American Journal of Medicine最新文献

{"title":"Removal notice to “Cervical Cancer Prevention in Women's Health” [The American Journal of Medicine 122 (2009) S24-S31]","authors":"Katherine A. Flores MD","doi":"10.1016/j.amjmed.2025.04.032","DOIUrl":"10.1016/j.amjmed.2025.04.032","url":null,"abstract":"","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":"138 7","pages":"Page 1117"},"PeriodicalIF":2.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144270325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Removal notice to “Cervical Oncogenic Human Papillomavirus Infection: The Natural History” [The American Journal of Medicine 122 (2009) S10-S15]","authors":"Niharika Khanna MD , Raymond Lewis MD , Stacy Garrett-Ray MD, MPH, MBAb","doi":"10.1016/j.amjmed.2025.04.033","DOIUrl":"10.1016/j.amjmed.2025.04.033","url":null,"abstract":"","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":"138 7","pages":"Page 1118"},"PeriodicalIF":2.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144270326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Reply","authors":"John E. Madias MD, FACC, FAHA","doi":"10.1016/j.amjmed.2025.02.033","DOIUrl":"10.1016/j.amjmed.2025.02.033","url":null,"abstract":"","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":"138 7","pages":"Page e143"},"PeriodicalIF":2.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144270323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Klebsiella pneumoniae Invasive Syndrome.","authors":"Atif Saleem Siddiqui","doi":"10.1016/j.amjmed.2025.05.050","DOIUrl":"10.1016/j.amjmed.2025.05.050","url":null,"abstract":"","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive Decline Overshadows Lifespan Gain: Alzheimer's Disease Demands Priority Over Longevity Research.","authors":"Haoyi Zheng","doi":"10.1016/j.amjmed.2025.06.009","DOIUrl":"10.1016/j.amjmed.2025.06.009","url":null,"abstract":"","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Atypical Cause of Pulmonary Ground Glass Opacities in a Chronic Hemodialysis Patient.","authors":"Yagmur Tahillioglu, Ahmet Burak Dirim, Ayse Serra Artan, Duygu Has Simsek, Aydin Turkmen, Halil Yazici","doi":"10.1016/j.amjmed.2025.06.010","DOIUrl":"10.1016/j.amjmed.2025.06.010","url":null,"abstract":"","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macaroni Sign: Point-of-Care Ultrasound Identification of Takayasu Arteritis.","authors":"Eric Zhang, Jennifer Smiechowski, Emma E M Spence, Stefana Pancic, Irene W Y Ma","doi":"10.1016/j.amjmed.2025.06.008","DOIUrl":"10.1016/j.amjmed.2025.06.008","url":null,"abstract":"","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatitis C Virus Associated Cryoglobulinemic Vasculitis.","authors":"Benjamin Y Hsieh, Mohamed Ismail, Menna-Allah Elaskandrany","doi":"10.1016/j.amjmed.2025.05.051","DOIUrl":"10.1016/j.amjmed.2025.05.051","url":null,"abstract":"","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlates of Polypharmacy and Prescription Changes in Internal Medicine: a Prospective Five-Year Study.","authors":"Marco Vincenzo Lenti, Carmine Frenna, Alice Silvia Brera, Antonio Di Sabatino, Catherine Klersy, Gino Roberto Corazza","doi":"10.1016/j.amjmed.2025.06.012","DOIUrl":"10.1016/j.amjmed.2025.06.012","url":null,"abstract":"<p><strong>Background: </strong>Data regarding polypharmacy in the internal medicine setting remain limited. We aimed to assess the prevalence of polypharmacy, examine its associations with clinical and socioeconomic factors, and evaluate its impact on mortality.</p><p><strong>Methods: </strong>This was part of the San MAtteo Complexity (SMAC) study (2017-2025), conducted in an internal medicine service of an academic medical center. Patients were consecutively and prospectively enrolled. Polypharmacy prevalence was assessed at admission and discharge. Sociodemographic data, Cumulative Illness Rating Scale (CIRS), Edmonton Frail Scale, comorbidity, multimorbidity, Short Blessed Test, and Barthel Index were collected. Associations with polypharmacy were analyzed using logistic regression, and early and late mortality were tracked using Kaplan-Meier analysis.</p><p><strong>Results: </strong>Among 1419 patients (median age 80 years, IQR 69-86; F:M ratio 1.14:1), polypharmacy was observed in 71.5 % at admission and 82.6 % at discharge. Patients with polypharmacy were significantly older, frailer, and had lower socioeconomic status. Independent predictors included age ≥65 years (OR 4.14, 95 % CI 1.60-10.69), CIRS >3 (OR 2.67, 95 % CI 1.98-3.58), frailty (OR 3.85, 95 % CI 0.68-1.50), comorbidity (OR 8.2, 95 % CI 2.19-30.7), multimorbidity (OR 20.91, 95 % CI 5.65-77.44), and cardiovascular disorders (OR 1.84, 95 % CI 1.33-2.55). In-hospital and 4-month mortality were significantly higher among patients who were deprescribed (i.e., discharged with ≤5 fewer medications). Five-year mortality was significantly higher in patients with polypharmacy (HR 2.83, 95 % CI 2.07-3.86; P<0.001), regardless of prescription changes.</p><p><strong>Conclusions: </strong>Polypharmacy is highly prevalent in internal medicine, and both deprescribing and polypharmacy are associated with increased mortality at different timepoints, underscoring the need for targeted medication optimization strategies.</p>","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Advances in Diagnosis and Treatment of Prostate Cancer.","authors":"Edward J Goetzl, Samuel L Washington","doi":"10.1016/j.amjmed.2025.06.002","DOIUrl":"10.1016/j.amjmed.2025.06.002","url":null,"abstract":"<p><p>The incidence of metastatic prostate cancer (mPC) in the U.S. has increased in the past 20 years, five-year survival after diagnosis is only about 20 % and treatment represents a major health care expense. Comprehensive summaries of important details of diagnosis and treatment of prostate cancer (PC) have been provided by several prominent medical organizations (http://www.urologyhealth.org). The present review summarizes recent advances in diagnosis and treatment of PC, including ⁶⁸gallium-prostate-specific membrane antigen (PSMA)-11 positron emission tomography (PET) as the preferred standard for initial staging and post-treatment detection of recurrence, different forms of radiation therapy, and applications of newly approved androgen receptor signaling inhibitors. Somatic and germline genetic analyses have identified PC patients with mutations in genes involved in DNA damage repair who benefit from use of poly (ADP-ribose) polymerase (PARP) inhibitors or immune check-point inhibitors. Developing novel therapies also are described as hopeful possibilities.</p>","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}