American Journal of Clinical Nutrition最新文献

{"title":"Maternal diet in pregnancy and the risk of inflammatory bowel disease in the offspring: a prospective cohort study","authors":"Annie Guo ,&nbsp;Anne Lise Brantsæter ,&nbsp;Tiril Cecilie Borge ,&nbsp;Elin M Hård af Segerstad ,&nbsp;Henrik Imberg ,&nbsp;Karl Mårild ,&nbsp;Ketil Størdal","doi":"10.1016/j.ajcnut.2024.10.017","DOIUrl":"10.1016/j.ajcnut.2024.10.017","url":null,"abstract":"<div><h3>Background</h3><div>Diet has been hypothesized as a risk factor for the development of inflammatory bowel disease (IBD).</div></div><div><h3>Objective</h3><div>The objective of this study was to explore associations between maternal diet diversity and quality in pregnancy and the offspring’s risk of IBD.</div></div><div><h3>Methods</h3><div>We used data from a nationwide cohort study on 85,129 Norwegian children followed from birth (1999–2009) with information on maternal diet in pregnancy from validated food frequency questionnaires. Hazard ratios (HRs) for IBD, Crohn disease (CD), and ulcerative colitis (UC) by maternal diet diversity, quality, and intake amounts of individual food groups were adjusted for maternal BMI, parental IBD, and sociodemographic factors. Sensitivity analyses were adjusted for the child’s early-life diet quality and antibiotic treatment. Dietary exposures were classified into tertiles, comparing low (reference) with medium, and high levels.</div></div><div><h3>Results</h3><div>During a mean follow-up time of 16.1 y (1,367,837 person-years of follow-up), 268 children developed IBD (CD, <em>n</em> = 119; UC, <em>n</em> = 76; IBD-unclassified, <em>n</em> = 73). High compared with low diet diversity in pregnancy was associated with a lower risk of UC in the offspring [adjusted HR (aHR) 0.46, 95% confidence interval: 0.25, 0.87], with consistent findings after further adjustment for the child’s early-life diet quality and antibiotic treatment. High compared with low diet diversity in pregnancy yielded aHRs of 0.81 for CD (0.51–1.28) and 0.75 for any IBD (0.55–1.02) in the offspring. A high compared with low diet quality in pregnancy or intakes of specific food groups were not associated with the offspring’s risk of IBD or its subtypes.</div></div><div><h3>Conclusions</h3><div>Our findings suggest that a higher maternal diet diversity in pregnancy may be associated with a lower risk of UC in the offspring.</div></div>","PeriodicalId":50813,"journal":{"name":"American Journal of Clinical Nutrition","volume":"121 1","pages":"Pages 32-39"},"PeriodicalIF":6.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11747187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142512440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intermittent compared with continuous calorie restriction for treatment of metabolic dysfunction-associated steatotic liver disease: a randomized clinical trial","authors":"Xiaoyang Sun ,&nbsp;Fan Li ,&nbsp;Hongmei Yan ,&nbsp;Xinxia Chang ,&nbsp;Xiuzhong Yao ,&nbsp;Xinyu Yang ,&nbsp;Shasha Wu ,&nbsp;Yue Suo ,&nbsp;Xiaopeng Zhu ,&nbsp;Chengyan Wang ,&nbsp;Jian Gao ,&nbsp;He Wang ,&nbsp;Yan Chen ,&nbsp;Mingfeng Xia ,&nbsp;Hua Bian ,&nbsp;Xin Gao","doi":"10.1016/j.ajcnut.2024.10.012","DOIUrl":"10.1016/j.ajcnut.2024.10.012","url":null,"abstract":"<div><h3>Background</h3><div>Calorie restriction has been demonstrated to be effective in treating metabolic dysfunction-associated steatotic liver disease (MASLD). However, it has been limited by poor long-term adherence.</div></div><div><h3>Objectives</h3><div>This study aimed to compare intermittent calorie restriction (ICR) with traditional continuous calorie restriction (CCR) for the treatment of MASLD.</div></div><div><h3>Methods</h3><div>We conducted a 12-wk, parallel-arm, randomized controlled trial that included 60 adults with MASLD and abnormal glucose metabolism. The participants were randomly assigned to either the ICR group (2 successive days of fasting [∼500 kcal/d] and 5 d of recovery per week) or the CCR group. The primary outcome was liver fat content (LFC) measured by ¹H-proton magnetic resonance spectroscopy. The secondary and exploratory outcomes included weight, body composition, glucose, insulin, lipids, and liver stiffness.