{"title":"Risk of cardiovascular events in patients diagnosed with venous thromboembolism.","authors":"Frida Lonnberg, Anwar J Siddiqui","doi":"10.1016/j.amjmed.2025.08.035","DOIUrl":"10.1016/j.amjmed.2025.08.035","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular disease is a leading cause of mortality globally. Whether venous thromboembolism (VTE) increases the risk of subsequent arterial cardiovascular events (ACVE) remains unclear. We examined the risk of future ACVE in a large emergency department (ED) cohort of patients with and without VTE.</p><p><strong>Methods: </strong>This retrospective cohort study included all adults (≥18 years) presenting to five EDs in Stockholm 2016-2017. Patients diagnosed with deep vein thrombosis (DVT) or pulmonary embolism (PE) were identified; the remaining patients formed the comparison group. Individuals with prior ACVE were excluded. Fine-Gray subdistribution hazard models estimated crude and adjusted hazard ratios (HRs) for ACVE, cardiovascular death, and all-cause mortality, adjusting for age, sex, and key comorbidities. Mean follow-up was 1.2 years for ACVE and 2.1 years for mortality.</p><p><strong>Results: </strong>Among 308,779 patients, 3,610 had DVT and 2,358 had PE. ACVE occurred in 70 (1.9%) of DVT and 59 (2.5%) of PE patients, versus 4,870 (1.6%) of patients in the comparison group. Adjusted HRs for ACVE in DVT were 0.77 (95% CI, 0.47-1.25) at 30 days, 0.76 (0.58-0.99) at 1 year, and 0.74 (0.59-0.94) at full follow-up. For PE, the corresponding HRs were 0.46 (0.22-0.96), 0.87 (0.65-1.16), and 0.86 (0.67-1.12), respectively. All-cause mortality was significantly elevated in both groups: HRs for DVT and PE were 1.64 (1.48-1.82) and 2.37 (2.14-2.63), respectively.</p><p><strong>Conclusions: </strong>VTE was not associated with an increased risk of ACVE. Both DVT and PE were linked to significantly elevated all-cause mortality.</p>","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
John Dunn, Parvathi Perumareddi, Charles H Hennekens
{"title":"Prospects for clinicians to reduce cognitive decline in elderly patients.","authors":"John Dunn, Parvathi Perumareddi, Charles H Hennekens","doi":"10.1016/j.amjmed.2025.08.042","DOIUrl":"10.1016/j.amjmed.2025.08.042","url":null,"abstract":"","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maleka Khambaty, Richard E Silbert, Chris R Stephenson, Matthew A Bartlett, Dennis W Regan, Jose J Sanchez, Karna K Sundsted, Karen F Mauck
{"title":"Practice changing updates in perioperative medicine literature 2024. A systematic review.","authors":"Maleka Khambaty, Richard E Silbert, Chris R Stephenson, Matthew A Bartlett, Dennis W Regan, Jose J Sanchez, Karna K Sundsted, Karen F Mauck","doi":"10.1016/j.amjmed.2025.08.037","DOIUrl":"10.1016/j.amjmed.2025.08.037","url":null,"abstract":"<p><p>Every year, new publications advance our understanding of perioperative medicine. These publications are spread over a variety of journals that require dedicated effort to identify. To aid this task, we have undertaken a multi-database literature search from January to December of 2024. We included original research articles, systematic reviews, meta-analyses, and guidelines. We excluded abstracts, case reports, letters, or literature pertaining to cardiovascular surgery, pediatrics, and obstetrics. Two authors reviewed each reference using the Distiller SR systematic review software (Evidence Partners Inc., Ottawa, Ontario, Canada). A modified Delphi technique was used to narrow down to seven of the most impactful publications and another seven tabular summaries. The purpose of this review is to understand the strength and limitations of the new literature in order to improve perioperative outcomes for patients.</p>","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hypokalemic Periodic Paralysis Can Be Attributed to Exogenous Hyperthyroidism Only After Exclusion of All Primary and Secondary Causes","authors":"Josef Finsterer MD, PhD","doi":"10.1016/j.amjmed.2025.04.002","DOIUrl":"10.1016/j.amjmed.2025.04.002","url":null,"abstract":"","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":"138 9","pages":"Page e195"},"PeriodicalIF":5.3,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Board Certification in the US—Time for a Change?!","authors":"Don C. Rockey MD","doi":"10.1016/j.amjmed.2025.04.025","DOIUrl":"10.1016/j.amjmed.2025.04.025","url":null,"abstract":"","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":"138 9","pages":"Page e189"},"PeriodicalIF":5.3,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144908192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Citation of a Retracted Paper Related to Predatory Publishing Blacklists","authors":"Jaime A. Teixeira da Silva PhD","doi":"10.1016/j.amjmed.2025.01.032","DOIUrl":"10.1016/j.amjmed.2025.01.032","url":null,"abstract":"","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":"138 9","pages":"Page e194"},"PeriodicalIF":5.3,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gender Equity in Academic Medicine: It's Not about Closing Our Eyes, but Rather Opening Them","authors":"Sherine Salib MD, MRCP, FACP","doi":"10.1016/j.amjmed.2025.03.019","DOIUrl":"10.1016/j.amjmed.2025.03.019","url":null,"abstract":"","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":"138 9","pages":"Page e187"},"PeriodicalIF":5.3,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}