requires a complex network of specialized cell types to defend against a range of threats. The specific roles and destinies of these cell types are enforced by a constellation of gene regulatory programs, which are orchestrated through lineage-specifying transcription factors. T Cell Factor 1 (TCF1) is a central transcription factor in many of these programs, guiding the development and functionality of both adaptive and innate lymphoid cells. This review highlights recent insights into the function of TCF1 in a variety of lymphoid cell subsets and its potential for translational applications in immune disorders and cancer.

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来源期刊

Advances in Immunology 医学-免疫学

CiteScore

9.90

自引率

0.00%

发文量

期刊介绍： Advances in Immunology has provided students and researchers with the latest information in Immunology for over 50 years. You can continue to rely on Advances in Immunology to provide you with critical reviews that examine subjects of vital importance to the field through summary and evaluation of current knowledge and research. The articles stress fundamental concepts, but also evaluate the experimental approaches.