</div></div><div><h3>Results</h3><div>The mean reduction in LFC was −20.5% [95% confidence interval (CI): −25.0, −15.9%] in the ICR group and −15.5% (95% CI: −20.3, −10.8%) in the CCR group. Changes in LFC were not significantly different between the 2 groups (<em>P</em> = 0.15), and were homogeneous among different liver segments. The analysis of exploratory endpoints provided clues that the ICR was associated with greater reductions in fat mass and glycosylated hemoglobin. There were no significant differences in changes of weight, lean mass, insulin resistance, triglyceride, and liver stiffness between the 2 groups. Participants showed high adherence to both the ICR and CCR schemes.</div></div><div><h3>Conclusions</h3><div>The ICR and CCR schemes had similar effects on reducing LFC, suggesting that the ICR 5:2 diet can be an effective alternative for treating MASLD with high adherence.</div></div><div><h3>Trial registration number</h3><div>This trial was registered at <span><span>clinicaltrials.gov</span><svg><path></path></svg></span> as NCT04283942.</div></div>","PeriodicalId":50813,"journal":{"name":"American Journal of Clinical Nutrition","volume":"121 1","pages":"Pages 158-166"},"PeriodicalIF":6.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142512439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"School-based nutrition education programs alone are not cost effective for preventing childhood obesity: a microsimulation study","authors":"Erica L Kenney ,&nbsp;Mary Kathryn Poole ,&nbsp;Stephanie M McCulloch ,&nbsp;Jessica L Barrett ,&nbsp;Kyla Tucker ,&nbsp;Zachary J Ward ,&nbsp;Steven L Gortmaker","doi":"10.1016/j.ajcnut.2024.11.006","DOIUrl":"10.1016/j.ajcnut.2024.11.006","url":null,"abstract":"<div><h3>Background</h3><div>Although interventions to change nutrition policies, systems, and environments (PSE) for children are generally cost effective for preventing childhood obesity, existing evidence suggests that nutrition education curricula, without accompanying PSE changes, are more commonly implemented.</div></div><div><h3>Objectives</h3><div>This study aimed to estimate the societal costs and potential for cost-effectiveness of 3 nutrition education curricula frequently implemented in United States public schools for childhood obesity prevention.</div></div><div><h3>Methods</h3><div>In 2021, we searched for nutrition education curricula in the Supplemental Nutrition Assistance Program (SNAP)-Ed Toolkit, a catalog of interventions for obesity prevention coordinated by the federal government. Standard costing methodologies estimated the societal costs from 2023 to 2032 of nationwide implementation of each identified curriculum. Using the Childhood Obesity Intervention Cost-Effectiveness Study (CHOICES) microsimulation model, which projects the costs, health care costs saved, and cases of obesity prevented for childhood obesity prevention interventions, we conducted threshold analyses for each curriculum, estimating the cost per quality-adjusted life-year for a range of hypothetical effects on child BMI to determine how large of an effect each curriculum would need to have to meet a cost-effectiveness threshold of $150,000 per quality-adjusted life-year.</div></div><div><h3>Results</h3><div>Three nutrition education curricula without PSE were identified from SNAP-Ed; none had evidence of an impact on obesity risk. From 2023 to 2032, the estimated implementation costs of the curricula nationwide ranged from $1.80 billion (95% upper interval: $1.79, $1.82 billion) to $3.48 billion (95% upper interval: $3.44, $3.51 billion). Each curriculum would have to reduce average child BMI by 0.10 kg/m² or more—an effect size that has not been reported by any of the 3 curricula, or by more comprehensive existing prevention programs—to be considered cost effective at this threshold.</div></div><div><h3>Conclusions</h3><div>SNAP-Ed–endorsed nutrition education curricula alone are unlikely to be cost effective for preventing childhood obesity. Continued efforts to implement interventions with strong evidence for effectiveness, including PSE approaches, are needed.</div></div>","PeriodicalId":50813,"journal":{"name":"American Journal of Clinical Nutrition","volume":"121 1","pages":"Pages 167-173"},"PeriodicalIF":6.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of alcohol intake with gut microbiome: a prospective study in a predominantly low-income Black/African American population","authors":"Lili Liu,&nbsp;Sang M Nguyen,&nbsp;Lei Wang,&nbsp;Jiajun Shi,&nbsp;Jirong Long,&nbsp;Qiuyin Cai,&nbsp;Martha J Shrubsole,&nbsp;Xiao-Ou Shu,&nbsp;Wei Zheng,&nbsp;Danxia Yu","doi":"10.1016/j.ajcnut.2024.11.007","DOIUrl":"10.1016/j.ajcnut.2024.11.007","url":null,"abstract":"<div><h3>Background</h3><div>Alcohol intake can alter gut microbiome, which may subsequently affect human health. However, limited population-based, prospective studies have investigated associations of habitual and recent alcohol intake with the gut microbiome, particularly among Black/African American individuals.</div></div><div><h3>Objective</h3><div>We examined the association of alcohol intake with gut microbiome in a predominantly low-income Black/African American population.</div></div><div><h3>Methods</h3><div>We investigated the dose- and type-specific associations of habitual and recent alcohol intake with the gut microbiome among 538 Black/African American adults (150 males and 388 females). Habitual and recent alcohol intakes were assessed at cohort baseline (2002–2009) and stool collection (2018–2021), respectively. Gut microbiome was profiled using shotgun metagenomic sequencing. Generalized linear models were employed to evaluate the associations between alcohol intakes and gut microbiome composition, with adjustments for sociodemographic characteristics, other lifestyle factors, and comorbidities. False discovery rate (FDR) &lt;0.1 was considered statistically significant.</div></div><div><h3>Results</h3><div>The mean age at enrollment was 53.2 ± 7.7 y, with a mean interval of 13.8 y (range: 9.0–18.1 y) between baseline and stool sample collection. Recent alcohol intake was not significantly associated with microbial taxa abundance. However, habitual alcohol intake, both total amount and types of alcoholic beverages, showed significant associations with several microbial taxa abundance, primarily in males, including species within classes <em>Clostridia, Bacilli,</em> and <em>Mahellia</em> within <em>Firmicutes</em>. Specifically, total alcohol, beer, and red wine intakes were all inversely associated with genus <em>MGYG-HGUT-02719</em> within class <em>Clostridia</em> (β = −2.26 to −0.09 per 1 drink/d increase)<em>.</em> Red wine consumption was also inversely associated with the abundance of genera <em>CAG-110</em>, <em>Oscillibacter</em>, and <em>Gemmiger</em> within class <em>Clostridia</em> (β = −3.88 to −2.69)<em>,</em> whereas positively associated with genus <em>Absiella</em> (β = 1.81) within class <em>Bacilli</em>. Most of these associations remained significant after additionally adjusting for BMI and baseline comorbidities.</div></div><div><h3>Conclusions</h3><div>We identified gut microbial taxa associated with habitual alcohol intake among Black/African American males, although the magnitudes of these associations were generally small. Further research is needed to determine if these bacteria modify alcohol-disease relationships.</div></div>","PeriodicalId":50813,"journal":{"name":"American Journal of Clinical Nutrition","volume":"121 1","pages":"Pages 134-140"},"PeriodicalIF":6.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11747185/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to DS Ludwig et al.","authors":"Kevin D Hall,&nbsp;Christina M Sciarrillo,&nbsp;Juen Guo,&nbsp;Aaron Hengist,&nbsp;Valerie L Darcey","doi":"10.1016/j.ajcnut.2024.11.005","DOIUrl":"10.1016/j.ajcnut.2024.11.005","url":null,"abstract":"","PeriodicalId":50813,"journal":{"name":"American Journal of Clinical Nutrition","volume":"121 1","pages":"Page 181"},"PeriodicalIF":6.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The fatal threat of carryover effects to the validity of crossover dietary trials","authors":"David S Ludwig ,&nbsp;Walter C Willett ,&nbsp;Mary E Putt","doi":"10.1016/j.ajcnut.2024.10.025","DOIUrl":"10.1016/j.ajcnut.2024.10.025","url":null,"abstract":"","PeriodicalId":50813,"journal":{"name":"American Journal of Clinical Nutrition","volume":"121 1","pages":"Pages 179-180"},"PeriodicalIF":6.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"10.1016/j.ajcnut.2024.12.006","DOIUrl":"10.1016/j.ajcnut.2024.12.006","url":null,"abstract":"","PeriodicalId":50813,"journal":{"name":"American Journal of Clinical Nutrition","volume":"121 1","pages":"Pages 182-188"},"PeriodicalIF":6.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143301182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between dietary fibers and gut microbiome composition in the EDIA longitudinal infant cohort","authors":"Marianne K Lalli ,&nbsp;Tuuli EI Salo ,&nbsp;Leena Hakola ,&nbsp;Mikael Knip ,&nbsp;Suvi M Virtanen ,&nbsp;Tommi Vatanen","doi":"10.1016/j.ajcnut.2024.11.011","DOIUrl":"10.1016/j.ajcnut.2024.11.011","url":null,"abstract":"<div><h3>Background</h3><div>The infant gut microbiome undergoes rapid changes in the first year of life, supporting normal development and long-term health. Although diet shapes this process, the role of fibers in complementary foods on gut microbiome maturation is poorly understood.</div></div><div><h3>Objectives</h3><div>We explored how the transition from human milk to fibers in complementary foods shapes the taxonomic and functional maturation of the gut microbiome within the first year of life.</div></div><div><h3>Methods</h3><div>We assessed the longitudinal and cross-sectional development of infant gut microbiomes (<em>N</em> = 68 infants) and metabolomes (<em>N</em> = 33 infants) using linear mixed models to uncover their associations to dietary fibers and their food sources. Fiber intakes were assessed with 3-d food records (months 3, 6, 9, and 12) relying on CODEX-compliant fiber fraction values, and questionnaires tracked the overall complementary food introduction. Bacterial species were identified and quantified via MetaPhlAn2 from metagenomic data, and metabolomic profiles were obtained using 4 LC-MS methods.</div></div><div><h3>Results</h3><div>We identified 176 complementary food fiber-bacterial species associations. First plant-based fibers associated with microbiota compositions similar to breastfeeding, and further associated with aromatic amino acid-derived metabolites, including 5-hydroxyindoleacetic acid (total dietary fiber – complementary foods (g) – β = 3.50, CI: 2.48, 4.52, <em>P</em> = 6.53 × 10^–5). Distinct fibers from different food categories showed unique associations with specific bacterial taxa. Key species, such as <em>Faecalibacterium prausnitznii</em>, associated with oat fibers (g/MJ, β = 2.18, confidence interval: 1.36, 2.84, <em>P</em> = 6.12 × 10^–6), reflective of maturing microbial communities. Fiber intake during weaning associated with shifts in metabolite profiles, including immunomodulatory metabolites, with fiber effects observed in a source- and timing-dependent manner, implicated in gradual microbiome diversification.</div></div><div><h3>Conclusions</h3><div>Introducing complementary dietary fibers during the weaning period supports gut microbiome diversification and stabilization. Even minor dietary variations shows significant associations with microbial taxa and functions from the onset of weaning, highlighting the importance of infant dietary recommendations that support the gut microbiome maturation during early life.</div><div>This trial was registered at <span><span>clinicaltrials.gov</span><svg><path></path></svg></span> as registration number NCT01735123.</div></div>","PeriodicalId":50813,"journal":{"name":"American Journal of Clinical Nutrition","volume":"121 1","pages":"Pages 83-99"},"PeriodicalIF":6.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11747200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Dietary Guidelines for Americans—is the evidence bar too low or too high?","authors":"Dariush Mozaffarian","doi":"10.1016/j.ajcnut.2024.11.013","DOIUrl":"10.1016/j.ajcnut.2024.11.013","url":null,"abstract":"","PeriodicalId":50813,"journal":{"name":"American Journal of Clinical Nutrition","volume":"121 1","pages":"Pages 3-4"},"PeriodicalIF":6.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of dietary choline intake with incidence of dementia, Alzheimer disease, and mild cognitive impairment: a large population-based prospective cohort study","authors":"Ying-ying Niu ,&nbsp;Hao-yu Yan ,&nbsp;Jian-feng Zhong ,&nbsp;Zhi-quan Diao ,&nbsp;Jing Li ,&nbsp;Cheng-ping Li ,&nbsp;Lian-hong Chen ,&nbsp;Wen-qi Huang ,&nbsp;Miao Xu ,&nbsp;Zhi-tong Xu ,&nbsp;Xiao-feng Liang ,&nbsp;Zhi-hao Li ,&nbsp;Dan Liu","doi":"10.1016/j.ajcnut.2024.11.001","DOIUrl":"10.1016/j.ajcnut.2024.11.001","url":null,"abstract":"<div><h3>Background</h3><div>Choline, an essential nutrient, plays a critical role in cognition, and may help prevent dementia and mild cognitive impairment. However, studies on dietary choline and its derivatives for preventing these conditions are limited and inconsistent.</div></div><div><h3>Objective</h3><div>The objective of this study was to explore the associations between dietary choline intake and the incidence of dementia, Alzheimer disease (AD), mild cognitive impairment (MCI), and current cognitive performance in the United Kingdom Biobank cohort.</div></div><div><h3>Methods</h3><div>Dietary choline intake was categorized into quartiles of consumption based on 24-h dietary recalls, with units expressed as milligrams per day. Diagnoses of dementia, AD, and MCI were identified using the International Classification of Diseases (ICD-9/10) codes. Current cognitive performance was assessed via the computerized touchscreen interface. After adjusting for sociodemographic factors, dietary and lifestyle behaviors, and comorbid conditions, Cox proportional hazards regression, logistic regression, and restricted cubic splines were used to analyze the association between choline intake and dementia or cognitive performance.</div></div><div><h3>Results</h3><div>Among 125,594 participants (55.8% female), with a mean age of 56.1 y (range: 40–70 years) at baseline and a median follow-up of 11.8 y, 1103 cases of dementia (including 385 AD and 87 cases of MCI) were recorded. U-shaped associations were observed between choline intake and dementia and AD. Participants in the 2nd quartile of total choline intake had lower risks than those in the lowest quartile, with HR of 0.80 (95% CI: 0.67, 0.96) for dementia and 0.76 (95% CI: 0.58, 1.00) for AD. Moderate intake of choline derivative, including free choline (HR, 0.77; 95%CI, 0.65, 0.92), phosphatidylcholine (HR 0.82; 95% CI: 0.68, 0.98), sphingomyelin (HR 0.82; 95% CI: 0.69, 0.98) and glycerophosphocholine (HR 0.83; 95% CI: 0.70, 1.00), were associated with a 17%–23% lower odds of dementia. Additionally, moderate total choline intake was associated with an 8%–13% lower odds of poor cognitive performance in visual attention (OR: 0.92; 95% CI: 0.86, 0.99), fluid intelligence (OR: 0.87; 95% CI: 0.82, 0.92), and complex processing speed (OR: 0.90; 95% CI: 0.84, 0.95).</div></div><div><h3>Conclusions</h3><div>In conclusion, our findings suggest that moderate dietary choline intake, ranging from 332.89 mg/d to 353.93 mg/d, is associated with lower odds of dementia and better cognitive performance.</div></div>","PeriodicalId":50813,"journal":{"name":"American Journal of Clinical Nutrition","volume":"121 1","pages":"Pages 5-13"},"PeriodicalIF":6.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}